LOCUS       NM_031801               2123 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus DEAF1 transcription factor (Deaf1), mRNA.
ACCESSION   NM_031801
VERSION     NM_031801.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2123)
  AUTHORS   Szewczyk,B., Kotarska,K., Daigle,M., Misztak,P., Sowa-Kucma,M.,
            Rafalo,A., Curzytek,K., Kubera,M., Basta-Kaim,A., Nowak,G. and
            Albert,P.R.
  TITLE     Stress-induced alterations in 5-HT1A receptor transcriptional
            modulators NUDR and Freud-1
  JOURNAL   Int J Neuropsychopharmacol 17 (11), 1763-1775 (2014)
   PUBMED   24946016
  REMARK    GeneRIF: In pregnancy stress, prefrontal cortex Deaf1 levels were
            reduced in rats.
REFERENCE   2  (bases 1 to 2123)
  AUTHORS   Vulto-van Silfhout,A.T., Rajamanickam,S., Jensik,P.J., Vergult,S.,
            de Rocker,N., Newhall,K.J., Raghavan,R., Reardon,S.N., Jarrett,K.,
            McIntyre,T., Bulinski,J., Ownby,S.L., Huggenvik,J.I.,
            McKnight,G.S., Rose,G.M., Cai,X., Willaert,A., Zweier,C.,
            Endele,S., de Ligt,J., van Bon,B.W., Lugtenberg,D., de Vries,P.F.,
            Veltman,J.A., van Bokhoven,H., Brunner,H.G., Rauch,A., de
            Brouwer,A.P., Carvill,G.L., Hoischen,A., Mefford,H.C.,
            Eichler,E.E., Vissers,L.E., Menten,B., Collard,M.W. and de
            Vries,B.B.
  TITLE     Mutations affecting the SAND domain of DEAF1 cause intellectual
            disability with severe speech impairment and behavioral problems
  JOURNAL   Am J Hum Genet 94 (5), 649-661 (2014)
   PUBMED   24726472
REFERENCE   3  (bases 1 to 2123)
  AUTHORS   Kieran,N., Ou,X.M. and Iyo,A.H.
  TITLE     Chronic social defeat downregulates the 5-HT1A receptor but not
            Freud-1 or NUDR in the rat prefrontal cortex
  JOURNAL   Neurosci Lett 469 (3), 380-384 (2010)
   PUBMED   20026183
  REMARK    GeneRIF: chronic social defeat stress downregulates the 5-HT1A
            receptor mRNA but does not significantly alter the levels of
            Freud-1 and NUDR in PFC; this stress paradigm could offer a useful
            rodent model for depression and other stress related disorders
REFERENCE   4  (bases 1 to 2123)
  AUTHORS   Iyo,A.H., Kieran,N., Chandran,A., Albert,P.R., Wicks,I.,
            Bissette,G. and Austin,M.C.
  TITLE     Differential regulation of the serotonin 1 A transcriptional
            modulators five prime repressor element under dual repression-1 and
            nuclear-deformed epidermal autoregulatory factor by chronic stress
  JOURNAL   Neuroscience 163 (4), 1119-1127 (2009)
   PUBMED   19647046
  REMARK    GeneRIF: results point to the importance of understanding the
            mechanism for the differential regulation of 5-HT1AR, Freud-1 and
            NUDR in the prefrontal cortex as a basis for understanding the
            related effects of chronic stress and stress-related disorders
REFERENCE   5  (bases 1 to 2123)
  AUTHORS   Yip,L., Su,L., Sheng,D., Chang,P., Atkinson,M., Czesak,M.,
            Albert,P.R., Collier,A.R., Turley,S.J., Fathman,C.G. and
            Creusot,R.J.
  TITLE     Deaf1 isoforms control the expression of genes encoding peripheral
            tissue antigens in the pancreatic lymph nodes during type 1
            diabetes
  JOURNAL   Nat Immunol 10 (9), 1026-1033 (2009)
   PUBMED   19668219
REFERENCE   6  (bases 1 to 2123)
  AUTHORS   Barker,H.E., Smyth,G.K., Wettenhall,J., Ward,T.A., Bath,M.L.,
            Lindeman,G.J. and Visvader,J.E.
  TITLE     Deaf-1 regulates epithelial cell proliferation and side-branching
            in the mammary gland
  JOURNAL   BMC Dev Biol 8, 94 (2008)
   PUBMED   18826651
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 2123)
  AUTHORS   Hahm,K., Sum,E.Y., Fujiwara,Y., Lindeman,G.J., Visvader,J.E. and
            Orkin,S.H.
  TITLE     Defective neural tube closure and anteroposterior patterning in
            mice lacking the LIM protein LMO4 or its interacting partner Deaf-1
  JOURNAL   Mol Cell Biol 24 (5), 2074-2082 (2004)
   PUBMED   14966286
REFERENCE   8  (bases 1 to 2123)
  AUTHORS   Sugihara,T.M., Bach,I., Kioussi,C., Rosenfeld,M.G. and Andersen,B.
