LOCUS       NM_001395094            4243 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus DENN domain containing 2B (Dennd2b), mRNA.
ACCESSION   NM_001395094 XM_008759737
VERSION     NM_001395094.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4243)
  AUTHORS   Yoshimura,S., Gerondopoulos,A., Linford,A., Rigden,D.J. and
            Barr,F.A.
  TITLE     Family-wide characterization of the DENN domain Rab GDP-GTP
            exchange factors
  JOURNAL   J Cell Biol 191 (2), 367-381 (2010)
   PUBMED   20937701
REFERENCE   2  (bases 1 to 4243)
  AUTHORS   Majidi,M., Hubbs,A.E. and Lichy,J.H.
  TITLE     Activation of extracellular signal-regulated kinase 2 by a novel
            Abl-binding protein, ST5
  JOURNAL   J Biol Chem 273 (26), 16608-16614 (1998)
   PUBMED   9632734
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Jun 3, 2021 this sequence version replaced XM_008759737.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643429.3027.1,
                                           SRR26360176.821941.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-38                JAXUCZ010000001.1  173129447-173129484 c
            39-128              JAXUCZ010000001.1  173073989-173074078 c
            129-233             JAXUCZ010000001.1  173026753-173026857 c
            234-1484            JAXUCZ010000001.1  173012129-173013379 c
            1485-1621           JAXUCZ010000001.1  173007665-173007801 c
            1622-1773           JAXUCZ010000001.1  173000011-173000162 c
            1774-1989           JAXUCZ010000001.1  172997385-172997600 c
            1990-2086           JAXUCZ010000001.1  172996352-172996448 c
            2087-2131           JAXUCZ010000001.1  172995474-172995518 c
            2132-2316           JAXUCZ010000001.1  172994752-172994936 c
            2317-2426           JAXUCZ010000001.1  172994065-172994174 c
            2427-2496           JAXUCZ010000001.1  172993402-172993471 c
            2497-2574           JAXUCZ010000001.1  172990436-172990513 c
            2575-2715           JAXUCZ010000001.1  172989799-172989939 c
            2716-2864           JAXUCZ010000001.1  172986156-172986304 c
            2865-3042           JAXUCZ010000001.1  172982405-172982582 c
            3043-3084           JAXUCZ010000001.1  172982143-172982184 c
            3085-3196           JAXUCZ010000001.1  172981150-172981261 c
            3197-3436           JAXUCZ010000001.1  172980428-172980667 c
            3437-3523           JAXUCZ010000001.1  172980138-172980224 c
            3524-4243           JAXUCZ010000001.1  172978895-172979614 c
FEATURES             Location/Qualifiers
     source          1..4243
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q33"
     gene            1..4243
                     /gene="Dennd2b"
                     /gene_synonym="St5"
                     /note="DENN domain containing 2B"
                     /db_xref="GeneID:308944"
                     /db_xref="RGD:1308995"
     exon            1..38
                     /gene="Dennd2b"
                     /gene_synonym="St5"
                     /inference="alignment:Splign:2.1.0"
     exon            39..128
                     /gene="Dennd2b"
                     /gene_synonym="St5"
                     /inference="alignment:Splign:2.1.0"
     exon            129..233
                     /gene="Dennd2b"
                     /gene_synonym="St5"
                     /inference="alignment:Splign:2.1.0"
