LOCUS       NM_001007613            2508 bp    mRNA    linear   ROD 07-MAY-2024
DEFINITION  Rattus norvegicus DEAD-box helicase 5 (Ddx5), mRNA.
ACCESSION   NM_001007613 XM_213508
VERSION     NM_001007613.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2508)
  AUTHORS   Hang,C., Zu,L., Luo,X., Wang,Y., Yan,L., Zhang,Z., Le,K., Huang,Y.,
            Ye,L., Ying,Y., Chen,K., Xu,X., Lv,Q. and Du,L.
  TITLE     Ddx5 Targeted Epigenetic Modification of Pericytes in Pulmonary
            Hypertension After Intrauterine Growth Restriction
  JOURNAL   Am J Respir Cell Mol Biol 70 (5), 400-413 (2024)
   PUBMED   38301267
  REMARK    GeneRIF: Ddx5 Targeted Epigenetic Modification of Pericytes in
            Pulmonary Hypertension After Intrauterine Growth Restriction.
REFERENCE   2  (bases 1 to 2508)
  AUTHORS   Wang,S.J., Du,L. and Shi,C.M.
  TITLE     Involvement of RNA helicase p68 in skin wound healing process in
            rats
  JOURNAL   Chin J Traumatol 20 (6), 311-317 (2017)
   PUBMED   29221657
  REMARK    GeneRIF: an important role of RNA helicase p68 in skin wound
            healing process.
REFERENCE   3  (bases 1 to 2508)
  AUTHORS   Fan,Y., Zhang,J., Chen,C.Y., Xiao,Y.B., Asico,L.D., Jose,P.A.,
            Xu,J.C., Qian,G.S. and Zeng,C.Y.
  TITLE     Macrophage migration inhibitory factor triggers vascular smooth
            muscle cell dedifferentiation by a p68-serum response factor axis
  JOURNAL   Cardiovasc Res 113 (5), 519-530 (2017)
   PUBMED   28165114
  REMARK    GeneRIF: MIF triggers vascular smooth muscle cell dedifferentiation
            by a p68-serum response factor signaling axis.
REFERENCE   4  (bases 1 to 2508)
  AUTHORS   Berg,J.M., Lee,C., Chen,L., Galvan,L., Cepeda,C., Chen,J.Y.,
            Penagarikano,O., Stein,J.L., Li,A., Oguro-Ando,A., Miller,J.A.,
            Vashisht,A.A., Starks,M.E., Kite,E.P., Tam,E., Gdalyahu,A.,
            Al-Sharif,N.B., Burkett,Z.D., White,S.A., Fears,S.C., Levine,M.S.,
            Wohlschlegel,J.A. and Geschwind,D.H.
  TITLE     JAKMIP1, a Novel Regulator of Neuronal Translation, Modulates
            Synaptic Function and Autistic-like Behaviors in Mouse
  JOURNAL   Neuron 88 (6), 1173-1191 (2015)
   PUBMED   26627310
REFERENCE   5  (bases 1 to 2508)
  AUTHORS   Dardenne,E., Polay Espinoza,M., Fattet,L., Germann,S.,
            Lambert,M.P., Neil,H., Zonta,E., Mortada,H., Gratadou,L.,
            Deygas,M., Chakrama,F.Z., Samaan,S., Desmet,F.O., Tranchevent,L.C.,
            Dutertre,M., Rimokh,R., Bourgeois,C.F. and Auboeuf,D.
  TITLE     RNA helicases DDX5 and DDX17 dynamically orchestrate transcription,
            miRNA, and splicing programs in cell differentiation
  JOURNAL   Cell Rep 7 (6), 1900-1913 (2014)
   PUBMED   24910439
REFERENCE   6  (bases 1 to 2508)
  AUTHORS   Wilson,B.J., Bates,G.J., Nicol,S.M., Gregory,D.J., Perkins,N.D. and
            Fuller-Pace,F.V.
  TITLE     The p68 and p72 DEAD box RNA helicases interact with HDAC1 and
            repress transcription in a promoter-specific manner
  JOURNAL   BMC Mol Biol 5, 11 (2004)
   PUBMED   15298701
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 2508)
  AUTHORS   Jurica,M.S., Licklider,L.J., Gygi,S.R., Grigorieff,N. and
            Moore,M.J.
  TITLE     Purification and characterization of native spliceosomes suitable
            for three-dimensional structural analysis
  JOURNAL   RNA 8 (4), 426-439 (2002)
   PUBMED   11991638
REFERENCE   8  (bases 1 to 2508)
  AUTHORS   Nicol,S.M., Causevic,M., Prescott,A.R. and Fuller-Pace,F.V.
