LOCUS       NP_001406785            1708 aa            linear   ROD 03-APR-2024
DEFINITION  DEXD/H-box helicase 60 [Rattus norvegicus].
ACCESSION   NP_001406785 XP_038951091
VERSION     NP_001406785.1
DBSOURCE    REFSEQ: accession NM_001419856.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 1708)
  AUTHORS   Miyashita,M., Oshiumi,H., Matsumoto,M. and Seya,T.
  TITLE     DDX60, a DEXD/H box helicase, is a novel antiviral factor promoting
            RIG-I-like receptor-mediated signaling
  JOURNAL   Mol Cell Biol 31 (18), 3802-3819 (2011)
   PUBMED   21791617
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            On Apr 20, 2023 this sequence version replaced XP_038951091.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643292.55973.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1708
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16p12"
     Protein         1..1708
                     /product="DEXD/H-box helicase 60"
                     /note="DEAD (Asp-Glu-Ala-Asp) box polypeptide 60; probable
                     ATP-dependent RNA helicase DDX60; mCG11385-like; probable
                     ATP-dependent RNA helicase DDX60-like"
                     /calculated_mol_wt=197016
     Region          760..937
                     /region_name="DEXHc_DDX60"
                     /note="DEXH-box helicase domain of DEAD box protein 60;
                     cd18025"
                     /db_xref="CDD:350783"
     Site            order(760..762,765,784..790)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:350783"
     Region          765..1440
                     /region_name="BRR2"
                     /note="Replicative superfamily II helicase [Replication,
                     recombination and repair]; COG1204"
                     /db_xref="CDD:440817"
     Site            order(814..815,846,860,862..863,866,896)
                     /site_type="other"
                     /note="nucleic acid binding site [nucleotide binding]"
                     /db_xref="CDD:350783"
     Region          1193..1336
                     /region_name="P-loop containing Nucleoside Triphosphate
                     Hydrolases"
                     /note="Members of the P-loop NTPase domain superfamily are
                     characterized by a conserved nucleotide phosphate-binding
                     motif, also referred to as the Walker A motif
                     (GxxxxGK[S/T], where x is any residue), and the Walker B
                     motif (hhhh[D/E], where h is a...; cl38936"
                     /db_xref="CDD:476819"
     Site            1321
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:350171"
     CDS             1..1708
                     /gene="Ddx60"
                     /gene_synonym="AABR07025140.1; RGD1560014"
                     /coded_by="NM_001419856.1:241..5367"
                     /db_xref="GeneID:100360801"
                     /db_xref="RGD:1560014"
ORIGIN      
        1 mekrctmfle gmsqlileni pradysslfn dfveseffli dgdsllltcv cemslepgqs
       61 lhffylvery lldvtskggq faivffkdae yayfsvpell tlrtslilhl qknttievwt
      121 mfsnclseew siclnqscpy flivadegld hlqthllnfv viqawaakvn vvlfsgqtsd
      181 ilrlyayfmq ssytnqmffk kneetimnvy kalieqleky rdraltplfg dlkfndmeke
      241 vseivsllkq lwpegsdirr vfcvtscslf lemyhsylen rekrastets evtqkpdncl
      301 tlkdvedfck lhclsvafql hlplsqrars rfitsnwiqd lqtvlkmkew ceyftlnnvd
      361 ifefwsldll hvsdlsdepl lkniafyyey enkggldlkv gdvimkeyih lwdtvsklvk
      421 kfdvgkptpl rttkvhfiek tlspikessq etmpnlgfip iscnlvdeft rdilkdlpfl
      481 ksddpivtsl vkhkefdelv hwhshrplsd dydrtkatfd dkkdpyylsr lqkyhrfqrl
      541 ygsslesvts kmittegpkp kkdcikskrt kahktkaeii vrenkkrlia eeeqkegqkw
      601 salsfsieee mrrnlnsgik kleeflksck sssvktqaer vglqaclkaw kehcraegkt
      661 tkdfniavnm mkrihsllek qseflqeadq kliarcltyl gfyeladslc ptqdtaddvk
      721 mtkkkysvgi gparfqlqym ghylireerk dpdprvqdfi pdtwqrelld vvdnyesavi
      781 vaptssgkty asyycmekvl kesnegvvvy vaptkalvnq vaatvqnryt knmpggealc
      841 gvftrdyrhe alnsqvlitv pacfeillla phrqnwvkri ryvifdevhc lggeigaeiw
      901 ehllvmircp flalsatisn pqhltewlqs vkrywkqvds tmeqgsvsqr naatrgsyhk
      961 drvqarqsyk vrlvlygery ndlekylcsv rqgdvcfdhf hpcaalttdh iekygfpsdl
     1021 alspresiql ydtmcqvwks wpqaqnlcpe nftqfknkiv ikkldarkye eslkeeftnw
     1081 vkngnekeaq lvlkklspdy hdysgqmldf fpclveklrk meklpalffl fsldtveeca
     1141 envcefleek qeekrppkad keayimankl rkvkkslekq kidekgqkss rrldqsimye
     1201 aehnyllksl eknleipkdc tyadqkaide etlqivfgrv kcgkkgdtlk klarrgigyh
     1261 hrsmtakekq lveilfrkgf irvvtatgtl alginmpcks vvfaqnsvyl dalnyrqmsg
     1321 ragrrgqdll gdvyffdipl pkigkliksk vpelrgqfpl sitlilrlml latkaddled
     1381 gkakalsvlk hsllsfkqpr atdmlklyfl yslqflvkeg hidqegnptg faglvthlny
     1441 hepsnlvfvs flvkglfhkl cqptskdskc fsedvmeklv lvlanlfgri yipakfyevn
     1501 tkfyqskvfl ddlpqdfsda llaynmqvtr dfasfllivs rladmkqeyq lplskiefag
     1561 kecedsplvs hlmsckegrm avspfvclsg nfdvdllspg vpnhvtlhti cinhaqapvl
     1621 wphrldsqgr kmplnayald fykhgsltgl vqdngihpgd aynllkdfyl tiksisvslr
     1681 elceneednv vlafeqlsks fhekfelv
//
