LOCUS       NM_001191717            2403 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus DEF6 guanine nucleotide exchange factor (Def6),
            mRNA.
ACCESSION   NM_001191717 XM_228031
VERSION     NM_001191717.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2403)
  AUTHORS   Liang,Y., Cucchetti,M., Roncagalli,R., Yokosuka,T., Malzac,A.,
            Bertosio,E., Imbert,J., Nijman,I.J., Suchanek,M., Saito,T.,
            Wulfing,C., Malissen,B. and Malissen,M.
  TITLE     The lymphoid lineage-specific actin-uncapping protein Rltpr is
            essential for costimulation via CD28 and the development of
            regulatory T cells
  JOURNAL   Nat Immunol 14 (8), 858-866 (2013)
   PUBMED   23793062
REFERENCE   2  (bases 1 to 2403)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000020.1.
            
            On Sep 9, 2022 this sequence version replaced NM_001191717.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360172.2530070.1,
                                           SRR26643429.57153.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-131               JAXUCZ010000020.1  6270323-6270453
            132-272             JAXUCZ010000020.1  6279121-6279261
            273-458             JAXUCZ010000020.1  6279884-6280069
            459-695             JAXUCZ010000020.1  6282021-6282257
            696-842             JAXUCZ010000020.1  6282352-6282498
            843-951             JAXUCZ010000020.1  6285960-6286068
            952-1250            JAXUCZ010000020.1  6286183-6286481
            1251-1417           JAXUCZ010000020.1  6288271-6288437
            1418-1616           JAXUCZ010000020.1  6288524-6288722
            1617-1707           JAXUCZ010000020.1  6290776-6290866
            1708-2403           JAXUCZ010000020.1  6291029-6291724
FEATURES             Location/Qualifiers
     source          1..2403
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="20"
                     /map="20p12"
     gene            1..2403
                     /gene="Def6"
                     /note="DEF6 guanine nucleotide exchange factor"
                     /db_xref="GeneID:309642"
                     /db_xref="RGD:1307945"
     exon            1..131
                     /gene="Def6"
                     /inference="alignment:Splign:2.1.0"
     CDS             36..1928
                     /gene="Def6"
                     /codon_start=1
                     /product="differentially expressed in FDCP 6 homolog"
                     /protein_id="NP_001178646.1"
                     /db_xref="GeneID:309642"
                     /db_xref="RGD:1307945"
                     /translation="MALRKELLKSIWYAFTALDVEKSGKVSKSQLKVLSHNLYTVLHI
                     PHDPVALEEHFRDDDDGPVSSQGYMPYLNKYILDKVEEGAFVKEHFDELCWTLTAKKN
                     YRVEGNGNSLLSNQDAFRLWCLFNFLSEDKYPLIMVPDEVEYLLKKLLGSLSLEMGLG
                     ELEELLAQDAQSAQTSGGLSVWQFLELFNSGRCLRGVGQDSLSMAIQEVYQELIQDVL
                     KQGYLWKRGHLRRNWTERWFQLQPSCLCYFGSEECKEKRGTIPLDAHCCVEVLPDREG
                     KRCMFCVKTASRTYEMSASDTRQRQEWTAAIQTAIRLQAEGKTSLHKDLKQKRREQRE
                     QRERRRAAKEEELLRLQQLQEEKERKLQELELLQEAQRQAERLLQEEEERRRSQHREL
                     QQALEGQLREAEQARASMQAEMELKKEEAARQRQRIAELEEMQERLQEALQLEVKARR
                     DEEAVRLAQTRLLEEEEEKLKQLMHLKEEQERYIERAQQEKQELQQEMALQSRSLQQA
                     QQQLEEVRQNRQRADEDVEAAQRKLRQASTNVKHWNVQMNRLMHPIEPGDKRPTTSSS
                     FTGFQAPPLARRDSSLKRLTRWGSQGNRTLSANSSEQKSLNGGDETPILALASQEEKL
                     DAAPEN"
     exon            132..272
                     /gene="Def6"
                     /inference="alignment:Splign:2.1.0"
     exon            273..458
                     /gene="Def6"
                     /inference="alignment:Splign:2.1.0"
     exon            459..695
                     /gene="Def6"
                     /inference="alignment:Splign:2.1.0"
