LOCUS       NM_139098               5924 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus DEAD-box helicase 46 (Ddx46), transcript variant
            1, mRNA.
ACCESSION   NM_139098
VERSION     NM_139098.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5924)
  AUTHORS   Chang,T.H., Tung,L., Yeh,F.L., Chen,J.H. and Chang,S.L.
  TITLE     Functions of the DExD/H-box proteins in nuclear pre-mRNA splicing
  JOURNAL   Biochim Biophys Acta 1829 (8), 764-774 (2013)
   PUBMED   23454554
  REMARK    Review article
REFERENCE   2  (bases 1 to 5924)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   3  (bases 1 to 5924)
  AUTHORS   Sigal,A., Milo,R., Cohen,A., Geva-Zatorsky,N., Klein,Y., Alaluf,I.,
            Swerdlin,N., Perzov,N., Danon,T., Liron,Y., Raveh,T.,
            Carpenter,A.E., Lahav,G. and Alon,U.
  TITLE     Dynamic proteomics in individual human cells uncovers widespread
            cell-cycle dependence of nuclear proteins
  JOURNAL   Nat Methods 3 (7), 525-531 (2006)
   PUBMED   16791210
REFERENCE   4  (bases 1 to 5924)
  AUTHORS   Sukegawa,J. and Blobel,G.
  TITLE     A putative mammalian RNA helicase with an arginine-serine-rich
            domain colocalizes with a splicing factor
  JOURNAL   J Biol Chem 270 (26), 15702-15706 (1995)
   PUBMED   7797571
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JACYVU010000284.1.
            
            [WARNING] On Apr 3, 2024 this sequence was replaced by NM_139098.3.
            
            On Jul 22, 2021 this sequence version replaced NM_139098.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U25746.1, BC107590.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-170               JACYVU010000284.1  8988271-8988440     c
            171-359             JACYVU010000284.1  8984184-8984372     c
            360-503             JACYVU010000284.1  8982487-8982630     c
            504-600             JACYVU010000284.1  8978581-8978677     c
            601-766             JACYVU010000284.1  8977618-8977783     c
            767-918             JACYVU010000284.1  8974861-8975012     c
            919-1032            JACYVU010000284.1  8973375-8973488     c
            1033-1198           JACYVU010000284.1  8972249-8972414     c
            1199-1319           JACYVU010000284.1  8971629-8971749     c
            1320-1495           JACYVU010000284.1  8970691-8970866     c
            1496-1617           JACYVU010000284.1  8969761-8969882     c
            1618-1696           JACYVU010000284.1  8965260-8965338     c
            1697-1779           JACYVU010000284.1  8963568-8963650     c
            1780-1944           JACYVU010000284.1  8961108-8961272     c
            1945-2107           JACYVU010000284.1  8960554-8960716     c
            2108-2301           JACYVU010000284.1  8958940-8959133     c
            2302-2439           JACYVU010000284.1  8952929-8953066     c
            2440-2589           JACYVU010000284.1  8952401-8952550     c
            2590-2766           JACYVU010000284.1  8949087-8949263     c
            2767-2985           JACYVU010000284.1  8947358-8947576     c
            2986-3130           JACYVU010000284.1  8946565-8946709     c
            3131-3204           JACYVU010000284.1  8945824-8945897     c
