LOCUS       NM_001077647            3024 bp    mRNA    linear   ROD 29-MAR-2024
DEFINITION  Rattus norvegicus DEAD-box helicase 4 (Ddx4), mRNA.
ACCESSION   NM_001077647 XM_001067709 XM_001074861
VERSION     NM_001077647.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3024)
  AUTHORS   Ozcan,P., Takmaz,T., Tok,O.E., Islek,S., Yigit,E.N. and
            Ficicioglu,C.
  TITLE     The protective effect of platelet-rich plasma administrated on
            ovarian function in female rats with Cy-induced ovarian damage
  JOURNAL   J Assist Reprod Genet 37 (4), 865-873 (2020)
   PUBMED   32020412
  REMARK    GeneRIF: The protective effect of platelet-rich plasma
            administrated on ovarian function in female rats with Cy-induced
            ovarian damage.
REFERENCE   2  (bases 1 to 3024)
  AUTHORS   Spade,D.J., Hall,S.J., Wortzel,J.D., Reyes,G. and Boekelheide,K.
  TITLE     All-trans Retinoic Acid Disrupts Development in Ex Vivo Cultured
            Fetal Rat Testes. II: Modulation of Mono-(2-ethylhexyl) Phthalate
            Toxicity
  JOURNAL   Toxicol Sci 168 (1), 149-159 (2019)
   PUBMED   30476341
REFERENCE   3  (bases 1 to 3024)
  AUTHORS   Spade,D.J., Dere,E., Hall,S.J., Schorl,C., Freiman,R.N. and
            Boekelheide,K.
  TITLE     All-Trans Retinoic Acid Disrupts Development in Ex Vivo Cultured
            Fetal Rat Testes. I: Altered Seminiferous Cord Maturation and
            Testicular Cell Fate
  JOURNAL   Toxicol Sci 167 (2), 546-558 (2019)
   PUBMED   30329139
REFERENCE   4  (bases 1 to 3024)
  AUTHORS   Wenda,J.M., Homolka,D., Yang,Z., Spinelli,P., Sachidanandam,R.,
            Pandey,R.R. and Pillai,R.S.
  TITLE     Distinct Roles of RNA Helicases MVH and TDRD9 in PIWI
            Slicing-Triggered Mammalian piRNA Biogenesis and Function
  JOURNAL   Dev Cell 41 (6), 623-637 (2017)
   PUBMED   28633017
REFERENCE   5  (bases 1 to 3024)
  AUTHORS   Kawahara,C., Yokota,S. and Fujita,H.
  TITLE     DDX6 localizes to nuage structures and the annulus of mammalian
            spermatogenic cells
  JOURNAL   Histochem Cell Biol 141 (1), 111-121 (2014)
   PUBMED   24141902
REFERENCE   6  (bases 1 to 3024)
  AUTHORS   Kuramochi-Miyagawa,S., Kimura,T., Ijiri,T.W., Isobe,T., Asada,N.,
            Fujita,Y., Ikawa,M., Iwai,N., Okabe,M., Deng,W., Lin,H., Matsuda,Y.
            and Nakano,T.
  TITLE     Mili, a mammalian member of piwi family gene, is essential for
            spermatogenesis
  JOURNAL   Development 131 (4), 839-849 (2004)
   PUBMED   14736746
REFERENCE   7  (bases 1 to 3024)
  AUTHORS   McClellan,K.A., Gosden,R. and Taketo,T.
  TITLE     Continuous loss of oocytes throughout meiotic prophase in the
            normal mouse ovary
  JOURNAL   Dev Biol 258 (2), 334-348 (2003)
   PUBMED   12798292
REFERENCE   8  (bases 1 to 3024)
  AUTHORS   Toyooka,Y., Tsunekawa,N., Takahashi,Y., Matsui,Y., Satoh,M. and
            Noce,T.
  TITLE     Expression and intracellular localization of mouse Vasa-homologue
            protein during germ cell development
  JOURNAL   Mech Dev 93 (1-2), 139-149 (2000)
   PUBMED   10781947
REFERENCE   9  (bases 1 to 3024)
  AUTHORS   Tanaka,S.S., Toyooka,Y., Akasu,R., Katoh-Fukui,Y., Nakahara,Y.,
            Suzuki,R., Yokoyama,M. and Noce,T.
  TITLE     The mouse homolog of Drosophila Vasa is required for the
            development of male germ cells
  JOURNAL   Genes Dev 14 (7), 841-853 (2000)
   PUBMED   10766740
REFERENCE   10 (bases 1 to 3024)
  AUTHORS   Komiya,T. and Tanigawa,Y.
