LOCUS       XM_008761248            6145 bp    mRNA    linear   ROD 11-JUN-2023
DEFINITION  PREDICTED: Rattus norvegicus DENN domain containing 4B (Dennd4b),
            transcript variant X1, mRNA.
ACCESSION   XM_008761248
VERSION     XM_008761248.3
DBLINK      BioProject: PRJNA677964
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_051337.1) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            [WARNING] On Feb 22, 2024 this sequence was replaced by
            XM_008761248.4.
            
            On Jan 21, 2021 this sequence version replaced XM_008761248.2.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_015227675.2-RS_2023_06
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.1
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 06/06/2023
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..6145
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN/NHsdMcwi"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /sex="male"
                     /tissue_type="kidney"
                     /geo_loc_name="USA: Wisconsin, Milwaukee, Medical College
                     of Wisconsin"
                     /collection_date="2019-03-08"
                     /collected_by="Rebecca Schilling"
     gene            1..6145
                     /gene="Dennd4b"
                     /note="DENN domain containing 4B; Derived by automated
                     computational analysis using gene prediction method:
                     Gnomon. Supporting evidence includes similarity to: 1
                     mRNA, 35 ESTs, 9 Proteins, and 100% coverage of the
                     annotated genomic feature by RNAseq alignments, including
                     169 samples with support for all annotated introns"
                     /db_xref="GeneID:361987"
                     /db_xref="RGD:1560320"
     CDS             853..5400
                     /gene="Dennd4b"
                     /codon_start=1
                     /product="DENN domain-containing protein 4B isoform X1"
                     /protein_id="XP_008759470.1"
                     /db_xref="GeneID:361987"
                     /db_xref="RGD:1560320"
                     /translation="MEADAVSEGGAMAEERPPRLVDYFVVAGLAGNGAPIPEETWVPE
                     PTGPLRPPRPAEPITDVAVIARALGEEVPQGYTCIQTSAGGHPLELSAGLLGGTQPVI
                     CYRRGRDKPPLVELGVLYDGKERPKPGFQVLDTTPYSHSANLAPPGPGHPRTYLMYRR
                     AAEGAGLHALGITDLCLVLPSKGESTPHTYCRLPRNLNPGMWGPAVFLCYKVGLAKAN
                     TLVYEAELLGRYPEEDNEAFPLPESVPVFCLPMGATIECWPAQTKYPVPVFSTFVLTG
                     AAGDKVYGAALQFYEAFPRARLSERQARALGLLSAVERGRALGGRAVRSRRAIAVLSR
                     WPAFPAFRAFLTFLYRYSVSGPHRLPLEAHISHFIHNVPFPSPQRPRILVQMSPYDNL
                     LLCQPVSSPLPLSGASFLQLLQNLGPELAITLLLAVLTEHKLLVHSLRPDLLTSVCEA
                     LVSMIFPLHWQCPYIPLCPLVLADVLSAPVPFIVGIHSSYFDLHDPPADVICVDLDTN
                     TLFQTEEKKPLSARTLPRRPYKLLLATLTNLYQQLDQTYTGPEEEASLEFLLTDYEAV
                     CGRRTRLEREVQGAFLRFMACLLKGYRNFLRPLTQAPSEGSRDVENLFYLQGFLKSRE