            3205-5924           JACYVU010000284.1  8942070-8944789     c
FEATURES             Location/Qualifiers
     source          1..5924
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="17"
                     /map="17p14"
     gene            1..5924
                     /gene="Ddx46"
                     /note="DEAD-box helicase 46"
                     /db_xref="GeneID:245957"
                     /db_xref="RGD:708480"
     exon            1..170
                     /gene="Ddx46"
                     /inference="alignment:Splign:2.1.0"
     CDS             154..3252
                     /gene="Ddx46"
                     /EC_number="3.6.4.13"
                     /note="isoform 1 is encoded by transcript variant 1;
                     probable ATP-dependent RNA helicase DDX46; DEAD
                     (Asp-Glu-Ala-Asp) box polypeptide 46; DEAD box protein 46;
                     helicase of 117.4 kDa"
                     /codon_start=1
                     /product="probable ATP-dependent RNA helicase DDX46
                     isoform 1"
                     /protein_id="NP_620798.1"
                     /db_xref="GeneID:245957"
                     /db_xref="RGD:708480"
                     /translation="MGRESRHYRKRSASRGRSGSRSRSRSPSDKRSKRGDDRRSRSRD
                     RDRRRERSRSRDKRRSRSRDRKRLRRSRSRERDRSRERRRSRSRDRRRSRSRSRGRRS
                     RSSSPGSKSKKAENRSRSKEKAEGGDSSKEKKKDKDDKEDEKEKDAGNFDQNKLEEEM
                     RKRKERVEKWREEQRKKAMENIGELKKEIEEMKQGKKWSLEDDDDDEDDPAEAEKEGN
                     EMEDEELDPLDAYMEEVKEEVKKFNMRSVKGGAGNEKKSGPTVTKVVTVVTTKKAVVD
                     ADKKKGELMENDQDAMEYSSEEEEVDLQTALTGYQTKQRKLLEPVDHGKIEYEPFRKN
                     FYVEVPELAKMSQEEVNVFRLEMEGITVKGKGCPKPIKSWVQCGISMKILNSLKKHGY
                     EKPTPIQTQAIPAIMSGRDLIGIAKTGSGKTIAFLLPMFRHIMDQRSLEEGEGPIAVI
                     MTPTRELALQITKECKKFSKTLGLRVVCVYGGTGISEQIAELKRGAEIIVCTPGRMID
                     MLAANSGRVTNLRRVTYVVLDEADRMFDMGFEPQVMRIVDNVRPDRQTVMFSATFPRA
                     MEALARRILSKPIEVQVGGRSVVCSDVEQQVIVIEEEKKFLKLLELLGHYQESGSVII
                     FVDKQEHADGLLKDLMRASYPCMSLHGGIDQYDRDSIINDFKNGTCKLLVATSVAARG
                     LDVKHLILVVNYSCPNHYEDYVHRAGRTGRAGNKGYAYTFITEDQARYAGDIIKALEL
                     SGTAVPPDLEKLWSDFKDQQKAEGKIIKKSSGFSGKGFKFDETEQALANERKKLQKAA
                     LGLQDSDDEDAAVDIDEQIESMFNSKKRVKDMAAPGTSSAPAPTAGNAEKLEIAKRLA
                     LRINAQKNLGIESQVDVMQQATNAILRGGPLLAPTVSAKTIAEQLAEKINAKLNYVPL
                     EKQEEERQEGGQSESFKRYEEELEINDFPQTARWKVTSKEALQRISEYSEAAITIRGT
                     YFPPGKEPKEGERKIYLAIESANELAVQKAKAEITRLIKEELIRLQNSYQPTNKGRYK
                     VL"
     exon            171..359
                     /gene="Ddx46"
                     /inference="alignment:Splign:2.1.0"
     exon            360..503
                     /gene="Ddx46"
                     /inference="alignment:Splign:2.1.0"
     exon            504..600
                     /gene="Ddx46"
                     /inference="alignment:Splign:2.1.0"
     exon            601..766
                     /gene="Ddx46"
                     /inference="alignment:Splign:2.1.0"
     exon            767..918
