LOCUS       NP_001007614             615 aa            linear   ROD 07-MAY-2024
DEFINITION  probable ATP-dependent RNA helicase DDX5 [Rattus norvegicus].
ACCESSION   NP_001007614 XP_213508
VERSION     NP_001007614.1
DBSOURCE    REFSEQ: accession NM_001007613.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 615)
  AUTHORS   Hang,C., Zu,L., Luo,X., Wang,Y., Yan,L., Zhang,Z., Le,K., Huang,Y.,
            Ye,L., Ying,Y., Chen,K., Xu,X., Lv,Q. and Du,L.
  TITLE     Ddx5 Targeted Epigenetic Modification of Pericytes in Pulmonary
            Hypertension After Intrauterine Growth Restriction
  JOURNAL   Am J Respir Cell Mol Biol 70 (5), 400-413 (2024)
   PUBMED   38301267
  REMARK    GeneRIF: Ddx5 Targeted Epigenetic Modification of Pericytes in
            Pulmonary Hypertension After Intrauterine Growth Restriction.
REFERENCE   2  (residues 1 to 615)
  AUTHORS   Wang,S.J., Du,L. and Shi,C.M.
  TITLE     Involvement of RNA helicase p68 in skin wound healing process in
            rats
  JOURNAL   Chin J Traumatol 20 (6), 311-317 (2017)
   PUBMED   29221657
  REMARK    GeneRIF: an important role of RNA helicase p68 in skin wound
            healing process.
REFERENCE   3  (residues 1 to 615)
  AUTHORS   Fan,Y., Zhang,J., Chen,C.Y., Xiao,Y.B., Asico,L.D., Jose,P.A.,
            Xu,J.C., Qian,G.S. and Zeng,C.Y.
  TITLE     Macrophage migration inhibitory factor triggers vascular smooth
            muscle cell dedifferentiation by a p68-serum response factor axis
  JOURNAL   Cardiovasc Res 113 (5), 519-530 (2017)
   PUBMED   28165114
  REMARK    GeneRIF: MIF triggers vascular smooth muscle cell dedifferentiation
            by a p68-serum response factor signaling axis.
REFERENCE   4  (residues 1 to 615)
  AUTHORS   Berg,J.M., Lee,C., Chen,L., Galvan,L., Cepeda,C., Chen,J.Y.,
            Penagarikano,O., Stein,J.L., Li,A., Oguro-Ando,A., Miller,J.A.,
            Vashisht,A.A., Starks,M.E., Kite,E.P., Tam,E., Gdalyahu,A.,
            Al-Sharif,N.B., Burkett,Z.D., White,S.A., Fears,S.C., Levine,M.S.,
            Wohlschlegel,J.A. and Geschwind,D.H.
  TITLE     JAKMIP1, a Novel Regulator of Neuronal Translation, Modulates
            Synaptic Function and Autistic-like Behaviors in Mouse
  JOURNAL   Neuron 88 (6), 1173-1191 (2015)
   PUBMED   26627310
REFERENCE   5  (residues 1 to 615)
  AUTHORS   Dardenne,E., Polay Espinoza,M., Fattet,L., Germann,S.,
            Lambert,M.P., Neil,H., Zonta,E., Mortada,H., Gratadou,L.,
            Deygas,M., Chakrama,F.Z., Samaan,S., Desmet,F.O., Tranchevent,L.C.,
            Dutertre,M., Rimokh,R., Bourgeois,C.F. and Auboeuf,D.
  TITLE     RNA helicases DDX5 and DDX17 dynamically orchestrate transcription,
            miRNA, and splicing programs in cell differentiation
  JOURNAL   Cell Rep 7 (6), 1900-1913 (2014)
   PUBMED   24910439
REFERENCE   6  (residues 1 to 615)
  AUTHORS   Wilson,B.J., Bates,G.J., Nicol,S.M., Gregory,D.J., Perkins,N.D. and
            Fuller-Pace,F.V.
  TITLE     The p68 and p72 DEAD box RNA helicases interact with HDAC1 and
            repress transcription in a promoter-specific manner
  JOURNAL   BMC Mol Biol 5, 11 (2004)
   PUBMED   15298701
  REMARK    Publication Status: Online-Only
REFERENCE   7  (residues 1 to 615)
  AUTHORS   Jurica,M.S., Licklider,L.J., Gygi,S.R., Grigorieff,N. and
            Moore,M.J.
