LOCUS       NM_022544                421 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Rattus norvegicus defensin beta 4 (Defb4), mRNA.
ACCESSION   NM_022544
VERSION     NM_022544.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 421)
  AUTHORS   Kolar,S.S., Baidouri,H., Hanlon,S. and McDermott,A.M.
  TITLE     Protective role of murine beta-defensins 3 and 4 and
            cathelin-related antimicrobial peptide in Fusarium solani keratitis
  JOURNAL   Infect Immun 81 (8), 2669-2677 (2013)
   PUBMED   23670560
REFERENCE   2  (bases 1 to 421)
  AUTHORS   Deng,L.X., Wu,G.X., Cao,Y., Fan,B., Gao,X., Luo,L. and Huang,N.
  TITLE     The chromosomal protein HMGN2 mediates lipopolysaccharide-induced
            expression of beta-defensins in A549 cells
  JOURNAL   FEBS J 278 (12), 2152-2166 (2011)
   PUBMED   21518253
  REMARK    GeneRIF: HMGN2 acts as a positive modulator of nuclear factor
            kappaB signalling to promote lipopolysaccharide-induced
            beta-defensin-2 expression.
REFERENCE   3  (bases 1 to 421)
  AUTHORS   Augustin,D.K., Heimer,S.R., Tam,C., Li,W.Y., Le Due,J.M.,
            Evans,D.J. and Fleiszig,S.M.
  TITLE     Role of defensins in corneal epithelial barrier function against
            Pseudomonas aeruginosa traversal
  JOURNAL   Infect Immun 79 (2), 595-605 (2011)
   PUBMED   21115716
REFERENCE   4  (bases 1 to 421)
  AUTHORS   Chen,L., Sun,B.B., Wang,T., Wang,X., Li,J.Q., Wang,H.X.,
            Zhang,S.F., Liu,D.S., Liu,L., Xu,D., Ou,X.M., Chen,Y.J., Yang,T.,
            Zhou,H. and Wen,F.Q.
  TITLE     Cigarette smoke enhances {beta}-defensin 2 expression in rat
            airways via nuclear factor-{kappa}B activation
  JOURNAL   Eur Respir J 36 (3), 638-645 (2010)
   PUBMED   20150208
  REMARK    GeneRIF: Cigarette smoke enhances {beta}-defensin 2 expression in
            rat airways via nuclear factor-{kappa}B activation
REFERENCE   5  (bases 1 to 421)
  AUTHORS   Rohrl,J., Yang,D., Oppenheim,J.J. and Hehlgans,T.
  TITLE     Specific binding and chemotactic activity of mBD4 and its
            functional orthologue hBD2 to CCR6-expressing cells
  JOURNAL   J Biol Chem 285 (10), 7028-7034 (2010)
   PUBMED   20068036
REFERENCE   6  (bases 1 to 421)
  AUTHORS   Ashitani,J., Kumamoto,K., Hiratsuka,T., Mukae,H., Nakazato,M. and
            Matsukura,S.
  TITLE     [Beta-defensins in plasma and bronchoalveolar lavage fluid in
            patients with non-tuberculous mycobacterium infection]
  JOURNAL   Nihon Kokyuki Gakkai Zasshi 39 (1), 12-16 (2001)
   PUBMED   11296379
REFERENCE   7  (bases 1 to 421)
  AUTHORS   Jia,H.P., Mills,J.N., Barahmand-Pour,F., Nishimura,D.,
            Mallampali,R.K., Wang,G., Wiles,K., Tack,B.F., Bevins,C.L. and
            McCray,P.B. Jr.
  TITLE     Molecular cloning and characterization of rat genes encoding
            homologues of human beta-defensins
  JOURNAL   Infect Immun 67 (9), 4827-4833 (1999)
   PUBMED   10456937
REFERENCE   8  (bases 1 to 421)
  AUTHORS   Hiratsuka,T., Nakazato,M., Ashitani,J. and Matsukura,S.
  TITLE     [A study of human beta-defensin-1 and human beta-defensin-2 in
            airway mucosal defense]
  JOURNAL   Kansenshogaku Zasshi 73 (2), 156-162 (1999)
   PUBMED   10213993
REFERENCE   9  (bases 1 to 421)
  AUTHORS   Singh,P.K., Jia,H.P., Wiles,K., Hesselberth,J., Liu,L.,
            Conway,B.A., Greenberg,E.P., Valore,E.V., Welsh,M.J., Ganz,T.,
            Tack,B.F. and McCray,P.B. Jr.
  TITLE     Production of beta-defensins by human airway epithelia
  JOURNAL   Proc Natl Acad Sci U S A 95 (25), 14961-14966 (1998)
   PUBMED   9843998
  REMARK    Erratum:[Proc Natl Acad Sci U S A 1999 Mar 2;96(5):2569]
REFERENCE   10 (bases 1 to 421)
  AUTHORS   Bals,R., Wang,X., Wu,Z., Freeman,T., Bafna,V., Zasloff,M. and
            Wilson,J.M.
  TITLE     Human beta-defensin 2 is a salt-sensitive peptide antibiotic
            expressed in human lung
  JOURNAL   J Clin Invest 102 (5), 874-880 (1998)
   PUBMED   9727055
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AY621374.1.
            
            On Nov 27, 2005 this sequence version replaced NM_022544.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY621374.1, AF068861.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN16676784, SAMN16676785
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..421
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16q12.5"
     gene            1..421
                     /gene="Defb4"
                     /gene_synonym="Defb2; Defb3"
                     /note="defensin beta 4"
                     /db_xref="GeneID:64389"
                     /db_xref="RGD:619944"
     exon            1..196
                     /gene="Defb4"
                     /gene_synonym="Defb2; Defb3"
                     /inference="alignment:Splign:2.1.0"
     CDS             139..330
                     /gene="Defb4"
                     /gene_synonym="Defb2; Defb3"
                     /note="beta-defensin 4; BD-2; BD-4; RBD-2; RBD-4; beta
                     defensin-2; defensin beta 3; beta-defensin 3"
                     /codon_start=1
                     /product="beta-defensin 4 precursor"
                     /protein_id="NP_071989.1"
                     /db_xref="GeneID:64389"
                     /db_xref="RGD:619944"
                     /translation="MRIHYLLFSFLLVLLSPLSAFTQSINNPITCLTKGGVCWGPCTG
                     GFRQIGTCGLPRVRCCKKK"
     exon            197..421
                     /gene="Defb4"
                     /gene_synonym="Defb2; Defb3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aaggtgctct gtatttcata attgtaatta gtggggttct actcagtgta gaatcctatg
       61 caggaggcag cacctggcac tatataaggc actgagctca agtctctctg catctctgta
      121 cctcaccagg cttcagtcat gaggatccat tacctcctct tctcatttct cctggtgctg
      181 ctgtcgcctc tttcagcctt tactcaaagt atcaacaatc caatcacatg cctgaccaaa
      241 ggaggcgtat gctggggtcc atgcactggc ggttttcgac agattggcac ttgtggactg
      301 cctagagtga gatgctgcaa gaaaaagtag ataaaaagac caagaaccaa tgagatgaac
      361 agaatttgct cctccatgaa aatgcacaaa acaaaccaaa ttaaagtact ttgataattt
      421 t
//
