LOCUS       NP_001101516             622 aa            linear   ROD 20-MAR-2023
DEFINITION  probable ATP-dependent RNA helicase DDX41 [Rattus norvegicus].
ACCESSION   NP_001101516 XP_001064233 XP_234441
VERSION     NP_001101516.1
DBSOURCE    REFSEQ: accession NM_001108046.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 622)
  AUTHORS   Lewinsohn M, Brown AL, Weinel LM, Phung C, Rafidi G, Lee MK,
            Schreiber AW, Feng J, Babic M, Chong CE, Lee Y, Yong A, Suthers GK,
            Poplawski N, Altree M, Phillips K, Jaensch L, Fine M, D'Andrea RJ,
            Lewis ID, Medeiros BC, Pollyea DA, King MC, Walsh T, Keel S,
            Shimamura A, Godley LA, Hahn CN, Churpek JE and Scott HS.
  TITLE     Novel germ line DDX41 mutations define families with a lower age of
            MDS/AML onset and lymphoid malignancies
  JOURNAL   Blood 127 (8), 1017-1023 (2016)
   PUBMED   26712909
REFERENCE   2  (residues 1 to 622)
  AUTHORS   Polprasert C, Schulze I, Sekeres MA, Makishima H, Przychodzen B,
            Hosono N, Singh J, Padgett RA, Gu X, Phillips JG, Clemente M,
            Parker Y, Lindner D, Dienes B, Jankowsky E, Saunthararajah Y, Du Y,
            Oakley K, Nguyen N, Mukherjee S, Pabst C, Godley LA, Churpek JE,
            Pollyea DA, Krug U, Berdel WE, Klein HU, Dugas M, Shiraishi Y,
            Chiba K, Tanaka H, Miyano S, Yoshida K, Ogawa S, Muller-Tidow C and
            Maciejewski JP.
  TITLE     Inherited and Somatic Defects in DDX41 in Myeloid Neoplasms
  JOURNAL   Cancer Cell 27 (5), 658-670 (2015)
   PUBMED   25920683
REFERENCE   3  (residues 1 to 622)
  AUTHORS   Zhu X, Wang D, Zhang H, Zhou Y, Luo R, Chen H, Xiao S and Fang L.
  TITLE     Molecular cloning and functional characterization of porcine DEAD
            (Asp-Glu-Ala-Asp) box polypeptide 41 (DDX41)
  JOURNAL   Dev Comp Immunol 47 (2), 191-196 (2014)
   PUBMED   25086295
  REMARK    GeneRIF: DDX41 is involved in the dsDNA- and dsDNA-virus-mediated
            type IFN-beta signaling pathway in porcine kidney cells. [DDX41]
REFERENCE   4  (residues 1 to 622)
  AUTHORS   Baltz AG, Munschauer M, Schwanhausser B, Vasile A, Murakawa Y,
            Schueler M, Youngs N, Penfold-Brown D, Drew K, Milek M, Wyler E,
            Bonneau R, Selbach M, Dieterich C and Landthaler M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   5  (residues 1 to 622)
  AUTHORS   Castello A, Fischer B, Eichelbaum K, Horos R, Beckmann BM, Strein
            C, Davey NE, Humphreys DT, Preiss T, Steinmetz LM, Krijgsveld J and
            Hentze MW.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   6  (residues 1 to 622)
  AUTHORS   Zhang Z, Yuan B, Bao M, Lu N, Kim T and Liu YJ.
  TITLE     The helicase DDX41 senses intracellular DNA mediated by the adaptor
            STING in dendritic cells
  JOURNAL   Nat Immunol 12 (10), 959-965 (2011)
   PUBMED   21892174
  REMARK    Erratum:[Nat Immunol. 2012 Feb;13(2):196]
            Publication Status: Online-Only
REFERENCE   7  (residues 1 to 622)
  AUTHORS   Ghosh D, Lippert D, Krokhin O, Cortens JP and Wilkins JA.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   8  (residues 1 to 622)
  AUTHORS   Jurica MS, Licklider LJ, Gygi SR, Grigorieff N and Moore MJ.
  TITLE     Purification and characterization of native spliceosomes suitable
            for three-dimensional structural analysis
  JOURNAL   RNA 8 (4), 426-439 (2002)
   PUBMED   11991638
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC166825.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XP_001064233.1, XP_234441.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC166825.1, SRR8487227.227573.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..622
                     /organism="Rattus norvegicus"
                     /db_xref="taxon:10116"
                     /chromosome="17"
                     /map="17p14"
     Protein         1..622
                     /product="probable ATP-dependent RNA helicase DDX41"
                     /EC_number="3.6.4.13"
                     /note="DEAD (Asp-Glu-Ala-Asp) box polypeptide 41; probable
                     ATP-dependent RNA helicase DDX41-like"
                     /calculated_mol_wt=69668
     Region          180..562
                     /region_name="SrmB"
                     /note="Superfamily II DNA and RNA helicase [Replication,
                     recombination and repair]; COG0513"
                     /db_xref="CDD:440279"
     CDS             1..622
                     /gene="Ddx41"
                     /coded_by="NM_001108046.2:6..1874"
                     /db_xref="GeneID:314336"
                     /db_xref="RGD:1311758"
ORIGIN      
        1 meeseperkr artneatagg srsedededd edyvpyvplr qrrqlllqkl lqrrrkgaae
       61 eeqqdsgsep rgdeddiplg pqsnvslldq hqhlkekaea rkesakekql keeekilesv
      121 aegralmsvk emakgitydd piktswtppr yvlsmseerh ervrkkyhil vegdgipppi
      181 ksfkemklpa ailrglkkkg ilhptpiqiq giptilsgrd migiaftgsg ktlvftlpvi
      241 mfcleqekrl pfskregpyg liicpsrela rqthgileyy crllqedssp llrcalcigg
      301 msvkeqmeti rhgvhmmvat pgrlmdllqk kmvsldicry laldeadrmi dmgfegdirt
      361 ifsyfkgqrq tllfsatmpk kiqnfaksal vkpvtinvgr agaasldviq eveyvkeeak
      421 mvylleclqk tpppvlifae kkadvdaihe ylllkgveav aihggkdqee rtkaieafre
      481 gkkdvlvatd vaskgldfpa iqhvinydmp eeienyvhri grtgrsgntg iattfinkac
      541 desvlmdlka llleakqkvp pvlqvlhcgd esmldigger gcafcgglgh ritdcpklea
      601 mqtkqvsnig rkdylahssm df
//
