LOCUS       XM_003751245            7823 bp    mRNA    linear   ROD 11-JUN-2023
DEFINITION  PREDICTED: Rattus norvegicus DENN domain containing 1B (Dennd1b),
            transcript variant X1, mRNA.
ACCESSION   XM_003751245
VERSION     XM_003751245.3
DBLINK      BioProject: PRJNA677964
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_051348.1) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            [WARNING] On Feb 22, 2024 this sequence was replaced by
            XM_003751245.4.
            
            On Jan 21, 2021 this sequence version replaced XM_003751245.2.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_015227675.2-RS_2023_06
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.1
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 06/06/2023
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..7823
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN/NHsdMcwi"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /sex="male"
                     /tissue_type="kidney"
                     /geo_loc_name="USA: Wisconsin, Milwaukee, Medical College
                     of Wisconsin"
                     /collection_date="2019-03-08"
                     /collected_by="Rebecca Schilling"
     gene            1..7823
                     /gene="Dennd1b"
                     /note="DENN domain containing 1B; Derived by automated
                     computational analysis using gene prediction method:
                     Gnomon. Supporting evidence includes similarity to: 51
                     ESTs, 5 Proteins, and 100% coverage of the annotated
                     genomic feature by RNAseq alignments, including 27 samples
                     with support for all annotated introns"
                     /db_xref="GeneID:289051"
                     /db_xref="RGD:1308441"
     CDS             117..2459
                     /gene="Dennd1b"
                     /codon_start=1
                     /product="DENN domain-containing protein 1B isoform X1"
                     /protein_id="XP_003751293.1"
                     /db_xref="GeneID:289051"
                     /db_xref="RGD:1308441"
                     /translation="MDRRTRENPERTFDLVLKVKCHASENEDPVVLWKFPEDFGDQEV
                     LQSVPRFCFPFDVERVSQNQVGQHFTFVLTDMESKQRFGFCRLTSGGRVCLCILSYLP
                     WFEVYYKLLNTLADYLAKELEDDLNETLKSLYSHPVPKANTPVHLSVNQELFIASEQV
                     LKDDPSLMPHSCFITPDITGLPTIPESRNLTEYFVAVDVNNMLRLYASMLHERRIIIT
                     SSKLSTLTACLHGSAALLYPMYWQHIYIPVLPPHLLDYCCAPMPYLIGIHSSLIERVK
                     NKSLEDVVMLNVDTNTLESPFNDVNSLPSDVVSALKNKLKKQSTATGDGVARAFLRAQ
                     AALFGSYRDALRYKPGEPITFCEESFVKHRSSVMKQFLETAVNLQLFKQFIDGRLAKL
                     NAGRGFSDIFEEEITSGGFCGGSPRSYQQWVYTVKKGGALFNTAVTKATPAVRTAYKF
                     AKSHARLGLKEVKSRLRHKDNEEDYGTCSGLVQYTPVYTLHHERGETREKQKLSQAHL
                     KRPHKSLDGTLYDDDDDIERASKISSEDGEETSAYFYESDDSVDAQVKAPYSGEMDLL
                     GEILDTLSTHSSDQGKLAPAKSLDFFRSMDDIDYKPTNKSNAPSENNLTLLCASGDQG
                     EWNLGQDDSALHGKHLPPSPRKRVCSSGLTDSLFILKEENTEKPFSADSVSVPTVVEK
                     SASTSDSGFQPATPEASQTHKGKPEVKQTLSQASDDLLVPSPGNRQSTFVPWEKAGKE
                     ETKPSKDVGLLQEVVSLCHMSCDFQQGLNISEESKSENQT"
ORIGIN      
