LOCUS       NM_001107546            4928 bp    mRNA    linear   ROD 29-MAR-2024
DEFINITION  Rattus norvegicus DENN domain containing 5A (Dennd5a), mRNA.
ACCESSION   NM_001107546 XM_001073504 XM_219270
VERSION     NM_001107546.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4928)
  AUTHORS   Han,C., Alkhater,R., Froukh,T., Minassian,A.G., Galati,M.,
            Liu,R.H., Fotouhi,M., Sommerfeld,J., Alfrook,A.J., Marshall,C.,
            Walker,S., Bauer,P., Scherer,S.W., Riess,O., Buchert,R.,
            Minassian,B.A. and McPherson,P.S.
  TITLE     Epileptic Encephalopathy Caused by Mutations in the Guanine
            Nucleotide Exchange Factor DENND5A
  JOURNAL   Am J Hum Genet 99 (6), 1359-1367 (2016)
   PUBMED   27866705
REFERENCE   2  (bases 1 to 4928)
  AUTHORS   Yoshimura,S., Gerondopoulos,A., Linford,A., Rigden,D.J. and
            Barr,F.A.
  TITLE     Family-wide characterization of the DENN domain Rab GDP-GTP
            exchange factors
  JOURNAL   J Cell Biol 191 (2), 367-381 (2010)
   PUBMED   20937701
REFERENCE   3  (bases 1 to 4928)
  AUTHORS   Wassmer,T., Attar,N., Harterink,M., van Weering,J.R., Traer,C.J.,
            Oakley,J., Goud,B., Stephens,D.J., Verkade,P., Korswagen,H.C. and
            Cullen,P.J.
  TITLE     The retromer coat complex coordinates endosomal sorting and
            dynein-mediated transport, with carrier recognition by the
            trans-Golgi network
  JOURNAL   Dev Cell 17 (1), 110-122 (2009)
   PUBMED   19619496
REFERENCE   4  (bases 1 to 4928)
  AUTHORS   Recacha,R., Boulet,A., Jollivet,F., Monier,S., Houdusse,A., Goud,B.
            and Khan,A.R.
  TITLE     Structural basis for recruitment of Rab6-interacting protein 1 to
            Golgi via a RUN domain
  JOURNAL   Structure 17 (1), 21-30 (2009)
   PUBMED   19141279
REFERENCE   5  (bases 1 to 4928)
  AUTHORS   Landsman,D. and Wolffe,A.P.
  TITLE     Common sequence and structural features in the heat-shock factor
            and Ets families of DNA-binding domains
  JOURNAL   Trends Biochem Sci 20 (6), 225-226 (1995)
   PUBMED   7631419
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Apr 18, 2009 this sequence version replaced NM_001107546.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360181.2385746.1,
                                           SRR26360176.1371208.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-349               JAXUCZ010000001.1  173428578-173428926 c
            350-421             JAXUCZ010000001.1  173404611-173404682 c
            422-531             JAXUCZ010000001.1  173403812-173403921 c
            532-1189            JAXUCZ010000001.1  173402729-173403386 c
            1190-1377           JAXUCZ010000001.1  173396662-173396849 c
            1378-1695           JAXUCZ010000001.1  173390949-173391266 c
            1696-1911           JAXUCZ010000001.1  173389248-173389463 c
            1912-2146           JAXUCZ010000001.1  173388588-173388822 c
            2147-2297           JAXUCZ010000001.1  173386290-173386440 c
            2298-2391           JAXUCZ010000001.1  173385056-173385149 c
            2392-2523           JAXUCZ010000001.1  173383703-173383834 c
            2524-2676           JAXUCZ010000001.1  173379119-173379271 c
            2677-2761           JAXUCZ010000001.1  173376926-173377010 c
            2762-2846           JAXUCZ010000001.1  173374446-173374530 c
