LOCUS       NM_001191548            3128 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus DEAD-box helicase 54 (Ddx54), mRNA.
ACCESSION   NM_001191548 XM_002727973
VERSION     NM_001191548.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3128)
  AUTHORS   Liu,P., Zhang,Y., Li,X. and Ma,M.
  TITLE     DEAD-box helicase 54 regulates microglial inflammatory response in
            rats with chronic constriction injuries through NF-kappaB/NLRP3
            signaling axis
  JOURNAL   J Neurophysiol 130 (2), 392-400 (2023)
   PUBMED   37377223
  REMARK    GeneRIF: DEAD-box helicase 54 regulates microglial inflammatory
            response in rats with chronic constriction injuries through
            NF-kappaB/NLRP3 signaling axis.
REFERENCE   2  (bases 1 to 3128)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   3  (bases 1 to 3128)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   4  (bases 1 to 3128)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   5  (bases 1 to 3128)
  AUTHORS   Rajendran,R.R., Nye,A.C., Frasor,J., Balsara,R.D., Martini,P.G. and
            Katzenellenbogen,B.S.
  TITLE     Regulation of nuclear receptor transcriptional activity by a novel
            DEAD box RNA helicase (DP97)
  JOURNAL   J Biol Chem 278 (7), 4628-4638 (2003)
   PUBMED   12466272
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000012.1.
            
            On Jul 17, 2010 this sequence version replaced XM_002727973.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-215               JAXUCZ010000012.1  41610324-41610538   c
            216-345             JAXUCZ010000012.1  41606909-41607038   c
            346-416             JAXUCZ010000012.1  41605793-41605863   c
            417-605             JAXUCZ010000012.1  41605236-41605424   c
            606-655             JAXUCZ010000012.1  41605089-41605138   c
            656-697             JAXUCZ010000012.1  41604373-41604414   c
            698-793             JAXUCZ010000012.1  41604183-41604278   c
            794-915             JAXUCZ010000012.1  41603682-41603803   c
            916-977             JAXUCZ010000012.1  41603531-41603592   c
            978-1109            JAXUCZ010000012.1  41603295-41603426   c
            1110-1320           JAXUCZ010000012.1  41602171-41602381   c
            1321-1458           JAXUCZ010000012.1  41600575-41600712   c
            1459-1689           JAXUCZ010000012.1  41600048-41600278   c
            1690-1763           JAXUCZ010000012.1  41599890-41599963   c
            1764-1955           JAXUCZ010000012.1  41599101-41599292   c
            1956-2098           JAXUCZ010000012.1  41597995-41598137   c
            2099-2212           JAXUCZ010000012.1  41597800-41597913   c
            2213-2317           JAXUCZ010000012.1  41597289-41597393   c
            2318-2454           JAXUCZ010000012.1  41596878-41597014   c
            2455-3128           JAXUCZ010000012.1  41596097-41596770   c
FEATURES             Location/Qualifiers
     source          1..3128
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12q16"
     gene            1..3128
                     /gene="Ddx54"
                     /gene_synonym="RGD1562539"
                     /note="DEAD-box helicase 54"
                     /db_xref="GeneID:360815"
                     /db_xref="RGD:1562539"
     exon            1..215
                     /gene="Ddx54"
                     /gene_synonym="RGD1562539"
                     /inference="alignment:Splign:2.1.0"
     CDS             45..2669
                     /gene="Ddx54"
                     /gene_synonym="RGD1562539"
                     /EC_number="3.6.4.13"
                     /note="DEAD (Asp-Glu-Ala-Asp) box polypeptide 54"
                     /codon_start=1
                     /product="ATP-dependent RNA helicase DDX54"
                     /protein_id="NP_001178477.1"
                     /db_xref="GeneID:360815"
                     /db_xref="RGD:1562539"
                     /translation="MAAGRRVGLGPRSHPAMAPWKKKRLRKRRTGASQARDSDSEDGE
                     FEIQAEDDARARKLGPGRALPSFPTSECVSDVEPDTREMVRAQNKKKKKSGGFQSMGL
