LOCUS       NM_001109292            2698 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus DEAD-box helicase 6 (Ddx6), mRNA.
ACCESSION   NM_001109292 XM_001067324 XM_576400
VERSION     NM_001109292.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2698)
  AUTHORS   Balak,C., Benard,M., Schaefer,E., Iqbal,S., Ramsey,K.,
            Ernoult-Lange,M., Mattioli,F., Llaci,L., Geoffroy,V., Courel,M.,
            Naymik,M., Bachman,K.K., Pfundt,R., Rump,P., Ter Beest,J.,
            Wentzensen,I.M., Monaghan,K.G., McWalter,K., Richholt,R., Le
            Bechec,A., Jepsen,W., De Both,M., Belnap,N., Boland,A., Piras,I.S.,
            Deleuze,J.F., Szelinger,S., Dollfus,H., Chelly,J., Muller,J.,
            Campbell,A., Lal,D., Rangasamy,S., Mandel,J.L., Narayanan,V.,
            Huentelman,M., Weil,D. and Piton,A.
  TITLE     Rare De Novo Missense Variants in RNA Helicase DDX6 Cause
            Intellectual Disability and Dysmorphic Features and Lead to P-Body
            Defects and RNA Dysregulation
  JOURNAL   Am J Hum Genet 105 (3), 509-525 (2019)
   PUBMED   31422817
REFERENCE   2  (bases 1 to 2698)
  AUTHORS   Bish,R., Cuevas-Polo,N., Cheng,Z., Hambardzumyan,D., Munschauer,M.,
            Landthaler,M. and Vogel,C.
  TITLE     Comprehensive Protein Interactome Analysis of a Key RNA Helicase:
            Detection of Novel Stress Granule Proteins
  JOURNAL   Biomolecules 5 (3), 1441-1466 (2015)
   PUBMED   26184334
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2698)
  AUTHORS   Guo,Z., Neilson,L.J., Zhong,H., Murray,P.S., Zanivan,S. and
            Zaidel-Bar,R.
  TITLE     E-cadherin interactome complexity and robustness resolved by
            quantitative proteomics
  JOURNAL   Sci Signal 7 (354), rs7 (2014)
   PUBMED   25468996
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2698)
  AUTHORS   Yang,G., Smibert,C.A., Kaplan,D.R. and Miller,F.D.
  TITLE     An eIF4E1/4E-T complex determines the genesis of neurons from
            precursors by translationally repressing a proneurogenic
            transcription program
  JOURNAL   Neuron 84 (4), 723-739 (2014)
   PUBMED   25456498
REFERENCE   5  (bases 1 to 2698)
  AUTHORS   Chen,Y., Boland,A., Kuzuoglu-Ozturk,D., Bawankar,P., Loh,B.,
            Chang,C.T., Weichenrieder,O. and Izaurralde,E.
  TITLE     A DDX6-CNOT1 complex and W-binding pockets in CNOT9 reveal direct
            links between miRNA target recognition and silencing
  JOURNAL   Mol Cell 54 (5), 737-750 (2014)
   PUBMED   24768540
REFERENCE   6  (bases 1 to 2698)
  AUTHORS   James,V., Zhang,Y., Foxler,D.E., de Moor,C.H., Kong,Y.W.,
            Webb,T.M., Self,T.J., Feng,Y., Lagos,D., Chu,C.Y., Rana,T.M.,
            Morley,S.J., Longmore,G.D., Bushell,M. and Sharp,T.V.
  TITLE     LIM-domain proteins, LIMD1, Ajuba, and WTIP are required for
            microRNA-mediated gene silencing
  JOURNAL   Proc Natl Acad Sci U S A 107 (28), 12499-12504 (2010)
   PUBMED   20616046
REFERENCE   7  (bases 1 to 2698)
  AUTHORS   Hu,J., Wang,F., Zhu,X., Yuan,Y., Ding,M. and Gao,S.
  TITLE     Mouse ZAR1-like (XM_359149) colocalizes with mRNA processing
            components and its dominant-negative mutant caused two-cell-stage
            embryonic arrest
  JOURNAL   Dev Dyn 239 (2), 407-424 (2010)
   PUBMED   20014101
REFERENCE   8  (bases 1 to 2698)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   9  (bases 1 to 2698)
  AUTHORS   Nonhoff,U., Ralser,M., Welzel,F., Piccini,I., Balzereit,D.,
            Yaspo,M.L., Lehrach,H. and Krobitsch,S.
  TITLE     Ataxin-2 interacts with the DEAD/H-box RNA helicase DDX6 and
            interferes with P-bodies and stress granules
  JOURNAL   Mol Biol Cell 18 (4), 1385-1396 (2007)
   PUBMED   17392519
REFERENCE   10 (bases 1 to 2698)
  AUTHORS   Wichroski,M.J., Robb,G.B. and Rana,T.M.