            2847-2975           JAXUCZ010000001.1  173373623-173373751 c
            2976-3097           JAXUCZ010000001.1  173369904-173370025 c
            3098-3243           JAXUCZ010000001.1  173368585-173368730 c
            3244-3362           JAXUCZ010000001.1  173367910-173368028 c
            3363-3544           JAXUCZ010000001.1  173367416-173367597 c
            3545-3627           JAXUCZ010000001.1  173366816-173366898 c
            3628-3751           JAXUCZ010000001.1  173366058-173366181 c
            3752-3920           JAXUCZ010000001.1  173365341-173365509 c
            3921-4928           JAXUCZ010000001.1  173362959-173363966 c
FEATURES             Location/Qualifiers
     source          1..4928
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q33"
     gene            1..4928
                     /gene="Dennd5a"
                     /gene_synonym="Rab6ip1"
                     /note="DENN domain containing 5A"
                     /db_xref="GeneID:308942"
                     /db_xref="RGD:1306759"
     exon            1..349
                     /gene="Dennd5a"
                     /gene_synonym="Rab6ip1"
                     /inference="alignment:Splign:2.1.0"
     CDS             241..4104
                     /gene="Dennd5a"
                     /gene_synonym="Rab6ip1"
                     /note="Rab6 interacting protein 1; DENN/MADD domain
                     containing 5A"
                     /codon_start=1
                     /product="DENN domain-containing protein 5A"
                     /protein_id="NP_001101016.2"
                     /db_xref="GeneID:308942"
                     /db_xref="RGD:1306759"
                     /translation="MSGGGGGGGSAPSRFADYFVICGLDTETGLEPDELSALCQYIQA
                     SKARDGASPFISSTTEGENFEQTPLRRTFKSKVLARYPENVDWNPFDQDAVGMLCMPK
                     GLAFKTQADPREPQFHAFIITREDGSRTFGFALTFYEEVTSKQICSAMQTLYHMHNAE
                     YDVLHAPLADGGDQSGMEDGEGIPGTKLQRFNSYDISRDTLYVSKCICLITPMSFMKA
                     CRSVLQQLHQAVTSPQPPPLPLESYIYNVLYEVPLPPPGRSLKFSGVYGPIICQRPST
                     NELPLFDFPVKEVFELLGVENVFQLFTCALLEFQILLYSQHYQRLMTVAETITALMFP
                     FQWQHVYVPILPASLLHFLDAPVPYLMGLHSNGLDDRSKLELPQEANLCFVDVDNHFI
                     ELPEDLPQFPNKLEFVQEVSEILMAFGVPPEGNLHCSESASKLKRIRASELVSDKKNG
                     NIAGSPLHSYELLKENETIARLQALVKRTGVSLEKLEVREDPSSNKDFKVQCDEEELR
                     IYQLNIQIREVFANRFTQMFADYEVFVIQPSQDKESWLSNREQMQNFDKASFLSDQPE
                     PYLPFLSRFLETQMFASFIDNKIMCHDDDDKDPVLRVFDSRVDKIRLLNVRTPTLRTS
                     MYQKCTTVDEAEKAIELRLAKIDHTAVHPHLLDMKIGQGKYEPGFFPKLQSDVLCTGP
                     ASNKWTKRNAPAQWRRKDRQKQHTEHLRLDNDQREKYIQEARNMGSTIRQPKLSNLSP
                     SVIAQTNWKFVEGLLKECRNKTKRMLVEKMGREAVELGHGEVNITGVEENTLIASLCD
                     LLERIWSHGLQVKQGKSALWSHLLHYQENRQRKLTSGSLSTSGILLDSERRKSDASAV
                     MSPLRVSLIQDMRHIQNIGEIKTDVGKARAWVRLSMEKKLLSRHLKQLLSDHELTKKL
                     YKRYAFLRCDDEKEQFLYHLLSFNAVDYFCFTNVFTTILIPYHILIVPSKKLGGSMFT
                     ANPWICISGELGETQILQIPRNVLEMTFECQNLGKLTTVQIGHDNSGLYAKWLVEYVM
                     VRNEITGHTYKFPCGRWLGKGMDDGSLERVLVGELLTSLPEVDERPCRTPPLQQSPSV
                     IRRLVTISPNNKPKLNTGQIQESIGEAVNGIVKHFHKPEKERGSLTLLLCGECGLVSA
                     LEQAFQHGFKSPRLFKNVFIWDFLEKAQTYYETLEQNDVVPEENWHTRARNFCRFVTA
