LOCUS       XM_008766393            8524 bp    mRNA    linear   ROD 11-JUN-2023
DEFINITION  PREDICTED: Rattus norvegicus DENN domain containing 4A (Dennd4a),
            transcript variant X4, mRNA.
ACCESSION   XM_008766393
VERSION     XM_008766393.3
DBLINK      BioProject: PRJNA677964
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_051343.1) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            [WARNING] On Jan 24, 2024 this sequence was replaced by
            NM_001427439.1.
            
            On Jan 21, 2021 this sequence version replaced XM_008766393.2.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_015227675.2-RS_2023_06
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.1
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 06/06/2023
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..8524
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN/NHsdMcwi"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /sex="male"
                     /tissue_type="kidney"
                     /geo_loc_name="USA: Wisconsin, Milwaukee, Medical College
                     of Wisconsin"
                     /collection_date="2019-03-08"
                     /collected_by="Rebecca Schilling"
     gene            1..8524
                     /gene="Dennd4a"
                     /note="DENN domain containing 4A; Derived by automated
                     computational analysis using gene prediction method:
                     Gnomon. Supporting evidence includes similarity to: 1
                     mRNA, 30 ESTs, 4 Proteins, and 100% coverage of the
                     annotated genomic feature by RNAseq alignments, including
                     173 samples with support for all annotated introns"
                     /db_xref="GeneID:315756"
                     /db_xref="RGD:1562639"
     CDS             362..5983
                     /gene="Dennd4a"
                     /codon_start=1
                     /product="C-myc promoter-binding protein isoform X1"
                     /protein_id="XP_008764615.1"
                     /db_xref="GeneID:315756"
                     /db_xref="RGD:1562639"
                     /translation="MIEDKGPRVADYFVVAGLTDISKPLEEEIHFNDACHKVARPKEP
                     ITDVSVIIKSLGEEVPQDYVCIDVTPTGLSADLNNGSLVGPQIYLCYKRGRDKPPLTD
                     LGVLYDWKERLKQGCEIIQSTPYGRPANISGSTSSQRIYITYRRASENTTQNTLAVTD
                     ICIIIPSKGESPPHTFCKVDKNLNNSMWGSAVYLCYKKSVAKTNTISYKAGLICRYPQ
                     EDYESFSLPESVPLFCLPMGATIECWPPDSKYPLPVFSTFVLTGASAEKVYGAAIQFY
                     EPYSEENLTEKQRLLLGLTSLVDGKSDGSRTIHTNKCICLLSHWPFFDAFRKFLTFLY
                     RYSISGPHALPIEKHISHFMHKVPFPSPQRPRILVQLSPHDNLILSQPVSSPLPLSGG
                     KFSTLLQNLGPENAVTLLVFAVTEHKILIHSLRPSVLTSVTEALVSMIFPFHWPCPYV
                     PLCPLALADVLSAPCPFIVGIDSRYFDLYDPPPDVSCVDLDTNTISQTGDKKNVAWKI
                     LPKKPCKNLMNTLHNLHQQLAKLQQRPRDDGLMDLAMNDYDFNSGKRLHMIDLEIQEA
                     FLFFMASILKGYRSYLRPITEAPSETATDATSLFALQAFLRSRDRSHQKFYNMMTKTQ
                     MFIRFIEECSFVSDKDASLAFFDDCVDKVDTDKSGEVRLIELDASFKSEHTVFVTPPE