  TITLE     The nuclear DEAD box RNA helicase p68 interacts with the nucleolar
            protein fibrillarin and colocalizes specifically in nascent
            nucleoli during telophase
  JOURNAL   Exp Cell Res 257 (2), 272-280 (2000)
   PUBMED   10837141
REFERENCE   9  (bases 1 to 2508)
  AUTHORS   Buelt,M.K., Glidden,B.J. and Storm,D.R.
  TITLE     Regulation of p68 RNA helicase by calmodulin and protein kinase C
  JOURNAL   J Biol Chem 269 (47), 29367-29370 (1994)
   PUBMED   7525583
REFERENCE   10 (bases 1 to 2508)
  AUTHORS   Lemaire,L. and Heinlein,U.A.
  TITLE     High-level expression in male germ cells of murine P68 RNA helicase
            mRNA
  JOURNAL   Life Sci 52 (11), 917-926 (1993)
   PUBMED   8445986
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC079036.1.
            
            On Nov 29, 2004 this sequence version replaced XM_213508.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC079036.1, SRR8487226.190798.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2508
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q32.1"
     gene            1..2508
                     /gene="Ddx5"
                     /note="DEAD-box helicase 5"
                     /db_xref="GeneID:287765"
                     /db_xref="RGD:619906"
     exon            1..89
                     /gene="Ddx5"
                     /inference="alignment:Splign:2.1.0"
     exon            90..274
                     /gene="Ddx5"
                     /inference="alignment:Splign:2.1.0"
     CDS             231..2078
                     /gene="Ddx5"
                     /EC_number="3.6.1.-"
                     /note="p68 RNA helicase; DEAD (Asp-Glu-Ala-Asp) box
                     helicase 5; ddx5 gene protein; DEAD (Asp-Glu-Ala-Asp) box
                     polypeptide 5"
                     /codon_start=1
                     /product="probable ATP-dependent RNA helicase DDX5"
                     /protein_id="NP_001007614.1"
                     /db_xref="GeneID:287765"
                     /db_xref="RGD:619906"
                     /translation="MSSYSSDRDRGRDRGFGAPRFGGSRTGPLSGKKFGNPGEKLVKK
                     KWNLDELPKFEKNFYQEHPDLARRTAQEVDTYRRSKEITVRGHNCPKPVLNFYEANFP
                     ANVMDVIARQNFTEPTAIQAQGWPVALSGLDMVGVAQTGSGKTLSYLLPAIVHINHQP
                     FLERGDGPICLVLAPTRELAQQVQQVAAEYCRACRLKSTCIYGGAPKGPQIRDLERGV
                     EICIATPGRLIDFLECGKTNLRRTTYLVLDEADRMLDMGFEPQIRKIVDQIRPDRQTL
                     MWSATWPKEVRQLAEDFLKDYIHINIGALELSANHNILQIVDVCHDVEKDEKLIRLME
                     EIMSEKENKTIVFVETKRRCDELTRKMRRDGWPAMGIHGDKSQQERDWVLNEFKHGKA
                     PILIATDVASRGLDVEDVKFVINYDYPNSSEDYIHRIGRTARSTKTGTAYTFFTPNNI
                     KQVSDLISVLREANQAINPKLLQLVEDRGSGRSRGRGGMKDDRRDRYSAGKRGGFNTF
                     RDRENYDRGYSSLLKRDFGAKTQNGVYSAANYTNGSFGSNFVSAGIQTSFRTGNPTGT
                     YQNGYDSTQQYGSNVANMHNGMNQQAYAYPATAAAAPMIGYPMPTGYSQ"
     exon            275..440
                     /gene="Ddx5"
                     /inference="alignment:Splign:2.1.0"
     exon            441..537
                     /gene="Ddx5"
                     /inference="alignment:Splign:2.1.0"
     exon            538..671
                     /gene="Ddx5"
                     /inference="alignment:Splign:2.1.0"
     exon            672..737
                     /gene="Ddx5"
                     /inference="alignment:Splign:2.1.0"
     exon            738..879
                     /gene="Ddx5"
                     /inference="alignment:Splign:2.1.0"
     exon            880..1040
                     /gene="Ddx5"
                     /inference="alignment:Splign:2.1.0"
     exon            1041..1213
                     /gene="Ddx5"
                     /inference="alignment:Splign:2.1.0"
