LOCUS       NM_001191569            4980 bp    mRNA    linear   ROD 27-MAR-2024
DEFINITION  Rattus norvegicus DENN domain containing 2C (Dennd2c), mRNA.
ACCESSION   NM_001191569 XM_002729114
VERSION     NM_001191569.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4980)
  AUTHORS   Yoshimura,S., Gerondopoulos,A., Linford,A., Rigden,D.J. and
            Barr,F.A.
  TITLE     Family-wide characterization of the DENN domain Rab GDP-GTP
            exchange factors
  JOURNAL   J Cell Biol 191 (2), 367-381 (2010)
   PUBMED   20937701
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000002.1 and BM385166.1.
            
            On Sep 9, 2010 this sequence version replaced XM_002729114.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643429.9552.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMN06621351
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-96                JAXUCZ010000002.1  193335230-193335325
            97-1080             JAXUCZ010000002.1  193339313-193340296
            1081-1211           JAXUCZ010000002.1  193341231-193341361
            1212-1324           JAXUCZ010000002.1  193341761-193341873
            1325-1495           JAXUCZ010000002.1  193343740-193343910
            1496-1592           JAXUCZ010000002.1  193346948-193347044
            1593-1637           JAXUCZ010000002.1  193354264-193354308
            1638-1825           JAXUCZ010000002.1  193356582-193356769
            1826-1935           JAXUCZ010000002.1  193360136-193360245
            1936-2005           JAXUCZ010000002.1  193362987-193363056
            2006-2083           JAXUCZ010000002.1  193363896-193363973
            2084-2224           JAXUCZ010000002.1  193365406-193365546
            2225-2373           JAXUCZ010000002.1  193366151-193366299
            2374-2551           JAXUCZ010000002.1  193366984-193367161
            2552-2593           JAXUCZ010000002.1  193370981-193371022
            2594-2699           JAXUCZ010000002.1  193371878-193371983
            2700-2936           JAXUCZ010000002.1  193374174-193374410
            2937-3023           JAXUCZ010000002.1  193375454-193375540
            3024-4280           JAXUCZ010000002.1  193377040-193378296
            4281-4980           BM385166.1         1-700               c
FEATURES             Location/Qualifiers
     source          1..4980
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q34"
     gene            1..4980
                     /gene="Dennd2c"
                     /gene_synonym="RGD1308197"
                     /note="DENN domain containing 2C"
                     /db_xref="GeneID:295333"
                     /db_xref="RGD:1308197"
     exon            1..96
                     /gene="Dennd2c"
                     /gene_synonym="RGD1308197"
                     /inference="alignment:Splign:2.1.0"
     exon            97..1080
                     /gene="Dennd2c"
                     /gene_synonym="RGD1308197"
                     /inference="alignment:Splign:2.1.0"
     CDS             284..3055
                     /gene="Dennd2c"
                     /gene_synonym="RGD1308197"
                     /note="DENN/MADD domain containing 2C"
                     /codon_start=1
                     /product="DENN domain-containing protein 2C"
                     /protein_id="NP_001178498.1"
                     /db_xref="GeneID:295333"
                     /db_xref="RGD:1308197"
                     /translation="MHPTGTMDVGFTRSAVQTLSRSHCKNIKQKISQWEGRANGVTQP