                     IPQLPNGEEPPLQYSYNGFPVLRNNLFERPEGFLQARKNKLPSKPSSPGSPSPMFRRT
                     KQEIKSAHKIAKRYSSIPQMWSRCLLRHCYGLWFICLPAYVKVCHSKVRALKTAYDVL
                     KKMQLKKMDPPDEVCYRILMQLCGQYDQPVLAVRVLFEMQKAGIDPNAITYGYYNKAV
                     LESTWPSRSRSGYFLWTKIRNVVLGVAQFKRALKKHPHLPQTALSGGRSDLGYSSLCK
                     DDVRREATSTEDIQGEKDKKGSDSSSLSENESAKGSADCLPSLSYQSSSTIVRLSGTN
                     QDGADKMSGECEESTPELLLVPSCNDTNEAQTMPSRCFRKRHKSDDESHLQQQMPWGN
                     RNRNLSGGVLMRFMLNRINQETNPGDMVEKLGADAKILSNVISKSTRPNSLDIGKPPV
                     RSKRDSLEKESSDDDTPFDASNCLDKVESPVIFDLEDLDTETDGSKVGCVAAQNPKRL
                     QRMNSSFSVKPSEKTDVVTGFDPLSLLVAETEQQQKVEEEDDEDDNKSISTPSARRNL
                     AEEIEMYMNNMSSPLTSRTPSIDLQRASDEKLTNKKSPTLVKACRRSSLPPNSPRPVR
                     LTKSKSYTKSEERPRDRLWSSPAFSPTCPFREGSQETLAHSSPSFNLDTLLVPKLDVL
                     RHSVFTAGKGVAEKASKWYSRFAMYTTSSKDQSSDRTSLSSVGAQDSESTSLTDEDVC
                     HELEGATSSQESSAASGTKGIDASRASLGSSASLEGSLSKFALPGKTETASSLNTSNT
                     NIFQNYAMEVLISSCSRCRTCDCLVHDEEIMAGWTADDSNLNTTCPFCGNLFLPFLNV
                     EIRDLRRPGRYFLKSSSSTETMHFASSFSSRTRQSCISASASGLDTSSLSVQGNLDLN
                     NKSKLQENPCARSIQIPAHRSKTVVSKCPLFPMARSISTCGPLDKDEPGGQKLIPTGS
                     LPATLQGPTDSLGLEWHLPSPDPVTVPYLSPLVVWKELESLLENEGDHAITVADFVDH
                     HPIVFWNLVWYFRRLDLPSNLPGLILSSEHCNKYSKIPRHCMSEDSKYVLIQMLWDNM
                     KLHQDPGQPLYILWNAHSQNRTLLFETQKYPMVHLLQKSDNSFNQELLKSMVKSIKMN
                     DVYGPMSQILETLSKCPHFKRQRSLYREILFLSLVALGRENIDIDAFDKEYKMAYDRL
                     TPSQVKSTHNCDRPPSTGVMECRKTFGEPYL"
ORIGIN      
        1 cgggccggga gatgagctaa gctggctgca agcgccgcgg cattcagccc cctcgtgtcc
       61 cgcccgccgc gcgtgagtgg ataggatccc gcatctcggg ctcttcccgg tgcttgcgcg
      121 ggggccggcg gggagtattt ctcaaatcct aaggcccaaa gaactcacac actaggaact
      181 cttttctcca accgaagctt cagtaatgta ggcagtctgt ctgggtagca catgcttgcc
      241 tactttgacc taatggagtg agataagaaa tcgaaagcgt ctggattggt cagagattga
      301 aaggagagca acaaaccaat ctccattagt tgctgaatgg atataaactc tgtgatggga
      361 gatgattgaa gacaaggggc ctcgtgttgc tgactacttt gttgtagcag gcttaactga
      421 catttcaaag cctcttgaag aggaaattca cttcaacgat gcctgtcaca aagtggcaag
      481 accaaaagaa cccatcacag atgtttctgt tatcatcaaa tcccttgggg aggaggtgcc
      541 tcaggactat gtgtgtattg acgtaacccc aactgggttg tcggcagatc ttaataatgg
      601 aagtcttgtg ggaccccaga tttatctttg ctataagaga gggagagata agcctccact
      661 tactgatctg ggggtattat atgactggaa agaaagattg aagcagggct gtgagattat
      721 tcagagcacc ccctatggcc gacctgccaa tattagcggc agcacctcat cacaaagaat
      781 ctacatcacc taccgaagag cctctgagaa caccactcag aacactctgg ccgtcacaga
      841 catatgcatt attataccca gtaaagggga gagcccacca cacactttct gcaaggtcga
      901 caagaatctc aacaacagta tgtggggatc tgcagtgtat ttatgctata aaaagtcagt
      961 ggcaaagact aacactatat cttacaaagc aggtctaatt tgcagatatc ctcaagaaga
     1021 ttatgagtcg ttctcactgc cagaatctgt tcccctcttt tgtttaccaa tgggggcaac
     1081 tattgaatgc tggccaccag atagcaaata ccctcttcct gtgttctcta catttgtgtt
