LOCUS       NM_001191747            4114 bp    mRNA    linear   ROD 24-OCT-2024
DEFINITION  Rattus norvegicus DENN domain containing 1A (Dennd1a), transcript
            variant 1, mRNA.
ACCESSION   NM_001191747 XM_231184
VERSION     NM_001191747.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4114)
  AUTHORS   Yoshimura,S., Gerondopoulos,A., Linford,A., Rigden,D.J. and
            Barr,F.A.
  TITLE     Family-wide characterization of the DENN domain Rab GDP-GTP
            exchange factors
  JOURNAL   J Cell Biol 191 (2), 367-381 (2010)
   PUBMED   20937701
REFERENCE   2  (bases 1 to 4114)
  AUTHORS   Allaire,P.D., Marat,A.L., Dall'Armi,C., Di Paolo,G., McPherson,P.S.
            and Ritter,B.
  TITLE     The Connecdenn DENN domain: a GEF for Rab35 mediating
            cargo-specific exit from early endosomes
  JOURNAL   Mol Cell 37 (3), 370-382 (2010)
   PUBMED   20159556
REFERENCE   3  (bases 1 to 4114)
  AUTHORS   Allaire,P.D., Ritter,B., Thomas,S., Burman,J.L., Denisov,A.Y.,
            Legendre-Guillemin,V., Harper,S.Q., Davidson,B.L., Gehring,K. and
            McPherson,P.S.
  TITLE     Connecdenn, a novel DENN domain-containing protein of neuronal
            clathrin-coated vesicles functioning in synaptic vesicle
            endocytosis
  JOURNAL   J Neurosci 26 (51), 13202-13212 (2006)
   PUBMED   17182770
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            On Jul 17, 2010 this sequence version replaced XM_231184.5.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA5760383, SAMEA5760386
                              [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-91                JAXUCZ010000003.1  42404513-42404603   c
            92-135              JAXUCZ010000003.1  42320976-42321019   c
            136-185             JAXUCZ010000003.1  42298198-42298247   c
            186-305             JAXUCZ010000003.1  42288485-42288604   c
            306-375             JAXUCZ010000003.1  42214167-42214236   c
            376-456             JAXUCZ010000003.1  42208187-42208267   c
            457-510             JAXUCZ010000003.1  42204729-42204782   c
            511-621             JAXUCZ010000003.1  42188884-42188994   c
            622-722             JAXUCZ010000003.1  42172532-42172632   c
            723-768             JAXUCZ010000003.1  42152324-42152369   c
            769-870             JAXUCZ010000003.1  42131094-42131195   c
            871-996             JAXUCZ010000003.1  42112127-42112252   c
            997-1101            JAXUCZ010000003.1  42033274-42033378   c
            1102-1189           JAXUCZ010000003.1  42032924-42033011   c
            1190-1230           JAXUCZ010000003.1  42030947-42030987   c
            1231-1302           JAXUCZ010000003.1  42028823-42028894   c
            1303-1359           JAXUCZ010000003.1  42027285-42027341   c
            1360-1491           JAXUCZ010000003.1  42019755-42019886   c
            1492-1580           JAXUCZ010000003.1  41991217-41991305   c
            1581-1839           JAXUCZ010000003.1  41976970-41977228   c
            1840-4114           JAXUCZ010000003.1  41974502-41976776   c
FEATURES             Location/Qualifiers
     source          1..4114
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q11-q12"
     gene            1..4114
                     /gene="Dennd1a"
                     /gene_synonym="RGD1307927"
                     /note="DENN domain containing 1A"
                     /db_xref="GeneID:311913"
                     /db_xref="RGD:1307927"
     CDS             1..3072