  TITLE     Purification and characterization of native spliceosomes suitable
            for three-dimensional structural analysis
  JOURNAL   RNA 8 (4), 426-439 (2002)
   PUBMED   11991638
REFERENCE   8  (residues 1 to 615)
  AUTHORS   Nicol,S.M., Causevic,M., Prescott,A.R. and Fuller-Pace,F.V.
  TITLE     The nuclear DEAD box RNA helicase p68 interacts with the nucleolar
            protein fibrillarin and colocalizes specifically in nascent
            nucleoli during telophase
  JOURNAL   Exp Cell Res 257 (2), 272-280 (2000)
   PUBMED   10837141
REFERENCE   9  (residues 1 to 615)
  AUTHORS   Buelt,M.K., Glidden,B.J. and Storm,D.R.
  TITLE     Regulation of p68 RNA helicase by calmodulin and protein kinase C
  JOURNAL   J Biol Chem 269 (47), 29367-29370 (1994)
   PUBMED   7525583
REFERENCE   10 (residues 1 to 615)
  AUTHORS   Lemaire,L. and Heinlein,U.A.
  TITLE     High-level expression in male germ cells of murine P68 RNA helicase
            mRNA
  JOURNAL   Life Sci 52 (11), 917-926 (1993)
   PUBMED   8445986
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC079036.1.
            
            On Nov 29, 2004 this sequence version replaced XP_213508.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC079036.1, SRR8487226.190798.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..615
                     /organism="Rattus norvegicus"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q32.1"
     Protein         1..615
                     /product="probable ATP-dependent RNA helicase DDX5"
                     /EC_number="3.6.1.-"
                     /note="p68 RNA helicase; DEAD (Asp-Glu-Ala-Asp) box
                     helicase 5; ddx5 gene protein; DEAD (Asp-Glu-Ala-Asp) box
                     polypeptide 5"
                     /calculated_mol_wt=69108
     Region          6..507
                     /region_name="DEAD-like_helicase_N"
                     /note="N-terminal helicase domain of the DEAD-box helicase
                     superfamily; cl28899"
                     /db_xref="CDD:475120"
     Site            order(114,116..118,121,139..146)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:350807"
     Region          498..532
                     /region_name="P68HR"
                     /note="P68HR (NUC004) repeat; pfam08061"
                     /db_xref="CDD:429808"
     Region          551..583
                     /region_name="P68HR"
                     /note="P68HR (NUC004) repeat; pfam08061"
                     /db_xref="CDD:429808"
     CDS             1..615
                     /gene="Ddx5"
                     /coded_by="NM_001007613.1:231..2078"
                     /db_xref="GeneID:287765"
                     /db_xref="RGD:619906"
ORIGIN      
        1 mssyssdrdr grdrgfgapr fggsrtgpls gkkfgnpgek lvkkkwnlde lpkfeknfyq
       61 ehpdlarrta qevdtyrrsk eitvrghncp kpvlnfyean fpanvmdvia rqnfteptai
      121 qaqgwpvals gldmvgvaqt gsgktlsyll paivhinhqp flergdgpic lvlaptrela
      181 qqvqqvaaey cracrlkstc iyggapkgpq irdlergvei ciatpgrlid flecgktnlr
      241 rttylvldea drmldmgfep qirkivdqir pdrqtlmwsa twpkevrqla edflkdyihi
      301 nigalelsan hnilqivdvc hdvekdekli rlmeeimsek enktivfvet krrcdeltrk
      361 mrrdgwpamg ihgdksqqer dwvlnefkhg kapiliatdv asrgldvedv kfvinydypn
      421 ssedyihrig rtarstktgt aytfftpnni kqvsdlisvl reanqainpk llqlvedrgs
      481 grsrgrggmk ddrrdrysag krggfntfrd renydrgyss llkrdfgakt qngvysaany
      541 tngsfgsnfv sagiqtsfrt gnptgtyqng ydstqqygsn vanmhngmnq qayaypataa
      601 aapmigypmp tgysq
//
