LOCUS       NM_001398752            4642 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus DEAD-box helicase 3, X-linked (Ddx3x), transcript
            variant 2, mRNA.
ACCESSION   NM_001398752 XM_006256652
VERSION     NM_001398752.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4642)
  AUTHORS   Feng,D., Li,J., Guo,L., Liu,J., Wang,S., Ma,X., Song,Y., Liu,J. and
            Hao,E.
  TITLE     DDX3X alleviates doxorubicin-induced cardiotoxicity by regulating
            Wnt/beta-catenin signaling pathway in an in vitro model
  JOURNAL   J Biochem Mol Toxicol 36 (8), e23077 (2022)
   PUBMED   35467791
  REMARK    GeneRIF: DDX3X alleviates doxorubicin-induced cardiotoxicity by
            regulating Wnt/beta-catenin signaling pathway in an in vitro model.
REFERENCE   2  (bases 1 to 4642)
  AUTHORS   Samir,P., Kesavardhana,S., Patmore,D.M., Gingras,S.,
            Malireddi,R.K.S., Karki,R., Guy,C.S., Briard,B., Place,D.E.,
            Bhattacharya,A., Sharma,B.R., Nourse,A., King,S.V., Pitre,A.,
            Burton,A.R., Pelletier,S., Gilbertson,R.J. and Kanneganti,T.D.
  TITLE     DDX3X acts as a live-or-die checkpoint in stressed cells by
            regulating NLRP3 inflammasome
  JOURNAL   Nature 573 (7775), 590-594 (2019)
   PUBMED   31511697
REFERENCE   3  (bases 1 to 4642)
  AUTHORS   Fu,R., Yang,P., Li,Z., Liu,W., Amin,S. and Li,Z.
  TITLE     Avenanthramide A triggers potent ROS-mediated anti-tumor effects in
            colorectal cancer by directly targeting DDX3
  JOURNAL   Cell Death Dis 10 (8), 593 (2019)
   PUBMED   31391454
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4642)
  AUTHORS   Chan,C.H., Chen,C.M., Lee,Y.W. and You,L.R.
  TITLE     DNA Damage, Liver Injury, and Tumorigenesis: Consequences of DDX3X
            Loss
  JOURNAL   Mol Cancer Res 17 (2), 555-566 (2019)
   PUBMED   30297359
REFERENCE   5  (bases 1 to 4642)
  AUTHORS   Fullam,A., Gu,L., Hohn,Y. and Schroder,M.
  TITLE     DDX3 directly facilitates IKKalpha activation and regulates
            downstream signalling pathways
  JOURNAL   Biochem J 475 (22), 3595-3607 (2018)
   PUBMED   30341167
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4642)
  AUTHORS   Shih,J.W., Tsai,T.Y., Chao,C.H. and Wu Lee,Y.H.
  TITLE     Candidate tumor suppressor DDX3 RNA helicase specifically represses
            cap-dependent translation by acting as an eIF4E inhibitory protein
  JOURNAL   Oncogene 27 (5), 700-714 (2008)
   PUBMED   17667941
REFERENCE   7  (bases 1 to 4642)
  AUTHORS   Chao,C.H., Chen,C.M., Cheng,P.L., Shih,J.W., Tsou,A.P. and Lee,Y.H.
  TITLE     DDX3, a DEAD box RNA helicase with tumor growth-suppressive
            property and transcriptional regulation activity of the
            p21waf1/cip1 promoter, is a candidate tumor suppressor
  JOURNAL   Cancer Res 66 (13), 6579-6588 (2006)
   PUBMED   16818630
REFERENCE   8  (bases 1 to 4642)
  AUTHORS   Chang,P.C., Chi,C.W., Chau,G.Y., Li,F.Y., Tsai,Y.H., Wu,J.C. and Wu
            Lee,Y.H.
  TITLE     DDX3, a DEAD box RNA helicase, is deregulated in hepatitis
            virus-associated hepatocellular carcinoma and is involved in cell
            growth control
  JOURNAL   Oncogene 25 (14), 1991-2003 (2006)
   PUBMED   16301996
REFERENCE   9  (bases 1 to 4642)
  AUTHORS   Owsianka,A.M. and Patel,A.H.