  TITLE     Cloning of a gene of the DEAD box protein family which is
            specifically expressed in germ cells in rats
  JOURNAL   Biochem Biophys Res Commun 207 (1), 405-410 (1995)
   PUBMED   7857296
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On Feb 18, 2021 this sequence version replaced NM_001077647.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643293.10427.1,
                                           SRR26360181.3185612.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-257               JAXUCZ010000002.1  46015695-46015951   c
            258-344             JAXUCZ010000002.1  46015084-46015170   c
            345-405             JAXUCZ010000002.1  46008092-46008152   c
            406-483             JAXUCZ010000002.1  46002312-46002389   c
            484-561             JAXUCZ010000002.1  45997591-45997668   c
            562-612             JAXUCZ010000002.1  45995421-45995471   c
            613-672             JAXUCZ010000002.1  45990148-45990207   c
            673-729             JAXUCZ010000002.1  45985945-45986001   c
            730-810             JAXUCZ010000002.1  45984912-45984992   c
            811-852             JAXUCZ010000002.1  45984402-45984443   c
            853-900             JAXUCZ010000002.1  45982230-45982277   c
            901-948             JAXUCZ010000002.1  45982088-45982135   c
            949-1091            JAXUCZ010000002.1  45981745-45981887   c
            1092-1244           JAXUCZ010000002.1  45980795-45980947   c
            1245-1399           JAXUCZ010000002.1  45980195-45980349   c
            1400-1529           JAXUCZ010000002.1  45971748-45971877   c
            1530-1696           JAXUCZ010000002.1  45970052-45970218   c
            1697-1842           JAXUCZ010000002.1  45967922-45968067   c
            1843-1942           JAXUCZ010000002.1  45963993-45964092   c
            1943-2213           JAXUCZ010000002.1  45963076-45963346   c
            2214-2327           JAXUCZ010000002.1  45962843-45962956   c
            2328-3024           JAXUCZ010000002.1  45961174-45961870   c
FEATURES             Location/Qualifiers
     source          1..3024
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q14"
     gene            1..3024
                     /gene="Ddx4"
                     /gene_synonym="RVLG"
                     /note="DEAD-box helicase 4"
                     /db_xref="GeneID:310090"
                     /db_xref="RGD:1308793"
     exon            1..257
                     /gene="Ddx4"
                     /gene_synonym="RVLG"
                     /inference="alignment:Splign:2.1.0"
     exon            258..344
                     /gene="Ddx4"
                     /gene_synonym="RVLG"
                     /inference="alignment:Splign:2.1.0"
     CDS             273..2414
                     /gene="Ddx4"
                     /gene_synonym="RVLG"
                     /EC_number="3.6.4.13"
                     /note="vasa-like gene protein; vasa homolog; DEAD box
                     protein 4; putative ATP-dependent RNA helicase DDX4; DEAD
                     (Asp-Glu-Ala-Asp) box polypeptide 4"
                     /codon_start=1
                     /product="probable ATP-dependent RNA helicase DDX4"
                     /protein_id="NP_001071115.2"
                     /db_xref="GeneID:310090"
                     /db_xref="RGD:1308793"
                     /translation="MGDEDWEAEILKPHVSSYVPVFEKDKYSSGANGDTFNRTSASSS
                     EMEDGPSGRDHFMRSGFSSGRNLGNRDIGESSKRETTSTTGGFGRGKGFGNRGFLNNK
                     FEEGDSSGFWKESTNDCEDTQTRSRGFSKRGGYPDGNDSEASGPFRRGGRDSEYDQDQ
                     GSQRGGGLFGSRKPAASDSGSGDTFQSRSGNGRGGYKGLNEEVVTGSGKNSWKSEAEG
                     GESSDIQGPKVTYIPPPPPEDEDSIFAHYQTGINFDKYDTILVEVSGHDAPPAILTFE