                     /gene="Ddx46"
                     /inference="alignment:Splign:2.1.0"
     exon            919..1032
                     /gene="Ddx46"
                     /inference="alignment:Splign:2.1.0"
     exon            1033..1198
                     /gene="Ddx46"
                     /inference="alignment:Splign:2.1.0"
     exon            1199..1319
                     /gene="Ddx46"
                     /inference="alignment:Splign:2.1.0"
     exon            1320..1495
                     /gene="Ddx46"
                     /inference="alignment:Splign:2.1.0"
     exon            1496..1617
                     /gene="Ddx46"
                     /inference="alignment:Splign:2.1.0"
     exon            1618..1696
                     /gene="Ddx46"
                     /inference="alignment:Splign:2.1.0"
     exon            1697..1779
                     /gene="Ddx46"
                     /inference="alignment:Splign:2.1.0"
     exon            1780..1944
                     /gene="Ddx46"
                     /inference="alignment:Splign:2.1.0"
     exon            1945..2107
                     /gene="Ddx46"
                     /inference="alignment:Splign:2.1.0"
     exon            2108..2301
                     /gene="Ddx46"
                     /inference="alignment:Splign:2.1.0"
     exon            2302..2439
                     /gene="Ddx46"
                     /inference="alignment:Splign:2.1.0"
     exon            2440..2589
                     /gene="Ddx46"
                     /inference="alignment:Splign:2.1.0"
     exon            2590..2766
                     /gene="Ddx46"
                     /inference="alignment:Splign:2.1.0"
     exon            2767..2985
                     /gene="Ddx46"
                     /inference="alignment:Splign:2.1.0"
     exon            2986..3130
                     /gene="Ddx46"
                     /inference="alignment:Splign:2.1.0"
     exon            3131..3204
                     /gene="Ddx46"
                     /inference="alignment:Splign:2.1.0"
     exon            3205..5924
                     /gene="Ddx46"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccacgctctg atggcggtca ctgctggagc tttggccatt tcgtagggcc ggtcctcgct
       61 cggtactgtg aggacttggt gcctccctcc tttgtcctct tcaccggtct gcgcatcgtc
      121 cccaagggcg caggccttcc gctggctggc agcatgggca gggagtctcg ccattaccga
      181 aaacggtcag catctcgagg tcgctctgga agtcggtcta ggagtcgctc accctctgac
      241 aaaagaagca aacgtggaga tgacaggcgt tccaggagta gagacagaga cagaaggaga
      301 gagaggtctc ggagcaggga caaaaggaga tctcggtcac gggacaggaa acgcctgaga
      361 cgttccagaa gtagagagcg tgacagaagc cgagagcgaa gaagatctcg aagccgggat
      421 agaaggcgct caaggagtcg gagccggggc aggcggtccc ggtcttccag tcctggcagc
      481 aaaagcaaga aagctgagaa caggtctagg tccaaagaga aagcagaagg tggggacagc
      541 tccaaggaga agaagaaaga caaggacgac aaggaggacg agaaagagaa ggatgctggg
      601 aattttgacc agaataagct ggaagaagaa atgagaaaac gaaaagaaag ggttgaaaaa
      661 tggcgagaag agcagcgtaa aaaggcgatg gagaacatag gggagctgaa gaaggagatc
      721 gaggagatga agcaggggaa gaagtggagc ctggaagatg acgacgatga tgaagatgac
      781 cctgccgagg ctgagaagga agggaatgaa atggaggacg aggagctgga cccattagat
