LOCUS       XM_039111087            7889 bp    mRNA    linear   ROD 11-JUN-2023
DEFINITION  PREDICTED: Rattus norvegicus DENN domain containing 4C (Dennd4c),
            transcript variant X1, mRNA.
ACCESSION   XM_039111087
VERSION     XM_039111087.1
DBLINK      BioProject: PRJNA677964
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_051340.1) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            [WARNING] On Feb 3, 2024 this sequence was replaced by
            NM_001427785.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_015227675.2-RS_2023_06
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.1
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 06/06/2023
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..7889
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN/NHsdMcwi"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /sex="male"
                     /tissue_type="kidney"
                     /geo_loc_name="USA: Wisconsin, Milwaukee, Medical College
                     of Wisconsin"
                     /collection_date="2019-03-08"
                     /collected_by="Rebecca Schilling"
     gene            1..7889
                     /gene="Dennd4c"
                     /note="DENN domain containing 4C; Derived by automated
                     computational analysis using gene prediction method:
                     Gnomon. Supporting evidence includes similarity to: 40
                     ESTs, 1 long SRA read, 10 Proteins, and 100% coverage of
                     the annotated genomic feature by RNAseq alignments,
                     including 131 samples with support for all annotated
                     introns"
                     /db_xref="GeneID:313340"
                     /db_xref="RGD:1308489"
     CDS             388..6243
                     /gene="Dennd4c"
                     /codon_start=1
                     /product="DENN domain-containing protein 4C isoform X1"
                     /protein_id="XP_038967015.1"
                     /db_xref="GeneID:313340"
                     /db_xref="RGD:1308489"
                     /translation="MIEDKGPRVTDYFVVAGLTDTSTLLDQEINRIDTNKSIGPKAPI
                     TDIAVIIKSAGETVPEGYTCVEATPSALQANLNYGSLKSPELFLCYRRGRDKPPLTDI
                     GVLYEGKERLIPGCEVIQATPYGRCANVNNSSTTSQRIFITYRRAPPVRSQNSLAVTD
                     ICVIITSKGETPPHTFCKVDKNLNCGMWGSNVFLCYKKSVPASNAIAYKAGLIFRYPE
                     EDYESFPLSESVPLFCLPMGATIECWDPQTKYPLPVFSTFVLTGSSAEKVYGAAIQFY
                     EPYSRDLLTEKQLSQLGLLTPVERKVVSKPINSNKCICLLSHWPFFEAFKKFLMFIYK
                     VSVSGPHPLPIEKHISHFMQNIPFPSPQRPRILVQLSVHDALILSQPVSTPLPLSGAN
                     FSSLLMNLGPENCATLLLLVLLESKILLHSLRPAVLTGVAEAVVAMIFPFQWQCPYIP
                     LCPLSLAGVLSAPLPFIVGVDSRYFDLHDPPQDVVCIDLDTNTLYVADEKKNTNWKQL
                     PKKPCKSLLGTLRKLYLQLCSVHRKPQESSAIEMTPIEADFSWQKKMTQLEMEIQETF
                     LRFMASVLKGYRSYLRPITEAPSNKATAADSLFDRQGFLKSRDRAYTKFYTLLSKTQI