                     EANLCQTLNNNIAKAGYTKLTPVQKYSIPIVLAGRDLMACAQTGSGKTAAFLLPILAH
                     MMRDGITASRFKELQEPECIIVAPTRELINQIYLEARKFSFGTCVRAVVIYGGTQFGH
                     SIRQIVQGCNILCATPGRLMDIIGKEKIGLKQVKYLVLDEADRMLDMGFGPEMKKLIS
                     CPGMPSKEQRQTLLFSATFPEEIQRLAGEFLKSNYLFVAVGQVGGACRDVQQSILQVG
                     QYSKREKLVEILRNIGDERTMVFVETKKKADFIATFLCQEKISTTSIHGDREQREREQ
                     ALGDFRCGKCPVLVATSVAARGLDIENVQHVINFDLPSTIDEYVHRIGRTGRCGNTGR
                     AISFFDTESDNHLAQPLVKVLSDAQQDVPAWLEEIAFSSYAPPSFSNSTRGAVFASVD
                     TRKNFQGKNTLNTAGISSAQAPNPVDDESWD"
     exon            345..405
                     /gene="Ddx4"
                     /gene_synonym="RVLG"
                     /inference="alignment:Splign:2.1.0"
     exon            406..483
                     /gene="Ddx4"
                     /gene_synonym="RVLG"
                     /inference="alignment:Splign:2.1.0"
     exon            484..561
                     /gene="Ddx4"
                     /gene_synonym="RVLG"
                     /inference="alignment:Splign:2.1.0"
     exon            562..612
                     /gene="Ddx4"
                     /gene_synonym="RVLG"
                     /inference="alignment:Splign:2.1.0"
     exon            613..672
                     /gene="Ddx4"
                     /gene_synonym="RVLG"
                     /inference="alignment:Splign:2.1.0"
     exon            673..729
                     /gene="Ddx4"
                     /gene_synonym="RVLG"
                     /inference="alignment:Splign:2.1.0"
     exon            730..810
                     /gene="Ddx4"
                     /gene_synonym="RVLG"
                     /inference="alignment:Splign:2.1.0"
     exon            811..852
                     /gene="Ddx4"
                     /gene_synonym="RVLG"
                     /inference="alignment:Splign:2.1.0"
     exon            853..900
                     /gene="Ddx4"
                     /gene_synonym="RVLG"
                     /inference="alignment:Splign:2.1.0"
     exon            901..948
                     /gene="Ddx4"
                     /gene_synonym="RVLG"
                     /inference="alignment:Splign:2.1.0"
     exon            949..1091
                     /gene="Ddx4"
                     /gene_synonym="RVLG"
                     /inference="alignment:Splign:2.1.0"
     exon            1092..1244
                     /gene="Ddx4"
                     /gene_synonym="RVLG"
                     /inference="alignment:Splign:2.1.0"
     exon            1245..1399
                     /gene="Ddx4"
                     /gene_synonym="RVLG"
                     /inference="alignment:Splign:2.1.0"
     exon            1400..1529
                     /gene="Ddx4"
                     /gene_synonym="RVLG"
                     /inference="alignment:Splign:2.1.0"
     exon            1530..1696
                     /gene="Ddx4"
                     /gene_synonym="RVLG"
                     /inference="alignment:Splign:2.1.0"
     exon            1697..1842
                     /gene="Ddx4"
                     /gene_synonym="RVLG"
                     /inference="alignment:Splign:2.1.0"
     exon            1843..1942
                     /gene="Ddx4"
                     /gene_synonym="RVLG"
                     /inference="alignment:Splign:2.1.0"
     exon            1943..2213
                     /gene="Ddx4"
                     /gene_synonym="RVLG"
                     /inference="alignment:Splign:2.1.0"
     exon            2214..2327
                     /gene="Ddx4"
                     /gene_synonym="RVLG"
                     /inference="alignment:Splign:2.1.0"
     exon            2328..3024
                     /gene="Ddx4"
                     /gene_synonym="RVLG"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccttggtctt gcttccaacc ctggctcagg gcgtcctaac caggcccggt agcctctggg