  TITLE     Human retroviral host restriction factors APOBEC3G and APOBEC3F
            localize to mRNA processing bodies
  JOURNAL   PLoS Pathog 2 (5), e41 (2006)
   PUBMED   16699599
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473975.1.
            
            [WARNING] On Oct 26, 2024 this sequence was replaced by
            NM_001109292.2.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_001067324.1, XM_576400.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMD00132266,
                              SAMD00132267 [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..2698
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q22"
     gene            1..2698
                     /gene="Ddx6"
                     /gene_synonym="RGD1564560"
                     /note="DEAD-box helicase 6"
                     /db_xref="GeneID:500988"
                     /db_xref="RGD:1564560"
     exon            1..88
                     /gene="Ddx6"
                     /gene_synonym="RGD1564560"
                     /inference="alignment:Splign:2.1.0"
     exon            89..553
                     /gene="Ddx6"
                     /gene_synonym="RGD1564560"
                     /inference="alignment:Splign:2.1.0"
     CDS             354..1805
                     /gene="Ddx6"
                     /gene_synonym="RGD1564560"
                     /EC_number="3.6.4.13"
                     /note="DEAD (Asp-Glu-Ala-Asp) box polypeptide 6; DEAD
                     (Asp-Glu-Ala-Asp) box helicase 6"
                     /codon_start=1
                     /product="probable ATP-dependent RNA helicase DDX6"
                     /protein_id="NP_001102762.1"
                     /db_xref="GeneID:500988"
                     /db_xref="RGD:1564560"
                     /translation="MSTARTENPVIMGLSSQNGQLRGPVKASAGPGGGGPQTQTQMNQ
                     LKNTSTINNGTQQQAQSMAATIKPGDDWKKTLKLPPKDLRIKTSDVTSTKGNEFEDYC
                     LKRELLMGIFEMGWEKPSPIQEESIPIALSGRDILARAKNGTGKSGAYLIPLLERLDL
                     KKDNIQAMVIVPTRELALQVSQICIQVSKHMGGAKVMATTGGTNLRDDIMRLDDTVHV
                     VIATPGRILDLIKKGVAKVDHVQMIVLDEADKLLSQDFVQIMEDIILTLPKNRQILLY
                     SATFPLSVQKFMNSHLQKPYEINLMEELTLKGVTQYYAYVTERQKVHCLNTLFSRLQI
                     NQSIIFCNSSQRVELLAKKISQLGYSCFYIHAKMRQEHRNRVFHDFRNGLCRNLVCTD
                     LFTRGIDIQAVNVVINFDFPKLAETYLHRIGRSGRFGHLGLAINLITYDDRFNLKSIE
                     EQLGTEIKPIPSNIDKSLYVAEYHSEPAEDEKP"
     exon            554..617
                     /gene="Ddx6"
                     /gene_synonym="RGD1564560"
                     /inference="alignment:Splign:2.1.0"
     exon            618..722
                     /gene="Ddx6"
                     /gene_synonym="RGD1564560"
                     /inference="alignment:Splign:2.1.0"
     exon            723..852
                     /gene="Ddx6"
                     /gene_synonym="RGD1564560"
                     /inference="alignment:Splign:2.1.0"
     exon            853..999
                     /gene="Ddx6"
                     /gene_synonym="RGD1564560"
                     /inference="alignment:Splign:2.1.0"
     exon            1000..1094
                     /gene="Ddx6"
                     /gene_synonym="RGD1564560"
                     /inference="alignment:Splign:2.1.0"
     exon            1095..1217
                     /gene="Ddx6"
                     /gene_synonym="RGD1564560"
                     /inference="alignment:Splign:2.1.0"
     exon            1218..1346
                     /gene="Ddx6"
                     /gene_synonym="RGD1564560"
                     /inference="alignment:Splign:2.1.0"
     exon            1347..1463
                     /gene="Ddx6"
                     /gene_synonym="RGD1564560"
                     /inference="alignment:Splign:2.1.0"
     exon            1464..1527
                     /gene="Ddx6"
                     /gene_synonym="RGD1564560"