     CDS             154..3558
                     /gene="Dennd2b"
                     /gene_synonym="St5"
                     /note="suppression of tumorigenicity 5 protein"
                     /codon_start=1
                     /product="DENN domain-containing protein 2B"
                     /protein_id="NP_001382023.1"
                     /db_xref="GeneID:308944"
                     /db_xref="RGD:1308995"
                     /translation="MTMTANKNSSITHGAGGTKAPRETLSRSQSVSPPPVLYPPRSPI
                     YPLSDSETSACRYPSHSKSQVLLKDRHSRNPSPLGQDPSPDTSPPICTLKATSFSYLD
                     RTPSLRRREDQRESVQGAVQDVEGVAACLPLAQSTPFLGSGPRSVLLSCTGTRAHNLG
                     IREKISAWEGRREASPRMNLCGEKREGPGSERSVSEGCPSVGCPSVVPSPCSSEKTFD
                     FKGLRRMSRTLSECSYPETEEESEALPVRDSLYRLEKRPSRTEPSALLRGHGIRKESS
                     AVLSRIQKIEQALKEQPGCGLPQLPSSCYSVDHGRRKTGTLGTSEEPAGTASVSSSSR
                     AGGATGVAREAGPPLDREGSGSMKSETPGNSSSPQLLPSKSSPDPAVNPVPKPKRTFE
                     YEADKNPKPKPSNGLPPSPTPAAPPPLPSTPAPPVTRRPKKDIRGHRKSQNRKSFEFE
                     DASSLQSLYPSSPTENGTESQPKFGSKSTLEENAYEDIVGGLPKENPYEDVDLKNRRA
                     GRKSQQLSENSLDSLHRMWSPQDRKYNNPPMQLSLKPSSQSLRSGNWSERKSHRLPRL
                     PKRHSHDDMMLLAQLSLPSSPSSLNEDSLSTTSELLSSRRARRIPKLVQRINSIYNAK
                     RGKKRLKKLSLSSLETASLRDENSESESDSDDRFKAHTQRLVHIQSMLKRAPSYRTLE
                     LELLEWQERELFEYFVVVSLKKKPSRNTYLPEVSYQFPKLDRPTKQMREAEERLKAIP
                     QFCFPDAKDWLPVSEYSSETFSFMLTGEDGSRRFGYCRRLLPNGKGPRLPEVYCVISR
                     LGCFGLFSKVLDEVERRRGISAALVYPFMRSLMESPFPAPGKTIKVKTFLPGAGNEVL
                     ELRRPMDSRLEHVDFECLFTCLSVRQLIRIFASLLLERRVIFVADKLSTLSSCSHAVV
                     ALLYPFSWQHTFIPVLPASMIDIVCCPTPFLVGLLSSSLPKLKELPVEEALMVNLGSD
                     RFIRQMDDEDTLLPRKLQAALEQALERKNELISQDSDSDSDDECNTLNGLVSEVFIRF
                     FVETVGHYSLFLTHSEKGERAFQREAFRKSVASKSIRRFLEVFMESQMFAGFIQDREL
                     RKCRAKGLFEQRVEQYLEELPDTEQSGMNKFLRGLGNKMKFLHKKN"
     exon            234..1484
                     /gene="Dennd2b"
                     /gene_synonym="St5"
                     /inference="alignment:Splign:2.1.0"
     exon            1485..1621
                     /gene="Dennd2b"
                     /gene_synonym="St5"
                     /inference="alignment:Splign:2.1.0"
     exon            1622..1773
                     /gene="Dennd2b"
                     /gene_synonym="St5"
                     /inference="alignment:Splign:2.1.0"
     exon            1774..1989
                     /gene="Dennd2b"
                     /gene_synonym="St5"
                     /inference="alignment:Splign:2.1.0"
     exon            1990..2086
                     /gene="Dennd2b"
                     /gene_synonym="St5"
                     /inference="alignment:Splign:2.1.0"
     exon            2087..2131
                     /gene="Dennd2b"
                     /gene_synonym="St5"
                     /inference="alignment:Splign:2.1.0"
     exon            2132..2316
                     /gene="Dennd2b"
                     /gene_synonym="St5"
                     /inference="alignment:Splign:2.1.0"
     exon            2317..2426
                     /gene="Dennd2b"
                     /gene_synonym="St5"
                     /inference="alignment:Splign:2.1.0"
     exon            2427..2496
                     /gene="Dennd2b"
                     /gene_synonym="St5"