  TITLE     Hepatitis C virus core protein interacts with a human DEAD box
            protein DDX3
  JOURNAL   Virology 257 (2), 330-340 (1999)
   PUBMED   10329544
REFERENCE   10 (bases 1 to 4642)
  AUTHORS   You,L.R., Chen,C.M., Yeh,T.S., Tsai,T.Y., Mai,R.T., Lin,C.H. and
            Lee,Y.H.
  TITLE     Hepatitis C virus core protein interacts with cellular putative RNA
            helicase
  JOURNAL   J Virol 73 (4), 2841-2853 (1999)
   PUBMED   10074132
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000021.1.
            
            On Dec 22, 2021 this sequence version replaced XM_006256652.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360194.28337.1,
                                           SRR26360186.583330.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-137               JAXUCZ010000021.1  12165847-12165983   c
            138-195             JAXUCZ010000021.1  12162636-12162693   c
            196-243             JAXUCZ010000021.1  12161790-12161837   c
            244-376             JAXUCZ010000021.1  12160527-12160659   c
            377-535             JAXUCZ010000021.1  12159513-12159671   c
            536-635             JAXUCZ010000021.1  12159337-12159436   c
            636-771             JAXUCZ010000021.1  12158980-12159115   c
            772-857             JAXUCZ010000021.1  12158438-12158523   c
            858-956             JAXUCZ010000021.1  12158059-12158157   c
            957-1117            JAXUCZ010000021.1  12157789-12157949   c
            1118-1262           JAXUCZ010000021.1  12157229-12157373   c
            1263-1407           JAXUCZ010000021.1  12156563-12156707   c
            1408-1589           JAXUCZ010000021.1  12156180-12156361   c
            1590-1707           JAXUCZ010000021.1  12155974-12156091   c
            1708-1861           JAXUCZ010000021.1  12155479-12155632   c
            1862-2001           JAXUCZ010000021.1  12155131-12155270   c
            2002-4642           JAXUCZ010000021.1  12152346-12154986   c
FEATURES             Location/Qualifiers
     source          1..4642
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="X"
                     /map="Xq12"
     gene            1..4642
                     /gene="Ddx3x"
                     /note="DEAD-box helicase 3, X-linked"
                     /db_xref="GeneID:317335"
                     /db_xref="RGD:1564771"
     exon            1..137
                     /gene="Ddx3x"
                     /inference="alignment:Splign:2.1.0"
     CDS             93..2081
                     /gene="Ddx3x"
                     /EC_number="3.6.4.13"
                     /note="isoform 2 is encoded by transcript variant 2;
                     ATP-dependent RNA helicase DDX3X; DEAD/H
                     (Asp-Glu-Ala-Asp/His) box polypeptide 3, X-linked; DEAD
                     (Asp-Glu-Ala-Asp) box polypeptide 3, X-linked; DEAD
                     (Asp-Glu-Ala-Asp) box helicase 3, X-linked"
                     /codon_start=1
                     /product="ATP-dependent RNA helicase DDX3X isoform 2"
                     /protein_id="NP_001385681.1"
                     /db_xref="GeneID:317335"
                     /db_xref="RGD:1564771"
                     /translation="MSHVAVENALGLDQQFAGLDLNSSDNQTGGSTASKGRYIPPHLR
                     NREATKGFYDKDSSGWSSSKDKDAYSSFGSRGDSRGKSSFFGDRGSGSRGRFDDRGRG
                     DYDGIGGRGDRSGFGKFERGGNSRWCDKSDEDDWSKPLPPSERLEQELFSGGNTGINF
