LOCUS       NM_001004448            3253 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus dual endothelin 1, angiotensin II receptor
            (Dear), mRNA.
ACCESSION   NM_001004448 XM_579140
VERSION     NM_001004448.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3253)
  AUTHORS   Kaneko,Y., Herrera,V.L., Didishvili,T. and Ruiz-Opazo,N.
  TITLE     Sex-specific effects of dual ET-1/ANG II receptor (Dear) variants
            in Dahl salt-sensitive/resistant hypertension rat model
  JOURNAL   Physiol Genomics 20 (2), 157-164 (2005)
   PUBMED   15561758
REFERENCE   2  (bases 1 to 3253)
  AUTHORS   Ruiz-Opazo,N., Hirayama,K., Akimoto,K. and Herrera,V.L.
  TITLE     Molecular characterization of a dual endothelin-1/Angiotensin II
            receptor
  JOURNAL   Mol Med 4 (2), 96-108 (1998)
   PUBMED   9508787
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On Jun 22, 2016 this sequence version replaced NM_001004448.1.
            
            ##Evidence-Data-START##
            Transcript is intronless :: AY664492.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3253              JAXUCZ010000002.1  172594990-172598242 c
FEATURES             Location/Qualifiers
     source          1..3253
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q34"
     gene            1..3253
                     /gene="Dear"
                     /gene_synonym="DEspR; Fbxw7-as1"
                     /note="dual endothelin 1, angiotensin II receptor"
                     /db_xref="GeneID:446170"
                     /db_xref="RGD:1303105"
     exon            1..3253
                     /gene="Dear"
                     /gene_synonym="DEspR; Fbxw7-as1"
                     /inference="alignment:Splign:2.1.0"
     CDS             2660..3043
                     /gene="Dear"
                     /gene_synonym="DEspR; Fbxw7-as1"
                     /note="FBXW7 antisense RNA 1 homolog; dual
                     endothelin-1/VEGFsp receptor; dual
                     endothelin-1/angiotensin-2 receptor"
                     /codon_start=1
                     /product="dual endothelin-1/VEGF signal peptide receptor"
                     /protein_id="NP_001004448.2"
                     /db_xref="GeneID:446170"
                     /db_xref="RGD:1303105"
                     /translation="MSTFYVTAVPKSHSSLPKCQAMMSRTLLTGMAMYLDSSHAGAAS
                     MQVSWPPLLTSLGSKEMKSRWNWGSITCIMCFTCVGSQLSMSSSKASNFSGPLQLYQR
                     GIGHITNPYRRPPAPAWPCSSSGTT"
ORIGIN      
        1 tttctaaatg attacttttc tagatacctg tttacaaaac agaagatcct ccctttgaaa
       61 ccaaactaaa ctacacttga agaatataaa gtgcacaaag gaagaccacg atgaatcagt
      121 accacccatc ttcccagcat tcaagaatgt tcagcgcaca ggaggtgcac agtaagtgtt
      181 cctgagagga gtggatacaa cactcaatta tctgggcatg taatgctgat ctgcggtttc
      241 ctttacatca gccggcctcc ttcccggttg ggatcaagga agtgaacaga tgcagactca
      301 ctctggcagg caccactgag ccagccattt actctcactg catagcaaag ttattttgtc
      361 aacttgtttc caggatcctc tgcttccaca gagcagaaac acctcgtcta ggggattctg
      421 atccttaccc tcttctttac atttctctct ccagagaagg ttatcctcag ccaaaatcct
      481 ccagtatcga cacgtctgag ccgcttgcag caggtctttg ggttccagga atgaaagtac
      541 atagagtgcc agctatggaa aaggaaataa gggaggcaca ctcagacaca tcacagaaga
      601 aaggttactc tacgaagggt gagcattgag ctgggactgc tggatttcag tgggctgaac
