LOCUS       NM_001037504             334 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus defensin beta 14 (Defb14), mRNA.
ACCESSION   NM_001037504
VERSION     NM_001037504.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 334)
  AUTHORS   Augustin,D.K., Heimer,S.R., Tam,C., Li,W.Y., Le Due,J.M.,
            Evans,D.J. and Fleiszig,S.M.
  TITLE     Role of defensins in corneal epithelial barrier function against
            Pseudomonas aeruginosa traversal
  JOURNAL   Infect Immun 79 (2), 595-605 (2011)
   PUBMED   21115716
REFERENCE   2  (bases 1 to 334)
  AUTHORS   Rohrl,J., Yang,D., Oppenheim,J.J. and Hehlgans,T.
  TITLE     Identification and Biological Characterization of Mouse
            beta-defensin 14, the orthologue of human beta-defensin 3
  JOURNAL   J Biol Chem 283 (9), 5414-5419 (2008)
   PUBMED   18167348
REFERENCE   3  (bases 1 to 334)
  AUTHORS   Maisetta,G., Batoni,G., Esin,S., Florio,W., Bottai,D., Favilli,F.
            and Campa,M.
  TITLE     In vitro bactericidal activity of human beta-defensin 3 against
            multidrug-resistant nosocomial strains
  JOURNAL   Antimicrob Agents Chemother 50 (2), 806-809 (2006)
   PUBMED   16436752
REFERENCE   4  (bases 1 to 334)
  AUTHORS   Patil,A.A., Cai,Y., Sang,Y., Blecha,F. and Zhang,G.
  TITLE     Cross-species analysis of the mammalian beta-defensin gene family:
            presence of syntenic gene clusters and preferential expression in
            the male reproductive tract
  JOURNAL   Physiol Genomics 23 (1), 5-17 (2005)
   PUBMED   16033865
REFERENCE   5  (bases 1 to 334)
  AUTHORS   Schulz,A., Kluver,E., Schulz-Maronde,S. and Adermann,K.
  TITLE     Engineering disulfide bonds of the novel human beta-defensins
            hBD-27 and hBD-28: differences in disulfide formation and
            biological activity among human beta-defensins
  JOURNAL   Biopolymers 80 (1), 34-49 (2005)
   PUBMED   15625724
REFERENCE   6  (bases 1 to 334)
  AUTHORS   Harder,J., Bartels,J., Christophers,E. and Schroder,J.M.
  TITLE     Isolation and characterization of human beta -defensin-3, a novel
            human inducible peptide antibiotic
  JOURNAL   J Biol Chem 276 (8), 5707-5713 (2001)
   PUBMED   11085990
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            On Sep 2, 2022 this sequence version replaced NM_001037504.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CB772014.1, AY621346.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-85                JAXUCZ010000016.1  77366796-77366880   c
            86-334              JAXUCZ010000016.1  77365892-77366140   c
FEATURES             Location/Qualifiers
     source          1..334
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16q12.5"
     gene            1..334
                     /gene="Defb14"
                     /note="defensin beta 14"
                     /db_xref="GeneID:641627"
                     /db_xref="RGD:1561378"
     exon            1..85
                     /gene="Defb14"
                     /inference="alignment:Splign:2.1.0"
     CDS             28..231
                     /gene="Defb14"
                     /note="BD-14; beta-defensin 14"
                     /codon_start=1
                     /product="beta-defensin 14 precursor"
                     /protein_id="NP_001032593.1"
                     /db_xref="GeneID:641627"
                     /db_xref="RGD:1561378"
                     /translation="MRLHYLLFVFLILFLVPAPGDTFIPKSLRRFFCRVRGGRCAILN
                     CLGKEEQIGRCSNRGQKCCRKKK"
     exon            86..334
                     /gene="Defb14"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tctcggcttg ttgggaagca gtcagctatg aggcttcatt atctgctatt tgttttcctc
       61 atcttgttct tggtgcctgc tccaggggac acattcatcc caaaaagcct ccgaaggttt
      121 ttctgcagag taagaggcgg ccggtgtgcc atactcaact gccttggaaa ggaagaacaa
      181 ataggtcgat gttctaacag aggtcaaaaa tgctgcagaa agaagaagta gacccagatt
      241 ggaaacgaga atgtcgccac gcagggtgag ggtgggggag gtcctcccag agatgtattt
      301 atatatatgt aaatttaaaa aaccagtagc ttaa
//
