LOCUS       NM_001108046            2075 bp    mRNA    linear   ROD 20-MAR-2023
DEFINITION  Rattus norvegicus DEAD-box helicase 41 (Ddx41), mRNA.
ACCESSION   NM_001108046 XM_001064233 XM_234441
VERSION     NM_001108046.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2075)
  AUTHORS   Lewinsohn M, Brown AL, Weinel LM, Phung C, Rafidi G, Lee MK,
            Schreiber AW, Feng J, Babic M, Chong CE, Lee Y, Yong A, Suthers GK,
            Poplawski N, Altree M, Phillips K, Jaensch L, Fine M, D'Andrea RJ,
            Lewis ID, Medeiros BC, Pollyea DA, King MC, Walsh T, Keel S,
            Shimamura A, Godley LA, Hahn CN, Churpek JE and Scott HS.
  TITLE     Novel germ line DDX41 mutations define families with a lower age of
            MDS/AML onset and lymphoid malignancies
  JOURNAL   Blood 127 (8), 1017-1023 (2016)
   PUBMED   26712909
REFERENCE   2  (bases 1 to 2075)
  AUTHORS   Polprasert C, Schulze I, Sekeres MA, Makishima H, Przychodzen B,
            Hosono N, Singh J, Padgett RA, Gu X, Phillips JG, Clemente M,
            Parker Y, Lindner D, Dienes B, Jankowsky E, Saunthararajah Y, Du Y,
            Oakley K, Nguyen N, Mukherjee S, Pabst C, Godley LA, Churpek JE,
            Pollyea DA, Krug U, Berdel WE, Klein HU, Dugas M, Shiraishi Y,
            Chiba K, Tanaka H, Miyano S, Yoshida K, Ogawa S, Muller-Tidow C and
            Maciejewski JP.
  TITLE     Inherited and Somatic Defects in DDX41 in Myeloid Neoplasms
  JOURNAL   Cancer Cell 27 (5), 658-670 (2015)
   PUBMED   25920683
REFERENCE   3  (bases 1 to 2075)
  AUTHORS   Zhu X, Wang D, Zhang H, Zhou Y, Luo R, Chen H, Xiao S and Fang L.
  TITLE     Molecular cloning and functional characterization of porcine DEAD
            (Asp-Glu-Ala-Asp) box polypeptide 41 (DDX41)
  JOURNAL   Dev Comp Immunol 47 (2), 191-196 (2014)
   PUBMED   25086295
  REMARK    GeneRIF: DDX41 is involved in the dsDNA- and dsDNA-virus-mediated
            type IFN-beta signaling pathway in porcine kidney cells. [DDX41]
REFERENCE   4  (bases 1 to 2075)
  AUTHORS   Baltz AG, Munschauer M, Schwanhausser B, Vasile A, Murakawa Y,
            Schueler M, Youngs N, Penfold-Brown D, Drew K, Milek M, Wyler E,
            Bonneau R, Selbach M, Dieterich C and Landthaler M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   5  (bases 1 to 2075)
  AUTHORS   Castello A, Fischer B, Eichelbaum K, Horos R, Beckmann BM, Strein
            C, Davey NE, Humphreys DT, Preiss T, Steinmetz LM, Krijgsveld J and
            Hentze MW.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   6  (bases 1 to 2075)
  AUTHORS   Zhang Z, Yuan B, Bao M, Lu N, Kim T and Liu YJ.
  TITLE     The helicase DDX41 senses intracellular DNA mediated by the adaptor
            STING in dendritic cells
  JOURNAL   Nat Immunol 12 (10), 959-965 (2011)
   PUBMED   21892174
  REMARK    Erratum:[Nat Immunol. 2012 Feb;13(2):196]
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 2075)
  AUTHORS   Ghosh D, Lippert D, Krokhin O, Cortens JP and Wilkins JA.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   8  (bases 1 to 2075)
  AUTHORS   Jurica MS, Licklider LJ, Gygi SR, Grigorieff N and Moore MJ.
  TITLE     Purification and characterization of native spliceosomes suitable
            for three-dimensional structural analysis
  JOURNAL   RNA 8 (4), 426-439 (2002)
   PUBMED   11991638
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC166825.1.