                     FIRFIEECSFVSDKDTGLAFFDDCIEKLFPDKGVEKTDKVDLDSAEDTKLIELDDSQK
                     SEHTVFITPPEPPPDDGSDLSPQYSYTYFPRLDLKLFDSPQEPKLRFSRHPPGSGITN
                     SPALMAKRTKQEIKTAHKLAKRCYTNPPQWAKYLFSHCYSLWFICLPAYVRVSHPKVR
                     ALQQAHDVLVKMRKTDVDPLDEVCYRVVMQLCGLWVHPVLAVRVLFEMKTARIKPNAI
                     TYGYYNKVVLESPWPSSTRSGIFLWTKVRNVVHGLAQFRQPLKKTGQKSQVFSISAPQ
                     NAACGSDGDTVSHGSVDSSNDANNGEHTVFVKDLISLDSIDNHSSTGGQSDQGYGSKD
                     ELVKEDADIHASEEHMPQELTATELHIEEESDLSTIVPKHSQPTPEPQSPTEPPAWGS
                     SIVKVPSGLFDTNNRTSSTGSSSNALFSTQAPVEDAVFGEATNFKKSGDRGEKRQKHF
                     PERSCSFSSESRAGMLLKKSSLDLNSSEMAIMMGADAKILTAALTCPKTSPLHVARTH
                     SFENVNCHLADNRTRVSEGIWDSEHRSSPVLEMLEESQELLEPVVGDTVAETAVEMSF
                     NNVQSNSNSNQSRDTKAGSQDTVNKRSSSYTTGKAIEREDVETGLDPLSLLATECVEK
                     TSDSEDKLFSPVISRNLADEIESYMNLKSPLGSKSSSMELHGEGNQEPGSPALFTHPL
                     ERRSSLPSAQDSTEIEKSPPAVSRSKTLTGRFKPQTPYRTYKDRSTSLSALVRSSPNS
                     SLGSVVNSLSGLKLDNILSGPKIDVLKSSMKQAATVASKMWVAVASAYSYSDDEEEPN
                     KDYSFPAGLEDHHILGESLSPTTSISGLVPSELTQSSTSLGSSSSSGDVGKSQCPTGE
                     VPFSRNIKGQDFEKSDHGSSQNTSMSSIYQNCAMEVLMSSCSQCRACGALVYDEEIMA
                     GWTADDSNLNTTCPFCKSNFLPLLNVEFKDLRGSASFFLKPSTSGDSLQSGSIPSANE
                     PLEHKPVSSSAEPDLISFMDYSKHSETITEEASYTVESSDEIKKTSDVQSVKMSSVPN
                     SLSKRNVSLTRSHSVGGPLQNIDVSQRPFHGISTVSLPNSLQEDVDHLGKRPNPPPVS
                     VPYLSPLVLRKELESLLENEGDQVIHTSSFINQHPIIFWNLVWYFRRLDLPSNLPGLI
                     LTSEHCNEGVQLPLSSLSQDSKLVYIQLLWDNINLHQEPGEPLYVSWRNLNSEKKLSL
                     LSEEQQAASALVETIRQSIQQNDVLKPINLLSQQMKPDTKRQRSLYREILFLSLVSLG
                     RENIDIEAFDNEYGLAYRSLSSEILEKLQKIDAPPSISVEWCRKCFGAPLI"
ORIGIN      
        1 ccgcccccgc agaaggaaag ggagagggac agagggaggg aaagtggtgt tctgtggaaa
       61 ggggcggaag gagtggaaag caaaagagaa aaggaaacag aaacatggcg gtctgtagtc
      121 gggacagtct cgccgcgggc agcgcctaga cctccgtcct cccgcagcac tcgcggcccg
      181 cgagcccctc ggtcggcagt tgctctcgct gcaggctgtg tccctggaga gccggccgcg
      241 ctgaggcgca ggcgcagagg ggccaccgga gtcccggccc tgccagcgag ggtgtccagg
      301 ccgcgtagcc ggcgctttct tgcctcagga agctacggtg tcggctcggt caccgactgg
      361 gcgggcgcag gaaatagaac agccatcatg atagaagaca aaggaccaag agtgacagac
      421 tactttgttg tggcaggtct cactgataca tccactcttt tggatcaaga aataaatcgt
      481 atagatacaa ataaatcaat tggccctaaa gctccaatca cagacattgc tgttattatc
      541 aaatcagctg gggaaactgt acctgaaggt tacacctgtg ttgaagccac tccatcagca
      601 ctccaagcaa acttgaatta tggaagtcta aaaagcccag agcttttcct gtgttatagg
      661 agggggagag ataaaccacc cctgacagat attggagtgc tatatgaagg gaaagaaagg
      721 cttattccag gatgtgaagt gatccaagcc acgccatatg gccgctgtgc caatgtcaac
      781 aatagttcaa ctacttctca gagaatcttt atcacctatc gaagggctcc tccagtgcgg
      841 tcccagaatt ccttggctgt aactgatatc tgtgttatta taaccagtaa aggagaaacc
