LOCUS       NM_001037507             324 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus defensin beta 2 (Defb2), mRNA.
ACCESSION   NM_001037507
VERSION     NM_001037507.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 324)
  AUTHORS   Dou,X., Yan,D., Ma,Z., Gao,N. and Shan,A.
  TITLE     Sodium butyrate alleviates LPS-induced kidney injury via inhibiting
            TLR2/4 to regulate rBD2 expression
  JOURNAL   J Food Biochem 46 (7), e14126 (2022)
   PUBMED   35322444
  REMARK    GeneRIF: Sodium butyrate alleviates LPS-induced kidney injury via
            inhibiting TLR2/4 to regulate rBD2 expression.
REFERENCE   2  (bases 1 to 324)
  AUTHORS   Agier,J., Brzezinska-Blaszczyk,E., Rozalska,S., Wiktorska,M.,
            Wawrocki,S. and Zelechowska,P.
  TITLE     beta-Defensin Strengthens Antimicrobial Peritoneal Mast Cell
            Response
  JOURNAL   J Immunol Res 2020, 5230172 (2020)
   PUBMED   32411798
  REMARK    GeneRIF: beta-Defensin Strengthens Antimicrobial Peritoneal Mast
            Cell Response.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 324)
  AUTHORS   Wu,M., McClellan,S.A., Barrett,R.P. and Hazlett,L.D.
  TITLE     Beta-defensin-2 promotes resistance against infection with P.
            aeruginosa
  JOURNAL   J Immunol 182 (3), 1609-1616 (2009)
   PUBMED   19155510
REFERENCE   4  (bases 1 to 324)
  AUTHORS   Xu,X.Y., Shi,Z. and Bao,J.M.
  TITLE     [Effect of recombinant beta-defensin-2 peptide on apoptosis of
            pulmonary tissue in rats with sepsis]
  JOURNAL   Zhejiang Da Xue Xue Bao Yi Xue Ban 35 (6), 600-604 (2006)
   PUBMED   17177330
REFERENCE   5  (bases 1 to 324)
  AUTHORS   Patil,A.A., Cai,Y., Sang,Y., Blecha,F. and Zhang,G.
  TITLE     Cross-species analysis of the mammalian beta-defensin gene family:
            presence of syntenic gene clusters and preferential expression in
            the male reproductive tract
  JOURNAL   Physiol Genomics 23 (1), 5-17 (2005)
   PUBMED   16033865
REFERENCE   6  (bases 1 to 324)
  AUTHORS   Wu,Q.P., Yao,S.L. and Fang,X.M.
  TITLE     [Study of rat beta-defensin-2 gene and protein expression in
            ventilator-associated pneumonia]
  JOURNAL   Zhongguo Wei Zhong Bing Ji Jiu Yi Xue 17 (6), 353-356 (2005)
   PUBMED   15970102
  REMARK    GeneRIF: The lowering of BD-2 expression mechanically ventilated
            rats after bacterial challenge might be one of the contributory
            factors in causing ventilator-associated pneumonia.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            On Sep 2, 2022 this sequence version replaced NM_001037507.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY621338.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-94                JAXUCZ010000016.1  76948191-76948284   c
            95-324              JAXUCZ010000016.1  76934341-76934570   c
FEATURES             Location/Qualifiers
     source          1..324
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16q12.5"
     gene            1..324
                     /gene="Defb2"
                     /note="defensin beta 2"
                     /db_xref="GeneID:641631"
                     /db_xref="RGD:1566125"
     exon            1..94
                     /gene="Defb2"
                     /inference="alignment:Splign:2.1.0"
     CDS             34..249
                     /gene="Defb2"
                     /note="beta-defensin 2"
                     /codon_start=1
                     /product="beta-defensin 2 precursor"
                     /protein_id="NP_001032596.1"
                     /db_xref="GeneID:641631"
                     /db_xref="RGD:1566125"
                     /translation="MRTLCSLLLIGCLLFSYATPVAGILGPLRIQTDYHRCLREKGFC
                     LNAVCPRSTLFVGTCFPYKFYCCKFKR"
     exon            95..324
                     /gene="Defb2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctctcaggag tcccagtgct cattctgcct gccatgagga ctctctgctc tctgctgctg
       61 ataggctgcc tccttttctc ctatgccact ccggttgctg gaattctagg acctcttcga
      121 atacaaacag attatcatcg atgtctaaga gagaaagggt tctgtctcaa tgctgtttgt
      181 cctcgttcta ccttgtttgt gggtacctgt ttcccataca agttctactg ttgcaagttt
      241 aaaagatgat tggaaggaag cacgtgggag tcaagtaaca gatgtgtaac tgatgtttta
      301 ataaaggaaa catttttaag ctta
//