       61 gcagacttag gccagaggct gctcacatgg gcctgcctgg ggcttgaggt cggcctctgg
      121 ggccttcccg ctcagactgg agtcttcatg ctgagtagag cggtgtgtga acacttgagg
      181 cctgcagggg agggaggccc agggaacctt ctgctcagcg cctaggcggc catttctcag
      241 aagaaacggt gtttgtggaa cctgaagcta tcatgggaga tgaagattgg gaggcagaaa
      301 tcctcaaacc tcatgtgtct tcctacgttc ctgtatttga gaaggataaa tattcttctg
      361 gggcaaatgg agacactttt aacaggactt cagcttcatc atcagaaatg gaagatggac
      421 cttctggaag agatcatttc atgagaagtg gattttcctc tggaagaaat ttaggaaaca
      481 gagatattgg cgagtctagt aaaagagaga ctacatctac aaccggtggc tttggaagag
      541 gaaagggttt tggaaacaga ggttttttaa ataacaagtt tgaagaaggt gacagctctg
      601 gtttctggaa agagtctact aatgactgtg aagatactca gactcggagc agagggtttt
      661 ccaagcgagg cggctatcca gatgggaatg attcggaagc ttcaggccca ttcagaagag
      721 gtggaagaga tagtgaatat gaccaagatc agggatcaca gcgtggtggt ggcctttttg
      781 gttctaggaa accagcagca agtgattcag gcagtggtga cactttccag agcagaagtg
      841 ggaatggccg aggtggctac aaaggcttaa atgaagaagt agtaacaggc tctggaaaga
      901 attcttggaa gtcagaagct gaaggaggcg aaagcagtga tattcaaggt ccaaaagtga
      961 catatatacc ccctcctcca ccagaggatg aggactccat ctttgcacat tatcagacag
     1021 gcataaactt tgataaatat gataccatac ttgttgaagt atctggacat gatgcaccac
     1081 cggcaatttt gacttttgaa gaagcgaatc tctgccagac cctgaataac aacattgcta
     1141 aggctggcta taccaagctc actcctgtgc agaagtacag cattcccatt gtgttagcag
     1201 gaagagattt gatggcttgt gctcaaacag ggtctgggaa gacggcagct tttctcttgc
     1261 ctattttggc tcatatgatg agggatggaa taactgccag tcgctttaaa gaactgcagg
     1321 aaccagagtg tattattgta gcaccaactc gagaattgat caaccaaatt tatttggaag
     1381 ccagaaaatt ttcttttggg acttgtgtaa gagctgttgt catatatgga ggaacccagt
     1441 ttgggcactc aattcgacag atagtgcaag ggtgtaatat attatgtgct actccaggga
     1501 ggctgatgga tatcataggc aaagaaaaga ttggtctcaa acaagtcaag tacttagttt
     1561 tggatgaagc tgatcgaatg ttggatatgg gttttggacc cgaaatgaag aagttaattt
     1621 cttgtccagg aatgccatca aaggaacagc gccaaactct tttattcagt gcaacttttc
     1681 cagaagaaat ccagaggttg gctggcgagt ttttaaagtc aaattatttg tttgttgctg
     1741 ttggacaagt gggaggagct tgcagagatg tgcagcagtc cattcttcaa gttggccagt
     1801 attcaaaaag agaaaaactt gttgagattc tacgaaacat aggtgatgaa agaactatgg
     1861 tctttgttga aaccaagaaa aaagcagatt tcattgcgac ttttctttgt caagaaaaaa
     1921 tatcaactac aagtattcat ggcgatcggg aacagaggga gcgagaacaa gctcttggag
     1981 attttcgctg tggaaagtgc ccagttcttg ttgctacttc agtggctgcc agaggacttg
     2041 atattgaaaa tgttcaacat gttatcaatt ttgaccttcc ttctaccatt gatgaatatg
     2101 ttcatcgaat tggacgtact ggacgttgtg gaaatactgg cagggcgatt tctttttttg
     2161 ataccgaatc tgataatcat ttagcacaac ctctagttaa agtactgtca gatgctcaac
     2221 aggatgttcc tgcgtggtta gaagagattg cctttagttc atatgcgcct cccagcttca
     2281 gtaatagcac aagaggggct gtgtttgcat ctgttgacac taggaagaat ttccagggca
     2341 agaacacact gaacacagct gggatttctt ctgcacaagc tcccaatcca gttgatgacg
     2401 agtcatggga ttaaagcaaa caagcatact gcaagtctga tggttttgat gcagagaaga
     2461 aaaacagttt ttatttttaa aattttaaca gaagtgtgaa acctgatatt cttatatctc
     2521 ctgttcttct gttcttactc ccaaccctta aaaaataacc agcttcattg attagttatg
     2581 cgaaatgctg aagttacaac attgcagtta ctgatacaaa tggtgttcac tggaaatatt
     2641 aaagcattct atgttttgct tatttctagt atattcttca gaaagttaaa gacatgtttc
     2701 atgtccaagt gctatgtctt agtatagtgt ttctgatcta taaaacaagc aataggatat
     2761 ggtgtactct tgtttaatta tcgggtctaa tttctacttg atcctttaaa agaatagtgt
     2821 gtcagtacaa tgtattaaca tgattttcat gaaacagtgg agactgaagc ctttcaaagt
     2881 tatttgattt ttagatcatc agacatgtaa tgaaaatggt tcagtttgca atgtgagctc
     2941 tgtacttggt ggtatgacaa atgtttgctt ttataatata cagattttcc ttggaaataa
     3001 aagatgaaac acatttcccc ctaa
//
