LOCUS       NM_057197               1146 bp    mRNA    linear   ROD 28-MAR-2024
DEFINITION  Rattus norvegicus 2,4-dienoyl-CoA reductase 1 (Decr1), mRNA;
            nuclear gene for mitochondrial product.
ACCESSION   NM_057197
VERSION     NM_057197.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1146)
  AUTHORS   Satoh,M., Haruta-Satoh,E., Yamada,M., Kado,S. and Nomura,F.
  TITLE     Overexpression of hydroxymethylglutaryl CoA synthase 2 and
            2,4-dienoyl-CoA reductase in rat pancreas following chronic alcohol
            consumption
  JOURNAL   Pancreas 42 (3), 475-482 (2013)
   PUBMED   23486364
  REMARK    GeneRIF: Data indicate that 2,4-dienoyl-CoA reductase and
            hydroxymethylglutaryl-CoA synthase (HMGCS2) were upregulated in
            alcohol-fed rats.
REFERENCE   2  (bases 1 to 1146)
  AUTHORS   de Mateo,S., Castillo,J., Estanyol,J.M., Ballesca,J.L. and Oliva,R.
  TITLE     Proteomic characterization of the human sperm nucleus
  JOURNAL   Proteomics 11 (13), 2714-2726 (2011)
   PUBMED   21630459
REFERENCE   3  (bases 1 to 1146)
  AUTHORS   Miinalainen,I.J., Schmitz,W., Huotari,A., Autio,K.J., Soininen,R.,
            Ver Loren van Themaat,E., Baes,M., Herzig,K.H., Conzelmann,E. and
            Hiltunen,J.K.
  TITLE     Mitochondrial 2,4-dienoyl-CoA reductase deficiency in mice results
            in severe hypoglycemia with stress intolerance and unimpaired
            ketogenesis
  JOURNAL   PLoS Genet 5 (7), e1000543 (2009)
   PUBMED   19578400
REFERENCE   4  (bases 1 to 1146)
  AUTHORS   Ursini-Siegel,J., Rajput,A.B., Lu,H., Sanguin-Gendreau,V., Zuo,D.,
            Papavasiliou,V., Lavoie,C., Turpin,J., Cianflone,K., Huntsman,D.G.
            and Muller,W.J.
  TITLE     Elevated expression of DecR1 impairs ErbB2/Neu-induced mammary
            tumor development
  JOURNAL   Mol Cell Biol 27 (18), 6361-6371 (2007)
   PUBMED   17636013
  REMARK    GeneRIF: Elevated expression of Decr1 impairs ErbB2/Neu-induced
            mammary tumor development.
REFERENCE   5  (bases 1 to 1146)
  AUTHORS   Alphey,M.S., Yu,W., Byres,E., Li,D. and Hunter,W.N.
  TITLE     Structure and reactivity of human mitochondrial 2,4-dienoyl-CoA
            reductase: enzyme-ligand interactions in a distinctive short-chain
            reductase active site
  JOURNAL   J Biol Chem 280 (4), 3068-3077 (2005)
   PUBMED   15531764
REFERENCE   6  (bases 1 to 1146)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   7  (bases 1 to 1146)
  AUTHORS   Hirose,A., Kamijo,K., Osumi,T., Hashimoto,T. and Mizugaki,M.
  TITLE     cDNA cloning of rat liver 2,4-dienoyl-CoA reductase
  JOURNAL   Biochim Biophys Acta 1049 (3), 346-349 (1990)
   PUBMED   2383590
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1, BC059120.1 and CO385941.1.