     exon            1214..1324
                     /gene="Ddx5"
                     /inference="alignment:Splign:2.1.0"
     exon            1325..1386
                     /gene="Ddx5"
                     /inference="alignment:Splign:2.1.0"
     exon            1387..1446
                     /gene="Ddx5"
                     /inference="alignment:Splign:2.1.0"
     exon            1447..1671
                     /gene="Ddx5"
                     /inference="alignment:Splign:2.1.0"
     exon            1672..2382
                     /gene="Ddx5"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgcttaaggg ctctcagatc ggcgtgcagg gcagccaggt cacccagcag cccggccgat
       61 ctcctggggg cgttagagcc gcgcttccgc tccggccctc gtcaccgccg tccctccgct
      121 ggtgacgccc ccgcaaaggc ttcgccgtcg ccgaggcctc ctttcagcga ctcgtcgcaa
      181 ctggattctc tttcactggg ttcctccagc acaccgcaac cattgacgcc atgtcgagtt
      241 attctagtga ccgagaccgc ggccgggatc gagggtttgg tgcacctcga tttggaggga
      301 gtagaacagg acccctatct ggaaagaagt ttggaaatcc tggggagaaa ctagttaaaa
      361 agaagtggaa tcttgatgag ctgcccaaat ttgagaagaa tttttatcag gaacaccctg
      421 atttggcaag gcgcaccgca caagaggtag atacgtacag aagaagcaag gaaattacag
      481 tcagaggtca caactgtcca aaacctgttc tgaattttta tgaagcaaac tttcctgcaa
      541 atgtcatgga tgtgattgca aggcagaact tcactgaacc cactgctatc caagctcagg
      601 gctggccagt tgctctcagt ggattggata tggttggagt agctcagact ggatctggga
      661 aaacattatc ttatttgctg cctgccattg tacacataaa ccaccagcca ttcttagaga
      721 gaggtgatgg gcctatttgc ttggtgctgg caccaactcg agaactggca cagcaggtgc
      781 agcaggtcgc tgctgaatat tgtagagctt gtcgcttgaa gtctacttgc atctatggtg
      841 gtgctcccaa aggaccgcag attcgtgatt tggagagagg tgtggaaatc tgtattgcaa
      901 cacctggaag actgattgac tttttagagt gtgggaaaac caatctgaga agaacaactt
      961 accttgtcct tgatgaagct gataggatgc ttgatatggg ctttgaaccc caaataagga
     1021 aaattgtgga tcaaataaga cctgataggc aaacactaat gtggagtgca acttggccaa
     1081 aagaagtaag acagcttgct gaagatttcc tgaaagacta tattcatatc aatattggtg
     1141 cactggaact gagtgcaaac cataacattc ttcagattgt ggatgtgtgt catgatgtcg
     1201 aaaaggatga aaaacttatt cgtctgatgg aagagatcat gagtgagaag gagaataaaa
     1261 ccattgtttt tgttgaaacc aaaagaagat gtgatgaact taccagaaaa atgaggagag
     1321 atgggtggcc tgccatgggc atccatggtg acaagagtca acaggaacga gactgggttc
     1381 taaatgaatt caaacatgga aaagctccta ttctgattgc taccgatgtg gcctccagag
     1441 ggctagatgt ggaagatgtg aaatttgtca tcaattatga ctaccctaac tcctcagagg
     1501 attatattca tcgaattgga agaactgctc gcagtaccaa aacaggcaca gcatacactt
     1561 tctttactcc caataacata aagcaagtga gcgacctcat ctctgtgctt cgggaagcca
     1621 atcaagcaat taatcccaag ttgcttcagt tggtcgaaga cagaggttca ggtcgttcca
     1681 ggggtagagg aggcatgaag gatgatcgtc gtgacagata ctctgcaggg aaaaggggtg
     1741 gatttaatac ctttagagac agggaaaact atgacagagg ctactctagt ctgcttaaga
     1801 gagattttgg ggctaaaact cagaatggtg tttacagtgc tgcaaattac accaatggga
     1861 gctttggaag taattttgta tctgctggca tacagaccag ttttaggact ggtaacccaa
     1921 cagggactta ccagaacggt tatgatagca ctcagcaata tggaagtaat gttgcaaata
     1981 tgcacaatgg gatgaaccaa caggcatatg catatcctgc taccgcagct gctgcgccta
     2041 tgattggcta tccaatgcca acagggtatt ctcaataaga ctttagaagt atatgtaaat
     2101 gtctgttttt cataattgct ctttatattg tgtgttatca gacaagatag ttatttaaga
     2161 aacatgggaa atgcagaaat gactgcagtg cagcagtaat tatggtgcac ttttttcgct
     2221 atttaagttg gatatttctc tacattcctg aaacaatttt taggtttttt ttgtactaga
     2281 aaatgcaggc agtgttttca caaaagtaac tgtacagtga tttcaaatac aataaatgaa
     2341 ggcaatgcat ggccttccaa taaaagatat ttgaagactg aaaaaaaaaa aaaaaaaaaa
     2401 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     2461 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaa
//