      901 cctcctcata ctttctgcaa agttgataaa aacttaaact gtggcatgtg gggttccaat
      961 gtgtttctgt gttacaagaa gtctgttcct gcttcaaatg caatagcata caaggctggt
     1021 ttgatttttc gatatccgga agaagactat gagtcttttc cgctctcaga atctgtgcct
     1081 ctcttctgcc ttcctatggg agccactatt gaatgctggg atcctcaaac caaatatcca
     1141 cttccggttt tctcaacatt tgtcctgaca ggttcttcag ctgaaaaggt atatggagct
     1201 gccatccagt tttatgagcc ttactctcgg gaccttctca cagagaaaca actgtcacag
     1261 ctgggcctgc tgacccccgt ggagagaaaa gtggtctcta agcccatcaa ttcaaacaag
     1321 tgcatttgtt tgctttcaca ctggcctttt tttgaagctt ttaagaaatt tcttatgttt
     1381 atttacaaag tctctgtgtc tggaccacat cctcttccca ttgaaaagca catttcacat
     1441 tttatgcaaa acatcccttt tccttcgcca caaagaccaa gaatccttgt acagctatcc
     1501 gtccacgatg ccttaatatt atcacaacca gtttccacac ctttgccgtt aagtggagcc
     1561 aactttagtt ccttgctgat gaatctgggt cctgagaatt gtgcaacatt gctgctgctg
     1621 gttttacttg agagtaagat tctgctacat tctcttaggc cagctgtact gactggggta
     1681 gccgaagctg ttgttgctat gatctttcca tttcagtggc agtgcccata tatccctctt
     1741 tgtcctcttt cattggctgg agtgcttagt gcacctttac catttatagt tggagtggac
     1801 tcaaggtact ttgatcttca tgacccacca caagatgttg tttgcattga cttggatacg
     1861 aacacgttat atgtagcgga tgaaaaaaag aacacaaact ggaagcagct tcccaaaaag
     1921 ccgtgcaaga gtctgcttgg caccctgagg aagctgtatc tccagctctg ctcagttcac
     1981 cgaaaacctc aggaaagttc agcaattgag atgactccaa ttgaagcaga tttctcttgg
     2041 caaaaaaaga tgacacaact tgagatggaa attcaagaga catttttgcg atttatggca
     2101 tctgttttaa aaggatacag gtcatatctc agaccaatca cagaagctcc ctccaataaa
     2161 gccacagctg cagactcact gtttgaccga cagggttttt tgaaaagtcg ggatcgtgcc
     2221 tatacaaaat tttatacact tttatccaaa acacagattt ttattcgttt cattgaagaa
     2281 tgcagttttg taagtgataa agatactgga ttagcatttt ttgatgattg cattgagaag
     2341 ttgtttccag ataaaggtgt agagaaaaca gacaaggttg atttggattc agcagaagac
     2401 accaaattga tagagctaga cgactcacag aaaagcgagc acactgtatt tataacgccc
     2461 cctgagcccc ctccagatga cgggagtgac ctgtcacctc agtacagtta cacatacttt
     2521 ccaagattgg atcttaagct ttttgacagc ccacaggagc cgaaattgcg cttcagtaga
     2581 catcctcctg ggagtggcat tacaaatagc cctgccctca tggctaaaag aactaaacag
     2641 gagataaaaa cagctcataa gttggcgaag agatgttata caaatccacc acaatgggcc
     2701 aagtatctat tcagccattg ttacagtttg tggtttattt gtctcccagc ctatgttaga
     2761 gtttctcacc ctaaggtccg agcactccag caggcacatg atgtgcttgt taagatgagg
     2821 aagacagacg tggatccact agatgaggtg tgctatcgag tggtaatgca gctttgtgga
     2881 ctttgggttc atcctgtctt agcagtgaga gtcttgttcg aaatgaaaac tgctagaata
     2941 aaaccaaatg ctattactta tggctattat aataaggtag ttttggagag cccatggccc
     3001 agcagcactc gcagtggtat tttcttgtgg acgaaagtac ggaatgtcgt acatggtttg
     3061 gcccaattta gacaaccact taaaaagact gggcaaaaat cacaggtctt ttcaatatca
     3121 gctcctcaga atgctgcatg tggaagtgat ggggacacag tgagccatgg tagtgtggat
     3181 agttctaacg atgctaacaa tggggagcac acagtcttcg tcaaagactt aatcagcctt