                     AKFHPKDFGVRYNNCHQERPPHKHPTGEERNGGLPRNTDARSHDQSEGESESRELKDP
                     HPLEGEPNSSRMCARVKQIESCQAVAVDPEASLPPGNFYTSQIPWKSIEGLTPNKVFT
                     VALSPCDFTEEEPELSVLDSSYRVAKSLENIYCEPEGQECGPSINPLPKPRRTFRYLS
                     ESDGMPYKERNCDQKNCESVCCADSSLASFQDPEPKRYGGKIRGRSKRKSFEFEDIQH
                     FRNSRKIHEELERNAGSALYYTQSEDNIYEDIIYPAKENPYEDIPVQSFPIWRSPSAW
                     RLPPAKSAFRTPKLPPKPQFLQRKTMELKNTQAYLRSKLTKDTTLPVTLTEWKLFRAG
                     EVANRKKRNLPRLVLKINDTFESKRGKKRVKLQPYTGKEAPSSKGETSGNESDAEYLP
                     KNRHKRLAQLQQSSKRSPHYQTLERDLIELQEQQLFELFVVVSLQKKASGMEYMPRVI
                     QQFPSKGDHGYKQSKDTEERLKVIPRFCFPDSEDCAPTLELKSETFSFVLTGEDGSRW
                     FGYCKKLLPEGRGKRLPEVYCMVSRLGCFNLFSKILDEVEKRREMSPALVYPFMRSVM
                     EAPFPAPGRTITVKSYLPGAGDESIELCRPLDSRLEHVDFECLFKCLSVRHLIRVCAS
                     LLLERRVIFVADSLSTLSKCGHAVVATLYPFTWQHTYIPVLPVSMIDIVCSPTPFFIG
                     ILSCSLPLLQDLPIEEVLIVDLCADKFLQEVSDEDEIMPPKLQAALVQILEERDEVLA
                     QERQFSQDVTLNSLVSEAFVRFFVELVGHYSLNMTVTERGERVFLREPFRKSHTSRSV
                     RHFLDLFMETQMFAGFVQDRELRQSGVKGLFEVRALQYLETIPESEPSGVNRILRSLG
                     SKMRFLHKK"
     exon            1081..1211
                     /gene="Dennd2c"
                     /gene_synonym="RGD1308197"
                     /inference="alignment:Splign:2.1.0"
     exon            1212..1324
                     /gene="Dennd2c"
                     /gene_synonym="RGD1308197"
                     /inference="alignment:Splign:2.1.0"
     exon            1325..1495
                     /gene="Dennd2c"
                     /gene_synonym="RGD1308197"
                     /inference="alignment:Splign:2.1.0"
     exon            1496..1592
                     /gene="Dennd2c"
                     /gene_synonym="RGD1308197"
                     /inference="alignment:Splign:2.1.0"
     exon            1593..1637
                     /gene="Dennd2c"
                     /gene_synonym="RGD1308197"
                     /inference="alignment:Splign:2.1.0"
     exon            1638..1825
                     /gene="Dennd2c"
                     /gene_synonym="RGD1308197"
                     /inference="alignment:Splign:2.1.0"
     exon            1826..1935
                     /gene="Dennd2c"
                     /gene_synonym="RGD1308197"
                     /inference="alignment:Splign:2.1.0"
     exon            1936..2005
                     /gene="Dennd2c"
                     /gene_synonym="RGD1308197"
                     /inference="alignment:Splign:2.1.0"
     exon            2006..2083
                     /gene="Dennd2c"
                     /gene_synonym="RGD1308197"
                     /inference="alignment:Splign:2.1.0"
     exon            2084..2224
                     /gene="Dennd2c"
                     /gene_synonym="RGD1308197"
                     /inference="alignment:Splign:2.1.0"
     exon            2225..2373
                     /gene="Dennd2c"
                     /gene_synonym="RGD1308197"
                     /inference="alignment:Splign:2.1.0"
     exon            2374..2551
                     /gene="Dennd2c"
                     /gene_synonym="RGD1308197"
                     /inference="alignment:Splign:2.1.0"
     exon            2552..2593
                     /gene="Dennd2c"
                     /gene_synonym="RGD1308197"
                     /inference="alignment:Splign:2.1.0"
