LOCUS       NM_001037549             436 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus defensin beta 5 (Defb5), mRNA.
ACCESSION   NM_001037549
VERSION     NM_001037549.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 436)
  AUTHORS   Augustin,D.K., Heimer,S.R., Tam,C., Li,W.Y., Le Due,J.M.,
            Evans,D.J. and Fleiszig,S.M.
  TITLE     Role of defensins in corneal epithelial barrier function against
            Pseudomonas aeruginosa traversal
  JOURNAL   Infect Immun 79 (2), 595-605 (2011)
   PUBMED   21115716
REFERENCE   2  (bases 1 to 436)
  AUTHORS   Rohrl,J., Yang,D., Oppenheim,J.J. and Hehlgans,T.
  TITLE     Specific binding and chemotactic activity of mBD4 and its
            functional orthologue hBD2 to CCR6-expressing cells
  JOURNAL   J Biol Chem 285 (10), 7028-7034 (2010)
   PUBMED   20068036
REFERENCE   3  (bases 1 to 436)
  AUTHORS   Maerki,C., Meuter,S., Liebi,M., Muhlemann,K., Frederick,M.J.,
            Yawalkar,N., Moser,B. and Wolf,M.
  TITLE     Potent and broad-spectrum antimicrobial activity of CXCL14 suggests
            an immediate role in skin infections
  JOURNAL   J Immunol 182 (1), 507-514 (2009)
   PUBMED   19109182
REFERENCE   4  (bases 1 to 436)
  AUTHORS   Patil,A.A., Cai,Y., Sang,Y., Blecha,F. and Zhang,G.
  TITLE     Cross-species analysis of the mammalian beta-defensin gene family:
            presence of syntenic gene clusters and preferential expression in
            the male reproductive tract
  JOURNAL   Physiol Genomics 23 (1), 5-17 (2005)
   PUBMED   16033865
REFERENCE   5  (bases 1 to 436)
  AUTHORS   Schulz,A., Kluver,E., Schulz-Maronde,S. and Adermann,K.
  TITLE     Engineering disulfide bonds of the novel human beta-defensins
            hBD-27 and hBD-28: differences in disulfide formation and
            biological activity among human beta-defensins
  JOURNAL   Biopolymers 80 (1), 34-49 (2005)
   PUBMED   15625724
REFERENCE   6  (bases 1 to 436)
  AUTHORS   Bals,R., Wang,X., Wu,Z., Freeman,T., Bafna,V., Zasloff,M. and
            Wilson,J.M.
  TITLE     Human beta-defensin 2 is a salt-sensitive peptide antibiotic
            expressed in human lung
  JOURNAL   J Clin Invest 102 (5), 874-880 (1998)
   PUBMED   9727055
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            On Sep 2, 2022 this sequence version replaced NM_001037549.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY621340.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN06680435, SAMN09767679
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-87                JAXUCZ010000016.1  77317742-77317828   c
            88-436              JAXUCZ010000016.1  77315424-77315772   c
FEATURES             Location/Qualifiers
     source          1..436
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16q12.5"
     gene            1..436
                     /gene="Defb5"
                     /gene_synonym="BD-5"
                     /note="defensin beta 5"
                     /db_xref="GeneID:641624"
                     /db_xref="RGD:1563630"
     exon            1..87
                     /gene="Defb5"
                     /gene_synonym="BD-5"
                     /inference="alignment:Splign:2.1.0"
     CDS             30..221
                     /gene="Defb5"
                     /gene_synonym="BD-5"
                     /note="beta-defensin 5"
                     /codon_start=1
                     /product="beta-defensin 5 precursor"
                     /protein_id="NP_001032638.1"
                     /db_xref="GeneID:641624"
                     /db_xref="RGD:1563630"
                     /translation="MRIHYLLFSFLLVLLSPLSVFTQSINNPVSCVTHGGICWGRCPG
                     SFRQIGTCGLGKVRCCKKK"
     exon            88..436
                     /gene="Defb5"
                     /gene_synonym="BD-5"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtatctctgc acctcaccag gcttcagtca tgaggatcca ttaccttctc ttctcatttc
       61 tcctggtgct gctgtcgccc ctttctgtct ttactcaaag catcaacaat ccagtctcat
      121 gtgtgaccca tggaggcata tgctggggtc ggtgccctgg cagttttcga cagattggca
      181 cttgtggact gggtaaagtc agatgctgca agaaaaaata gataaaaaga ccaagaacct
      241 gtgagatgaa taaattgcca gagtctgctc ctccatgaaa atgcacaaag caaaccgaat
      301 taaagatctt tgataacctt ccaggagttc cagcaccttc ttttgacctt tatggagaac
      361 atatacacaa tacaaaaata ccatacccag aaacttaata atagtaataa gtataatttt
      421 aaaaatacag tcattg
//
