LOCUS       NM_134391                653 bp    mRNA    linear   ROD 20-MAR-2023
DEFINITION  Rattus norvegicus defensin beta 22 (Defb22), mRNA.
ACCESSION   NM_134391
VERSION     NM_134391.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 653)
  AUTHORS   Diao H, Yu HG, Sun F, Zhang YL and Tanphaichitr N.
  TITLE     Rat recombinant beta-defensin 22 is a heparin-binding protein with
            antimicrobial activity
  JOURNAL   Asian J Androl 13 (2), 305-311 (2011)
   PUBMED   21151152
  REMARK    GeneRIF: Demonstrated the antimicrobial activity of recombinant
            beta-defensin 22 against E coli and Candida albicans. It has
            lectin-like ability, binding to heparin beads. This heparin-binding
            activity implies potential roles in fertilisation capabilities of
            sperm.
REFERENCE   2  (bases 1 to 653)
  AUTHORS   Huang L, Leong SS and Jiang R.
  TITLE     Soluble fusion expression and characterization of bioactive human
            beta-defensin 26 and 27
  JOURNAL   Appl Microbiol Biotechnol 84 (2), 301-308 (2009)
   PUBMED   19373462
REFERENCE   3  (bases 1 to 653)
  AUTHORS   Yudin AI, Tollner TL, Treece CA, Kays R, Cherr GN, Overstreet JW
            and Bevins CL.
  TITLE     Beta-defensin 22 is a major component of the mouse sperm glycocalyx
  JOURNAL   Reproduction 136 (6), 753-765 (2008)
   PUBMED   18787081
REFERENCE   4  (bases 1 to 653)
  AUTHORS   Patil AA, Cai Y, Sang Y, Blecha F and Zhang G.
  TITLE     Cross-species analysis of the mammalian beta-defensin gene family:
            presence of syntenic gene clusters and preferential expression in
            the male reproductive tract
  JOURNAL   Physiol Genomics 23 (1), 5-17 (2005)
   PUBMED   16033865
REFERENCE   5  (bases 1 to 653)
  AUTHORS   Rao J, Herr JC, Reddi PP, Wolkowicz MJ, Bush LA, Sherman NE, Black
            M and Flickinger CJ.
  TITLE     Cloning and characterization of a novel sperm-associated isoantigen
            (E-3) with defensin- and lectin-like motifs expressed in rat
            epididymis
  JOURNAL   Biol Reprod 68 (1), 290-301 (2003)
   PUBMED   12493725
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AJ309150.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ309150.1, AY621353.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..653
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="W"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q41"
     gene            1..653
                     /gene="Defb22"
                     /gene_synonym="2D6glycoprotein"
                     /note="defensin beta 22"
                     /db_xref="GeneID:171412"
                     /db_xref="RGD:708352"
     exon            1..316
                     /gene="Defb22"
                     /gene_synonym="2D6glycoprotein"
                     /inference="alignment:Splign:2.1.0"
     CDS             259..594
                     /gene="Defb22"
                     /gene_synonym="2D6glycoprotein"
                     /note="beta-defensin 22; 2D6 glycoprotein; E-3 epididymal
                     fluid protein; beta-defensin 126"
                     /codon_start=1
                     /product="beta-defensin 126 precursor"
                     /protein_id="NP_599218.1"
                     /db_xref="GeneID:171412"
                     /db_xref="RGD:708352"
                     /translation="MKSLLSALMIIMFLAHLVTGNWYVRKCANKLGTCRKTCRKGEYQ
                     TDPATGKCSIGKLCCILDLKLAGQCGGADGNQAAAGTQAAGGTRAAGGTQGTGGTGAT
                     GAAATTAAP"
     exon            317..653
                     /gene="Defb22"
                     /gene_synonym="2D6glycoprotein"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctgtgcttta agagagctca cacctccaag tcttcctgtt tccccgaagg catggctagt
       61 gcaggcctct gggtggtgct ttctcaatta gagctgctgg ccaatagacc gaagtcatgg
      121 ttgacacagt agcctttatt cttctgttct actggctgag ccgaggctcc tcctaaggga
      181 caataaggat ctgcatccag agtcatactg cctgagagtc ttggactcca tagaacctac
      241 tgcctactga caggagccat gaagtcccta ttgtctgctc ttatgatcat tatgttcctg
      301 gcccacttgg tcacaggtaa ctggtacgtt cgaaagtgtg caaacaaatt gggcacctgt
      361 aggaagacgt gcagaaaagg ggagtaccag acagaccctg caacggggaa atgctccata
      421 ggaaaactgt gctgtattct ggacctcaaa cttgctggtc aatgtggggg cgcagatgga
      481 aaccaagctg ctgcggggac acaggcggca ggggggacac gggcggcagg gggaacacag
      541 ggaacagggg gaactggggc cacaggtgca gcggccacca ctgctgcacc ctgaacgctg
      601 ctgcctcttg tcttatgacc taatatccct gattgattaa agcaaagagg cct
//