        1 tccccgcgag gccgcggagg gcgccgtggg ccgaccgccg ctcggagcag cgcgtcccgg
       61 acggcgtgcg ggcgtgcggg cgcggggcga cggcggcccc gcagcgacat gtgaccatgg
      121 accgcaggac cagggaaaat ccagaaagaa ctttcgactt ggtattaaaa gtgaagtgtc
      181 atgcctctga aaatgaagat cctgtggtat tgtggaaatt cccagaggac tttggagatc
      241 aggaagttct gcagagtgtg cccaggttct gttttccctt cgatgtggaa agggtgtctc
      301 agaatcaagt tggacagcac tttaccttcg tcctgacaga catggaaagt aagcaacgat
      361 ttgggttctg caggctcaca tctggaggca gagtttgttt gtgtattctt agttacttgc
      421 catggtttga agtgtattat aaacttctaa atactctggc agattacttg gccaaggaac
      481 tggaagatga tttgaatgaa actcttaaat cactctatag ccacccagta ccgaaggcaa
      541 atactcccgt ccacttgagt gtgaaccaag agctatttat tgccagtgag caagttctga
      601 aagatgaccc ctcactaatg ccgcactcct gtttcatcac accggacata actggacttc
      661 caaccatccc ggagagtaga aacctgacgg agtacttcgt agctgtggat gtgaacaaca
      721 tgctgcggtt gtacgccagc atgctgcacg agaggcgcat cattattacc tcgagcaaat
      781 taagcacttt aactgcctgt ctccatggat cggccgctct gctctacccg atgtactggc
      841 aacacatata tatccctgtg cttcctccac acctgctgga ctactgctgt gccccaatgc
      901 catacctgat tggaatacac tccagtctca tagagagagt gaaaaataaa tcattggaag
      961 atgtggttat gttaaatgtt gacacaaaca cattagaatc accatttaat gacgtgaaca
     1021 gcctgcccag tgatgtggtc tcggccttga aaaataagct gaagaagcag tccacagcta
     1081 cgggagatgg agtggctcgg gcctttctga gggcgcaggc agctttgttt ggctcctacc
     1141 gagatgctct gagatacaag cctggcgagc ccatcacctt ctgtgaggag agctttgtaa
     1201 agcaccgctc aagtgtgatg aaacaattcc tggagactgc agttaacctt cagctgttta
     1261 agcagtttat tgacggtcga ctggcaaaac tcaatgcagg aagaggtttc tctgatatat
     1321 tcgaagagga gatcacttca ggtggcttct gtggagggag cccgcggtca tatcaacagt
     1381 gggtgtatac agtcaagaaa ggaggtgcat tgttcaacac agcagtgacc aaagcgactc
     1441 ctgctgtgcg gacagcctac aaatttgcaa agagtcacgc cagactgggt ctgaaggagg
     1501 tgaagagcag actgagacac aaggacaatg aggaggatta tgggacctgt tctggtttgg
     1561 tacagtacac accagtatac accttgcacc atgaaagggg agaaaccaga gagaagcaga
     1621 agctttccca ggcacacttg aaaaggcccc ataagagcct cgacggcacc ctgtatgatg
     1681 atgatgatga catcgaaagg gcaagcaaga tatcttctga agacggtgaa gaaacatctg
     1741 cctatttcta tgagagcgac gactctgttg atgcacaggt gaaggctcct tactcaggtg
     1801 agatggattt actgggcgag atcctggaca cgctgagcac acacagctct gaccaaggaa
     1861 agctggcacc cgccaagagc ctggatttct tcagatccat ggacgacatt gactacaagc
     1921 ccacgaacaa gtccaacgct cccagtgaga ataacctgac cctactgtgt gcttctggcg
     1981 atcagggaga gtggaatctc gggcaggatg acagcgccct ccatggcaag cacctccctc
     2041 catcccccag gaaaagagtt tgctccagtg ggttgacaga ttccctattt atcttgaaag
     2101 aggagaacac tgagaagccc ttcagtgctg acagtgtaag tgtccctact gtggtggaaa
     2161 agtccgcttc tacttcagat tccggtttcc agccagccac tcctgaagct tctcagacgc
     2221 ataaaggaaa accagaggtg aagcaaacac taagtcaagc ttcagatgat ctgctggtac
     2281 ccagccctgg gaaccgccag tctacttttg ttccctggga aaaagctggg aaagaggaga
     2341 cgaagccttc aaaagatgtt ggacttctcc aagaagtagt gtcattgtgt cacatgtcat
     2401 gtgacttcca acaaggttta aacatttcag aagaaagcaa aagtgaaaac caaacttaag
     2461 gtaccagtag aggggtcagt tgcttgcctc ttggcttctc cagagacatg gaattacttc
     2521 cccatgatgg gaacagtaaa gagaatcact gataggaatg ataaccttac tgctgtctag
     2581 ttggtttccc tgtctgttca tctcatggat ctatattacc attggttccc cagcataaaa