                     VNNTPRNIGKDGKFQMLVCLGARDHLLHHWIALLADCPITAHMYEDVALIKDHTLVNS
                     LIRVLQTLQEFNITLDTSLVKGIDI"
     exon            350..421
                     /gene="Dennd5a"
                     /gene_synonym="Rab6ip1"
                     /inference="alignment:Splign:2.1.0"
     exon            422..531
                     /gene="Dennd5a"
                     /gene_synonym="Rab6ip1"
                     /inference="alignment:Splign:2.1.0"
     exon            532..1189
                     /gene="Dennd5a"
                     /gene_synonym="Rab6ip1"
                     /inference="alignment:Splign:2.1.0"
     exon            1190..1377
                     /gene="Dennd5a"
                     /gene_synonym="Rab6ip1"
                     /inference="alignment:Splign:2.1.0"
     exon            1378..1695
                     /gene="Dennd5a"
                     /gene_synonym="Rab6ip1"
                     /inference="alignment:Splign:2.1.0"
     exon            1696..1911
                     /gene="Dennd5a"
                     /gene_synonym="Rab6ip1"
                     /inference="alignment:Splign:2.1.0"
     exon            1912..2146
                     /gene="Dennd5a"
                     /gene_synonym="Rab6ip1"
                     /inference="alignment:Splign:2.1.0"
     exon            2147..2297
                     /gene="Dennd5a"
                     /gene_synonym="Rab6ip1"
                     /inference="alignment:Splign:2.1.0"
     exon            2298..2391
                     /gene="Dennd5a"
                     /gene_synonym="Rab6ip1"
                     /inference="alignment:Splign:2.1.0"
     exon            2392..2523
                     /gene="Dennd5a"
                     /gene_synonym="Rab6ip1"
                     /inference="alignment:Splign:2.1.0"
     exon            2524..2676
                     /gene="Dennd5a"
                     /gene_synonym="Rab6ip1"
                     /inference="alignment:Splign:2.1.0"
     exon            2677..2761
                     /gene="Dennd5a"
                     /gene_synonym="Rab6ip1"
                     /inference="alignment:Splign:2.1.0"
     exon            2762..2846
                     /gene="Dennd5a"
                     /gene_synonym="Rab6ip1"
                     /inference="alignment:Splign:2.1.0"
     exon            2847..2975
                     /gene="Dennd5a"
                     /gene_synonym="Rab6ip1"
                     /inference="alignment:Splign:2.1.0"
     exon            2976..3097
                     /gene="Dennd5a"
                     /gene_synonym="Rab6ip1"
                     /inference="alignment:Splign:2.1.0"
     exon            3098..3243
                     /gene="Dennd5a"
                     /gene_synonym="Rab6ip1"
                     /inference="alignment:Splign:2.1.0"
     exon            3244..3362
                     /gene="Dennd5a"
                     /gene_synonym="Rab6ip1"
                     /inference="alignment:Splign:2.1.0"
     exon            3363..3544
                     /gene="Dennd5a"
                     /gene_synonym="Rab6ip1"
                     /inference="alignment:Splign:2.1.0"
     exon            3545..3627
                     /gene="Dennd5a"
                     /gene_synonym="Rab6ip1"
                     /inference="alignment:Splign:2.1.0"