                     /inference="alignment:Splign:2.1.0"
     exon            2497..2574
                     /gene="Dennd2b"
                     /gene_synonym="St5"
                     /inference="alignment:Splign:2.1.0"
     exon            2575..2715
                     /gene="Dennd2b"
                     /gene_synonym="St5"
                     /inference="alignment:Splign:2.1.0"
     exon            2716..2864
                     /gene="Dennd2b"
                     /gene_synonym="St5"
                     /inference="alignment:Splign:2.1.0"
     exon            2865..3042
                     /gene="Dennd2b"
                     /gene_synonym="St5"
                     /inference="alignment:Splign:2.1.0"
     exon            3043..3084
                     /gene="Dennd2b"
                     /gene_synonym="St5"
                     /inference="alignment:Splign:2.1.0"
     exon            3085..3196
                     /gene="Dennd2b"
                     /gene_synonym="St5"
                     /inference="alignment:Splign:2.1.0"
     exon            3197..3436
                     /gene="Dennd2b"
                     /gene_synonym="St5"
                     /inference="alignment:Splign:2.1.0"
     exon            3437..3523
                     /gene="Dennd2b"
                     /gene_synonym="St5"
                     /inference="alignment:Splign:2.1.0"
     exon            3524..4243
                     /gene="Dennd2b"
                     /gene_synonym="St5"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gctccagatc cagacaatcc ttggtggatg gtgccgaggc agacaggaga ctgcttaggc
       61 tctggcacta gtaccatggg accctgtact ggttaaaagc cggctccagg acctgaacag
      121 acaacaaggg ctctgggctt gcagagagcc gaaatgacca tgactgccaa caagaactcc
      181 agtatcactc atggagccgg aggcactaag gcccctcggg agacgctgag caggtctcag
      241 tcagtttctc cgcctccagt tttataccca ccaagaagtc ccatctaccc actcagtgat
      301 agtgaaacct cagcctgcag gtatcccagc cactctaaat cccaggtgct tctcaaggac
      361 cggcactccc gaaatccttc acctctaggt caagacccct ccccagacac ttcaccaccc
      421 atctgtaccc tcaaggctac cagcttcagc tacttggaca gaaccccttc attacgcaga
      481 agagaggacc agagggagag cgttcaaggt gcagtccagg atgtagaggg tgtggctgct
      541 tgccttcccc ttgcccagag caccccattc ctagggtctg gcccacggag tgtcttgctg
      601 agttgcactg gtacccgagc ccacaacctg ggtatccgag agaagatttc agcatgggaa
      661 ggtcgccgag aggcttcacc caggatgaat ctgtgtggag agaagcggga gggccctggg
      721 agcgagagat cggtcagtga gggctgccct agcgtgggct gccccagtgt ggtgccatcc
      781 ccttgcagct cagaaaagac ctttgatttc aaaggcctcc ggaggatgag caggacctta
      841 tctgagtgtt cctaccctga gacagaggag gagtcagagg cacttcctgt acgggactct
      901 ttataccggc tggagaagcg tccaagccgg actgagccca gtgccttgct caggggccat
      961 ggcatcagga aagagagctc agcagtgctg agccggatcc agaaaattga acaagcccta
     1021 aaggagcagc ctggctgtgg tctcccccag ctccctagca gctgctacag tgtagaccat
     1081 gggaggagga agactggaac cttgggcacc tcggaggagc cagcaggaac tgcaagtgta
     1141 agctccagca gcagggcagg aggagccacc ggagttgcca gggaggcagg cccacccctg
     1201 gacagggaag gcagtggttc catgaagtca gagactcctg gaaatagctc tagtccccag
     1261 ctgctgcctt caaagagctc ccctgatccc gctgtgaacc ctgttcccaa acccaagcgt
     1321 acctttgagt acgaggctga caagaatccc aagccgaagc caagcaatgg tctacctcct
     1381 tcacccacac ctgctgctcc acctccctta ccttccaccc cagccccacc agtcacccgg
     1441 aggccaaaga aggatattcg tggtcaccgg aagtcacaga acagaaaatc ctttgagttt