                     RSSHKLYSQLLHTQMFSQFIEECSFGSTRHAALEFFDSCVDKVHPEQEKPEPTPLVEL
                     EELSGSELTVFITPPEEPPVLEGSESTPQYCYDGFPELKAELFESPQEQQGALPVPGP
                     SRSAPSSPAPRRTKQEMKVAQRVAQKSATVPELWARCLLGHCYGLWFLCLPAYVRSAP
                     SRVRALHTAYHVLREMESRKVVLPDEVCYRVLMQLCSNYGQPVLSVRVMLEMRRAGIV
                     PNTITYGYYNKAVLESKWPSGTPGGRLRWAKLRNVVWGAAQFRQPLKDRRRLQQEQQE
                     QQQQQQQQQQQVAEQQKSGSSQTEPCLERPSPTRPLQRQTTWAGRSLREPSSPIGRLV
                     KSGSLGSARGAQPTVEAGVAHMIEALGVLEPRGSPVPWQDGSLSDLSLTGEELAPGSS
                     PGGSGSALSAQSTEALEGISGRGSKTSGCQEEAGTPRKGLGARLQQLLTPSRRSSASR
                     ISVPELPPDLPPAARRSPMDSLLWPRERPGSTASEVSSASLGSEWDISESSLSSLSLR
                     RSSERLSDTPGAFQPPSLEILMSSCSLCHACDSLVYDEEIMAGWAPDDSNLNTTCPFC
                     ACPFVPLLSVQTLDSRPSAPSPKSALAGAGGCKDAPVPGGPGPVLSDRRLCLALDEPQ
                     LCNGHMGSASRRVENGAWAYLSPLVLRKELESLVENEGIEVLALPELPAAHPIIFWNL
                     LWYFQRLRLPSILPGLVLASCNGPPPSQLSQGPSSWLTPDPASVHVRLLWDVLIPDPN
                     SCPPLYVLWRVHSQIPQRVVWPGPVPSCLSLALLESVLRHFGLNEVHKAVGLLLETLG
                     PPPTGLHLQRGIYREILFLTMAALGKDHVDIVAFDKKYKSAFNKLASSMGKEELRQRR
                     AQMPSPKAIDCRKCFGAPLEC"
ORIGIN      
        1 gctgccgtca cgtcctcggc agtccctgcg cgcgcttctc tcggccctcc ggcctcttgc
       61 tcagccacct cccccgcgcc gcgccctctg ccctaacccc gacttcccgt cattcagcat
      121 gtgggcgttg ggacccaaag tggctttagt gccgttgttt tcccccaagg gagaaggggc
      181 tgcattctat aagactcttc cctggctgga taagggaagg cctggatact taagtcgtgt
      241 tgatccgggc tcacccactt gcctatagag agggtctcac ctaacggctt ttgcctactg
      301 tcttgggtca cagaactact attggcctgc agtggaatag agagtgagct gtgtcctgga
      361 gttaaatcag gaggctgacg cggactcctg gcttcacctc tcagatgtgg agaagctcaa
      421 gctaaattta gcttgagttg gggcatgtgt gtccagaggc caggttaaaa agacaggcgg
      481 cttggctcta gttctctgag gaagagtggg aggttaaata gactgtgcat tctggagaca
      541 ttggaagctt ccctgccttg cacgggatcc ttagtgtgag tgaggtctgc cttggtctga
      601 gactgtgctg gcaccttcaa cagtactgct cccaaggccc ccagcggtac cgctcaccca
      661 taggctgact tgtgctgaac tagctacagc ttccccttcg cagacagccg tttcaggaag
      721 taacctccct tcccctctga agcactctct cagcctctag ccccttgcta gccacccacc
      781 acgcttcttc ccaccttcag cactctgggg cacctcagga ctcttggggc ttccactccc
      841 cgggggcagg ccatggaggc agatgcagtg agtgaagggg gggccatggc agaggagcgg
      901 cctccccggt tggtggatta cttcgtggtg gctgggcttg caggaaatgg agcacctata
      961 cctgaggaga cgtgggttcc tgagcctact gggcccctgc gccctccccg gccagctgaa
     1021 cctatcacag atgtggcagt catcgctagg gcactgggcg aagaggtgcc ccagggctat
     1081 acatgcattc agacttctgc tggtggtcac cccttggagc tcagtgctgg gctcctgggt
     1141 ggaactcaac cagtcatctg ctaccgcagg gggcgtgaca agccccccct tgttgagctg
     1201 ggggtattat atgacgggaa agaacgacct aagcctgggt tccaagtgct tgacacgacg
     1261 ccatatagcc actcagccaa cctggcccct ccaggccctg ggcacccccg cacctacctc
     1321 atgtaccggc gtgcagcaga aggggcaggt ctgcatgccc tgggcatcac tgacctctgc