                     /inference="alignment:Splign:2.1.0"
     exon            1528..1629
                     /gene="Ddx6"
                     /gene_synonym="RGD1564560"
                     /inference="alignment:Splign:2.1.0"
     exon            1630..1812
                     /gene="Ddx6"
                     /gene_synonym="RGD1564560"
                     /inference="alignment:Splign:2.1.0"
     exon            1813..2698
                     /gene="Ddx6"
                     /gene_synonym="RGD1564560"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggagcttcga gtcaacaata aaggaccgag ggtgcggagc gggagtggcc tgggtggtag
       61 gactcgggcc cgagccgcgg ggcgtgggat tgaagtgagt gaattcagat ataattcaag
      121 cttgttagag cgctttaaaa aaatacaaag ttgattcgtt gcttgagagc aagttaacta
      181 ctgctgctta ccggtgagag acttacaggt gcttgcctga attgcaataa aggactcata
      241 tattgagcaa gacttattta tctcttcatt ttggagagcc tcataaactg ttattacagt
      301 ttctctactg actttgaaaa gtttgaaaga gacacctgtg cagctaagaa agcatgagca
      361 cggccaggac agagaaccct gttatcatgg gtctgtccag tcagaacggc cagctgaggg
      421 gccctgtgaa ggccagtgcc ggccctggag gagggggccc acagacacag acacagatga
      481 accagttgaa gaacaccagc acaatcaata atggcactca gcagcaagca cagagcatgg
      541 ccgccaccat taaacctggt gatgactgga aaaagacttt aaaactccct ccaaaggatc
      601 taagaattaa aacttcggat gtgacctcca caaaaggaaa tgagtttgaa gattactgtt
      661 tgaaacgaga gttgctaatg ggaatttttg aaatgggctg ggaaaaacca tctcctattc
      721 aggaggagag cattcccatt gctttatctg gtagggatat cttagctaga gcaaaaaatg
      781 gaacaggcaa aagcggtgcc tacctcatcc ccttacttga acggctggac ctgaagaagg
      841 acaatattca agcaatggtg attgttccca ctagagaact tgctctacag gtcagtcaaa
      901 tttgcatcca ggtcagcaaa cacatgggag gggccaaagt gatggcgacc actggaggaa
      961 ccaatttacg ggatgacata atgaggcttg acgatacagt gcatgtggtg attgctaccc
     1021 ctggcagaat cctggatctt atcaagaaag gagtagcaaa ggttgatcat gtccagatga
     1081 tagtattgga tgaggcagat aagttgttgt cacaggactt tgtgcagata atggaggata
     1141 ttattctcac actacctaaa aataggcaga ttttactata ttccgctact ttccctctta
     1201 gtgtacaaaa gtttatgaat tcccatctgc aaaaacccta cgagataaac ctgatggagg
     1261 agctaactct gaaaggggtg acccagtact acgcatatgt aacggagcgc caaaaagtgc
     1321 actgcctcaa tacactcttc tccaggcttc agataaacca gtcgatcatt ttctgcaact
     1381 cttctcagag agttgagtta ctggccaaga agatttctca gctgggttac tcttgcttct
     1441 atatccatgc taaaatgagg caggaacata gaaatcgtgt ctttcatgat ttccgaaatg
     1501 gcttatgccg caatcttgtt tgcactgatc tgtttacccg aggtattgat atacaagctg
     1561 tgaatgtggt aataaacttt gacttcccaa agctggcaga gacctatctt catcggattg
     1621 gaaggtcagg tcgctttggt catcttggct tagccatcaa cttgatcaca tatgatgatc
     1681 gcttcaacct gaagagtatt gaggagcagc tggggacaga gatcaaaccc atcccaagca
     1741 acattgacaa gagcctgtat gtggcagaat accacagtga gcctgcagaa gatgagaaac
     1801 cttaacaagc acgctttgac aaactacaga aggctccttg gatctgtgac gcatcatttt
     1861 tggggcgggg ggtgctcttc tccttgtggg tttttcatct ttattttgga actatgaaga
     1921 gttatataag agctcagaca tctttctttt ttttaactgg tgaagaaaaa ctgaaaagaa
     1981 gaaatggacc ttttttgttc ccttgtttgc actgtgtgct gactgaacgt ttcgttgcac
     2041 taactgctgg tttttaaaaa tgttttctgg ggaaagggga caaggaagga ggaaaaagaa
     2101 agggagaaac cctaaaaaga gaagaatctt ggtggacacg cacctgtcta cagttctccg
     2161 atagccgact ctactgcatt tcaacttctc cctggttact catccgtttt taagcctgaa
     2221 gagcttacta cttatttgtg caaagtgcct tacgctacga gaccattaag aatatcatct
     2281 tttaccacag cccgaggaat caacaaagtc acgttctatt ttcttttctt ttttatttct
     2341 ttgcctcttc atttggtttc aagttgaagt cttgcttcct gttctaccag tactcatgcc
     2401 cagggccgga aggtggacta gtgatggtag cgccattttc cttttcttta tatggaggag
     2461 ttgattcaca actgcagtcc atccacactg taaatacatg tatttaaaaa aaaaaaacaa
     2521 taccaagtaa aattttcttc tgggctgagt agacgcacca tcgtcgctcc caaaggaaag
     2581 agcagcctct cactgcagga gccatatgac aagcctctgt gctctacggc ggaacactaa
     2641 cctggctcac acgcttccat gagcagtaag gcactgggtg caaagacttg tcggagcc
//
