LOCUS       NM_031810                397 bp    mRNA    linear   ROD 28-MAR-2024
DEFINITION  Rattus norvegicus defensin beta 1 (Defb1), mRNA.
ACCESSION   NM_031810
VERSION     NM_031810.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 397)
  AUTHORS   Munipalli,S.B., Mounika,M.R., Aisha,J. and Yenugu,S.
  TITLE     Tlr1-13, Nod1/2 and antimicrobial gene expression in the epididymis
            and testis of rats with alloxan-induced diabetes
  JOURNAL   Andrologia 51 (11), e13437 (2019)
   PUBMED   31637753
  REMARK    GeneRIF: expression perturbed in diabetes
REFERENCE   2  (bases 1 to 397)
  AUTHORS   Diao,R., Fok,K.L., Chen,H., Yu,M.K., Duan,Y., Chung,C.M., Li,Z.,
            Wu,H., Li,Z., Zhang,H., Ji,Z., Zhen,W., Ng,C.F., Gui,Y., Cai,Z. and
            Chan,H.C.
  TITLE     Deficient human beta-defensin 1 underlies male infertility
            associated with poor sperm motility and genital tract infection
  JOURNAL   Sci Transl Med 6 (249), 249ra108 (2014)
   PUBMED   25122636
REFERENCE   3  (bases 1 to 397)
  AUTHORS   De Paula,V.S., Gomes,N.S., Lima,L.G., Miyamoto,C.A., Monteiro,R.Q.,
            Almeida,F.C. and Valente,A.P.
  TITLE     Structural basis for the interaction of human beta-defensin 6 and
            its putative chemokine receptor CCR2 and breast cancer
            microvesicles
  JOURNAL   J Mol Biol 425 (22), 4479-4495 (2013)
   PUBMED   23938203
REFERENCE   4  (bases 1 to 397)
  AUTHORS   Augustin,D.K., Heimer,S.R., Tam,C., Li,W.Y., Le Due,J.M.,
            Evans,D.J. and Fleiszig,S.M.
  TITLE     Role of defensins in corneal epithelial barrier function against
            Pseudomonas aeruginosa traversal
  JOURNAL   Infect Immun 79 (2), 595-605 (2011)
   PUBMED   21115716
REFERENCE   5  (bases 1 to 397)
  AUTHORS   Crovella,S., Segat,L., Amato,A., Athanasakis,E., Bezzerri,V.,
            Braggion,C., Casciaro,R., Castaldo,G., Colombo,C., Covone,A.E., De
            Rose,V., Gagliardini,R., Lanzara,C., Minicucci,L., Morgutti,M.,
            Nicolis,E., Pardo,F., Quattrucci,S., Raia,V., Ravazzolo,R.,
            Seia,M., Stanzial,V., Termini,L., Zazzeron,L., Cabrini,G. and
            Gasparini,P.
  TITLE     A polymorphism in the 5' UTR of the DEFB1 gene is associated with
            the lung phenotype in F508del homozygous Italian cystic fibrosis
            patients
  JOURNAL   Clin Chem Lab Med 49 (1), 49-54 (2011)
   PUBMED   21077791
REFERENCE   6  (bases 1 to 397)
  AUTHORS   Matsushita,I., Hasegawa,K., Nakata,K., Yasuda,K., Tokunaga,K. and
            Keicho,N.
  TITLE     Genetic variants of human beta-defensin-1 and chronic obstructive
            pulmonary disease
  JOURNAL   Biochem Biophys Res Commun 291 (1), 17-22 (2002)
   PUBMED   11829455
REFERENCE   7  (bases 1 to 397)
  AUTHORS   Hiratsuka,T., Nakazato,M., Date,Y., Mukae,H. and Matsukura,S.
  TITLE     Nucleotide sequence and expression of rat beta-defensin-1: its
            significance in diabetic rodent models
  JOURNAL   Nephron 88 (1), 65-70 (2001)
   PUBMED   11340353
REFERENCE   8  (bases 1 to 397)
  AUTHORS   Jia,H.P., Mills,J.N., Barahmand-Pour,F., Nishimura,D.,
            Mallampali,R.K., Wang,G., Wiles,K., Tack,B.F., Bevins,C.L. and
            McCray,P.B. Jr.
  TITLE     Molecular cloning and characterization of rat genes encoding
            homologues of human beta-defensins
  JOURNAL   Infect Immun 67 (9), 4827-4833 (1999)
   PUBMED   10456937
REFERENCE   9  (bases 1 to 397)
  AUTHORS   Page,R., Morris,C., Williams,J., von Ruhland,C. and Malik,A.N.
  TITLE     Isolation of diabetes-associated kidney genes using differential
            display
  JOURNAL   Biochem Biophys Res Commun 232 (1), 49-53 (1997)
   PUBMED   9125149
REFERENCE   10 (bases 1 to 397)
  AUTHORS   Bensch,K.W., Raida,M., Magert,H.J., Schulz-Knappe,P. and
            Forssmann,W.G.
  TITLE     hBD-1: a novel beta-defensin from human plasma
  JOURNAL   FEBS Lett 368 (2), 331-335 (1995)
   PUBMED   7628632
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            On Nov 26, 2020 this sequence version replaced NM_031810.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF093536.1, FM127743.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760433
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-127               JAXUCZ010000016.1  77015942-77016068   c
            128-397             JAXUCZ010000016.1  77001326-77001595   c
FEATURES             Location/Qualifiers
     source          1..397
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16q12.5"
     gene            1..397
                     /gene="Defb1"
                     /gene_synonym="CDK4"
                     /note="defensin beta 1"
                     /db_xref="GeneID:83687"
                     /db_xref="RGD:619943"
     exon            1..127
                     /gene="Defb1"
                     /gene_synonym="CDK4"
                     /inference="alignment:Splign:2.1.0"
     CDS             67..276
                     /gene="Defb1"
                     /gene_synonym="CDK4"
                     /note="BD-1; rBD-1; beta-defensin 1"
                     /codon_start=1
                     /product="beta-defensin 1 precursor"
                     /protein_id="NP_113998.1"
                     /db_xref="GeneID:83687"
                     /db_xref="RGD:619943"
                     /translation="MKTHYFLLVMLFFLFSQMELGAGILTSLGRRTDQYRCLQNGGFC
                     LRSSCPSHTKLQGTCKPDKPNCCRS"
     exon            128..397
                     /gene="Defb1"
                     /gene_synonym="CDK4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atctgtcagc tcaactacct gggagtctca cgtcctctct gcactctgga ccctgacttc
       61 accgacatga aaactcatta ctttctcctg gtgatgttat tttttctctt ctcccagatg
      121 gagctgggtg ctggcattct cacaagtctt ggacgcagaa cagatcaata ccgatgcctc
      181 caaaatggag gattctgtct ccgctccagc tgcccatctc ataccaaact acaaggaaca
      241 tgtaaaccag ataagcccaa ctgttgcagg agttgacagt ggtttgaaga atggacataa
      301 aggacaagca agggattgta aaattagtgt tttaataaat gaaatgtttt tgaagtttat
      361 ttacatcatc tcaaaataaa ttttatgcct cagttta
//