     1381 ctggttctgc ccagcaaggg tgagagcact cctcatactt actgccggtt accccgcaac
     1441 ctcaaccctg gcatgtgggg cccagcagtg ttcctgtgct acaaggtggg cctggcgaag
     1501 gccaacacac tggtgtatga ggcagagctg ctaggccgct acccagagga agacaatgag
     1561 gcgtttccgc tgcctgagtc agtgccagtc ttctgcctgc ccatgggagc cactatcgag
     1621 tgctggcctg cccagaccaa gtacccagta cccgtctttt ccacctttgt gctcacggga
     1681 gctgctggtg ataaggtgta tggtgccgcg ttgcagttct atgaagcgtt cccgagggcc
     1741 aggctgtcag agaggcaggc acgggcactg ggcctcctga gtgccgtgga acggggacgg
     1801 gccctgggag gccgagcagt gcgcagtcgg agagccattg ctgtgctgtc ccgctggccc
     1861 gccttcccgg ccttccgagc cttcctcacc ttcctttacc gctactccgt ctcaggcccc
     1921 catcgtctgc ccctggaagc gcacatctcc cacttcattc acaacgtccc gttcccttcc
     1981 ccacagagac cacgcatcct agtgcagatg tctccctatg acaacctgct cctctgtcaa
     2041 cctgtctcct cacccctgcc cctgagtggt gctagctttt tacagctgct gcagaacctg
     2101 ggcccagaat tggctattac attgctgctg gctgtgctca cagagcacaa actgctggtc
     2161 cactctctgc ggccagatct gcttaccagt gtctgcgagg cccttgtctc aatgattttc
     2221 cctctgcact ggcagtgccc ctacattccg ctgtgcccgc tagtgctggc ggatgtgctg
     2281 agtgcccctg tgcccttcat tgtgggtatc cactccagtt atttcgatct gcatgaccca
     2341 cctgctgacg tcatctgtgt tgatcttgac accaacacgc tctttcaaac ggaggaaaag
     2401 aagcccctct ctgctaggac cctgccccga agaccttaca agcttctgct ggccacactg
     2461 acgaatctgt accagcagct ggaccagact tacactggac cagaggaaga ggcctccctg
     2521 gaattcctgc tgacagacta tgaggcagtg tgtggccgca ggactcgcct agaacgggaa
     2581 gtccagggag ccttcctgcg cttcatggcc tgtctgctca aaggctaccg gaacttcctt
     2641 cgacctctca cccaggcccc ctctgagggg tctcgagatg ttgagaacct tttctacctt
     2701 cagggtttcc ttaagtcccg ggaacgctcc agtcacaagc tgtactctca gctcctacac
     2761 acgcagatgt tctcccagtt catcgaggaa tgctctttcg gctctacccg gcatgcagcc
     2821 ctggaattct ttgactcttg tgttgacaag gttcacccag agcaggagaa gcctgagcca
     2881 acacccttag tggagctgga ggaactatcg ggaagtgagc tcactgtctt tatcacaccc
     2941 ccagaggaac cgccagtact ggaaggcagt gaatctactc ctcagtactg ttatgatggg
     3001 tttccagagc tgaaggctga gctatttgag tctcctcagg aacaacaggg ggcactccct
     3061 gtgccaggcc catcccgtag tgcccccagc agtcctgcac ctcgccgtac caaacaggag
     3121 atgaaggttg cacagcgcgt ggcacagaag tcagccactg tacctgagct gtgggcccgg
     3181 tgcctgctgg gtcactgcta tggactgtgg ttcttatgcc tacctgccta tgtgcgttct
     3241 gcaccttccc gggtgcgagc attacacaca gcctaccatg tattacgtga gatggagagc
     3301 cgcaaggtgg tgctccctga tgaggtctgt taccgggtac tgatgcagct ctgctcaaac
     3361 tatgggcaac ccgtgttgtc tgtgcgagtc atgctggaga tgcgacgggc aggcattgtg
     3421 cccaacacca tcacctatgg ctactacaac aaggctgtgc tggaaagcaa atggccatct
     3481 ggtactccgg gtggacgcct acgctgggcc aagctccgga atgttgtctg gggggcggct
     3541 cagttccgcc agcccttaaa ggaccgaagg cggctgcagc aggagcagca ggagcagcag
     3601 cagcagcagc agcagcagca gcaacaggtg gccgagcagc aaaagtcggg cagctctcag
     3661 acagagccct gtctggagcg tccttcccca acccgccctc ttcagcgcca gactacttgg
     3721 gctggacgca gtctacggga gccatcttca cccatcgggc gcctggtcaa gagcggcagc