     3241 gattccattg ataatcactc tagcacaggc ggtcagtctg accagggcta tggctcgaag
     3301 gatgagctcg taaaggagga tgcagacatc cacgcatcgg aagagcacat gccacaggaa
     3361 ctgacagcca cagaactgca cattgaagag gagtctgacc tatctaccat tgtcccaaaa
     3421 cactcgcaac ctactccaga acctcagagt cctactgagc ctcctgcatg gggcagcagt
     3481 attgtgaaag tcccatccgg gttatttgat accaacaata ggacaagtag tactggtagt
     3541 tcttcaaatg cgctattttc tactcaagct ccagtcgagg atgcagtctt cggtgaggct
     3601 actaatttca agaagagtgg tgatagagga gaaaaaagac agaagcattt tccagagagg
     3661 agctgtagct ttagttctga aagtcgagcg gggatgctgc ttaagaagag cagtttggat
     3721 ctcaattcca gtgaaatggc catcatgatg ggagctgatg ccaagatcct cacagcagca
     3781 ctgacatgtc ctaagacttc tccgcttcac gtcgcaagaa ctcatagctt cgagaacgtt
     3841 aactgtcatc tagctgacaa taggactcgt gtgtccgaag gcatctggga ttctgagcat
     3901 agatcatctc ctgtgctaga gatgctggag gaaagccagg agctcctgga acctgtggtt
     3961 ggtgatactg tggcagagac tgcagtagag atgtcattta acaatgtaca aagtaacagt
     4021 aacagtaacc agtccagaga cacaaaagca ggatcccaag atacagtgaa taagaggagc
     4081 agttcctata ctactgggaa agccattgag agggaagatg ttgaaactgg actagatcct
     4141 ttgtctcttt tagccactga atgtgtagaa aaaacttctg attccgaaga taagttattt
     4201 tctccagtaa tttcacgtaa tctggctgat gaaattgaaa gttacatgaa cctaaagagt
     4261 ccgctaggta gtaaatcttc tagtatggaa ttgcatggag aggggaacca agaacctggc
     4321 tctcctgctt tgtttactca ccctttagaa aggagatcga gtctaccttc agcacaagac
     4381 agtactgaga ttgagaagag cccccctgca gtgtccaggt ctaaaacgct gactgggcgt
     4441 ttcaagccac agactcctta ccgcacttac aaagaccggt ccacttcctt atctgcatta
     4501 gtccgttctt caccaaacag ctctctgggt tctgtagtaa attctctatc agggctaaag
     4561 ttggacaata tactctcagg gcccaagata gatgtcctaa aatctagtat gaaacaagca
     4621 gcaacagtag ccagtaagat gtgggtggct gtagcgtctg cctacagcta ctcagatgat
     4681 gaggaagaac ctaataaaga ttatagtttc ccagctggcc tagaagatca tcatatactg
     4741 ggggagagtc tgtcgcctac tacaagtatc tcagggttgg ttcccagtga acttacccag
     4801 agcagcacca gcctcggcag tagtagcagc agtggagatg ttgggaaatc gcagtgtcca
     4861 acaggtgaag ttccattttc aagaaatatc aaagggcagg actttgaaaa atcagaccat
     4921 ggttcttctc agaataccag tatgtctagc atctatcaaa attgtgcgat ggaggttttg
     4981 atgtcaagtt gctcgcagtg tagagcttgt ggagctctgg tttacgatga agaaatcatg
     5041 gctgggtgga cagcagatga ctcaaatttg aatacaacct gcccattctg taaaagcaac
     5101 ttcttgcctc ttctcaatgt agagtttaaa gacctgagag gctctgccag ctttttcttg
     5161 aaaccaagta catctggtga cagtttacaa agtggcagca ttccatctgc aaatgagccc
     5221 ttggaacaca aacctgtgtc cagttcagca gaacctgact tgatcagctt tatggactat
     5281 tcgaaacaca gcgagaccat aacagaagaa gcaagttata cagtcgaatc gagtgatgaa
     5341 ataaagaaaa ccagtgatgt ccagagtgtg aaaatgtcct ctgtgcctaa tagtttatct
     5401 aaacgaaatg tatctttgac tcgaagtcat agtgttggag gtcctctgca aaatattgac
     5461 gtctcccagc gaccatttca tggcatttca acagttagtc ttccaaatag tctacaggaa
     5521 gatgtggatc atctaggaaa gcggcccaat cctcctcctg tgtctgtgcc ctatttgagt
