LOCUS       NP_001178477             874 aa            linear   ROD 24-JUN-2024
DEFINITION  ATP-dependent RNA helicase DDX54 [Rattus norvegicus].
ACCESSION   NP_001178477 XP_002728019
VERSION     NP_001178477.1
DBSOURCE    REFSEQ: accession NM_001191548.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 874)
  AUTHORS   Liu,P., Zhang,Y., Li,X. and Ma,M.
  TITLE     DEAD-box helicase 54 regulates microglial inflammatory response in
            rats with chronic constriction injuries through NF-kappaB/NLRP3
            signaling axis
  JOURNAL   J Neurophysiol 130 (2), 392-400 (2023)
   PUBMED   37377223
  REMARK    GeneRIF: DEAD-box helicase 54 regulates microglial inflammatory
            response in rats with chronic constriction injuries through
            NF-kappaB/NLRP3 signaling axis.
REFERENCE   2  (residues 1 to 874)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   3  (residues 1 to 874)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   4  (residues 1 to 874)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   5  (residues 1 to 874)
  AUTHORS   Rajendran,R.R., Nye,A.C., Frasor,J., Balsara,R.D., Martini,P.G. and
            Katzenellenbogen,B.S.
  TITLE     Regulation of nuclear receptor transcriptional activity by a novel
            DEAD box RNA helicase (DP97)
  JOURNAL   J Biol Chem 278 (7), 4628-4638 (2003)
   PUBMED   12466272
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000012.1.
            
            On Jul 17, 2010 this sequence version replaced XP_002728019.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
FEATURES             Location/Qualifiers
     source          1..874
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12q16"
     Protein         1..874
                     /product="ATP-dependent RNA helicase DDX54"
                     /EC_number="3.6.4.13"
                     /note="DEAD (Asp-Glu-Ala-Asp) box polypeptide 54"
                     /calculated_mol_wt=97803
     Region          95..299
                     /region_name="DEADc_DDX54"
                     /note="DEAD-box helicase domain of DEAD box protein 54;
                     cd17959"
                     /db_xref="CDD:350717"
     Site            order(114..115,117..119,122,140..147)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:350717"
     Region          310..441
                     /region_name="SF2_C_DEAD"
                     /note="C-terminal helicase domain of the DEAD box
                     helicases; cd18787"
                     /db_xref="CDD:350174"
     Site            order(400,402,427,430..431)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:350174"
     Region          705..765
                     /region_name="DBP10CT"
                     /note="DBP10CT (NUC160) domain; pfam08147"
                     /db_xref="CDD:462373"
     CDS             1..874
                     /gene="Ddx54"
                     /gene_synonym="RGD1562539"
                     /coded_by="NM_001191548.1:45..2669"
                     /db_xref="GeneID:360815"
                     /db_xref="RGD:1562539"
ORIGIN      
        1 maagrrvglg prshpamapw kkkrlrkrrt gasqardsds edgefeiqae ddararklgp
       61 gralpsfpts ecvsdvepdt remvraqnkk kkksggfqsm glsypvfkgi mkkgykvptp
      121 iqrktipvil dgkdvvamar tgsgktacfl lpmferlkar saqtgarali lsptrelalq
      181 tmkftkelgk ftglktalil ggdkmedqfa alhenpdiii atpgrlvhva vemnlklqsv
      241 eyvvfdeadr lfemgfaeql qeiigrlpgg hqtvlfsatl pkllvefara gltepvlirl
      301 dvdsklneql ktsfflvred tktavllyll qnvvrpqdqn vvfvatkhha eyltelltgq
      361 gvscahiysa ldqtarkinl akfthnkcst livtdlaarg ldiplldnvi nysfpakgkl
      421 flhrvgrvar agrsgtaysl vapdevpyll dlhlflgrsv tlarpheeps sgavgrdgvl
      481 grvpqsvvdd edsslqtalq aslelqglqr vannaqqqyl rsrpapspes ikrakeldla
      541 elglhplfss cfeegelqrl rlvdsiknyr trttifeina sskdpssqmm rakrqrdrka
      601 itsfhqgrqe rqdgpadpvp qrelpqkeee dmvetvegvf tevvgqkqpr pgpnqgakrr
      661 rkeasqrdqe fyvpyrpkdf dserglsvsg aggafeqqva gavldlmgde aqnmsrgrqq
      721 lkwdrkkkrf vgqsgqedkk kiktesgrfi sssykrdlyq kwkqkqkidd rdseeegpsn
      781 rrgpgphrgg krgrsqggqg rwyassvptg hmrselktke qilkqrrqaq kqrflqrggl
      841 kqlsarnrrr aqelrqsafg rgaptrkgkm rkrm
//