                     SYPVFKGIMKKGYKVPTPIQRKTIPVILDGKDVVAMARTGSGKTACFLLPMFERLKAR
                     SAQTGARALILSPTRELALQTMKFTKELGKFTGLKTALILGGDKMEDQFAALHENPDI
                     IIATPGRLVHVAVEMNLKLQSVEYVVFDEADRLFEMGFAEQLQEIIGRLPGGHQTVLF
                     SATLPKLLVEFARAGLTEPVLIRLDVDSKLNEQLKTSFFLVREDTKTAVLLYLLQNVV
                     RPQDQNVVFVATKHHAEYLTELLTGQGVSCAHIYSALDQTARKINLAKFTHNKCSTLI
                     VTDLAARGLDIPLLDNVINYSFPAKGKLFLHRVGRVARAGRSGTAYSLVAPDEVPYLL
                     DLHLFLGRSVTLARPHEEPSSGAVGRDGVLGRVPQSVVDDEDSSLQTALQASLELQGL
                     QRVANNAQQQYLRSRPAPSPESIKRAKELDLAELGLHPLFSSCFEEGELQRLRLVDSI
                     KNYRTRTTIFEINASSKDPSSQMMRAKRQRDRKAITSFHQGRQERQDGPADPVPQREL
                     PQKEEEDMVETVEGVFTEVVGQKQPRPGPNQGAKRRRKEASQRDQEFYVPYRPKDFDS
                     ERGLSVSGAGGAFEQQVAGAVLDLMGDEAQNMSRGRQQLKWDRKKKRFVGQSGQEDKK
                     KIKTESGRFISSSYKRDLYQKWKQKQKIDDRDSEEEGPSNRRGPGPHRGGKRGRSQGG
                     QGRWYASSVPTGHMRSELKTKEQILKQRRQAQKQRFLQRGGLKQLSARNRRRAQELRQ
                     SAFGRGAPTRKGKMRKRM"
     exon            216..345
                     /gene="Ddx54"
                     /gene_synonym="RGD1562539"
                     /inference="alignment:Splign:2.1.0"
     exon            346..416
                     /gene="Ddx54"
                     /gene_synonym="RGD1562539"
                     /inference="alignment:Splign:2.1.0"
     exon            417..605
                     /gene="Ddx54"
                     /gene_synonym="RGD1562539"
                     /inference="alignment:Splign:2.1.0"
     exon            606..655
                     /gene="Ddx54"
                     /gene_synonym="RGD1562539"
                     /inference="alignment:Splign:2.1.0"
     exon            656..697
                     /gene="Ddx54"
                     /gene_synonym="RGD1562539"
                     /inference="alignment:Splign:2.1.0"
     exon            698..793
                     /gene="Ddx54"
                     /gene_synonym="RGD1562539"
                     /inference="alignment:Splign:2.1.0"
     exon            794..915
                     /gene="Ddx54"
                     /gene_synonym="RGD1562539"
                     /inference="alignment:Splign:2.1.0"
     exon            916..977
                     /gene="Ddx54"
                     /gene_synonym="RGD1562539"
                     /inference="alignment:Splign:2.1.0"
     exon            978..1109
                     /gene="Ddx54"
                     /gene_synonym="RGD1562539"
                     /inference="alignment:Splign:2.1.0"
     exon            1110..1320
                     /gene="Ddx54"
                     /gene_synonym="RGD1562539"
                     /inference="alignment:Splign:2.1.0"
     exon            1321..1458
                     /gene="Ddx54"
                     /gene_synonym="RGD1562539"
                     /inference="alignment:Splign:2.1.0"
     exon            1459..1689
                     /gene="Ddx54"
                     /gene_synonym="RGD1562539"
                     /inference="alignment:Splign:2.1.0"
     exon            1690..1763
                     /gene="Ddx54"
                     /gene_synonym="RGD1562539"
                     /inference="alignment:Splign:2.1.0"
     exon            1764..1955
                     /gene="Ddx54"
                     /gene_synonym="RGD1562539"
                     /inference="alignment:Splign:2.1.0"
     exon            1956..2098
                     /gene="Ddx54"
                     /gene_synonym="RGD1562539"
                     /inference="alignment:Splign:2.1.0"
     exon            2099..2212
                     /gene="Ddx54"
                     /gene_synonym="RGD1562539"
                     /inference="alignment:Splign:2.1.0"
     exon            2213..2317
                     /gene="Ddx54"
                     /gene_synonym="RGD1562539"
                     /inference="alignment:Splign:2.1.0"
     exon            2318..2454
                     /gene="Ddx54"
                     /gene_synonym="RGD1562539"
                     /inference="alignment:Splign:2.1.0"