      841 gcctacatgg aggaagtgaa agaagaggta aaaaagttta acatgaggag cgtgaaaggc
      901 ggcgcaggaa atgagaagaa gtccggaccg actgtcacga aagtggttac tgtggtaaca
      961 accaagaaag cagtagtaga tgccgacaag aagaagggag agctgatgga gaatgaccag
     1021 gacgccatgg agtactcctc ggaggaggaa gaggttgacc ttcagacggc cctcacaggc
     1081 taccagacaa aacagagaaa gcttctagag ccagtggatc atgggaaaat tgagtatgag
     1141 ccattcagaa aaaactttta cgttgaagtt ccagaattag cgaaaatgtc tcaagaagag
     1201 gtgaatgtgt ttcggttgga aatggagggc attacagtta aaggaaaagg ttgccccaag
     1261 ccaattaaat catgggtcca gtgtggaatt tccatgaaga tactgaattc cctcaaaaag
     1321 catggctatg aaaagcccac accaatccaa actcaagcaa ttcctgctat aatgtctgga
     1381 cgagatttga ttggcattgc caagacagga agtggaaaaa ccattgcttt tcttttgccc
     1441 atgtttagac acatcatgga tcagaggtca ttggaagaag gagagggacc aatcgctgtc
     1501 atcatgactc caactcgaga actggcttta caaatcacta aagaatgtaa gaagttttcg
     1561 aagaccttgg gactgagagt ggtctgtgtg tatggaggga caggaatcag cgagcagatt
     1621 gctgagctga agagaggcgc tgagatcatt gtttgcacac ctggccggat gatcgacatg
     1681 ctggcagcta acagtggtcg ggtcacaaat cttcgaagag tgacatatgt tgttttagat
     1741 gaagcagaca gaatgtttga catgggtttt gaaccacagg tcatgcgcat tgtggacaat
     1801 gtccgtcctg accgacagac agttatgttc tcagctactt tcccaagagc tatggaagcg
     1861 ttggcccgca ggatcttgag caagcccatt gaagttcagg ttggaggccg gagtgtggtt
     1921 tgctcagatg tggaacaaca agtgattgtg attgaagaag agaagaaatt cttgaaattg
     1981 ctggagcttt taggccatta tcaggagtca ggatctgtca ttatatttgt ggataagcag
     2041 gaacacgctg atggtcttct gaaggacttg atgagagctt cctacccttg catgtctctt
     2101 cacggaggta ttgatcagta tgacagggac agtatcataa atgactttaa gaatggaacc
     2161 tgcaaacttc tcgtagccac gtctgttgcc gcccgtggtc tagatgtgaa acatctcatt
     2221 cttgtagtaa attacagctg ccccaatcat tacgaagatt acgtgcacag ggctgggcgg
     2281 actggaagag caggcaacaa gggttatgcc tacaccttca tcacagaaga ccaagctcga
     2341 tatgctgggg acatcattaa agctcttgaa ctgtcgggga cggcggtgcc tcctgaccta
     2401 gagaaactat ggagtgactt caaagatcag cagaaagctg aaggaaaaat aattaaaaag
     2461 agcagcggct tctctggcaa ggggttcaag tttgatgaga cagagcaggc tttagccaat
     2521 gagaggaaaa agctacaaaa agctgccctt ggcctgcagg attctgatga cgaggacgcc
     2581 gcagttgata ttgacgagca gattgaaagc atgtttaatt ccaagaagag agtgaaagac
     2641 atggctgctc ccggcacatc cagtgcgcct gctccgactg cgggcaatgc tgagaagcta
     2701 gagattgcca agaggttggc gcttagaatc aacgctcaga agaacctggg catcgagtct
     2761 caggtagatg tgatgcagca ggccacaaat gccatcctca gaggtggccc tcttctggct
     2821 cccaccgtgt ctgcaaaaac catcgcagag cagcttgccg agaagatcaa tgccaagctc
     2881 aattacgtgc ctttggagaa acaggaagaa gagagacagg agggtgggca gagcgaatct
     2941 ttcaagagat acgaggaaga attagaaatt aatgacttcc cacagacggc gaggtggaaa
     3001 gttacctcta aggaagcctt gcagaggatc agtgagtact cggaagccgc catcacaatc
     3061 agagggacct acttcccgcc tggcaaagag cccaaggaag gagagcggaa gatctacttg
     3121 gcgattgaaa gtgccaacga gctggctgtg cagaaagcaa aggcagagat caccaggctc
     3181 ataaaagagg agctgatccg actgcaaaat tcataccaac ccaccaacaa aggacgatac
     3241 aaagtattat aaacaccgga gccactttgt acccgtgctg tctgtgacgt ttacagtgta
     3301 ttgtaaagta agacttttaa aattctgtct tgcttatttt ttaagtacaa gaaaccagtg