     exon            3628..3751
                     /gene="Dennd5a"
                     /gene_synonym="Rab6ip1"
                     /inference="alignment:Splign:2.1.0"
     exon            3752..3920
                     /gene="Dennd5a"
                     /gene_synonym="Rab6ip1"
                     /inference="alignment:Splign:2.1.0"
     exon            3921..4928
                     /gene="Dennd5a"
                     /gene_synonym="Rab6ip1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccgcccttcc tctagcttgc tccggctgcg gtgcttagga cagcgtccag gatgcggcgc
       61 ggggtggcct ggcgcccccc tgccccagca cggcagcggc ggccgctagg acccggcgag
      121 gcccgggggc agcggccgga gcctcggtag cggcggcgga gggagcggcg gctgagggcg
      181 agcgggcggc cgggggcggg ggctcggctc cgcgcggctc gccccgctcg gcccggcgcc
      241 atgagcggcg gcggcggcgg agggggctcg gcccccagtc gcttcgccga ctattttgtc
      301 atctgcgggc tggacaccga gaccgggttg gagccggacg agctgtcggc attatgccag
      361 tacattcagg cttctaaagc cagggatggt gccagccctt tcatttcaag tacgactgaa
      421 ggagaaaatt ttgagcagac gccattgaga cgaacattca agtctaaggt ccttgcccga
      481 taccctgaga atgtagactg gaatccgttt gaccaggatg cagtgggaat gctgtgcatg
      541 cccaaagggc tggcattcaa gacccaggct gatcccaggg agccacagtt ccatgccttt
      601 attatcacaa gggaggatgg ctctcggaca tttgggtttg cccttacctt ttatgaagaa
      661 gttaccagca agcagatctg cagtgcaatg cagaccctct accacatgca caacgctgag
      721 tatgatgtcc ttcatgctcc acttgctgat ggtggagacc agagtggcat ggaagacggt
      781 gaaggcattc ctgggaccaa gctgcagcgc ttcaactcct atgacattag cagggacaca
      841 ctctatgttt ctaaatgcat ctgtctcatc acacccatgt ctttcatgaa ggcatgtcgg
      901 agtgtgctgc agcagctcca ccaggcagtc acgtcacctc agccccctcc tctgcccctc
      961 gagagctaca tatacaatgt actctatgag gtgccacttc cacctcctgg ccgctccctg
     1021 aagttttctg gggtctatgg gccaataatc tgccagagac caagtaccaa tgagcttcct
     1081 ctatttgatt tccctgtcaa agaggtcttt gaactgcttg gggtggagaa tgtgtttcag
     1141 ctttttactt gtgcccttct ggagtttcaa atactgctct actcacagca ttaccagaga
     1201 ctgatgaccg tggcggagac aattacagct ctgatgtttc ctttccaatg gcagcatgtc
     1261 tatgtcccca ttctcccagc ttctctcctg catttcttag acgctcctgt tccgtacctg
     1321 atggggttgc actccaacgg cttggatgac cgctcaaagt tggagctgcc tcaggaggct
     1381 aacctctgct ttgtggatgt tgacaaccac ttcattgagt tgccagagga cttgcctcaa
     1441 tttcctaaca aactggagtt tgtccaggag gtctctgaga tcctcatggc cttcggcgtt
     1501 ccccctgaag ggaacctcca ctgcagcgaa agtgcttcga agctgaagag gatccgagcc
     1561 tccgagcttg tgtctgacaa gaagaacggg aacattgcgg gctccccttt gcattcctat
     1621 gagctcctca aggaaaatga aacgatcgct cggttgcaag ctttggtcaa gaggactgga
     1681 gtgagtttgg aaaaactgga agttcgtgaa gatcccagta gcaataaaga tttcaaagtt
     1741 cagtgtgatg aagaagaact caggatttac cagctaaaca ttcagatccg ggaagttttt
     1801 gccaatcgct ttacccagat gtttgctgat tatgaagtgt ttgtcatcca gcccagccag
     1861 gataaggagt cctggctcag caacagggag cagatgcaga actttgataa agcgtccttt
     1921 ctgtcagatc agcctgagcc ctacctgccc ttcctctcaa gattcctaga gacccagatg
     1981 tttgcatctt ttattgacaa caagatcatg tgtcacgatg atgacgataa agaccctgtc
     2041 ctccgggtct ttgactcaag ggtagacaag atcagactgt tgaatgttcg aacacctact
     2101 cttaggacat ccatgtacca gaaatgtacc actgtggatg aagcagaaaa agcaattgag
     2161 ctacgtctgg caaaaattga ccacactgca gttcaccctc atcttcttga catgaaaatt
     2221 ggacaaggaa aatatgaacc tggctttttc cctaagctac aatcagatgt actttgcacc