            
            On May 11, 2008 this sequence version replaced NM_001108046.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC166825.1, SRR8487227.227573.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2075
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="17"
                     /map="17p14"
     gene            1..2075
                     /gene="Ddx41"
                     /note="DEAD-box helicase 41"
                     /db_xref="GeneID:314336"
                     /db_xref="RGD:1311758"
     exon            1..32
                     /gene="Ddx41"
                     /inference="alignment:Splign:2.1.0"
     CDS             6..1874
                     /gene="Ddx41"
                     /EC_number="3.6.4.13"
                     /note="DEAD (Asp-Glu-Ala-Asp) box polypeptide 41; probable
                     ATP-dependent RNA helicase DDX41-like"
                     /codon_start=1
                     /product="probable ATP-dependent RNA helicase DDX41"
                     /protein_id="NP_001101516.1"
                     /db_xref="GeneID:314336"
                     /db_xref="RGD:1311758"
                     /translation="MEESEPERKRARTNEATAGGSRSEDEDEDDEDYVPYVPLRQRRQ
                     LLLQKLLQRRRKGAAEEEQQDSGSEPRGDEDDIPLGPQSNVSLLDQHQHLKEKAEARK
                     ESAKEKQLKEEEKILESVAEGRALMSVKEMAKGITYDDPIKTSWTPPRYVLSMSEERH
                     ERVRKKYHILVEGDGIPPPIKSFKEMKLPAAILRGLKKKGILHPTPIQIQGIPTILSG
                     RDMIGIAFTGSGKTLVFTLPVIMFCLEQEKRLPFSKREGPYGLIICPSRELARQTHGI
                     LEYYCRLLQEDSSPLLRCALCIGGMSVKEQMETIRHGVHMMVATPGRLMDLLQKKMVS
                     LDICRYLALDEADRMIDMGFEGDIRTIFSYFKGQRQTLLFSATMPKKIQNFAKSALVK
                     PVTINVGRAGAASLDVIQEVEYVKEEAKMVYLLECLQKTPPPVLIFAEKKADVDAIHE
                     YLLLKGVEAVAIHGGKDQEERTKAIEAFREGKKDVLVATDVASKGLDFPAIQHVINYD
                     MPEEIENYVHRIGRTGRSGNTGIATTFINKACDESVLMDLKALLLEAKQKVPPVLQVL
                     HCGDESMLDIGGERGCAFCGGLGHRITDCPKLEAMQTKQVSNIGRKDYLAHSSMDF"
     exon            33..143
                     /gene="Ddx41"
                     /inference="alignment:Splign:2.1.0"
     exon            144..303
                     /gene="Ddx41"
                     /inference="alignment:Splign:2.1.0"
     exon            304..378
                     /gene="Ddx41"
                     /inference="alignment:Splign:2.1.0"
     exon            379..439
                     /gene="Ddx41"
                     /inference="alignment:Splign:2.1.0"
     exon            440..576
                     /gene="Ddx41"
                     /inference="alignment:Splign:2.1.0"
     exon            577..649
                     /gene="Ddx41"
                     /inference="alignment:Splign:2.1.0"
     exon            650..803
                     /gene="Ddx41"
                     /inference="alignment:Splign:2.1.0"
     exon            804..940
                     /gene="Ddx41"
                     /inference="alignment:Splign:2.1.0"
     exon            941..1103
                     /gene="Ddx41"
                     /inference="alignment:Splign:2.1.0"
     exon            1104..1235
                     /gene="Ddx41"
                     /inference="alignment:Splign:2.1.0"
     exon            1236..1307
                     /gene="Ddx41"