      661 gaatcaagag aagcagcatt ttaagagcaa agaaaatgct catcattctc acattaggaa
      721 tctgaggctt tactctgggt aacctgtgat tctattggta tttccttaca aagtgagaac
      781 aatgccactt atcacaagtt tcttgtgtga gcccagtgct caagctctta gataatccaa
      841 ataaatgttg ataaagagac tttatattgt tcataccaat tatcaaaaaa tacaagtaca
      901 tttcatgtca gtgtggtaat aatgttttaa ataacacact tccctacagg gttaagtcta
      961 tgccattatt cttccacgca gacatcaagc acttcccaaa tgaagaacac cccagtagtc
     1021 agaaacaaaa accatagctg atatgctaag acagggctct ctcctttgta acttcttttt
     1081 tcctcaggaa gtctttgaaa gaacacagaa gccaagagaa tcttttgggg ttttaccttt
     1141 tattaatcat ctgtgcttac ttcttaaaat tctaaaacac tttcaaattt gggggactgg
     1201 tgatggctca gtcagtaagg tttcatgaag atgagggctc ggaaagtcag gcatggcagt
     1261 tctagctata gtcactgctc actggacagc cagccaccgt agctaaaggc gtaagctcca
     1321 gactcagtga aagacgacat ggcaaaaaca acatggatca gctgagggat acacctctgg
     1381 cctccacggg cacatacgtg caggagcatc tgaatgtact tatgtatacc cacacgaata
     1441 catacacatc ctacacacat acacactcta caggaggtat cgggcatgta agataatcca
     1501 gacgaatatt cacttcacgc cctgatggca gcaaagggat ctcgtgttac tttcataagt
     1561 ttagtcaaag agttctgatg tagaaaaagc tcacaagagc aaacactttt cttctgggac
     1621 actgtcacct ttaaaaagta ctcaaaaggg gggaaagtgc caggaaaaag atgatttatc
     1681 aatttgcttt cccccagaat tatattttaa ttcatcaatt ttactcaaat ctaatgccag
     1741 attctaacta ggactatatt taatgccact aggactttag agtgatcatc taagaaagga
     1801 gaaagcaaga ctcttcctgt tcaaatgagg tttcgggatc atctgtatga aggatgtgtt
     1861 agttttttgt gctgtctttt taactgctat ttataacatg tgtatagtaa tttgagaaaa
     1921 tatggactat ggggcattat ctaatatcac attatttctt ccttttgata aaaattaagc
     1981 tatgaagtct aatgtcaata tgtgcattat atttaaacca tcagccacac atggctgtat
     2041 gactaagtgc ctaagaatcc aatttttttg tggtatctct ctctctccct ctctccgtat
     2101 gtgtgtgtct ttctctgtct ctgtctctct ctctctttct ctctgacgaa ggatgataag
     2161 tagaaatgcc ataaaaacat atagataaat tttatatatt gggggctgga gagatggctc
     2221 agtggttgag aacactgact gttcttcaga ggtcctgagt taaattccca gcaaccacat
     2281 ggtagctcac aaccatctat attggcatct gatgccctct tctggtgtgt ctaaagacag
     2341 ctaccgtata cttacatata ataaataaat ctttaaaaaa attttttata tattaaaaaa
     2401 aatcacataa tgtaataacc agagaaatac aacaatcata aaattactgg tcttgaaggg
     2461 gcattaaata attagcaaaa taaaaacaaa attaatattg ttgcttagtg aatccagaat
     2521 tttgaaaaca tccactatat ataataaaca taccaactaa ctaaagtcag cctttagata
     2581 acccagggaa aactgaagag actcggcgac ttcacatgaa gccttacttt atccaagcgg
     2641 aagaaagcag caccttggta tgagcacatt ttatgtaaca gctgtaccaa aaagccacag
     2701 cagtttgcca aagtgtcaag ccatgatgag caggacactg cttacaggca tggctatgta
     2761 tctggacagc agccatgcgg gtgctgcatc catgcaggtg agctggccgc ccttactcac
     2821 ctctttgggg agcaaggaga tgaagtctcg ctggaactgg ggctcgatca cttgcatcat
     2881 gtgcttcact tgtgtgggtt cacagctatc gatgagctca tctaaggcca gcaacttctc
     2941 tggtccactc cagctctacc aaagaggaat tggacacatt acaaatccat acagaagacc
     3001 accagcacct gcatggccat gttcgagcag tggaactaca tgaaagggga ccgtggacag
     3061 agaccttgtc tccagaagcc accagagcga tagcagtttt tagtttcagc aagtttactc
     3121 agtacctttc ccgcaaagca ttaaaagtca tgactggcag aaaaataagt ctgcatttat
     3181 ttttaattat aagacttatg ctaacaccaa gacactggga gacacacaat atccatctgg
     3241 gttattgact agg
//