            
            On Apr 1, 2010 this sequence version replaced NM_057197.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ218387.1, FQ209689.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760393,
                                           SAMEA5760400 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-114               JAXUCZ010000005.1  34235920-34236033   c
            115-462             BC059120.1         103-450
            463-610             CO385941.1         448-595
            611-993             BC059120.1         599-981
            994-1146            JAXUCZ010000005.1  34208195-34208347   c
FEATURES             Location/Qualifiers
     source          1..1146
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q13"
     gene            1..1146
                     /gene="Decr1"
                     /note="2,4-dienoyl-CoA reductase 1"
                     /db_xref="GeneID:117543"
                     /db_xref="RGD:70999"
     exon            1..114
                     /gene="Decr1"
                     /inference="alignment:Splign:2.1.0"
     CDS             46..1053
                     /gene="Decr1"
                     /EC_number="1.3.1.124"
                     /note="2,4-dienoyl-CoA reductase, mitochondrial;
                     4-enoyl-CoA reductase; 2,4-dienoyl CoA reductase 1,
                     mitochondrial; 2,4-dienoyl-CoA reductase
                     [(3E)-enoyl-CoA-producing], mitochondrial"
                     /codon_start=1
                     /product="2,4-dienoyl-CoA reductase
                     [(3E)-enoyl-CoA-producing], mitochondrial precursor"
                     /protein_id="NP_476545.2"
                     /db_xref="GeneID:117543"
                     /db_xref="RGD:70999"
                     /translation="MALLARAFFAGVSRLPCDPGPQRFFSFGTKTLYQSIDAPQSKFF
                     PPILKPMLPPNAFQGKVAFITGGGTGLGKAMTTFLSSLGAQCVIASRNIDVLKATAEE
                     ITSKTGNKVYAIRCDVRDPDMVHNTVLELIKVAGHPDVVINNAAGNFISPSERLSPNG
                     WKTITDIVLNGTAYVTLEIGKQLIKAQKGAAFLAITTIYAESGSGFVMPSSSAKSGVE
                     AMNKSLAAEWGRYGMRFNIIQPGPIKTKGAFSRLDPTGKFEKDMIERIPCGRLGTVEE
                     LANLATFLCSDYASWINGAVIRFDGGEEVFLSGEFNSLKKVTKEEWDVIEGLIRKTKG
                     S"
     exon            115..317
                     /gene="Decr1"
                     /inference="alignment:Splign:2.1.0"
     exon            318..375
                     /gene="Decr1"
                     /inference="alignment:Splign:2.1.0"
     exon            376..462
                     /gene="Decr1"
                     /inference="alignment:Splign:2.1.0"
     exon            463..610
                     /gene="Decr1"
                     /inference="alignment:Splign:2.1.0"
     exon            611..710
                     /gene="Decr1"
                     /inference="alignment:Splign:2.1.0"
     exon            711..783
                     /gene="Decr1"
                     /inference="alignment:Splign:2.1.0"
     exon            784..930
                     /gene="Decr1"
                     /inference="alignment:Splign:2.1.0"
     exon            931..993
                     /gene="Decr1"
                     /inference="alignment:Splign:2.1.0"
     exon            994..1146
                     /gene="Decr1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggcggggcg gaccctgaca ctaaggactc agttctgctg caaacatggc gctgctggcc
       61 cgtgcgttct ttgctggggt gtcccgcctc ccctgcgatc ccggtcctca gaggtttttc
      121 agctttggaa cgaaaaccct gtatcaaagc atcgatgctc cacagtctaa attcttccca
      181 cccattttaa agcctatgct accacctaat gcctttcaag gaaaagtggc tttcatcacg
      241 ggaggaggca ctggccttgg caaggcaatg acaactttcc tgtccagcct gggtgcccag
      301 tgtgtgatcg cgagcaggaa tattgatgtt ctgaaagcta ctgcagaaga gattacttct
      361 aaaactggaa ataaggtcta tgcgattcgg tgtgacgttc gagatcctga tatggtacac
      421 aacacagtac tggagctgat caaagttgca gggcatcctg atgtggtgat aaacaatgcg
      481 gcagggaact tcatttctcc cagtgagaga ctgtctccca atggttggaa gaccataact
      541 gacatagttc tcaatggtac agcctatgtg acgctagaaa ttggaaagca gctaattaaa
      601 gcacagaaag gagctgcctt tcttgctatc actacgatct atgctgagag cggatcaggc
      661 tttgtaatgc caagttcttc agccaaatca ggcgtggaag ccatgaataa gtctcttgca
      721 gctgaatggg gtagatacgg aatgcgtttc aacataattc agccagggcc tatcaaaacc
      781 aaaggtgcct ttagccgttt ggacccgact ggaaaatttg agaaagatat gatcgagaga
      841 atcccctgtg gtcggctggg aactgtggag gaacttgcca atctagcgac tttcctttgc
      901 agtgattatg cctcttggat caatggggca gtcattcgat ttgacggtgg agaggaagtg
      961 tttctgtcag gtgaattcaa ctctctaaag aaggtcacca aggaggagtg ggatgtaatc
     1021 gaaggcctca tcagaaagac aaaaggctcc taagacgttc atggcttcct ctgcgacaaa
     1081 ctaaagttta gggactatat agatggacat ttgagttaat aaattttttg tctgataatt
     1141 tttgta
//