     2281 gggccagcca gcaacaagtg gacaaaaagg aatgcccctg cccagtggag gcggaaagac
     2341 cggcagaagc agcacacgga acacttgcgc ttagacaatg accagaggga gaagtacatc
     2401 caggaagcca ggaatatggg cagtaccatc cgtcagccca aactgtccaa cctgtctccc
     2461 tcggtcattg cccagaccaa ctggaagttt gtagaaggcc tgctgaagga atgccgaaac
     2521 aagaccaaga ggatgctggt agagaagatg ggtcgagagg cagtggagct ggggcatggg
     2581 gaagtgaaca tcaccggtgt ggaagagaat actttgattg ccagcctctg tgaccttctg
     2641 gaaaggatct ggagccacgg gctacaagta aaacagggga agtcagcttt gtggtctcat
     2701 ttgttacatt atcaggaaaa ccggcagaga aaactcacat caggaagcct cagtacctca
     2761 ggaatacttc ttgattcaga acggagaaag tctgacgcca gtgctgtcat gtctcccctg
     2821 agggtctcct taatccagga tatgaggcac attcagaata ttggggaaat caagactgat
     2881 gtgggaaagg ccagagcatg ggtgcgactg tccatggaga agaagctact ctccagacat
     2941 ctgaagcagc ttctttcaga ccatgagctc accaagaagc tgtacaagcg ttatgccttc
     3001 ctgcgctgcg atgacgagaa ggagcagttc ctctatcacc tgctctcctt caacgcagtg
     3061 gactacttct gcttcaccaa tgtcttcaca accatcctga tcccatacca cattttgatt
     3121 gtaccaagca agaagctggg gggctccatg ttcaccgcca atccatggat ctgtatatca
     3181 ggagaactgg gtgaaacaca gatcctgcag atccccagga atgtgctaga gatgactttt
     3241 gagtgccaga acctggggaa gctcacaact gtccagattg gccacgataa ttctgggctg
     3301 tatgccaaat ggcttgtgga atatgtgatg gtcaggaatg agatcacagg acatacctac
     3361 aagtttccat gtggccgatg gctgggcaag ggtatggatg atggaagcct ggagcgtgtg
     3421 cttgttgggg agctgctcac gtccctaccc gaggtagacg agaggccttg tcggactcca
     3481 ccactgcagc agtcccccag cgtcatccgg agacttgtga ccatctcacc caacaataag
     3541 cccaagctga acacagggca gatccaggaa tccatcgggg aggcggtcaa tggcattgtg
     3601 aagcacttcc ataaacctga gaaagagcgt ggcagtctga cgctgttgct ttgtggagag
     3661 tgtggtctcg tttcagcact ggagcaagct ttccagcatg gatttaaatc accccggctc
     3721 ttcaaaaatg tcttcatttg ggacttcctg gagaaagcac aaacctatta tgagacgtta
     3781 gagcagaatg atgtagtccc agaggaaaac tggcacacac gggcccgcaa cttctgccga
     3841 tttgtcaccg cagtcaacaa cacgcctcgg aacatcggca aggacggcaa atttcagatg
     3901 ctggtgtgcc tgggagccag agatcacctc ctgcaccact ggatagcctt gctggccgac
     3961 tgtcccatca ctgcacacat gtatgaggat gtggcactga tcaaggacca cacgctcgtc
     4021 aattctttga tccgagtgct gcagaccctg caagaattca acatcacact ggacacctcc
     4081 cttgtgaagg gcattgacat ctgagctccc ggccccagcc agcagcaaga cccaggagga
     4141 cgccccacag ctcggcctcc tcatcccaga gggacccaag caggccgtga gggacagaga
     4201 ggatgtgtat actcactgta aaaagaaaac tagaggattt ttggaaaaaa taatctattt
     4261 tagagtttat ttgcttcctg ctttttacac actttcatgt gagagagaca ggagagggcg
     4321 aggctggtgc tgcttgtttt gaagctggtg cctcccttgc acggccgcac gctgggagcc
     4381 tgtggcctcc caggctgagc ctgcacacac gtcacatcga tgaggccatt ccacatcgtt
     4441 tttaactaat gttttctata ttaacattat tctggctctc tggctttcac gggccatgca
     4501 caggtgtgcg agtgggagat cccatgctca aagggatttt tagcagtgcc tgtgatcaag
     4561 cactgcggag tcagccccac atccgtttcc cccttcccct tttttgtcag tattatttgg
     4621 gaaggagata tgccaggaca atgtcatcgt gctaccgtca tgcagaaaat catgtttcct
     4681 gttggcacaa cgttgcgcag aagtaaacat gagcatgttg taaccagttt gtcccgtctt
     4741 catctatctt atttatttaa cctgccagtg tgtgtctaag tatttgtttt gttttctttt
     4801 ttcctcttta agaaaaggaa aagcttgtca caatctaact ggctatgtta ttactgttaa
     4861 atttatgttg ttttgcaact tagaaaccag ctacagtatg gcccacttaa taaaacacct
     4921 gagacaaa
//