                     /gene="Dennd1a"
                     /gene_synonym="RGD1307927"
                     /note="isoform a is encoded by transcript variant 1; DENN
                     domain-containing protein 1A; DENN/MADD domain containing
                     1A"
                     /codon_start=1
                     /product="DENN domain-containing protein 1A isoform a"
                     /protein_id="NP_001178676.1"
                     /db_xref="GeneID:311913"
                     /db_xref="RGD:1307927"
                     /translation="MICFLCRQNPETTFEVYVEVAYPRTGGTLSDPEVQRQFPEDYSD
                     QEVLQTLTKFCFPFYVDSLSVSQVGQNFTFVLTDIDSKQRFGFCRLSSGAKSCFCILS
                     YLPWFEVFYKLLNILADYTTKQQESQWNELLETLHRLPIPDPGVSVHLSVHSYFTVPD
                     SRELPSIPENRNLTEYFVAVDVNNMLHLYASMLYERRILIICSKLSTLTACIHGSAAM
                     LYPMYWQHVYIPVLPPHLLDYCCAPMPYLIGIHLSLMEKVRNMALDDVVILNVDTNTL
                     ETPFDDLQSLPNDVISSLKNRLKKVSTTTGDGVARAFLKAQAAFFGSYRNALKIEPEE
                     PITFSEEAFVSHYRSGAMRQFLQNATQLQLFKQFIDGRLDLLNSGEGFSDVFEEEISM
                     GEYAGSDKLYHQWLSTVRKGSGAILNTVKTKANPAMKTVYKFAKDHAKMGIKEVKNRL
                     KQKDITENGCASSAEDPLPKTIPSPLAEAKDPKLREDRRPITVHFGQVRPPRPHVIKR
                     PKSNMAVEGRRTSISSPEQPQPYRTLKESDSAEGDETESPEQPTREPWGPTPAPPDRA
                     ASIDLLEDVFSSLDVEAPLQPLGQAKSLEDLRVPRDLREQSGSFDYQRLDLCRSERGL
                     SMAAALKFAHPYTQLWSLGQDDMAIPSKPSMTSPEKPSALLGTLPALPVRPQNQEGIL
                     SPSIKEETPVPAPGSITIPRPQGRKTPELGIVPPPPTARPAKLQGAGGPLGDFSSEPL
                     QMDLERQAALSPALLSGLLPRAGPQGSTELVQSPSPAPGAAGTGSDALLALLDPLNTA
                     WSGSTIPSYPTTPSVATPFTPQLSFPSTVTPSPFAQTPLNPFVPSVPVVPPTMSLGST
                     PARPFGTPPASLGPAYAPSILLSGSSFCAPHRSQPTLSALSMPNLFGQIPMGAHTSPL
                     QPLGPPAVAPSRIRTLPLPRSSARAAEAKQGLALRPGESPLLPPRPPQNLQPTLQPSA
                     PTQARDPFEDLLRKTKQDVSPSPVPAPAPAPAPASASTSVEQLRRQWETFE"
     exon            1..91
                     /gene="Dennd1a"
                     /gene_synonym="RGD1307927"
                     /inference="alignment:Splign:2.1.0"
     exon            92..135
                     /gene="Dennd1a"
                     /gene_synonym="RGD1307927"
                     /inference="alignment:Splign:2.1.0"
     exon            136..185
                     /gene="Dennd1a"
                     /gene_synonym="RGD1307927"
                     /inference="alignment:Splign:2.1.0"
     exon            186..305
                     /gene="Dennd1a"
                     /gene_synonym="RGD1307927"
                     /inference="alignment:Splign:2.1.0"
     exon            306..375
                     /gene="Dennd1a"
                     /gene_synonym="RGD1307927"
                     /inference="alignment:Splign:2.1.0"
     exon            376..456
                     /gene="Dennd1a"
                     /gene_synonym="RGD1307927"
                     /inference="alignment:Splign:2.1.0"
     exon            457..510
                     /gene="Dennd1a"
                     /gene_synonym="RGD1307927"
                     /inference="alignment:Splign:2.1.0"
     exon            511..621
                     /gene="Dennd1a"
                     /gene_synonym="RGD1307927"
                     /inference="alignment:Splign:2.1.0"
     exon            622..722
                     /gene="Dennd1a"
                     /gene_synonym="RGD1307927"
                     /inference="alignment:Splign:2.1.0"
     exon            723..768
                     /gene="Dennd1a"
                     /gene_synonym="RGD1307927"