     1141 aactggagcc tcagctgaaa aggtttatgg tgctgctatt caattttatg aaccatactc
     1201 cgaggagaac cttacagaaa aacagagact tcttttgggt ttaacgtctc tggtagatgg
     1261 aaagtctgat ggttctagaa cgattcacac taacaaatgc atttgtctgc tttcccactg
     1321 gccttttttt gatgcattca gaaaatttct gacttttctg tatcgttatt ccatctctgg
     1381 acctcatgcc cttccaattg agaagcatat ttcccatttt atgcataaag ttccctttcc
     1441 gtcccctcag aggccacgga ttttagttca gttatcccca catgataatt tgattctcag
     1501 tcagcctgtt tcttcacctc ttccattaag tggtgggaag ttttcaacac tactccagaa
     1561 tcttggccct gagaacgctg ttacactgct ggtgtttgct gtaacagaac ataaaatcct
     1621 tatccattcc cttcgaccct ccgtgctcac cagtgtgacg gaagcattag tgtccatgat
     1681 tttccctttc cactggccct gcccatatgt tcctctctgc ccattggctc tcgcagatgt
     1741 cctcagtgca ccatgtccat tcatagtagg cattgattca agatactttg atctttatga
     1801 ccctccacca gatgtcagtt gtgtcgactt agataccaac accatttctc aaactggtga
     1861 caaaaagaat gtagcttgga agattcttcc gaagaagccg tgtaagaatc tgatgaacac
     1921 actgcataat ttgcaccagc agttggcaaa actgcagcag agaccaagag atgatggact
     1981 aatggactta gcaatgaatg actatgattt taattccgga aagaggttgc acatgataga
     2041 tctggaaatc caggaggcat tcttgttttt catggcctct attttaaaag gttatagatc
     2101 atacttaagg ccaataacag aagccccatc tgagacagcg acagatgcaa cctcgctgtt
     2161 tgcccttcaa gctttcttaa gaagccggga tcgatcacat caaaaattct ataacatgat
     2221 gaccaaaaca caaatgttta ttcgcttcat tgaggaatgt tcttttgtca gcgataaaga
     2281 tgcaagcctg gccttttttg atgactgtgt ggataaagtg gatacggaca agagtggtga
     2341 agttcgactt atagaactgg atgcgtcttt caaaagtgaa catactgtct ttgtgacacc
     2401 acccgagatc ccccagctgc ccaacgggga agaaccacca ttgcagtaca gctataatgg
     2461 attcccagtt ctcaggaaca atttatttga gaggcctgaa ggatttctac aagcgagaaa
     2521 gaacaaacta ccgtcaaaac caagcagtcc tggcagtcct tctcccatgt tcagaagaac
     2581 aaagcaggaa atcaaatcag cccataagat tgcaaagagg tattcctcta tccctcagat
     2641 gtggtcgcgg tgtctgctcc gtcactgtta tggattgtgg tttatttgtc tcccagctta
     2701 tgtgaaggtt tgtcattcca aagtcagggc tctgaaaaca gcgtatgatg tacttaagaa
     2761 aatgcagctg aagaagatgg atccacctga tgaggtatgc taccgcattc tcatgcagct
     2821 ctgtggacag tacgaccagc ctgtgcttgc agttcgagtg ctttttgaaa tgcagaaagc
     2881 tggtattgac cccaatgcaa tcacttatgg gtactacaat aaggctgttt tggaaagtac
     2941 atggccttca agaagtcgta gtggctattt cctctggaca aaaataagaa atgttgtttt
     3001 aggagttgca cagttcaaaa gagctttaaa gaaacatcca cacttaccac agacagcgct
     3061 ctcaggtggc cggtctgatc ttggatatag ttcattatgt aaagacgatg ttagaagaga
     3121 ggctacatct actgaagaca ttcaagggga aaaggataaa aaagggagcg actctagttc
     3181 cttgtcagag aatgagagtg caaaaggaag tgctgactgc cttccttctc tcagttacca
     3241 gagttcttcc actatagttc gcctcagtgg tacaaatcag gacggtgctg ataaaatgtc
     3301 tggagaatgt gaggaaagca ctcctgagct gctcttagtg ccatcttgta atgacacaaa
     3361 tgaagcacaa accatgccaa gcagatgctt taggaaaagg cataaaagtg atgatgaatc
     3421 tcatttgcag cagcaaatgc cttggggaaa caggaaccgt aatcttagtg gtggggtact
     3481 gatgagattt atgctgaaca gaattaacca ggaaacaaac cctggagata tggttgaaaa
     3541 gttaggcgct gatgcaaaga ttctttcaaa tgttatctca aaaagcacaa gaccaaatag
