LOCUS       NM_001017457            1317 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus delta(4)-desaturase, sphingolipid 2 (Degs2),
            mRNA.
ACCESSION   NM_001017457 XM_234532
VERSION     NM_001017457.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1317)
  AUTHORS   Devlin,C.M., Lahm,T., Hubbard,W.C., Van Demark,M., Wang,K.C.,
            Wu,X., Bielawska,A., Obeid,L.M., Ivan,M. and Petrache,I.
  TITLE     Dihydroceramide-based response to hypoxia
  JOURNAL   J Biol Chem 286 (44), 38069-38078 (2011)
   PUBMED   21914808
  REMARK    GeneRIF: overexpression of DEGS1 or DEGS2 attenuates the DHC
            accumulation and increased cell proliferation during hypoxia
            Erratum:[J Biol Chem. 2012 May 18;287(21):17425]
REFERENCE   2  (bases 1 to 1317)
  AUTHORS   Beauchamp,E., Goenaga,D., Le Bloc'h,J., Catheline,D., Legrand,P.
            and Rioux,V.
  TITLE     Myristic acid increases the activity of dihydroceramide
            Delta4-desaturase 1 through its N-terminal myristoylation
  JOURNAL   Biochimie 89 (12), 1553-1561 (2007)
   PUBMED   17716801
REFERENCE   3  (bases 1 to 1317)
  AUTHORS   Enomoto,A., Omae,F., Miyazaki,M., Kozutsumi,Y., Yubisui,T. and
            Suzuki,A.
  TITLE     Dihydroceramide:sphinganine C-4-hydroxylation requires Des2
            hydroxylase and the membrane form of cytochrome b5
  JOURNAL   Biochem J 397 (2), 289-295 (2006)
   PUBMED   16571104
REFERENCE   4  (bases 1 to 1317)
  AUTHORS   Omae,F., Miyazaki,M., Enomoto,A. and Suzuki,A.
  TITLE     Identification of an essential sequence for dihydroceramide C-4
            hydroxylase activity of mouse DES2
  JOURNAL   FEBS Lett 576 (1-2), 63-67 (2004)
   PUBMED   15474011
REFERENCE   5  (bases 1 to 1317)
  AUTHORS   Ternes,P., Franke,S., Zahringer,U., Sperling,P. and Heinz,E.
  TITLE     Identification and characterization of a sphingolipid delta
            4-desaturase family
  JOURNAL   J Biol Chem 277 (28), 25512-25518 (2002)
   PUBMED   11937514
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC098701.1.
            
            On Dec 15, 2005 this sequence version replaced NM_001017457.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC098701.1, AJ938082.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMN14984036
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1317
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q32"
     gene            1..1317
                     /gene="Degs2"
                     /gene_synonym="RGD1305023"
                     /note="delta(4)-desaturase, sphingolipid 2"
                     /db_xref="GeneID:314438"
                     /db_xref="RGD:1305023"
     exon            1..149
                     /gene="Degs2"
                     /gene_synonym="RGD1305023"
                     /inference="alignment:Splign:2.1.0"
     CDS             68..1039
                     /gene="Degs2"
                     /gene_synonym="RGD1305023"
                     /EC_number="1.14.18.5"
                     /EC_number="1.14.19.17"
                     /note="sphingolipid delta(4)-desaturase/C4-hydroxylase
                     DES2; sphingolipid C4-hydroxylase/delta 4-desaturase;
                     sphingolipid 4-desaturase; sphingolipid C4-monooxygenase"
                     /codon_start=1
                     /product="sphingolipid
                     delta(4)-desaturase/C4-monooxygenase DES2"
                     /protein_id="NP_001017457.1"
                     /db_xref="GeneID:314438"
                     /db_xref="RGD:1305023"
                     /translation="MGNSAARSDFEWVYSDQPHTQRRKEMLAKYPSIKALMRPDPNIK
                     WTVLGMVLVQVLACWLVRGLSWRWLLFWAYAFGGCINHSLTLAIHDISHNTAFGTRCA
                     SRNRWFAVFANLPIGLPYATSFKKYHVDHHRYLGGDGLDVDIPTDFEGWFFCTPARKL
                     LWLVLQPFFYSLRPLYVNPKAVTRMEILNALVQLAFNVTIFALWGIKAIVYLLASSLL
                     GLGLHPISGHFVAEHYMFLKGHETYSYYGPLNWITFNVGYHVEHHDFPSIPGCYLPLV
                     RMIAPEYYDHLPQHHSWVKVLWDFVFEDSLGPYSRVKRKCKLAKDQL"
     exon            150..892
                     /gene="Degs2"
                     /gene_synonym="RGD1305023"
                     /inference="alignment:Splign:2.1.0"
     exon            893..1285
                     /gene="Degs2"
                     /gene_synonym="RGD1305023"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cctgggtatc ctgcgacagg tgaacactgc gaagcagaga gctcgctaga gctccaacgt
       61 ccccatcatg ggtaacagcg cagcccgcag cgacttcgag tgggtctaca gcgaccagcc
      121 gcacacccag aggcgcaaag agatgctcgc caagtaccca tccatcaagg ccctgatgcg
      181 gccagacccc aacatcaagt ggaccgtgct gggaatggta ctggtgcagg tgctggcctg
      241 ctggctggta cgggggctct cttggcgatg gttgctgttt tgggcctatg cctttggcgg
      301 ctgcatcaac cactcactga cactggccat ccatgacatc tcgcacaaca ctgcctttgg
      361 cacacgctgt gcctcccgca accgctggtt tgccgtcttt gctaatctgc ccattggcct
      421 accttacgcc acgtccttca aaaagtacca cgtggaccac catcgttacc tgggcggaga
      481 cgggctggat gtggatatcc ccacagactt cgagggctgg ttcttctgca caccggcccg
      541 caagctgctt tggctggtgc ttcaaccctt cttctactca ctcaggccac tctatgtgaa
      601 ccccaaggcg gtgacgcgta tggagatcct caatgccctg gtgcagttgg catttaatgt
      661 caccatcttt gccctctggg ggatcaaagc catagtctac cttctagcca gctctctcct
      721 gggcctgggc ctgcacccta tctctggcca cttcgtggca gagcattata tgttcctgaa
      781 gggccacgag acgtactcct actatgggcc tctcaactgg attaccttca atgttggcta
      841 ccacgtggaa caccacgact tccccagcat ccccggttgc tacctgccac tggtacggat
      901 gattgcaccc gaatactacg accatctgcc gcagcaccac tcctgggtga aagtgctctg
      961 ggacttcgtg tttgaggact ctctgggacc ctactccagg gttaagcgca agtgcaagct
     1021 ggcgaaggac cagctgtgag ccccgctggc cagtagtcca gatccagcag ccacaggctc
     1081 ctgcccacgt ggccagggcc acatccactc ctgcagtcta agctggttct ggctctgttg
     1141 ggcccagcaa gtagatccag gttggagtga ccaggtttac ctgatctttc tgggtcttag
     1201 ctatgactgg ccaggatact ctgtgcaggc agtcccatgg cttctctttt tctatgcccc
     1261 acattaaatg taatacatct ttataaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaa
//