     1501 gaggatgcat ccagtctcca gtccctgtac ccctcttctc ctactgagaa tggtactgag
     1561 agtcaaccca agtttggatc caaaagcact ttagaagaga atgcatatga agatattgtg
     1621 ggagggcttc ccaaggagaa tccctatgag gatgtggact taaagaaccg aagagctgga
     1681 cgaaaatccc agcaactgtc tgagaactcc ctggactctt tgcacaggat gtggagtcct
     1741 caagacagga agtacaacaa cccacccatg cagctgtccc tgaaacccag cagccagtcc
     1801 ctgcgcagtg ggaactggtc agaaaggaag agccatcgtt tgccacgatt acccaagagg
     1861 catagccatg atgacatgat gctgctggct cagctgagcc tgccatcttc accctccagc
     1921 ctcaatgagg acagcctcag caccacaagt gagctgctgt ccagccgcag ggcccgtcgc
     1981 attcccaagc ttgtccaaag aattaactct atctataatg ccaagagagg aaagaagagg
     2041 ttgaaaaagc tgtctctgtc cagccttgag acagcctcat tgagagatga gaacagtgaa
     2101 agtgagagtg actctgatga caggttcaaa gcccacacac agcgcttggt ccacatccag
     2161 tcaatgctga agcgcgcacc cagctatcgg acactggagc tggagctgct cgaatggcag
     2221 gagcgggagc tctttgaata ctttgtggtt gtgtccctca agaagaagcc atctcgtaac
     2281 acctacctcc ctgaagtctc ctaccagttt cccaagctgg accgacccac caagcagatg
     2341 cgggaggcag aagaaaggct caaagctatc ccccagtttt gctttccaga tgccaaggac
     2401 tggctccctg tgtcagaata cagcagtgaa accttttctt tcatgctgac tggggaagac
     2461 ggtagcagac gctttggcta ttgtaggcgc ttactgccaa atgggaaagg gcctcggttg
     2521 ccagaggtgt actgtgtcat cagccgccta ggctgcttcg gcctgttttc caaggtccta
     2581 gatgaggtgg agcgccggcg tggaatctca gctgctctgg tctacccctt tatgagaagt
     2641 ctcatggaat cgccctttcc agccccaggg aaaaccatca aagtgaagac attcctgcct
     2701 ggtgctggca atgaggtgtt agagctgcgt cggccgatgg actcccggct ggagcacgtg
     2761 gactttgagt gcctcttcac ctgcctcagt gtgcgccagc tgatccgaat ctttgcctca
     2821 ttgctgttgg aacgcagagt catttttgta gcagataagc tcagtaccct gtccagctgc
     2881 tctcatgcgg tggtggcctt gctctacccc ttctcctggc agcacacctt cattcctgtc
     2941 ctcccagcct ccatgattga cattgtctgc tgtcccaccc ctttcctggt tggcctgctc
     3001 tccagctccc ttcccaaact gaaggagctg cctgtggaag aggcactgat ggtgaatcta
     3061 ggatctgacc gattcatccg acagatggat gatgaggaca cactgttacc taggaagtta
     3121 caggctgctc tggagcaggc tctggagagg aagaacgagc tgatctccca ggattctgac
     3181 agtgactctg atgatgaatg taataccctc aatggacttg tgtcagaggt gtttatccgg
     3241 ttctttgtgg agaccgtggg gcactactcc ctcttcctga cacacagtga gaagggagaa
     3301 agggcttttc agcgcgaggc cttccgaaag tctgtggcct ccaaaagcat ccgccgtttc
     3361 cttgaggttt ttatggagtc tcagatgttt gctggcttca tccaagacag ggagctaaga
     3421 aagtgtcgag caaagggcct ctttgagcag cgagtagagc agtatctaga agagctccct
     3481 gacactgagc agagtgggat gaacaagttt ctccgtggct tgggcaacaa gatgaagttc
     3541 ctccacaaga agaattaaat atctagtagt agagtctaag tgctttgcag agcccaggga
     3601 gagggcccag cctgggaccc tgtgggatgt tgtggctacc ttgcttctac agaccccacc
     3661 tccaaagcca gtgcacctct gccttcatca tatcccagga taccgtttgt aaataatctg
     3721 ctgtaagctt tcctgttttt gtaacaagca aagagaatct gataaatatt tgtatatccc
     3781 aaagggccgg gtgctttctt gccttgtctg agcatggaag gagtcttgct gggtgctggt
     3841 gactggccag ttatgtgcag ctgactgtct cagccaaacc actgtttcct gaagacttct
     3901 ggcctgtctc cctgaggccc tgctgccagt tttgggccct ggagagcagg tgctgtctta
     3961 attatgtgta agaggactgt ttttctggtt gtttctattt ttacttctta gtttgcctat
     4021 ctgccaagcc tgtttctgaa aggcaagaac caccctgtcc ctatttgcaa tgtaaagcca
     4081 gacgcttggg cctggttttt gttccttcca ccgtctgaca tgggtcagtt gaatcatggt
     4141 tagtggagct cccagtcagt ggtggccatg atgcggtaca gggcaatttt ccttccacca
     4201 tccaccgatg ttctcaataa actgtacatt cattttggct gaa
//