     exon            2455..3128
                     /gene="Ddx54"
                     /gene_synonym="RGD1562539"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tcccacaggc tccgccctct tccgggtccg agtgcccggc ccgcatggct gccggcagac
       61 gtgtggggct tggcccgcgg tcgcatcccg ccatggctcc gtggaagaag aagaggctgc
      121 ggaaacgccg aactggggct tcccaggccc gcgacagcga ttcggaggac ggcgagttcg
      181 agatccaagc agaggatgac gcccgggcgc ggaagctggg ccctggcaga gccttgccct
      241 catttcccac ctcagagtgc gtatcagatg tggagcctga cacccgagag atggtacgag
      301 cccagaacaa gaaaaagaag aagtctggag gcttccagtc catgggcttg agctacccag
      361 tgttcaaggg gatcatgaag aagggctaca aggtgccaac acccatccag aggaagacca
      421 tccccgtgat cttggatggc aaggatgtgg tggctatggc ccggacaggc agtggcaaga
      481 cagcctgttt cctcctcccg atgtttgagc ggctgaaggc acgcagtgca cagacggggg
      541 ctcgggccct catcctctca cccacccggg agctggccct gcagaccatg aagttcacta
      601 aagagctagg caagttcact ggcctcaaga ctgccttgat cctgggtgga gacaaaatgg
      661 aagaccagtt tgcagccctg cacgagaacc ctgacataat cattgccacc cctgggcggc
      721 tggtgcatgt cgctgtggag atgaacttaa agctgcagag tgtggagtat gtggtttttg
      781 atgaagcaga caggctcttt gaaatgggct ttgctgagca gctacaggag atcataggcc
      841 gccttcctgg gggccaccag acagtgctgt tctcagccac actgcccaaa ctgctggtgg
      901 aatttgcacg agcaggcctc acagagcccg tgctcatccg cctggatgta gactccaaac
      961 tcaatgaaca gctcaagact tccttcttcc ttgtgcgtga ggacaccaag actgctgtgc
     1021 tcctctacct gctacagaat gtcgttcggc cccaggacca gaacgtggtg tttgtagcca
     1081 cgaagcacca cgcagagtac ctcacagagt tgctgacggg ccagggtgtg agctgcgccc
     1141 acatctacag tgccttggac cagacggccc gcaagatcaa cttggccaag ttcacacaca
     1201 acaaatgttc cacccttatc gtgactgacc tggctgcccg gggcctggac atcccactgc
     1261 tggacaacgt catcaactac agcttccctg ccaagggcaa gctttttcta caccgagtgg
     1321 gccgagtggc cagagcaggc cgaagtggca cagcctattc cctggtggcc ccagacgaag
     1381 ttccctacct gctcgacctt cacctgttcc tgggccgctc tgtcacccta gcccggcctc
     1441 atgaggaacc ttcttcaggt gcagttggca gggatggtgt gctgggtcgg gtgccacaga
     1501 gtgtagtgga tgacgaggac agcagcctgc agaccgccct gcaggcgtca ctggaacttc
     1561 agggtctgca gcgtgtggcc aacaatgctc agcagcagta cctgcgctcg cgtccggcac
     1621 cctcaccgga gtccatcaag agagccaagg aactggacct ggcagagctg ggcctgcacc
     1681 cactcttcag ctcgtgcttt gaggagggag agctccagcg cctgaggctg gtagacagca
     1741 tcaagaacta tcgcacacgc acaaccatct tcgagatcaa tgcctccagc aaagacccaa
     1801 gcagccagat gatgcgtgcc aagcggcaga gggaccggaa agctattacc agctttcatc
     1861 aggggcggca ggaaaggcag gacggcccag ctgacccagt ccctcagagg gagctgcctc
     1921 agaaggaaga ggaggacatg gttgagactg tggagggtgt cttcacagag gttgtgggcc
     1981 agaaacagcc aaggccagga cccaaccaag gagccaagag gcggaggaag gaggccagtc
     2041 agcgagacca ggaattttat gtcccctacc ggcccaagga tttcgacagt gagcgggggc
     2101 tgagtgtcag tggggctgga ggggcctttg agcagcaggt ggccggtgcc gtccttgatc
     2161 tgatggggga tgaagcccag aacatgagcc gagggcggca gcagctcaag tgggaccgga
     2221 agaagaagcg gtttgtgggg cagtcaggcc aagaggacaa gaaaaagatc aagacagaga
     2281 gtggccggtt tatcagcagc tcttacaagc gcgacctcta ccagaagtgg aagcagaagc
     2341 agaaaattga tgaccgggac tccgaggaag aaggaccatc caaccggcga ggccctgggc
     2401 cccacagagg tggaaagcga ggtcgtagtc aaggtgggca gggcaggtgg tatgcttcca
     2461 gtgtacccac aggccacatg cgctccgaac tcaagaccaa ggaacagatc ctcaagcagc
     2521 gccgtcaagc ccagaagcag cgcttcctgc agcgaggggg cctgaagcag ctttcagcac
     2581 gcaaccgccg ccgagcccag gagttgcgcc agagcgcctt tggccggggt gctcccacca
     2641 ggaagggcaa gatgaggaaa aggatgtaaa gagccagact cagccctggg gcttcctagt
     2701 agccctggtg cggacatcag ggacatgttt ccatgtgctg ttggcagatc cttccacaga
     2761 ggagccagtg tctatgagga gcagtgccac atggccacag aaagcaacaa ctgcttttga
     2821 ctgggacact gggtggactc ttagaggagg atgcataggc gtctagctat ggaaagcagg
     2881 ccgaccaagt cctgagcctg caagtcagct agctgcttcc atttctatgc attcagggtt
     2941 cagagattgg ggccatatgg atgcctccga ctcagtattg agttttaatg agtaaacttt
     3001 actgcctcta gtagaccagg agtgtagctt gcttaggata ctggaaggtg tctcagctga
     3061 ggctgagagc aagtggccat gcctgtgtgt cgctcctggc cgccgaatga agaaaatgag
     3121 tggctgga
//