     2641 tgaattctac tgtgctgtta aatcaggtac taatttgtac ataggctgaa agtgtgtttt
     2701 gaacttaagc tttcccagta tttggtgctt aatgctgttc attttattta aaataagtgt
     2761 gcatatataa cccctacata tagccagtag gtactgtact aatctggctg agcatgaact
     2821 gatcaagatg tcaaaactga acaaaaatag cctgacactg atgaaactgt taacccacta
     2881 attgccttaa tcctccagtt atgttaagca tacagataac acgtgatgct acatgcgaag
     2941 cttgaaagag gagttgtctt gtcctgcaga gcaataatgc ctttttctat caggaattaa
     3001 gctcaccatt tctttcaagt tcaaatgcac tctagtggaa attacgtgct ttttataaag
     3061 acatgcagcc atgttttcca aacaagtgaa tgtgtgtatt cacctttcag tgaactatat
     3121 taagtgctga attacaatgt gaagtgaaaa gcttctgctt acaaagaagc cccgcagaca
     3181 atgttcgatc tctgtgtaca tgttaactac agtccacctc cagaaagcca aatgccctgt
     3241 ggagtccaga taggcagttg tccagctctt ctcctaactg acttgctgtg aagatgctca
     3301 tagccttacc ttgtgtttgc tttttaaata attaactttg tattttaaac gttgtagatt
     3361 tgtaggaaaa tgcaaagatg gtactgagtt cccatagcca tggatcctgt gtctgctgtt
     3421 gctagcatcc tgtgtagtat gctgccattg ccgtattgtt gactcgctgc acggcatggc
     3481 attcagagct ctggctgttc cctggtgtcc cattctgtcc cgttctcccc ctcagagttc
     3541 tcaagtacct ctgcgatcac gtctgctgag gtgtctcctc accctggcac ttcactttct
     3601 tagttttgat ggccttgaag tttttaggaa tattgatcag atgtccagct cctgtaaagt
     3661 atgtagtatg tttctcagta ttgcatgagc tcataggctt gagggagaag attacagaag
     3721 agaagtacca ttttcacagc gtctgaaggg gtgtgccatg ctgtgctgac ttggaacgcc
     3781 tgtggggttc tccactagga atgtgtccct cacctgttct gtggcagtag agcaggagag
     3841 agagaagaaa ggaagagcag gcacagagaa ttatttaggg cagacaagta tcagaataca
     3901 gcccttgtag ttctttatgg tacctgcctc cctcacagtt tacctttgga gcacatctga
     3961 agcacatgca ggtccctcat gctagatgtg cagttggttt atttgaacct gccatgtttc
     4021 tgttctatac atcctcaaac gtgatgattg attttcagaa atcttttagt aaaaaaaaaa
     4081 aaagtttgca aagccattga aggccatact ctaaagtgtt tacttaaaga atagaatttt
     4141 agccagaatt ttaggagatt tgtttaacat agcccttaaa atatttacac aggtcatttt
     4201 ttaaaactgc attccaaaat ataaataggt agttgtgctt gaggtaacaa ttccctcctt
     4261 tgtagtggac ggtggagctt gtcgttatga ggatgggcct gttatagaag ggcatattta
     4321 atcctcattt ttgcacatta atagcagtca aggctgtgag attttgcctg cgtgtgccct
     4381 tcattattcc cagtttactg aataacagga aagccacata tcggaagggg atatgagtgg
     4441 gaggaggaag gttagtgtgg cggctccatt gctgggcaag cattctcaca gggtgctggg
     4501 caagcattct cacagggctc tggacagagt gtagagcttt caatgtgatt tttcaagtga
     4561 gctctctgtt ttcatgtcag aattcattgt ctaaaagtga gaccatcctg attgcagctt
     4621 aaaacactgg cttccagtcc ttgtccttga taaacctatg gccacaggtt catggttctc
     4681 tgctttgagt cagcttgtga gatgctccac tgtcgcacta ggctatttgg aaacatttat
     4741 ccactcacaa ataatgtctt aagccactta agtgatctgt gccttactgt aacaagcaaa
     4801 aacagctact ttatgttaaa aagaaaaaac aaaactgtac accttattct tttaaaaaat
     4861 gtccagaaaa ctggaagcaa gtgggtgctt cacaaacctt gagtatttga agttggcttt
     4921 taaatgagac ttcgcagtat tatgatggag acagtagaaa aaagtaagag actataagat
     4981 gagttctgaa atttaaaaaa acagggaata tcttttgctt tgcctaaacc aaaccaaata
     5041 taagttccct gctattgaga atacatgttt ctgcttgcac tgtctgttag aaactgagag
     5101 ctcccaaact aaacatttca gagaagccgc ttctgctcct ctagagactt gagctctggc
     5161 ttccgcatct tgtgcttcat gtgttgctaa tccaacccct gagctgtgcc tggtcttgag