     exon            696..842
                     /gene="Def6"
                     /inference="alignment:Splign:2.1.0"
     exon            843..951
                     /gene="Def6"
                     /inference="alignment:Splign:2.1.0"
     exon            952..1250
                     /gene="Def6"
                     /inference="alignment:Splign:2.1.0"
     exon            1251..1417
                     /gene="Def6"
                     /inference="alignment:Splign:2.1.0"
     exon            1418..1616
                     /gene="Def6"
                     /inference="alignment:Splign:2.1.0"
     exon            1617..1707
                     /gene="Def6"
                     /inference="alignment:Splign:2.1.0"
     exon            1708..2403
                     /gene="Def6"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agagccgccc ctgggccggg gcgggcacct cagccatggc cctgcgcaag gagctgctca
       61 aatccatctg gtacgccttc actgcactgg acgtggagaa aagcggcaag gtctccaagt
      121 ctcaactcaa ggtgctgtcc cacaacctgt acacggtcct tcacatccct catgaccccg
      181 tggccctgga ggaacacttc cgggatgacg acgacggccc cgtgtccagt caaggataca
      241 tgccctacct caacaagtac atcctagaca aggtggagga gggggctttc gttaaggagc
      301 actttgatga gttgtgctgg acactgacgg ccaagaagaa ctaccgagtt gaaggcaacg
      361 gaaacagcct gctctccaat caggacgctt tccgtctctg gtgcctcttc aacttcctgt
      421 ctgaggacaa gtacccgctg atcatggttc cggatgaggt tgagtatctg ctgaagaagc
      481 tcctcgggag cttgagcttg gagatgggcc tcggggagct ggaggaactc ttggcccagg
      541 acgcccaatc agcccagacc tccggggggc tcagcgtctg gcaatttctg gagctcttca
      601 actcaggccg ctgcctgcgg ggtgtggggc aggactccct cagcatggcc atccaagaag
      661 tctaccagga gctcatccaa gacgtcctga aacagggcta tctgtggaaa agagggcacc
      721 tgaggaggaa ttggaccgag cgctggttcc agctgcaacc cagctgcctc tgctactttg
      781 ggagtgagga atgcaaggag aaacgaggca ccatacccct ggacgcgcac tgctgtgtgg
      841 aggtgcttcc ggaccgcgaa ggaaagcgct gcatgttttg tgtgaagact gccagccgca
      901 cgtacgagat gagcgcctca gacacgcgcc agcgccagga gtggacggcc gccatccaga
      961 ccgcgatccg gctacaggca gaggggaaga cgtcgctgca caaggacctg aagcagaagc
     1021 ggcgggagca gcgggagcag cgcgagaggc gccgggcagc caaggaggag gagctgctgc
     1081 ggctgcagca gctgcaggag gaaaaggaga ggaagctgca ggagctggag ctgctgcagg
     1141 aggctcagcg gcaggcggag cggctgctgc aggaggagga ggagcgccgc cgtagccagc
     1201 acagggagct gcagcaagct ctggagggcc agctgcggga ggcggagcag gcccgggcct
     1261 ctatgcaggc tgagatggag ctgaagaagg aagaggcggc ccggcaacgg cagcgcatcg
     1321 cggagctgga ggagatgcag gagcggctgc aggaagcttt gcaactggag gtgaaagcta
     1381 ggcgagatga ggaggccgtg cgcctcgccc agaccaggct gctggaggag gaggaggaga
     1441 agctgaagca gctgatgcat ctgaaggagg agcaagagcg ctacattgag cgagcgcagc
     1501 aggagaagca ggagcttcag caggagatgg cgctgcagag ccgttccctg cagcaggccc
     1561 agcagcagct ggaggaggtg cggcagaacc ggcagagggc agacgaggac gtggaggctg
     1621 cccagaggaa gttgcgccag gccagcacca acgtgaaaca ctggaacgtc cagatgaaca
     1681 ggctcatgca tccgatcgag cctggagata agcgtcccac caccagcagc tccttcaccg
     1741 gcttccaggc ccctccgctc gcccgccgtg actcctctct aaagcgcctg acccgctggg
     1801 ggtcccaagg caacagaacc ctctcggcca acagcagcga acagaagtcc ctcaatggtg
     1861 gggacgagac tcccatcctg gctttggcct ctcaggaaga gaaactggat gcagcgccag
     1921 aaaattagcc tccgatgaga cccccttgtt cttccgatgc tgtgtccacg gacctggtcc
     1981 cagcagacct gtgggtgact cccgcctctg gtaaagtcct ggtgctacca cctgctgacc
     2041 aaaagccagt ccaggatcgg actaggttgc cattctcagc aggccgagac catggaggct
     2101 gtccgggata ttaatacttg agaatatggt tttgtcctaa agaacactgg ggccagagct
     2161 gggaaagatg aggaacgacc aagatgcccc ttaggctgga gagatggctt agagcactgt
     2221 ctgctcttcc agaggtcctg agttcaattc cctgcaacca catggtggct cccaaccatc
     2281 tgtcatggga tctggtgccc tcttctggcc ttcgggcaca tatgcaggca gaatgctgta
     2341 cacgtaacat aaatttttct taaaaaaaaa aaaataaaaa aagatcacac gcccctccct
     2401 cca
//