     3361 tttgttcaag aggtcatctg taagtactac cctataccca tccaaactcc atttaaatca
     3421 gagctgtttt cagagtgtga tgttcttcga tgtaaacctt agataccaac actttaaata
     3481 tctggagaca ttgggatttt gtactgaatg cagtaataaa gtgtgtcagg cactaaggga
     3541 ccactggcct atcctttcgg tggaattgtg atgtgctcat cgcctgagaa caggtaaaga
     3601 aagtccttgt cacttcttgt tgctgcctct aagcttatgt cttcctggac agaatggacc
     3661 gtagtaactg gatctcagaa tgttggggga gaagtttaca tgacaggctc agagtttttc
     3721 attttaattt tatcggaatg ataaatgagt aatagtcaag ccttggttat aaaattaaag
     3781 agaaaagtat aatgggattt ttgcgtttct ttcttttttt tttttttttt tttttttttt
     3841 tttttttcgg agctggggac cgaacccagg gcctaagcgc tctaccactg agctaaatcc
     3901 ccaacccctg catttctttc ttattcctac ttttgagaga gtccctgtgg agcatgggct
     3961 aagggctggc cttgaactta cgatcctccc tatctgcctc tccagggctt gtttttacca
     4021 cactcagctt ccacttcttt ttactgtgct agtgtttcta cttcaggttc tctctcaacc
     4081 tctggttttg ccaagtatga actcctttat tgacttcctt tagagaaaag gattgtgacc
     4141 aatatactac atgtcatgcc catccctcaa aaatgttcct tcactcatcg atattatggt
     4201 ccatacaagc actgaaataa ttcaacttgg attttccttc aggatgacgg agttataagt
     4261 tgtccccctt gttaaaacaa ggcctggtgg tgcattgcct gtactcacgg cccctgggag
     4321 gcaggggtag aaagatcatg aatttgaagt acagtttggc cgtacataat aaagcctcgt
     4381 gtcaaaaaac taaacagaca aggctgggga tttaggtcag tgggaacgca cttgcttaag
     4441 tgaaccccat gtctgacaca ggataaagcc aaagtgtttt gtgctaacta ctgattgttg
     4501 ggccggtgag gtgactctgg ctgttgggcc ggtgaggtga tgcagtgggt atggtttttg
     4561 ctgtcacacc tgatcacctc ggttccatca cttggatcca tatagcagag tgcaagttgt
     4621 tctgtaatat gtgttaacgg gtgtgtgtgt gtgtgtgtgt ctgtgtgtgt gtgtgtctgc
     4681 tctgtgataa tacatctcaa acacagctat aaataaacgc aggaaacgga agtaaacaaa
     4741 ttacatcaaa tgctggcatt tgcattacgg accacagcat ttcttagtaa gatttagtgc
     4801 acaaagaacc aagaattgct cttcagagca ctgaggtcta attctgaata atcgcattac
     4861 ctaaagggac agaacaattt tttattctcg atttaaacca ggtttagggg cccccacctg
     4921 taattccagc ccttaggagc cagaggcagg atggaccctg agttcaagac cagcctgttc
     4981 tttcctgcat gtagttctac atagtgagtt tcaggtcggg gttggggatt tagctcagtg
     5041 gtagagcgct tgcctagcaa gcgcaaggcc ctgggttcgg tccccagctc caaaaaaaag
     5101 aaaaaaaaaa aaaaaaaaga gtttcaggtc agccagagct acacagtgag acccagtctt
     5161 gtaaaaagag aacaggcaga tgtatatgta tatgttgttg atgtagaggt tgattttaag
     5221 tcagagcata cgatagttgt taaacacttt taaggctagt ggtaattcag tggtcagagg
     5281 acccaggttc agttctcagc acccacatgg cagcttacag ttgtctgtaa ttctagtggc
     5341 taaatctaaa gaacagtaaa ccaatgtaac atagttaaaa gccaggtgac agccatgtgt
     5401 cctacttgtt agtgtaactg taaagtctcc ttgggaaata cttttagacc ttcacatgcc
     5461 cagtcacttc actccgagca aacaaaggag tcaccaggac agcagaaggc aatgcactct
     5521 acactggaac cccaggcacc agcttttctt cccgccctcc cccttggttg gttcattgct
     5581 tctctccatc gcccaggtgt agtttgttac tttcagagta tgcagcagcc acactggtac
     5641 agtggtgctc cctgaactcc acactggtgc agtggtgctc cctgaactcc ctggctccct
     5701 ggagattcag aagttacatc atatcacatt gtctgtttgt gtatctaact gtgaagagac
     5761 accgatagca ttttgttcta aaatgagata ttgttgatct gttagtgtca acactggttt
     5821 ttaaagtttt aatgctgtac agagttaaat tcatttttga tgcaatatca atatttgctt
     5881 gcactctcta aatttcttac agaataaagt taagtcagcc ggca
//