     5221 tctctctcag gctctgcatc cacggagtca ggggcctaaa gataggagaa cagatgtgga
     5281 gccgcagctt tgttaaagtg aagatgtcgc tgagtaaagt acagtggtgg tcacctgatt
     5341 tagcctctcc tgtatcagac tgttgcaggg ttacttttcc aattcaaagt tagtaactct
     5401 ccttcactga gaaaatattt attgattttt ttgtaccagt caggagcaag gtataataat
     5461 taaggatgta agggtgtggg aataaacaat tacccagctc cagggaatca attaaaaggg
     5521 aagggaagtg caggcgttaa gataataatt aacaataata ataaaatgca gaaaagatgt
     5581 atttgcttac acggtacttg ctcaagaatc aacaccaaga gatgcttttc aagaactgct
     5641 gctgtattta aagtatgttc taatgacaga atcattaact ctttgagtaa ttacgtgagc
     5701 cactagaatg ctgctaagat cccactttaa aggatagatt tggaggcact gctaggctga
     5761 gtccttgctt tgaccatcca caggacatgc agtatcgatg gccacatccc caagttcaag
     5821 agtaacttag ggtacataaa ggaagaacct agcatgctga tgggagtcca gattttacat
     5881 taaaaaaaaa tcttggtagc aacattttct agatagcctt tttcttctta gctaaaggtg
     5941 tgactgttac taagatccta tgctgatcta atgctaatgg tgtgacccag gaatgaccat
     6001 gaagtagttg ttggttaaca aagggaaaat tcctggtcaa cagcaaatga ctgtggacat
     6061 tctcgcaatc aacagccatt cattctctgc tcagacttcc aggacaagtt gatccctttt
     6121 atgagtaaat tgtctcctga aaaccccact gcttgctgtc aatgcgtctt cagtctgaga
     6181 agatatttga aaatcagaat aaaaattcaa aatggaaaat gaacccctaa acgtagggtc
     6241 tccccaagca tctcttaatg taggtagtca tttttttttt ttagcaagcc aattctctgt
     6301 gagcattttc cccatgttga gcccagagtc ctgttagtgt tggtttttta aaacttcaag
     6361 gactagaaag gctttgtaac agccagttga tgttatgatt tgtttataaa atagggaatt
     6421 atgtatattg agacagaaat attttatttt aaaacatagg attttgtgca atatttttct
     6481 tgcgtcgttt agtttatata aatatgcaca tctgcttttc tggcagatgc cttaaggtca
     6541 tgtctttcag tatttgccta aaactgtatg tagcaatgtt ctatgtgatt tcagaaaaaa
     6601 aaattactct ttgtattgtt agcagaagtg ctcttgttta tttaaaataa ttgtggagat
     6661 tgcattattg tatcatacct aactgcctca gccacagtaa atatgcaata agaaaatcac
     6721 gttcctttga ttagtattga caacactgtt actttaacag aaatgtgtgt gctaccgagc
     6781 gctggctgtc tgtattcctt taacagctac tctgcggcac atggatctga acggtctatc
     6841 tatgtgatag ccatgtgtgt ggattaggac actttgtgat gcgtctttgt tgaggcttct
     6901 gaagggcatt gccagtacct tctgactgta aattaattgt tgtatgatgt atagtttgtt
     6961 tagccttgga gcttctatag atttctactt ttattatact tgaatgaggc aggaagcact
     7021 gtgggcagga tgcaacttgc agataaacca aaaataaacc aaggtactga acagcaatgc
     7081 tgacggagtg ctttatagtc caggagtccg tgtttttcca gccacatttt agggaaatga
     7141 agtaattgaa gataatacag tcttttatct agacagtata gtctcaaatg attacctcct
     7201 cgatgtgtca acagtgtgtg tcctttttaa acttccgtat cagtccttag atagcttagt
     7261 tgagggccat ccatgctccc tcctcggacc actcagtgtc taggacggaa caaaccaact
     7321 acattgtgca tattagatgc actgtctgtg tgaagtcact gtgttttaga tggagtagct
     7381 ttcataggta gctttgagaa ctctttaata atcatatacc aaaaactaaa acctaaattt
     7441 ttaaagatca gttattcctt agctgtgcct aaaaactctt agtcatgaag gccacatgag
     7501 ggactcagga ttgaatgttc ccaaagtgtg tgttcgttcc tttagctgaa gagttactta
     7561 ttcaacataa cctgtagctc agaaaacaaa actaagcaaa aacaaaacaa ccacgagcaa
     7621 caagacggtg agatgtgctt cattgtcctt gcccctgcgg ctacaggccg ccatctcgga
     7681 acgagactcc tatgggaaga tgttctgtat aaaggtactg cttgggagct ttttttaata
     7741 tgcaaaataa aatgttggat gaactctgct ttgccataaa gtacccaaca atgtcgttga
     7801 aaataaaatt ggtcacaatc aaa
//
