LOCUS       NM_001013053             418 bp    mRNA    linear   ROD 27-MAR-2024
DEFINITION  Rattus norvegicus defensin alpha 24 (Defa24), mRNA.
ACCESSION   NM_001013053 XM_214386
VERSION     NM_001013053.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 418)
  AUTHORS   Zhang,T., Zhuang,S., Casteel,D.E., Looney,D.J., Boss,G.R. and
            Pilz,R.B.
  TITLE     A cysteine-rich LIM-only protein mediates regulation of smooth
            muscle-specific gene expression by cGMP-dependent protein kinase
  JOURNAL   J Biol Chem 282 (46), 33367-33380 (2007)
   PUBMED   17878170
  REMARK    GeneRIF: CRP4 mediates cGMP/PKG stimulation of SM-specific gene
            expression, and PKG plays an important role in regulating the
            phenotype of VSMCs
REFERENCE   2  (bases 1 to 418)
  AUTHORS   Condon,M.R., Viera,A., D'Alessio,M. and Diamond,G.
  TITLE     Induction of a rat enteric defensin gene by hemorrhagic shock
  JOURNAL   Infect Immun 67 (9), 4787-4793 (1999)
   PUBMED   10456932
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            On Dec 7, 2020 this sequence version replaced NM_001013053.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BQ202352.1, AF115768.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760434, SAMN06680426
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-197               JAXUCZ010000016.1  77052850-77053046   c
            198-418             JAXUCZ010000016.1  77052014-77052234   c
FEATURES             Location/Qualifiers
     source          1..418
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16q12.5"
     gene            1..418
                     /gene="Defa24"
                     /gene_synonym="Defcr24; Defcr4; defensin 6; defensin 7;
                     defensin-5; Rd5"
                     /note="defensin alpha 24"
                     /db_xref="GeneID:290856"
                     /db_xref="RGD:1304852"
     exon            1..197
                     /gene="Defa24"
                     /gene_synonym="Defcr24; Defcr4; defensin 6; defensin 7;
                     defensin-5; Rd5"
                     /inference="alignment:Splign:2.1.0"
     CDS             26..307
                     /gene="Defa24"
                     /gene_synonym="Defcr24; Defcr4; defensin 6; defensin 7;
                     defensin-5; Rd5"
                     /note="defensin 5; enteric defensin alpha 5; RD-5;
                     alpha-defensin, 24; defensin related cryptdin 4; defensin
                     related cryptdin 24"
                     /codon_start=1
                     /product="defensin 5 precursor"
                     /protein_id="NP_001013071.2"
                     /db_xref="GeneID:290856"
                     /db_xref="RGD:1304852"
                     /translation="MKTLVLLSALVLLALQVQAEPTPKTDEGTKTDEQPGKEDQVVSV
                     SIEGQGDPAFQDAVLRDLKCFCRAKSCNWGEGIMGICNKRYGSLILCCR"
     exon            198..418
                     /gene="Defa24"
                     /gene_synonym="Defcr24; Defcr4; defensin 6; defensin 7;
                     defensin-5; Rd5"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccagtactcc aagtgacttc cagccatgaa gacacttgtc ctcctttctg cccttgtcct
       61 gctggcccta caggtccaag ctgaacctac cccaaaaaca gatgaaggga ctaaaactga
      121 tgagcagcca gggaaagagg accaggttgt ttctgtctcc attgaaggcc aaggagaccc
      181 tgcttttcaa gatgcagtct taagagatct gaaatgcttc tgtcgagcaa aatcctgcaa
      241 ttggggagaa ggcattatgg ggatctgcaa caagagatac ggaagcctca tactctgttg
      301 ccgctgagca cagagatcag agagagcaaa gctactatga gttctgaggc caccgatgct
      361 gatgttgatg actactctgc ttgagcttct ttatcttcaa taaatcgctt gcactaaa
//
