LOCUS       NM_001033076             428 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus defensin alpha 6 (Defa6), mRNA.
ACCESSION   NM_001033076
VERSION     NM_001033076.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 428)
  AUTHORS   Ayabe,T., Satchell,D.P., Wilson,C.L., Parks,W.C., Selsted,M.E. and
            Ouellette,A.J.
  TITLE     Secretion of microbicidal alpha-defensins by intestinal Paneth
            cells in response to bacteria
  JOURNAL   Nat Immunol 1 (2), 113-118 (2000)
   PUBMED   11248802
REFERENCE   2  (bases 1 to 428)
  AUTHORS   Ouellette,A.J., Hsieh,M.M., Nosek,M.T., Cano-Gauci,D.F.,
            Huttner,K.M., Buick,R.N. and Selsted,M.E.
  TITLE     Mouse Paneth cell defensins: primary structures and antibacterial
            activities of numerous cryptdin isoforms
  JOURNAL   Infect Immun 62 (11), 5040-5047 (1994)
   PUBMED   7927786
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            On Oct 6, 2022 this sequence version replaced NM_001033076.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY623750.1, SRR26643288.56208.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN06680426, SAMN06680427
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-217               JAXUCZ010000016.1  77107681-77107897
            218-428             JAXUCZ010000016.1  77108485-77108695
FEATURES             Location/Qualifiers
     source          1..428
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16q12.5"
     gene            1..428
                     /gene="Defa6"
                     /note="defensin alpha 6"
                     /db_xref="GeneID:613223"
                     /db_xref="RGD:1562293"
     exon            1..217
                     /gene="Defa6"
                     /inference="alignment:Splign:2.1.0"
     CDS             46..333
                     /gene="Defa6"
                     /note="alpha-defensin 6"
                     /codon_start=1
                     /product="alpha-defensin 6 precursor"
                     /protein_id="NP_001028248.1"
                     /db_xref="GeneID:613223"
                     /db_xref="RGD:1562293"
                     /translation="MKTLVLLSALVLVAYQVQADPIQGAEEETKTEEQPSDEDQDVSV
                     SFEGPEASALQDFEIGRPVRRCRCRANCGPKEYATAFCAQGPFKQFKFCCT"
     exon            218..428
                     /gene="Defa6"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acacactggt ctccagctca ccaatcctcc aggtgacttc cagccatgaa gacacttgtc
       61 ctcctctctg cccttgtcct ggtggcctac caggtccagg ctgatcccat tcaaggggca
      121 gaagaagaga ctaaaactga agagcaacca tcagatgagg accaggatgt gtctgtctcc
      181 tttgaaggcc cagaagcctc tgctcttcaa gattttgaga taggaaggcc agtgaggagg
      241 tgccgttgca gagcaaactg cggacctaaa gaatatgcca ctgcgttctg tgctcaaggt
      301 ccatttaaac agttcaaatt ctgctgcaca tgaaaatgga tcccaagtct gagataacca
      361 cgtgctctgg gacctcacaa tctgtcatta ttgtgcttga cctcaactgc ttttccttct
      421 ccaataaa
//