                     /inference="alignment:Splign:2.1.0"
     exon            769..870
                     /gene="Dennd1a"
                     /gene_synonym="RGD1307927"
                     /inference="alignment:Splign:2.1.0"
     exon            871..996
                     /gene="Dennd1a"
                     /gene_synonym="RGD1307927"
                     /inference="alignment:Splign:2.1.0"
     exon            997..1101
                     /gene="Dennd1a"
                     /gene_synonym="RGD1307927"
                     /inference="alignment:Splign:2.1.0"
     exon            1102..1189
                     /gene="Dennd1a"
                     /gene_synonym="RGD1307927"
                     /inference="alignment:Splign:2.1.0"
     exon            1190..1230
                     /gene="Dennd1a"
                     /gene_synonym="RGD1307927"
                     /inference="alignment:Splign:2.1.0"
     exon            1231..1302
                     /gene="Dennd1a"
                     /gene_synonym="RGD1307927"
                     /inference="alignment:Splign:2.1.0"
     exon            1303..1359
                     /gene="Dennd1a"
                     /gene_synonym="RGD1307927"
                     /inference="alignment:Splign:2.1.0"
     exon            1360..1491
                     /gene="Dennd1a"
                     /gene_synonym="RGD1307927"
                     /inference="alignment:Splign:2.1.0"
     exon            1492..1580
                     /gene="Dennd1a"
                     /gene_synonym="RGD1307927"
                     /inference="alignment:Splign:2.1.0"
     exon            1581..1839
                     /gene="Dennd1a"
                     /gene_synonym="RGD1307927"
                     /inference="alignment:Splign:2.1.0"
     exon            1840..4114
                     /gene="Dennd1a"
                     /gene_synonym="RGD1307927"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgatttgtt tcctttgtag acaaaacccg gagactacat ttgaagtgta tgtggaagtg
       61 gcctatccta ggacaggtgg cacgctttca gatcctgagg tgcagaggca attcccggag
      121 gactacagtg accaggaagt tctacagact ttgaccaagt tttgttttcc cttctatgtg
      181 gacagcctct cagttagcca agttggccag aacttcacat ttgtgctcac tgacattgac
      241 agcaaacaga gattcgggtt ctgccgctta tcttcaggag ccaagagctg cttctgtatc
      301 ttaagctacc tcccctggtt tgaggtattt tataagctcc ttaacatctt ggcagattac
      361 acaacaaaac aacaggaaag tcagtggaat gaacttcttg aaactctgca cagacttccc
      421 attccagacc ccggagtgtc tgttcacctc agcgtgcatt cttacttcac tgtgcctgat
      481 agcagagagc ttcccagcat acctgagaat agaaatctga cagaatattt tgtggctgtg
      541 gatgtgaaca acatgttgca tctgtacgcc agcatgctgt atgagcgccg gatcctcatc
      601 atctgcagca agctgagtac cttgacggcc tgcatccacg gctctgctgc catgctctac
      661 cccatgtact ggcagcatgt gtacatccct gtgctgcccc cacatctgct ggactactgc
      721 tgtgctccca tgccctacct cataggaatc catttaagtt taatggagaa ggtcagaaac
      781 atggccctag atgatgttgt gatcttgaat gtggacacca acaccctgga aacccctttt
      841 gatgaccttc agagcctccc aaatgatgtg atctcctccc tgaagaacag gctgaagaag
      901 gtctccacaa ccacaggcga tggggtggcc agagccttcc tcaaggccca ggctgctttc
      961 tttggcagct accggaatgc actgaaaatt gagccagaag aacccatcac tttcagtgag
     1021 gaggccttcg tgtcccacta ccgctctgga gccatgagac agttcctaca gaatgccaca
     1081 cagttgcagc tcttcaagca gtttatcgat ggccgactag accttctcaa ttccggtgaa
     1141 ggtttcagtg atgtctttga ggaggagatc agcatgggag aatatgccgg cagtgataaa
     1201 ctgtaccatc agtggctgtc cacagtccgg aaaggaagtg gagcgattct gaatactgta