     5581 cctctggtgc ttcggaagga actggaatct ttgctagaaa atgaagggga tcaggttatt
     5641 catacatcct cgtttatcaa tcaacaccca atcattttct ggaacctggt ttggtatttc
     5701 agacgtttgg accttcctag caacttgcca ggacttattc tcacctctga acactgtaat
     5761 gaaggtgtgc agcttcctct atcatctttg tcccaggaca gcaaactggt atatatacaa
     5821 ctgctatggg ataatatcaa ccttcatcag gagccaggag agcctctgta tgtctcttgg
     5881 aggaacttga attctgagaa gaagctgtcc cttctgtcag aggagcagca ggcagccagc
     5941 gcgttagtgg agacgatccg gcagagtatt cagcagaatg atgttctgaa gcccatcaac
     6001 ctgctttccc agcaaatgaa gccagacacc aaaagacaaa ggagtttata cagagaaatc
     6061 cttttcttat cattagtgtc tcttgggaga gaaaacattg atattgaggc ttttgacaat
     6121 gaatatggac tcgcatatag aagtctgtct tcagagattc ttgaaaagtt acagaaaatc
     6181 gatgccccac ccagtatcag tgtggagtgg tgcaggaagt gttttggagc acctctcatt
     6241 taaataagat tcattcaaat tttggtagag tattggggaa atagacctgt cgggaaactg
     6301 ttcttcccaa atcataactt ggtgaaagct gaggatgaaa tacaaatgaa ctgtatttca
     6361 tactgaatct ctcagaatgt aaaacaccac tcagttcccc aaggcttatt gatgttggag
     6421 attcctgacc tatttccctg cctctgctga aaacgcatag tatgtgtaaa aaaaaaaatg
     6481 aaattttcat ctttctatat aatttgcttt tattgaaact gtccagctag ggaatggcaa
     6541 atcaaatttg cctaaccgaa agacatgcta tatttcactt acaagagtag ctgtgtatga
     6601 ttgtatgtgt gaggctatgt agtcaattta tgtgtatgtg tgtctattta ttacaatact
     6661 gaggttgcat gttgcagcag ttttctgaag gaggcctcgt tgccccgtca gtgactacta
     6721 cacttgtttg tagtcagcag ttccaaaaac atttaggtct ttcttaacaa ctgccttccc
     6781 tgtgacatat ctttgccttt taaattatgt actatcttgc ttaataggtt atatcttaga
     6841 tatccaggtg ctcctttcca tcttcttcca atactaagtt aatctgcaat gctttcattg
     6901 gaatccaata ggtaaaatga aattaatttt tgttacctaa caaaattatc cagaacatgt
     6961 tttaaaatgc taatgaatag tctttgaccc caaaatcctt attcaggcag gccacttgtt
     7021 ggtgttgttt acttttttat aatcctggtt tcatgggaga cagaggcagg aggatctcaa
     7081 gttcaaggcc agcctgaaca acctttagtg agccctgtct caaaaacttg aaaggagatc
     7141 taggaatgta gctcactagt agagcacttg cctagcatac atgaggttct aggttcagtt
     7201 cctagtacca caaaataagt aagtaagtaa ataaatacat agataaaacc tgtgggatgg
     7261 agaatttgca ctgcacataa aagttttatt cttgtacaat attttgattt atatgcttgt
     7321 gaataaaagt gtgtatttgt aaatactgtt tttttaggtt gaatcaatta agtctaaaaa
     7381 ctttaaagct tattgagctc attggcaggt ttaaggaaat catgacctca catgccccac
     7441 cttgacataa attgtgcttt ttgttaaaac atccatttaa gaacagcaag tttgccttag
     7501 ctgtctgtgt ggtttagaaa accagtggct atgtgtgcac ttataataat agtgcagatg
     7561 actaaaccgg ttgacagact tacctcaaca tggtacacgc taatagcatg aatctcttca
     7621 atgtggtggg aactttttaa aattatgtac caacatttca atgttaacat taaaagttgt
     7681 taatctgact ttgcagattc tagtctgaat ttgagtgtta aaagttttat cagagttttg
     7741 taaaggcttt cttacattta aattggatct tttacagttt caaatatata tattttttac
     7801 agcttatacc ttaacattta ttgacccaac aaattttgaa attatcttac atatataaaa
     7861 ttaaagttga ataaaaagaa aaacctcaa
//