                     EKYDDIPVEATGNNCPPHIESFSDVEMGEIIMGNIELTRYTRPTPVQKHAIPIIKEKR
                     DLMACAQTGSGKTAAFLLPILSQIYADGPGEALRAMKENGRYGRRKQYPISLVLAPTR
                     ELAVQIYEEARKFSYRSRVRPCVVYGGAEIGQQIRDLERGCHLLVATPGRLVDMMERG
                     KIGLDFCKYLVLDEADRMLDMGFEPQIRRIVEQDTMPPKGVRHTMMFSATFPKEIQML
                     ARDFLDEYIFLAVGRVGSTSENITQKVVWVEEIDKRSFLLDLLNATGKDSLTLVFVET
                     KKGADSLEDFLYHEGYACTSIHGDRSQRDREEALHQFRSGKSPILVATAVAARGLDIS
                     NVKHVINFDLPSDIEEYVHRIGRTGRVGNLGLATSFFNERNINITKDLLDLLVEAKQE
                     VPSWLENMAFEHHYKGSSRGRSKSSRFSGGFGARDYRQSSGASSSSFSSSRASSSRSG
                     GGGHGSSRGFGGGGYGGFYNSDGYGGNYNSQGVDWWGN"
     exon            138..195
                     /gene="Ddx3x"
                     /inference="alignment:Splign:2.1.0"
     exon            196..243
                     /gene="Ddx3x"
                     /inference="alignment:Splign:2.1.0"
     exon            244..376
                     /gene="Ddx3x"
                     /inference="alignment:Splign:2.1.0"
     exon            377..535
                     /gene="Ddx3x"
                     /inference="alignment:Splign:2.1.0"
     exon            536..635
                     /gene="Ddx3x"
                     /inference="alignment:Splign:2.1.0"
     exon            636..771
                     /gene="Ddx3x"
                     /inference="alignment:Splign:2.1.0"
     exon            772..857
                     /gene="Ddx3x"
                     /inference="alignment:Splign:2.1.0"
     exon            858..956
                     /gene="Ddx3x"
                     /inference="alignment:Splign:2.1.0"
     exon            957..1117
                     /gene="Ddx3x"
                     /inference="alignment:Splign:2.1.0"
     exon            1118..1262
                     /gene="Ddx3x"
                     /inference="alignment:Splign:2.1.0"
     exon            1263..1407
                     /gene="Ddx3x"
                     /inference="alignment:Splign:2.1.0"
     exon            1408..1589
                     /gene="Ddx3x"
                     /inference="alignment:Splign:2.1.0"
     exon            1590..1707
                     /gene="Ddx3x"
                     /inference="alignment:Splign:2.1.0"
     exon            1708..1861
                     /gene="Ddx3x"
                     /inference="alignment:Splign:2.1.0"
     exon            1862..2001
                     /gene="Ddx3x"
                     /inference="alignment:Splign:2.1.0"
     exon            2002..4642
                     /gene="Ddx3x"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 caaagccgca gttctcccgt gagagggtct ttgcggtaaa gccagcactt gctcagcagc
       61 ggaagactcc gaattttcgg tactcttcag ggatgagtca tgtggcagtg gaaaatgcgc
      121 tcgggctgga ccagcagttt gctggcctag acctgaactc ttcagataat cagactggag
      181 gaagtacagc aagcaaaggg cgctatatcc ctcctcattt aaggaacaga gaagctacta
      241 aaggattcta tgacaaagac agttcagggt ggagttctag taaagataaa gatgcataca
      301 gcagctttgg atcccggggt gactcacgag ggaagtctag cttctttggt gatcgtggaa
      361 gtggatcaag gggaaggttt gatgatcgtg gacggggaga ctatgatggc attggtggcc
      421 gtggagatag gagtggcttt ggcaaatttg aaagaggtgg aaatagtcgc tggtgtgata
      481 aatcagatga agatgactgg tcaaagccac tcccaccaag tgaacgcttg gaacaggaac
      541 tcttttctgg aggcaatact gggattaact ttgagaaata tgatgacatt ccagttgaag
      601 caacaggcaa caactgtcct ccacatattg aaagtttcag tgatgttgag atgggagaaa
      661 ttattatggg aaacattgag cttactcgtt atactcgtcc aactccagtg cagaagcatg
