LOCUS       NM_171996               1472 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus 2,4-dienoyl-CoA reductase 2 (Decr2), mRNA.
ACCESSION   NM_171996
VERSION     NM_171996.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1472)
  AUTHORS   Ghosh,D. and Berg,J.M.
  TITLE     A proteome-wide perspective on peroxisome targeting signal
            1(PTS1)-Pex5p affinities
  JOURNAL   J Am Chem Soc 132 (11), 3973-3979 (2010)
   PUBMED   20178365
REFERENCE   2  (bases 1 to 1472)
  AUTHORS   Kikuchi,M., Hatano,N., Yokota,S., Shimozawa,N., Imanaka,T. and
            Taniguchi,H.
  TITLE     Proteomic analysis of rat liver peroxisome: presence of
            peroxisome-specific isozyme of Lon protease
  JOURNAL   J Biol Chem 279 (1), 421-428 (2004)
   PUBMED   14561759
REFERENCE   3  (bases 1 to 1472)
  AUTHORS   Amery,L., Mannaerts,G.P., Subramani,S., Van Veldhoven,P.P. and
            Fransen,M.
  TITLE     Identification of a novel human peroxisomal 2,4-dienoyl-CoA
            reductase related protein using the M13 phage protein VI phage
            display technology
  JOURNAL   Comb Chem High Throughput Screen 4 (7), 545-552 (2001)
   PUBMED   11669066
REFERENCE   4  (bases 1 to 1472)
  AUTHORS   De Nys,K., Meyhi,E., Mannaerts,G.P., Fransen,M. and Van
            Veldhoven,P.P.
  TITLE     Characterisation of human peroxisomal 2,4-dienoyl-CoA reductase
  JOURNAL   Biochim Biophys Acta 1533 (1), 66-72 (2001)
   PUBMED   11514237
REFERENCE   5  (bases 1 to 1472)
  AUTHORS   Das,A.K., Uhler,M.D. and Hajra,A.K.
  TITLE     Molecular cloning and expression of mammalian peroxisomal
            trans-2-enoyl-coenzyme A reductase cDNAs
  JOURNAL   J Biol Chem 275 (32), 24333-24340 (2000)
   PUBMED   10811639
REFERENCE   6  (bases 1 to 1472)
  AUTHORS   Fransen,M., Van Veldhoven,P.P. and Subramani,S.
  TITLE     Identification of peroxisomal proteins by using M13 phage protein
            VI phage display: molecular evidence that mammalian peroxisomes
            contain a 2,4-dienoyl-CoA reductase
  JOURNAL   Biochem J 340 (Pt 2) (Pt 2), 561-568 (1999)
   PUBMED   10333503
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC070959.1.
            
            On Aug 31, 2012 this sequence version replaced NM_171996.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC070959.1, AF044574.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1472              BC070959.1         2-1473
FEATURES             Location/Qualifiers
     source          1..1472
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q12"
     gene            1..1472
                     /gene="Decr2"
                     /gene_synonym="Dcrakl;
                     putativeperoxisomal24-dienoyl-CoAreductase"
                     /note="2,4-dienoyl-CoA reductase 2"
                     /db_xref="GeneID:64461"
                     /db_xref="RGD:71002"
     exon            1..170
                     /gene="Decr2"
                     /gene_synonym="Dcrakl;
                     putativeperoxisomal24-dienoyl-CoAreductase"
                     /inference="alignment:Splign:2.1.0"
     CDS             91..969
                     /gene="Decr2"
                     /gene_synonym="Dcrakl;
                     putativeperoxisomal24-dienoyl-CoAreductase"
                     /EC_number="1.3.1.124"
                     /note="putative peroxisomal 2,4-dienoyl-CoA reductase;
                     2-4-dienoyl-Coenzyme A reductase 2, peroxisomal; DCR-AKL;
                     pVI-AKL; putative peroxisomal 24-dienoyl-CoA reductase;
                     2,4-dienoyl CoA reductase 2, peroxisomal"
                     /codon_start=1
                     /product="peroxisomal 2,4-dienoyl-CoA reductase
                     [(3E)-enoyl-CoA-producing]"
                     /protein_id="NP_741993.1"
                     /db_xref="GeneID:64461"
                     /db_xref="RGD:71002"
                     /translation="MTQQPPDVEEDDCLSEYHHLFCPDLLQDKVAFITGGGSGIGFRI
                     AEIFMRHGCHTVIVSRSLPRVSEAAKKLVAATGKRCLPLSMDVRVPPAVMAAVDQALK