     3601 tcttgatatt ggaaagccac cagtaagatc aaaaagagac agcctggaga aggagtctag
     3661 tgacgatgac acacctttcg atgcttctaa ctgcttggat aaagtggagt ctcctgttat
     3721 ttttgactta gaagatttag acacagaaac agatggttca aaagtgggat gtgtcgctgc
     3781 acaaaatccc aagaggcttc agcgaatgaa cagcagcttt tcagttaaac cgtctgaaaa
     3841 aacagatgtt gtaacaggat ttgaccctct ctcgctcttg gttgctgaga ctgagcagca
     3901 gcagaaagta gaagaggaag acgatgaaga cgacaacaag agcatctcaa cgccatctgc
     3961 caggcgtaat ttagctgaag aaattgagat gtacatgaat aacatgagca gtcctttgac
     4021 aagccgtaca ccaagcattg atttacagcg agcatctgat gagaagttaa ccaataagaa
     4081 aagtccaaca ttggtcaagg cctgcagaag atcaagcctg cctcctaatt ctcctaggcc
     4141 agtgagactt accaaatcca aaagttacac caaaagtgag gagagaccaa gggatagact
     4201 gtggtcctca ccagccttct cacccacttg tccatttagg gaaggatcgc aagaaacact
     4261 agcccattca tcaccttcat ttaacttaga cacactgctg gtacctaaac ttgatgttct
     4321 aagacacagt gtgttcactg ctgggaaagg agttgcagag aaagcaagca aatggtactc
     4381 aaggttcgcc atgtatacca cgtcatcaaa ggatcaaagt tctgatcgta ccagtctttc
     4441 ttcagtggga gcccaggatt ctgaatctac ctctttgaca gatgaagatg tctgccatga
     4501 gttggaagga gccacttcct cccaagaaag cagtgcggct tcagggacca agggaattga
     4561 tgccagccgg gccagcctgg ggagctctgc ctccttagaa ggatccctgt caaagtttgc
     4621 cttacctgga aaaacagaga ctgcatcttc tctcaatacc agtaacacca atatcttcca
     4681 gaactatgca atggaggttc tcatttcaag ttgctctcgg tgtaggactt gtgactgtct
     4741 cgtccatgat gaggaaatca tggctggctg gacagcagat gattcgaatc tcaatactac
     4801 atgcccgttt tgtggcaatc tcttcttacc ctttctgaat gttgaaatca gagatttaag
     4861 aagacctgga cgatatttct tgaagtccag ctcatcaaca gaaactatgc actttgcatc
     4921 ttctttctca agtcggacaa ggcagtcttg catttcagca tcagcctctg gtcttgacac
     4981 atcttctctc tctgttcaag ggaacttaga tctaaataac aaatctaaac tacaggaaaa
     5041 tccatgtgcc cgaagtattc agatccctgc tcacagatca aaaactgttg tgtcaaaatg
     5101 cccgttgttc ccaatggcca ggagcatcag cacatgtggc cccttggata aggacgagcc
     5161 tgggggacag aagctcattc ctacaggcag cctgccggcc actttacaag gacctacaga
     5221 ttctttaggg ttagaatggc acctaccaag tccagaccct gtcactgtcc cataccttag
     5281 ccctttagtg gtgtggaagg aacttgagag cttattggaa aatgaaggtg accatgcaat
     5341 aacagtggca gactttgtgg accatcatcc gattgtcttt tggaacctgg tgtggtattt
     5401 tagacgcctc gacttgccca gtaacctgcc tggattgatt ctttcttctg agcattgtaa
     5461 taagtattca aagattcccc gccactgtat gtctgaagat agcaagtatg ttttaataca
     5521 gatgttatgg gacaacatga aattacatca ggatccaggg caacccctgt acatcctctg
     5581 gaatgcccac agtcagaacc gcactcttct gtttgagact caaaaatatc caatggtcca
     5641 tttgttacaa aaaagtgata actcctttaa ccaggaactg ttgaaaagca tggtgaaaag
     5701 cattaaaatg aacgatgtct atggacccat gagtcagatt ttagagaccc tgagtaagtg
     5761 tccacacttc aaaagacagc ggagtttata tagagaaata ttatttctct cacttgtggc
     5821 actgggaaga gaaaacattg atatagatgc gtttgacaaa gaatacaaga tggcttatga
     5881 tcgtctcaca ccaagtcaag tcaagagtac acataactgt gacaggccac caagcacggg
     5941 agtgatggag tgccggaaaa cctttggtga accttatctt taagacgtgt gtgtatatgt
     6001 atacattcaa tatatattgt atagtcagtg tacaaagtaa cacttttaga ctctaaactc