     3781 ctaggcagcg cccgcggggc acagcccact gtggaggctg gcgtggctca catgatagag
     3841 gccttggggg tccttgaacc ccgtggatca cctgtgcctt ggcaggatgg aagtctctca
     3901 gacctgagtc tgacagggga agaactggca cctggaagca gcccaggggg ctcaggctca
     3961 gccctgagtg cccagtccac tgaggcccta gaagggatca gtgggcgggg ttccaaaact
     4021 agtggatgtc aggaggaggc gggcaccccc agaaaagggc tgggtgcccg cctccaacag
     4081 ctgcttaccc cttcccgccg ctcctctgct tcccggatct ccgtacctga gttgccccct
     4141 gacctgcctc ctgcggctcg ccggagtccc atggatagcc ttctgtggcc ccgagaacgc
     4201 cctggatcca ctgcttctga ggtaagttct gcttctctgg gcagtgagtg ggatatctca
     4261 gagtcttctc tcagcagcct gagtcttcga cgttcctcag agcgtctcag cgacacccct
     4321 ggagctttcc aaccaccctc cctagaaatt ctgatgtcta gctgctccct gtgccatgcc
     4381 tgtgattccc tggtgtatga tgaggaaatc atggccggct gggcaccgga tgactctaac
     4441 ctcaatacga cttgtccctt ctgcgcctgt cccttcgtgc ccctgcttag tgtccagact
     4501 cttgattctc gacccagtgc gcctagtcca aagtctgccc ttgctggtgc cggtggctgc
     4561 aaagatgctc ctgtccctgg gggtcctggc cctgtgctca gtgaccggag gctgtgcctt
     4621 gccctggatg agccccagct ctgcaatggg catatgggga gtgcttcccg gcgagttgag
     4681 aatggggcat gggcgtacct cagccctctg gtgctgcgta aagaactaga gtccctggta
     4741 gagaatgagg gcatcgaggt gttggcgttg cctgaactgc ctgctgccca ccctatcatc
     4801 ttctggaacc tcctgtggta tttccaacgg ctacgcctgc ctagtattct gccaggcctg
     4861 gtgttggcct cctgtaatgg gccgccaccc agccagctct cccagggacc atcttcatgg
     4921 ctcacccctg atccagcttc tgtgcatgtg cgtctgctgt gggacgtcct gatccctgac
     4981 cccaatagct gcccgcctct ctacgtgctc tggagggtcc acagccagat cccacagcgg
     5041 gtggtgtggc caggtccagt accctcctgt cttagcttgg cattactgga gtcagtgctg
     5101 cgccatttcg gactcaacga ggttcataaa gctgttggac ttctgttgga gactctaggg
     5161 ccccctccca ctggcctgca cctgcagagg ggaatctacc gtgagatctt attcctgacg
     5221 atggctgctc tgggcaagga ccacgtggat atagtggcct tcgacaagaa gtacaagtct
     5281 gcctttaaca agctggccag cagcatgggc aaggaagagc tgaggcagcg gcgggcacag
     5341 atgccttccc ccaaagccat cgactgccga aagtgttttg gagcacctct ggaatgctag
     5401 ggacccttaa gcccctctct ccagccttgg gtggagaggc gaggaagagt ggattctaga
     5461 catagcctga ctccttgttc ccttcacaga ggaagtggga gtaggctgtt cagccatagg
     5521 ttccaagtgg gagtagcagg aagagggagg gactcaccag tacctgaagt cacaattccc
     5581 ctgtcttagc ctgccctgtt tgtccaagct cgtgtgggga agagctaggg aggttggcac
     5641 aactccgtct ttctccatcc cattccaggg gctcctctcc agggtatcct cagatctgca
     5701 gtgccctggt agacttagaa gtttttgttt taaaaaacaa ttggaaagat tcagagctcc
     5761 tgagcctttg ccctgaatgg aagggaggaa cttcattccc cactcttctt ccctgactgc
     5821 taaaggagcc caaggcaatc ttagcgttgt attttattta gctatttatt ctgaggccac
     5881 agctcctata cttatgagag tctcaaggag tatggtaaag agaaggaaat tagatttgga
     5941 gcaccttgag agccatgcac tgggacccag aggagtccca agcttccctt aggaagaact
     6001 ggtgcctctt ctagtcccga tccttcttgt ccactccgcc ttgggaaatg cctctcctat
     6061 ccatggcctt gacctgtgca ataaggattg ttctctgcaa agttttgttg gatgtaaata
     6121 tagtaaaagc tgcttctgtc ttttt
//