  TITLE     Mouse deformed epidermal autoregulatory factor 1 recruits a LIM
            domain factor, LMO-4, and CLIM coregulators
  JOURNAL   Proc Natl Acad Sci U S A 95 (26), 15418-15423 (1998)
   PUBMED   9860983
REFERENCE   9  (bases 1 to 2123)
  AUTHORS   Huggenvik,J.I., Michelson,R.J., Collard,M.W., Ziemba,A.J.,
            Gurley,P. and Mowen,K.A.
  TITLE     Characterization of a nuclear deformed epidermal autoregulatory
            factor-1 (DEAF-1)-related (NUDR) transcriptional regulator protein
  JOURNAL   Mol Endocrinol 12 (10), 1619-1639 (1998)
   PUBMED   9773984
REFERENCE   10 (bases 1 to 2123)
  AUTHORS   LeBoeuf,R.D., Ban,E.M., Green,M.M., Stone,A.S., Propst,S.M.,
            Blalock,J.E. and Tauber,J.D.
  TITLE     Molecular cloning, sequence analysis, expression, and tissue
            distribution of suppressin, a novel suppressor of cell cycle entry
  JOURNAL   J Biol Chem 273 (1), 361-368 (1998)
   PUBMED   9417089
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On May 28, 2015 this sequence version replaced NM_031801.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF055884.1, U59659.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760434,
                                           SAMEA5760476 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-391               JAXUCZ010000001.1  205864716-205865106 c
            392-489             JAXUCZ010000001.1  205860875-205860972 c
            490-619             JAXUCZ010000001.1  205859909-205860038 c
            620-766             JAXUCZ010000001.1  205859507-205859653 c
            767-906             JAXUCZ010000001.1  205858981-205859120 c
            907-972             JAXUCZ010000001.1  205857986-205858051 c
            973-1099            JAXUCZ010000001.1  205852024-205852150 c
            1100-1228           JAXUCZ010000001.1  205851495-205851623 c
            1229-1357           JAXUCZ010000001.1  205851041-205851169 c
            1358-1605           JAXUCZ010000001.1  205847938-205848185 c
            1606-1695           JAXUCZ010000001.1  205839419-205839508 c
            1696-2123           JAXUCZ010000001.1  205831428-205831855 c
FEATURES             Location/Qualifiers
     source          1..2123
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q41"
     gene            1..2123
                     /gene="Deaf1"
                     /gene_synonym="NUDR"
                     /note="DEAF1 transcription factor"
                     /db_xref="GeneID:83632"
                     /db_xref="RGD:620671"
     exon            1..391
                     /gene="Deaf1"
                     /gene_synonym="NUDR"
                     /inference="alignment:Splign:2.1.0"
     CDS             103..1800
                     /gene="Deaf1"
                     /gene_synonym="NUDR"
                     /note="nuclear DEAF-1-related transcriptional regulator;
                     suppressin; DEAF-1 related transcriptional regulator
                     (NUDR)"
                     /codon_start=1
                     /product="deformed epidermal autoregulatory factor 1
                     homolog"
                     /protein_id="NP_113989.2"
                     /db_xref="GeneID:83632"
                     /db_xref="RGD:620671"
                     /translation="MEDSDSAAKQLGLAEAAAVAAAAAVAAAAAAAAESEAEEPVLSR
                     DEDSEEDADSEAERETRRVTAVAVMAAESGHMDMGTEALPSPDEAAAAAAFAEVTTVT
                     VANVGSSADNVFTTSVANAASISGHVLSGRTALQIGDSLNTEKATLIVVHTDGSIVET
                     TGLKGPAAPLTPGPQSPPTPLAPGQEKGGTKYNWDPSVYDSELPVRCRNISGTLYKSR
                     LGSGGRGRCIKQGENWYSPTEFEAMAGRASSKDWKRSIRYAGRPLQCLIQDGILNPHA
                     ASCTCAACCDDMTLSGPVRLFVPYKRRKKENELPTTPVKKDSPKNITLLPATAATTFT
                     VTPSGQITTSGALTFDRASTVEATAVISESPAQGDVFAGATVQEAGVQPPCRVGHPEP
                     HYPGYQDSCQIAPFPEAALPTSHPKIVLTSLPALAVPPSTPTKAVSPTVVSGLEMSEH
                     RSWLYLEEMVNSLLNTAQQLKTLFEQAKQASSCREAAVTQARMQVDAERKEQSCVNCG
                     REAMSECTGCHKVNYCSTFCQRKDWKDHQHVCGQSASVTVQADDVHVEESVIEKVTV"
     exon            392..489
                     /gene="Deaf1"
                     /gene_synonym="NUDR"
                     /inference="alignment:Splign:2.1.0"
     exon            490..619
                     /gene="Deaf1"