     1261 aaaacaaaag ctaacccagc catgaagact gtctacaagt ttgcaaaaga tcatgcaaaa
     1321 atgggaataa aagaggtgaa aaaccgcttg aagcaaaagg acatcaccga gaatggctgt
     1381 gcatcctctg cagaagatcc actgccaaag accataccat ccccactggc agaggccaag
     1441 gaccccaaac ttcgagaaga ccggagacca atcacagtcc actttgggca ggtaagaccg
     1501 cctcggccgc atgtcatcaa gagacccaag agcaacatgg ctgtggaagg ccggaggacg
     1561 tccatctcaa gccccgagca gccacagcca tacaggactt tgaaagaatc agacagcgca
     1621 gaaggtgatg agaccgagag tccagagcag ccaactcggg agccctgggg gcctacccct
     1681 gctccacctg accgagctgc cagcattgac cttctagaag atgtcttcag cagcctagat
     1741 gtggaggcac cactgcagcc gctgggccaa gccaagagcc tggaggatct tcgggtcccc
     1801 agagacttgc gggaacagtc aggcagcttt gattaccaga ggctggacct atgcagaagt
     1861 gagaggggcc ttagcatggc tgcagccttg aagtttgctc atccatatac tcagctctgg
     1921 agtctcggac aagacgacat ggccatcccc agcaagccct ccatgacctc ccctgagaag
     1981 ccctcagctc tgcttggtac tttgccagca ctgcctgtca gaccccagaa ccaggagggc
     2041 atcctgagcc ccagcatcaa ggaggagact cccgtgccag ctccaggcag catcaccatt
     2101 cccaggccac aaggcagaaa gacccctgag cttggcattg tgcctccacc acccactgcc
     2161 cggccagcca agctccaggg tgctggcggc ccacttggtg acttctcttc agagccacta
     2221 cagatggacc tggaaagaca agctgctctg agtccagccc tcttgtcagg gctgctcccg
     2281 agagctggtc cccaaggctc cacagaactt gtgcagtcac ccagcccagc cccaggagct
     2341 gcaggcacag gcagcgatgc cctgcttgct ctcctggacc cacttaacac agcctggtca
     2401 ggcagcacca tcccatccta tcctactacc cccagtgtag ccaccccatt caccccccag
     2461 ctcagcttcc cctcaacagt gacaccctcc ccttttgcac agacaccact caatcccttt
     2521 gtcccctctg tgccagtagt accacccacc atgtccctgg gctctacacc agccagacct
     2581 tttgggacgc ctccagcatc cctagggcca gcatatgcac ctagcatcct attgtctggt
     2641 tctagcttct gtgcccctca caggtctcag cccaccctct ctgctctctc tatgcccaac
     2701 ctctttggcc agatcccaat gggtgcccac actagtcccc tgcagccact tggcccccca
     2761 gccgttgccc cctccaggat ccgaacattg cctctgcccc gctcaagtgc cagggctgct
     2821 gaggccaagc aggggttggc cctgaggcca ggtgaatccc cactgctgcc tcctagacca
     2881 ccacagaatc tacagccaac cctgcagccc tctgctccta cacaggccag agaccccttt
     2941 gaggatttgc tacggaaaac caagcaagat gtgagcccaa gcccagtccc ggccccggcc
     3001 ccagccccag ccccagcctc agcctccacc tctgtggagc agctccgcag gcagtgggag
     3061 accttcgagt gaccatgcct atgccactgt ccagtaccgt gcctccccag tgtcccgttc
     3121 ctggccaggc ttcaccgggg caaagggact ctgcccctct cctccatagc ccatctctga
     3181 ggcctggccc tgggagctcg tcccagagga gagagctgcc tgccaccacc ctcagcaccc
     3241 tgtgtgggtt ttgcactata tgtcagctgg gccagctgtg tcccaccacc ttccctccct
     3301 tagtccaaga ggagtcaaga agctcgaggc tgctctcaag cccagctctc ctcctttgct
     3361 gggccctacc ccacagggca gatgtcagta acgcactgtg taagcacatc tttgggggac
     3421 ataggtgttt ggggggctgg aatgaggacc actcctgggc tggcatttct ccctggtggt
     3481 catctccaaa cctcactaag caatacactc tttgctgagt cttcacctaa ccaccaaact
     3541 cgagttgttc ctaaagggcc agcggtctgg agacctaatg gtcaacaagc ccagccccag
     3601 ccagcccttc cagggctcgg gaacaccagc aactctaatt tatacgacga cccccaaacc
     3661 tgagtcgaag gagctgcctt tagctctgcc acctccatac ctctgggctt tcctgtcaat
     3721 caaagctcag gctcagcctc ctgcccatgg agcttatggg caccagtgat ggagtccagc
     3781 tcaaaggaca agcttcctga cacaggcaaa agagagggca gctgcttgag ctcctgggtc
     3841 aagatcaggt ggggccccag gcccccaggg gccccgtgga gtgaatatac acatggcctc
     3901 tgagcctggg gcgggtgggg cccagccctc cccactgtct ccagcctctc gccagcgcag
     3961 aaattcctga gtccaagtca ccaaagttat aatgaaatgt ttgttattgt ttctttgatc
     4021 ttgcttttcc tttttacctt attgatttga tgaatcttga aaattgattc ctttcaataa
     4081 accaaggtaa aacacagact aaccatttaa gaaa
//