     exon            2594..2699
                     /gene="Dennd2c"
                     /gene_synonym="RGD1308197"
                     /inference="alignment:Splign:2.1.0"
     exon            2700..2936
                     /gene="Dennd2c"
                     /gene_synonym="RGD1308197"
                     /inference="alignment:Splign:2.1.0"
     exon            2937..3023
                     /gene="Dennd2c"
                     /gene_synonym="RGD1308197"
                     /inference="alignment:Splign:2.1.0"
     exon            3024..4970
                     /gene="Dennd2c"
                     /gene_synonym="RGD1308197"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtcctgtgtg cctactgtgt aatatctgaa attgtggtct tctgtacagt tttgtagctg
       61 caccagcaag gcaagaccac accatcatgg ctacagaacc attcatgata cagttgtagc
      121 tgtttccaac aaagttcagt gatgaaaatt gttattttta acgagaaacc tccaagttaa
      181 agatgaaagg aaaacactgg gaccatttcc attctgacaa ggtgacgagt acagcatttt
      241 ccagctaact tgtcatggca ccttgctaag agtgactctt gtcatgcacc ccactgggac
      301 catggatgtg ggctttacgc ggtctgctgt tcagaccctg tccaggagcc actgcaaaaa
      361 catcaagcaa aagatctccc agtgggaagg aagagccaat ggtgtaactc agccagccaa
      421 gtttcaccca aaggattttg gtgtgagata taataactgc caccaggagc gtcctcctca
      481 taagcatccc accggtgagg aaaggaatgg gggtttaccc agaaacacgg acgccagaag
      541 ccacgatcaa agtgagggtg aaagcgagag tcgagagctt aaagaccccc accccttgga
      601 aggtgaacca aactccagcc gcatgtgtgc ccgggtcaaa caaatcgaaa gctgccaagc
      661 tgttgctgtg gatccagagg cttcgctacc tccaggaaac ttctatacct cgcagatacc
      721 gtggaagagc atagaagggc ttaccccgaa caaagtcttc actgtggcct tatcaccttg
      781 tgactttaca gaagaggaac cggagctcag tgttctggat agttcttaca gagtagccaa
      841 gagcttggaa aatatttatt gtgaacctga ggggcaggaa tgtggcccct ctataaatcc
      901 tttgcccaaa ccccgtagga cattcaggta tttatctgaa tctgatggca tgccatataa
      961 agaaaggaac tgtgaccaaa agaactgtga gagtgtttgc tgtgcagact cttcgttggc
     1021 ctcttttcag gatcccgagc cgaagagata tggtgggaag atcagaggga ggtccaaaag
     1081 gaaatctttt gaatttgaag atattcagca ctttcggaac tcacggaaga ttcatgaaga
     1141 acttgagaga aatgctggct cagcacttta ttacacacag tcggaggata atatctatga
     1201 ggatattata tacccagcca aggaaaatcc ctatgaagat atcccagtgc agtcattccc
     1261 catttggaga tccccttcag catggaggct gccacctgct aagagtgcct tccgaacacc
     1321 caagcttcct cccaaacccc agttccttca gcggaagact atggaactga agaacactca
     1381 ggcgtatttg cgatcaaaac tcacgaagga taccacttta cctgtcacct taacggaatg
     1441 gaaacttttc cgagctggag aagtggctaa caggaaaaag agaaatctcc ctcggcttgt
     1501 tttgaaaatc aatgatacgt ttgaatctaa gagagggaag aagagggtaa agttacagcc
     1561 ttacaccgga aaagaagccc cctcctcaaa aggtgaaacc agtgggaacg agagcgatgc
     1621 tgagtacctg ccaaagaacc gccacaagcg cttggcacag ctgcagcagt cctccaagag
     1681 gagcccccac taccagacct tggagcggga tctgatcgaa ctgcaggaac agcagctttt
     1741 tgaactcttc gtggtggttt ctcttcagaa gaaggcatca gggatggagt acatgccccg
     1801 ggtcatacag cagttcccta gcaagggtga ccatggctac aagcagtcca aagacactga
     1861 ggagaggctc aaagtcatcc ccagattttg ttttcctgat tctgaggact gtgcaccaac
     1921 cttagaactc aagagtgaaa cgttctcctt cgtgctgact ggggaagatg gaagtcggtg
     1981 gtttggctac tgtaagaagc ttttgccaga aggcagaggg aagcggctcc ccgaggtgta
     2041 ctgcatggtt agtcgcttgg gctgcttcaa tcttttctca aagattctgg atgaagtaga
     2101 gaagagaaga gaaatgtccc cagcccttgt ttacccattc atgcgaagtg tcatggaagc
     2161 ccctttccca gctcctggcc gcaccatcac agttaagagc tacctccctg gggctggaga