                     /inference="alignment:Splign:2.1.0"
     exon            1308..1404
                     /gene="Ddx41"
                     /inference="alignment:Splign:2.1.0"
     exon            1405..1554
                     /gene="Ddx41"
                     /inference="alignment:Splign:2.1.0"
     exon            1555..1626
                     /gene="Ddx41"
                     /inference="alignment:Splign:2.1.0"
     exon            1627..1737
                     /gene="Ddx41"
                     /inference="alignment:Splign:2.1.0"
     exon            1738..2050
                     /gene="Ddx41"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctacgatgga ggagtcggaa cccgagcgga agcgggctcg cacgaacgag gcgactgcgg
       61 gtgggagccg ctccgaggac gaagatgagg acgacgagga ctacgtgccc tacgtgccgt
      121 tgcggcagcg ccggcagctt ctgctccaga agctgctgca gcgaagacgc aagggagctg
      181 cagaggaaga gcagcaggac agtggcagtg agccccgagg agatgaggac gacatcccgc
      241 tgggtcctca gtccaatgtc agcctcctgg atcagcacca gcacctcaaa gagaaggctg
      301 aagcacgcaa ggagtccgcc aaggaaaagc aactgaagga agaagaaaag attctggaga
      361 gtgtggctga aggccgagcc ttgatgtcag tgaaggaaat ggccaaaggc attacctacg
      421 acgatccaat caaaactagt tggacacccc cgcgctatgt cctgagcatg tcagaagagc
      481 ggcacgagcg tgttcggaag aagtaccaca tcctggtgga gggagacggt atcccgccac
      541 ccatcaagag cttcaaggaa atgaagctcc ctgcagctat ccttcgaggc ctgaagaaaa
      601 agggcatcct ccacccaaca cccattcaga tccagggcat ccctaccatt ctgtctggtc
      661 gggacatgat tggcatcgcc ttcacggggt caggcaagac tctggtattc acactgcccg
      721 tcatcatgtt ctgcctggaa caagagaagc ggttgccttt ctccaagcgg gaagggcctt
      781 atggacttat catctgcccc tcacgagagc tggctcggca gacccatggc atcctggagt
      841 attactgccg tctgctgcag gaagacagct cccctctcct gcgctgcgca ctctgcatcg
      901 ggggcatgtc ggtgaaggag cagatggaga ccatccgaca tggtgtgcac atgatggtag
      961 ccacaccggg acgcctcatg gatttgctgc agaagaaaat ggtcagccta gacatctgcc
     1021 gctacctggc cctggatgag gctgaccgca tgatcgacat gggctttgag ggtgacatcc
     1081 gtaccatctt ctcctacttc aagggccagc ggcagactct gctcttcagt gccaccatgc
     1141 cgaagaagat tcagaacttc gccaagagcg ccctggtcaa gcctgtcacc atcaatgttg
     1201 gtcgtgctgg agcagccagc cttgacgtca tccaggaggt ggaatatgtg aaggaggaag
     1261 ccaagatggt gtacctgctt gagtgcttgc agaagacgcc cccacctgta ctcatctttg
     1321 cagagaagaa agcagatgtg gatgccattc acgaatacct cctgctcaaa ggagttgagg
     1381 ctgtggccat tcatgggggc aaagaccagg aagagcggac caaggccatt gaggcattcc
     1441 gggaaggcaa gaaggacgtc ttagtggcca cggacgtggc ctctaaaggc ctagactttc
     1501 ctgccatcca gcacgtcatc aactatgaca tgcctgaaga aatcgagaac tatgtgcacc
     1561 gaatcggccg cactgggcgc tcaggaaaca caggcattgc caccaccttt atcaacaagg
     1621 cctgcgatga gtcagtgctc atggacctca aagccttgct gctggaggcc aagcagaagg
     1681 taccacctgt tctgcaagtg ctgcactgtg gggatgagtc catgctggac atcggaggag
     1741 aacggggctg cgccttctgt ggaggccttg gtcatcgaat cactgactgc cccaaactcg
     1801 aagctatgca gaccaagcag gtcagcaaca ttggccgcaa ggactacctg gcgcacagct
     1861 ccatggactt ctgagcttcc ctcttctccc caagagtcca gtcccaggac atcagccatg
     1921 tgcacaccag ccctcaagac aagaagccag cctccttggc ccagctggcc tgggccaccc
     1981 caatgccccc aaaattacta tttttgttct cttccccagc tgccattaaa gcacaatccc
     2041 ttttcttgga aaaaaaaaaa aaaaaaaaaa aaaaa
//