                     /gene_synonym="NUDR"
                     /inference="alignment:Splign:2.1.0"
     exon            620..766
                     /gene="Deaf1"
                     /gene_synonym="NUDR"
                     /inference="alignment:Splign:2.1.0"
     exon            767..906
                     /gene="Deaf1"
                     /gene_synonym="NUDR"
                     /inference="alignment:Splign:2.1.0"
     exon            907..972
                     /gene="Deaf1"
                     /gene_synonym="NUDR"
                     /inference="alignment:Splign:2.1.0"
     exon            973..1099
                     /gene="Deaf1"
                     /gene_synonym="NUDR"
                     /inference="alignment:Splign:2.1.0"
     exon            1100..1228
                     /gene="Deaf1"
                     /gene_synonym="NUDR"
                     /inference="alignment:Splign:2.1.0"
     exon            1229..1357
                     /gene="Deaf1"
                     /gene_synonym="NUDR"
                     /inference="alignment:Splign:2.1.0"
     exon            1358..1605
                     /gene="Deaf1"
                     /gene_synonym="NUDR"
                     /inference="alignment:Splign:2.1.0"
     exon            1606..1695
                     /gene="Deaf1"
                     /gene_synonym="NUDR"
                     /inference="alignment:Splign:2.1.0"
     exon            1696..2123
                     /gene="Deaf1"
                     /gene_synonym="NUDR"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cggcccaact cgggcggcct cttcgggccc cgcttcgggc tcggtgcctg gcgcttcggg
       61 cggtcccgga cagcgccttc gggcggactc ggtggagtcc gtatggagga ctcggactcg
      121 gcggcaaaac agctgggcct ggccgaggcg gcagcggtgg cggccgctgc cgctgtggcg
      181 gcggccgccg cggccgcagc ggaaagcgag gcggaggagc cggtgttaag cagagacgag
      241 gactcggagg aggacgcaga ctccgaggcg gagcgcgaga cgcggcgggt cacggctgtg
      301 gcggtgatgg cggccgaatc tgggcacatg gatatgggta ccgaggctct gcccagccct
      361 gatgaggccg ccgccgccgc cgcctttgca gaagtgacca cagtgactgt ggccaacgtg
      421 gggtcctctg cagataacgt cttcacaaca tcagtggcaa atgcagcctc gatatcagga
      481 catgtcctgt ctggtaggac agccctgcag atcggggaca gcctgaacac tgagaaagcc
      541 acactaatag ttgtacacac agatgggagc attgtggaaa ccaccgggct gaagggccca
      601 gcagcacctc tcaccccagg tcctcagtct cctcctaccc cactggcacc tggccaggag
      661 aaaggtggta ccaagtacaa ctgggaccct tcggtgtatg acagcgagct gcctgtgcgc
      721 tgtcggaaca tcagtggcac gctctacaag agtcggctcg gctcaggtgg ccgggggcgg
      781 tgtatcaagc agggagaaaa ctggtacagc ccaaccgagt ttgaagccat ggcaggaaga
      841 gccagcagca aggactggaa gagaagcatc cgctatgcgg gcagacccct gcagtgcctc
      901 atccaggatg gtattttgaa ccctcacgct gcctcctgca cctgtgctgc ctgttgcgat
      961 gacatgactc taagtggccc tgtcaggctc ttcgtcccct ataaaaggcg caagaaagag
     1021 aatgagctgc ccacgactcc agttaagaag gattccccca agaacatcac gctgctccct
     1081 gccacggcgg ccaccacctt cactgtgaca ccctcaggac agatcactac ctctggagca
     1141 ctaacctttg accgagcatc cactgtggag gccactgctg tcatctctga gagcccagcc
     1201 caaggggatg tctttgcagg agccacagtg caagaggcag gcgtgcagcc cccctgcagg
     1261 gttggccacc ctgaacccca ctaccctggc tatcaggaca gctgccagat cgccccgttt
     1321 ccagaagctg cattgccaac atcacatccc aaaattgtcc tgacatcgct gcccgccttg
     1381 gccgtgccgc cctccacccc caccaaagct gtctctccca ccgtggtcag tgggctggag
     1441 atgtcagagc atcggagctg gctgtacctg gaagagatgg tcaactccct cctcaacaca
     1501 gcccagcagc tgaagacgtt gtttgaacaa gccaagcagg cgagctcttg cagggaagct
     1561 gctgtgaccc aggcgagaat gcaggttgat gcagagagga aggagcagtc atgtgtcaac
     1621 tgcggccggg aggccatgag tgagtgcacc ggctgccaca aggttaacta ctgctctacg
     1681 ttctgccagc gcaaggactg gaaagaccat cagcatgtat gtggccagtc agcatctgtc
     1741 actgtccagg ctgatgacgt ccatgttgaa gaaagtgtga tagaaaaagt tactgtctga
     1801 gccaggcttc tccctgagct ctactgagaa gccatcacag gcttaggctc tgactttggg
     1861 ggctgctgag aagagggccc tgggaaactt gccggacaag ttattaacag actgtgccct
     1921 tggaaacaaa ctcctgccag agaccaagga acgctggcag cttgcaggat ggggcactct
     1981 gccacagccc agggtcctct gcctatcacg gtgctctttc ttccctggat catgagtgtc
     2041 ctactaccct cggggtgccc tagccacgtg tacatacctg ttttatctgt taataaagat
     2101 gtaaataaag ctcccacccc aca
//
