LOCUS       NM_001115023            1555 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus DEAD-box helicase 49 (Ddx49), mRNA.
ACCESSION   NM_001115023
VERSION     NM_001115023.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1555)
  AUTHORS   Awasthi,S., Verma,M., Mahesh,A., K Khan,M.I., Govindaraju,G.,
            Rajavelu,A., Chavali,P.L., Chavali,S. and Dhayalan,A.
  TITLE     DDX49 is an RNA helicase that affects translation by regulating
            mRNA export and the levels of pre-ribosomal RNA
  JOURNAL   Nucleic Acids Res 46 (12), 6304-6317 (2018)
   PUBMED   29618122
REFERENCE   2  (bases 1 to 1555)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC158855.1.
            
            [WARNING] On Mar 21, 2025 this sequence was replaced by
            NM_001115023.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC158855.1, SRR8487227.309253.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132262, SAMD00132263
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1555
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16p14"
     gene            1..1555
                     /gene="Ddx49"
                     /note="DEAD-box helicase 49"
                     /db_xref="GeneID:290660"
                     /db_xref="RGD:1311124"
     exon            1..141
                     /gene="Ddx49"
                     /inference="alignment:Splign:2.1.0"
     CDS             27..1469
                     /gene="Ddx49"
                     /EC_number="3.6.4.13"
                     /note="DEAD (Asp-Glu-Ala-Asp) box polypeptide 49"
                     /codon_start=1
                     /product="probable ATP-dependent RNA helicase DDX49"
                     /protein_id="NP_001108495.1"
                     /db_xref="GeneID:290660"
                     /db_xref="RGD:1311124"
                     /translation="MAGFAELRLSSWLVEQCRQLGLKQPTPVQLGCIPAILEGRDCLG
                     CAKTGSGKTAAFVLPILQKLSEDPYGIFCLVLTPTRELAYQIAEQFRVLGKPLGLKDC
                     IIVGGMDMVTQALELSRKPHVVIATPGRLADHLRSSNTFNMKKIRFLVLDEADRLLEQ
                     GCTDFTADLETILSAVPARRQTLLFSATLTDTLKELQGLATNQPFFWEAQATVRMVEQ
                     LDQRYLLVPEKVKDAYLVHLVQTFQDQLEDCSIIIFTNTCKTCQILCMMLRKFNFPTV
                     ALHSMMKQKERFAALARFKSSTYRILIATDVASRGLDIPTVQVVINHNTPGLPKIYIH
                     RVGRTARAGRQGQAITLVTQYDIHLLHAIEEEIKQQLAELAVEEAQVLQILTQVNVVR
                     RECEIKLEASHFDEKKEINKRKQMILEGKDPDLEAKRKAELAKIKQQNRRFKEKVEQT
                     LRQQKAGSTGRRSRPPRPRPQEPARAEAQN"
     exon            142..265
                     /gene="Ddx49"
                     /inference="alignment:Splign:2.1.0"
     exon            266..351
                     /gene="Ddx49"
                     /inference="alignment:Splign:2.1.0"
     exon            352..473
                     /gene="Ddx49"
                     /inference="alignment:Splign:2.1.0"
     exon            474..661
                     /gene="Ddx49"
                     /inference="alignment:Splign:2.1.0"
     exon            662..802
                     /gene="Ddx49"
                     /inference="alignment:Splign:2.1.0"
     exon            803..878
                     /gene="Ddx49"
                     /inference="alignment:Splign:2.1.0"
     exon            879..955
                     /gene="Ddx49"
                     /inference="alignment:Splign:2.1.0"
     exon            956..1053
                     /gene="Ddx49"
                     /inference="alignment:Splign:2.1.0"
     exon            1054..1128
                     /gene="Ddx49"
                     /inference="alignment:Splign:2.1.0"
     exon            1129..1217
                     /gene="Ddx49"
                     /inference="alignment:Splign:2.1.0"
     exon            1218..1289
                     /gene="Ddx49"
                     /inference="alignment:Splign:2.1.0"
     exon            1290..1540
                     /gene="Ddx49"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctaggttctc tacactagtc tgaagcatgg cggggttcgc tgagctccgg ctatcgtcgt
       61 ggctggtgga acagtgtcga cagctggggt tgaagcagcc cacgccggtg cagctcgggt
      121 gcatcccggc catcctggaa ggtcgggact gcttgggttg tgcaaaaaca ggaagtggca
      181 agacagcagc ctttgtactt cccatcctgc agaagctgtc tgaggaccct tatggcatct
      241 tctgcctggt tttgacaccc actagagagc tggcctacca gatagctgag cagttccgag
      301 tgctggggaa gcctctgggc ctaaaggact gcatcatcgt tggtggcatg gacatggtga
      361 cgcaggccct ggagctctct cggaagccac acgtggttat tgccacccct gggcgcctgg
      421 ctgaccacct gcgcagttcc aacactttca acatgaagaa aatcagattc ttggtgttgg
      481 acgaggccga taggctgctg gagcagggtt gcaccgactt cactgcagac ctggagacca
      541 tcctgtcagc tgttccagca cgcaggcaaa ccctcctgtt cagtgccaca ctgacggaca
      601 cactcaagga gctgcagggc ctggctacca accagccctt cttttgggag gcacaggcca
      661 cggttcgcat ggtggagcag cttgaccagc gctatctgct ggtgcctgag aaggtgaagg
      721 acgcctacct ggttcacctg gtccagacct tccaggacca gctggaggac tgctccatca
      781 tcatcttcac caatacctgc aagacctgcc agatcctttg tatgatgctt cgaaagttca
      841 acttccccac agtggcactg cactccatga tgaagcagaa agagcgcttt gcagccctgg
      901 ccagattcaa gtccagcacc tatcggattc ttattgctac tgacgtggcc tccagaggcc
      961 tggacatccc cactgtgcag gtggtcatca accacaacac ccctgggctc cccaagatct
     1021 acatccatag ggtcggtcgc acagcccgtg cagggaggca gggacaggcc atcacactgg
     1081 tgacgcagta cgacatccac ctgttgcatg ccatcgagga ggagatcaaa cagcagctgg
     1141 ctgaattggc agtggaggag gcccaggtcc tgcagatcct cacacaggtc aacgtggtgc
     1201 gcagggagtg tgaaatcaaa ctggaggctt cgcattttga tgaaaagaag gagatcaaca
     1261 agcggaaaca gatgatcctg gaggggaagg acccggacct ggaggccaag cgcaaagctg
     1321 agctggccaa gattaagcaa cagaaccggc gcttcaagga gaaagtggag cagacgcttc
     1381 ggcagcagaa agcagggagc acaggccggc ggtcgcgtcc tcccagacct cgtccccaag
     1441 agccagccag ggctgaggct cagaactgag ctgtaaacct actgcaggtg gcccctgact
     1501 tcagtaaatg ctctttgaac ctgtcagtca gacttgaaaa aaaaaaaaaa aaaaa
//