     6061 cacgttttga gaatgcattt gtaaatggat tggaaagttc aggtggcttt gtacagaacg
     6121 cttttgtgag acaacagtga ccgacaggga gagagccact tacttcccat ttatttcttc
     6181 tttatcaccc ctgtaaagta atcaagtact cgatgatgag gaagtctctt ttaaaacatt
     6241 ggttgccaca aaattagact ttcttatggt ttctcttgga agagacaggt gggaaaatca
     6301 cgtgtggagc gtaagcagag atgtcagatc caagtgtgtc ctgctttcgt ggacgtccgt
     6361 ggactgttca cgcgttacca tgaagttcta ttatacatat tttaaattgt ttatagtaag
     6421 ttgatatttt tttaattttt aaatttaata tagcaaactt aaaatgaatt taaacttatg
     6481 aaacaagtgt ttattttctt tgtgtctgct ctttgaagta attcgcacag ctgcagatct
     6541 ctgtatatct acctatattt tttttattac ttgagaggaa gaactttaac aggtcagtgc
     6601 cagtgtcagt gcccttggat tgcacgatag ctcccctgag tctgactggg gagagggact
     6661 gagggaggca gggtgagccc tgtgcacgga gcaccagaca gagcgcctgc gccatgcctg
     6721 ccgtctcctc cactagagta gatgcgaaag tacccagggg aaaaaactca caacccaaac
     6781 gtcaacataa atcttagtat gctatgtgaa aacttacaga ggggaattac tgacaactga
     6841 ctcttccaaa ttttacccaa aatattgggt atgaaacaaa ttgcactata aaatatgtat
     6901 ctgaaatatg gtttaatggg gtattctgtt aatactatat atagagagat tcaaagtatt
     6961 tttggaagca gaaaaatagt aaccgtctaa aagtgcatcc agagagaatt tcccatattg
     7021 aggaacttag ttttttcagt aagcttcagg atctgaagtt catggaatct caaatgtaaa
     7081 ctatacatga tcagacaata aactcaatgt ttaaacacca ggagtattaa attgacttaa
     7141 aatacatttt taattatatt atttctaaaa ccactttttt tgaataattt ctcataaaaa
     7201 aaggcatcct ttggcctctg gaattaatta ttcatgtatt ttcagtgtat gtatatacat
     7261 ttgcaagggt tgtcatttgt aaaggaaggc tagccatttt aaaacgaaga aaaaaggggt
     7321 ggtcccaaac ctgatgttta aagcaagtgg agtccatgat gcttgacctg gaaataaaat
     7381 aacttaagcg ccccaagact cagcagttca gccgcagaaa agctgccttt cagtccctgc
     7441 caccactgag tagccaggct gaagcatttt ttttcacagc ttttgccctc tggcaagttg
     7501 tggggagagc ataaaatgtg aatcttgagt tcagttggtt tgaggctgaa cttacttact
     7561 tgaaaacact ggtgctatgc gcgcatacct acggctcctg tcgatccact tggcctcgcg
     7621 gcctcactgc ttcacattct ccaagtcact gagaagtaca tccagtctct tcagagactg
     7681 agaatgttcc aaaggaggtg tttggcactg gtggtaaaca tgccctctaa caagatttgg
     7741 gctctcgtcc gtgctttctt ctttcttccc tcacgagagc agtttgcact gctgcctcca
     7801 gtttctgtaa tgcaaactgt gtggtttgtt ggattcagat gtctgccaag cacagagagg
     7861 caaagctggc cctcacactc actcggaaag ctgagcatga cttctgcctc ccgcccttcc
     7921 ctgagttttg ttctctgtct ctgaataaag ttatattttt cctgctttta atccccagga
     7981 atgttactgt atgaagataa tctttaaaaa taatacctaa acatggacta gaactcagtc
     8041 agtcctgctc caaagaaaac taaaataagg attgtctttt gaaacaattt aatccaagct
     8101 gtttttcagt ttttttattt accatacatt ttggaatatt atggccaata atgttggaaa
     8161 gtggtgtcct ttccctctac tccttatttt ccattcttag tgttgcttat gtttaaattg
     8221 ttggaaataa accatgctct tgttaatata gtttaagact ctcattaggt ttgaatgttc
     8281 ctgtgtatgt acatatactt taaatagtca gcgttccctc ctgtcaccag atgtcacagt
     8341 atgtagctgt tcatcttctg gttttgttct cttttctgtt tttttctaac ctttaaaccc
     8401 ccaacactat caacttatct tactataagg ttgtctagta tgtcttccca tttttgtaca
     8461 tagagaagtg accctgaaaa tgttggttca gcattttagg caataaatac ttatttttac
     8521 ttca
//