                     EFGKIDILINCAAGNFLCPASALSFNAFKTVVDIDTLGTFNVSRVLYEKFFRDHGGVI
                     VNITATLSMRGQVLQLHAGAAKAAVDAMTRHLAVEWGPQNIRVNSLAPGAISGTEGLR
                     RLGGPKASSKFKYLSSPIPRLGTKTEIAHSVLYLASPLASYVSGIVLVVDGGSWMTLP
                     NDIGRLLEFESSSAKL"
     exon            171..239
                     /gene="Decr2"
                     /gene_synonym="Dcrakl;
                     putativeperoxisomal24-dienoyl-CoAreductase"
                     /inference="alignment:Splign:2.1.0"
     exon            240..291
                     /gene="Decr2"
                     /gene_synonym="Dcrakl;
                     putativeperoxisomal24-dienoyl-CoAreductase"
                     /inference="alignment:Splign:2.1.0"
     exon            292..427
                     /gene="Decr2"
                     /gene_synonym="Dcrakl;
                     putativeperoxisomal24-dienoyl-CoAreductase"
                     /inference="alignment:Splign:2.1.0"
     exon            428..552
                     /gene="Decr2"
                     /gene_synonym="Dcrakl;
                     putativeperoxisomal24-dienoyl-CoAreductase"
                     /inference="alignment:Splign:2.1.0"
     exon            553..646
                     /gene="Decr2"
                     /gene_synonym="Dcrakl;
                     putativeperoxisomal24-dienoyl-CoAreductase"
                     /inference="alignment:Splign:2.1.0"
     exon            647..751
                     /gene="Decr2"
                     /gene_synonym="Dcrakl;
                     putativeperoxisomal24-dienoyl-CoAreductase"
                     /inference="alignment:Splign:2.1.0"
     exon            752..969
                     /gene="Decr2"
                     /gene_synonym="Dcrakl;
                     putativeperoxisomal24-dienoyl-CoAreductase"
                     /inference="alignment:Splign:2.1.0"
     exon            970..1450
                     /gene="Decr2"
                     /gene_synonym="Dcrakl;
                     putativeperoxisomal24-dienoyl-CoAreductase"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcgagcaacc cgcaaaacgt tgtgcattgc gttgaaaagg tgcatctggt tcccgattct
       61 actccccacc cgcgaccgca cacagcaaac atgacccagc agccgcctga cgttgaggag
      121 gatgactgtc tttctgaata ccaccacctc ttctgcccgg accttctcca ggacaaagtg
      181 gcttttatca ctggtggtgg ttctgggatt ggcttccgga tcgccgagat tttcatgagg
      241 catggctgcc acactgtcat cgtcagcagg agtctgccga gagtgtccga ggctgctaag
      301 aagttggttg ctgccactgg aaagcggtgt ctccctctgt ctatggatgt ccgagttccc
      361 ccagctgtca tggctgctgt ggaccaagcg ctgaaagaat ttggcaaaat cgacatcctc
      421 attaactgtg ctgcagggaa ctttttatgc cctgccagtg cattgtcttt caatgccttt
      481 aagactgtgg tggacattga cacccttggc accttcaatg tgtctcgtgt gctttatgag
      541 aagttcttcc gggaccatgg aggagtgatc gtgaacatta ccgccaccct cagtatgcgg
      601 gggcaggtgc tgcagctcca tgcaggcgct gccaaggcgg ctgtggatgc tatgacgcga
      661 cacttggctg tggagtgggg tccccagaat atccgtgtca acagcctggc tcctggtgcc
      721 atcagcggca ctgagggtct gcggagatta ggaggcccca aggccagttc gaaatttaag
      781 tatctttcaa gtcctattcc aagactcgga accaagacag aaatcgccca cagcgtgctg
      841 tacctagcca gccctctggc ttcctatgtc tcagggattg tgttggtggt tgatggtggt
      901 agctggatga cgctcccaaa tgacattggg cgactgctag agtttgaatc ctcctctgct
      961 aagctgtagt gtttgaagag cacacccaag gcttcaagca tgttaaagca acagaatcaa
     1021 ctgaactacg tcctctaccc caggatacct tttttgacac ataaacattg attgcgctta
     1081 agaaagttgt actgaggagg ccgtgttctt catggggaag gcttcctgtc tcacataggt
     1141 ctatagtcac acgaggaatg ttgaatctga ttgggaaatc caagcccacc tgcccttcct
     1201 ccgggatcaa gctatttcca agctctgcct ctcctttgcc cacatcctga gtagaaatgg
     1261 ccggattgtg agcctagcct gatacttgct tacagtatct gaagagttac tatgatttta
     1321 ccagaaaaaa aaaatgcact ttcttgtaaa aaaaaaatca tcttttttac tgtaaaaata
     1381 gctgagttgg aatttgtaaa agtttctaga aagaaaattt aaaagattgc tgactgattc
     1441 tgtcactgaa aaaaaaaaaa aaaaaaaaaa aa
//
