LOCUS       NM_173329                505 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus defensin alpha 5 (Defa5), mRNA.
ACCESSION   NM_173329
VERSION     NM_173329.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 505)
  AUTHORS   Dranitsina,A.S., Dvorshchenko,K.O., Morgaienko,O.O. and
            Ostapchenko,L.L.
  TITLE     [Not Available]
  JOURNAL   Tsitol Genet 50 (3), 57-65 (2016)
   PUBMED   30480410
  REMARK    GeneRIF: The data obtained may indicate involvement of genes Tlr2,
            Muc2, Defa in development of inflammation in the duodenum due to
            dysbiotic changes under conditions of prolonged hypochlorhydria.
REFERENCE   2  (bases 1 to 505)
  AUTHORS   Wanniarachchi,Y.A., Kaczmarek,P., Wan,A. and Nolan,E.M.
  TITLE     Human defensin 5 disulfide array mutants: disulfide bond deletion
            attenuates antibacterial activity against Staphylococcus aureus
  JOURNAL   Biochemistry 50 (37), 8005-8017 (2011)
   PUBMED   21861459
REFERENCE   3  (bases 1 to 505)
  AUTHORS   Szyk,A., Wu,Z., Tucker,K., Yang,D., Lu,W. and Lubkowski,J.
  TITLE     Crystal structures of human alpha-defensins HNP4, HD5, and HD6
  JOURNAL   Protein Sci 15 (12), 2749-2760 (2006)
   PUBMED   17088326
REFERENCE   4  (bases 1 to 505)
  AUTHORS   Ericksen,B., Wu,Z., Lu,W. and Lehrer,R.I.
  TITLE     Antibacterial activity and specificity of the six human
            {alpha}-defensins
  JOURNAL   Antimicrob Agents Chemother 49 (1), 269-275 (2005)
   PUBMED   15616305
REFERENCE   5  (bases 1 to 505)
  AUTHORS   Porter,E.M., van Dam,E., Valore,E.V. and Ganz,T.
  TITLE     Broad-spectrum antimicrobial activity of human intestinal defensin
            5
  JOURNAL   Infect Immun 65 (6), 2396-2401 (1997)
   PUBMED   9169780
REFERENCE   6  (bases 1 to 505)
  AUTHORS   Yount,N.Y., Wang,M.S., Yuan,J., Banaiee,N., Ouellette,A.J. and
            Selsted,M.E.
  TITLE     Rat neutrophil defensins. Precursor structures and expression
            during neutrophilic myelopoiesis
  JOURNAL   J Immunol 155 (9), 4476-4484 (1995)
   PUBMED   7594610
REFERENCE   7  (bases 1 to 505)
  AUTHORS   Eisenhauer,P., Harwig,S.S., Szklarek,D., Ganz,T. and Lehrer,R.I.
  TITLE     Polymorphic expression of defensins in neutrophils from outbred
            rats
  JOURNAL   Infect Immun 58 (12), 3899-3902 (1990)
   PUBMED   2254017
REFERENCE   8  (bases 1 to 505)
  AUTHORS   Eisenhauer,P.B., Harwig,S.S., Szklarek,D., Ganz,T., Selsted,M.E.
            and Lehrer,R.I.
  TITLE     Purification and antimicrobial properties of three defensins from
            rat neutrophils
  JOURNAL   Infect Immun 57 (7), 2021-2027 (1989)
   PUBMED   2543629
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            On Oct 7, 2022 this sequence version replaced NM_173329.2.
            
            Sequence Note:.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U16686.1, CB725988.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN06680441 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-81                JAXUCZ010000016.1  77047238-77047318   c
            82-266              JAXUCZ010000016.1  77045750-77045934   c
            267-505             JAXUCZ010000016.1  77044994-77045232   c
FEATURES             Location/Qualifiers
     source          1..505
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16q12.5"
     gene            1..505
                     /gene="Defa5"
                     /gene_synonym="Defa; ratNP-1; ratNP-2"
                     /note="defensin alpha 5"
                     /db_xref="GeneID:286995"
                     /db_xref="RGD:727951"
     exon            1..81
                     /gene="Defa5"
                     /gene_synonym="Defa; ratNP-1; ratNP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            82..266
                     /gene="Defa5"
                     /gene_synonym="Defa; ratNP-1; ratNP-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             95..379
                     /gene="Defa5"
                     /gene_synonym="Defa; ratNP-1; ratNP-2"
                     /note="neutrophil antibiotic peptide NP-1; neutrophil
                     antibiotic peptide NP-2; neutrophil defensin 1; neutrophil
                     defensin 2; alpha-defensin 5, Paneth cell-specific;
                     defensin NP-2; defensin, alpha 5, Paneth cell-specific"
                     /codon_start=1
                     /product="neutrophil antibiotic peptide NP-2 precursor"
                     /protein_id="NP_775451.2"
                     /db_xref="GeneID:286995"
                     /db_xref="RGD:727951"
                     /translation="MRTLTLLTALLLLALHTQAKSPQGTAEEAPDQEQLVMEDQDISI
                     SFGGDKGTALQDADVKAGVTCYCRSTRCGFRERLSGACGYRGRIYRLCCR"
     exon            267..505
                     /gene="Defa5"
                     /gene_synonym="Defa; ratNP-1; ratNP-2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aaggtgctct tgtatcccca ggtctggaca gaagagtgct gtctctcttg ctctgctctc
       61 cgtgattacc ctcaaagatc tgagacccac agccatgagg acgctcactc tgcttaccgc
      121 ccttctcctg ctggccctcc acacccaggc aaaatctccc caaggaaccg ctgaggaggc
      181 tccagaccag gagcagctgg tcatggagga ccaggatatt tccatatcct ttggagggga
      241 taaaggcact gctctccaag atgcagatgt gaaggcaggc gtgacctgct attgcagaag
      301 cacacgctgt ggttttagag aacggctctc tggggcctgt ggttaccgtg gccgcatcta
      361 cagactgtgc tgccgctgag cactccgacc aagaagaatc catttgtcaa atgatctgag
      421 atcttgaacg agactgctat ttgtcagatg ttatgtcctt gagtttcctc ttcctttaca
      481 ctcaaataaa gttcttacag caagt
//