     2221 tgagtcaatt gaactctgcc gaccactgga ctcacgactg gaacatgtgg attttgaatg
     2281 tctttttaag tgcttgagtg tgcgccatct catccgggtc tgtgcctccc tgcttctcga
     2341 gcggagggta atctttgttg ccgacagcct aagcaccctt tcaaaatgtg gccatgccgt
     2401 ggtggctaca ctgtatccgt tcacctggca gcacacctac atcccagtgt tgccagtgtc
     2461 catgattgac atcgtgtgct cacctactcc attctttatt gggatcttgt cttgttcctt
     2521 acccctactc caggatcttc ccattgaaga ggtgctgata gtcgatctct gtgcagacaa
     2581 gttcctacag gaggtgtctg acgaggatga gatcatgcca cctaaactcc aagctgcctt
     2641 ggtgcagatt ttagaagagc gagatgaagt cttggcccag gagcggcagt tttcgcaaga
     2701 tgtgactctc aattctctgg tgtcagaagc atttgtcagg ttttttgtgg aactcgtggg
     2761 gcattattct ctgaatatga ctgtcacgga gcgtggggag cgtgtgttcc taagggagcc
     2821 attccggaag tcccacacct cccgaagtgt ccgccacttc ctagatctct tcatggagac
     2881 acagatgttt gcaggattcg tccaggaccg ggagcttcgg caaagtggag ttaaaggttt
     2941 gtttgaagtc cgggctcttc aatatttaga aacaattcct gagtcggaac ccagcggggt
     3001 gaatagaatt ttacggagtc ttggaagcaa aatgagattt cttcacaaga agtgaaatct
     3061 ttgtcttcat tctacgcata actgaaagtg ccaaggacag tatgttccca aggatctgga
     3121 tgctttgagg agccctgtga tgtccttgtg attgtaagag gagaaaaact gtcagagggc
     3181 tctcctgttg ctgcagacca actgggaaca gtgtggaacc agtgcgcgct gctcttctga
     3241 ttcggggact gtttgtcttt gagacggggt ttgtatatat agccctgact gtgatggaac
     3301 ttgccactgt ggagatcagg ctggcctcaa atcctgatct cacaaatctc aaagatctta
     3361 caaagtgtgc ttgcctctgc ctcccaagcg ctgggattaa aggcatatgc caccatgcct
     3421 gggcaagtta cttttactgt ggtgttttat ctttggttat tgatgagcac aagaagctcc
     3481 actttgtgct tagtctatga aagtagttgt cttttacaag agaaagactg agaaatactt
     3541 ggtgttgcat tttctaaaaa caatgcaaag atgagatcaa cgagagataa gaatactgag
     3601 agtttcaggt actagacaca tggaggacac catggtcaca cgattcttat tactgaagcg
     3661 tcgggttact ttaaatccat ggactgtttg tgctttgaaa ttccagtact gttgccattg
     3721 ataaccccct tttgtcccat gtcctatctt ggaggatttc actcatgtta gaactttaaa
     3781 aagcagacac catgcagggc ccccccagaa tacgtgtcct gctgggataa cttgcttctt
     3841 atatgtcagc attatgcttt atggaatgga gccaatatga aaatgtcctt ttaagggcat
     3901 agcttctgtt tattgagttt tggtgtctac aatttgctgc actgtgataa tctacatgtc
     3961 atcttattca agctttagat cagcttcatg atgttttaca agaaactgga gttcagagag
     4021 gctaagtaat ttggccagtt atatacaaga cagaactaag ccaaacactt gacttacgaa
     4081 cacatacaaa gctggttagt cctacaggtg taaatgaact gtttatagtg atgtttaaag
     4141 ttcttagtgg agcacaccag agcttcctct tggctctgat gagactctaa gctgtgggtg
     4201 tctaggcaag gtttgttcct ctgctgctgg tgatagaacc cagcgccttc tgtgcgttct
     4261 gccacgctgg ttatttttac atcggtgtga gtttcactta gtgtttccta agcctatacc
     4321 tcttcatcaa ccagatgctg gaaatctaaa gtcctagggc ctgggaaagg gagtttgtca
     4381 gtgagggtgc agttttcatt gagaggtgat agacgttgtg ataaatgtca gttgttttct
     4441 gtagcctttg ctcatggctt tacctggcat ggaaaatatt tattcagact tggaaagtgt
     4501 tgtacgttgt gttgtacaca accgactgtt gtacagtatt gttattgtca cttatgcagc
     4561 tgtatttgaa cgaatccatt taagactggt gctgtgcaat atagttccta gatgtggtcc
     4621 agggaagaga actgagcctg tcttttaaaa tgttaatgca gcttaccgaa gtggagcccc
     4681 tcccagacac ctctctcatt tgggctcttc ttactccaat cccaatggaa cagttcctaa
     4741 ctgattgtgt ataaggtggg gtaggagggt ctactgtggt caatcatgac tgtccctctg
     4801 cagggagagt cttaccttct tacagtctaa agctgcttcc tttccttgag tttgttgtac
     4861 tttgtttttg taaatgttgt gaattctaca tacgtttgta aagagaattg ttcaacattt
     4921 ctatcaaatg tttacagatc ttttaatgaa taaagacatt ttaaaaaaaa aaaaaaaaaa
//