      721 ctattcctat tatcaaagag aaaagagact tgatggcttg tgctcaaaca ggctctggaa
      781 aaactgcagc atttctcttg cccatcttga gtcagattta tgctgatggt cccggagagg
      841 ctctgagggc catgaaggaa aatggaagat atgggcgtcg taaacagtat ccaatctcct
      901 tggtactggc accaacgaga gaattggcag tgcagatcta tgaggaagcc agaaaattct
      961 cataccggtc tagagtccgt ccttgcgtgg tttatggtgg tgctgaaatt ggtcagcaga
     1021 ttcgagactt agaacgtgga tgccacttgt tagtagccac tccaggacgt ctagtggaca
     1081 tgatggagag agggaagatc gggctagact tctgcaaata cctggtgtta gatgaagctg
     1141 accggatgtt agatatgggg tttgaacctc agatacgtag aatagttgaa caagacacta
     1201 tgcctccaaa aggtgtccgc cacactatga tgtttagtgc tacttttcct aaggaaatac
     1261 agatgctggc ccgtgatttc ttagatgagt acatatttct ggctgtagga agagttgggt
     1321 ctacttcaga gaacatcaca caaaaagtgg tttgggtgga ggagatagac aaaagatcat
     1381 ttctgcttga cctcctaaat gcaacaggca aggattccct gactctagtg tttgtggaga
     1441 ccaaaaaggg tgcagattcg ctggaggatt tcttatacca tgaaggatat gcctgtacca
     1501 gtatccatgg agaccgttct cagagagata gggaagaggc ccttcaccag ttccgctcag
     1561 gaaaaagccc aattctagta gctacagcag tagcagcaag aggactggat atttcaaatg
     1621 tgaagcatgt tattaatttt gacctgccta gtgatatcga agaatatgtg catcgcatag
     1681 gccgtacagg gcgtgtagga aaccttggtc ttgccacctc attctttaat gaaagaaata
     1741 taaatattac taaggattta ctggatcttc ttgttgaagc aaaacaagaa gtgccatctt
     1801 ggttggaaaa catggctttt gaacaccact ataagggtag cagccgtgga cgttctaaga
     1861 gcagtcgatt tagtggaggg tttggtgcca gagactatcg acagagtagc ggcgccagca
     1921 gttccagctt cagcagcagc cgcgcaagca gcagccggag tggtggaggt ggccatggca
     1981 gcagcagagg atttggtgga ggtggctatg gaggctttta caacagtgat ggatacggag
     2041 gaaattacaa ctcccagggg gttgactggt ggggaaactg agcctgcttt gtagtaggtc
     2101 accctgccaa acaagctaat atggaaacca catgtaactt agccagacta taccttgtgt
     2161 agcttcaaga actcgcagta cattaccagc tgtgattctc cactgaaatt tttttttttt
     2221 taagggagct caaggtcaca agtaaagatg aaaggaacaa tcagcagccc tgttctgaag
     2281 gtggtttgaa gacttcattg ctgtagtttg gattaactcc cctcccgcct acccctatcc
     2341 caaactgcat ttataatttt gtgactgagg atcatttgtt tgttaatgta ctgtgccttt
     2401 aactttagac aactttttat tttgatgtcc tgttggctca gtaatgctca agattccaat
     2461 tgtttttgac aaaataaatt tactgaactt gggctaaaat caaaccttgg cacacaggtg
     2521 tgatacaact taacaggaat catcgattca tccataacta atataaggaa aaactcaagt
     2581 ggtagcctgc ctaagggctt ttgatacttg cagattgggg aaatcaaaca acaaacgtct
     2641 tgaagcatat taatggaatt agtttctaat gtggcaaact gtattaagtt aaagttctga
     2701 tttgctcact ctatcctgga taggtattta gaacctgata atagtcttta aacaagccat
     2761 tccagtcatg atgaggtgat gtatgaatac atgcatacat tcaaagcact gttctcaaag
     2821 ttaatgcaag taaatacagc aattcctctt tcaatgttta ggcagatcgt taactatgag
     2881 ctagccaaat gtgggcatgt tattacaggg aaagtttaaa ggtctgataa cttgaaatag
     2941 gtttttagga gaattcatct acttagactt tttaaatgcc tgccatacaa gaaattgaaa
     3001 tggtagaatg gctgaccaca gcaatgacca gccctcactc agggctctgg atgatttttt
     3061 ggtctaataa cgcatgctag tgttgatgtt ttttggtcaa gatggggatg aacaggaaga
     3121 attatgcagc aggctttatt ttaaatgccg attcacatta ctctgttcaa gctgcgttga
     3181 gatgttaaac tggcttacta tagactttgt aaaaaacaaa aacaaatggc tccagaagaa
     3241 taccaaactg aaatctgaga tcacacaggt tggaaatatg tacataactg cacaaggtgt
     3301 cagttctgct ctacagtgca gtttagtcag ttttagttgc ataggtttcc attgtattta
     3361 tagtctgttt atgctaaatc tggccaaaga tgagcattgt ccaccactaa aatgcctatg
     3421 ccacttggaa ttctgggcta attttgtgac cagaatgcag tgatcaaaac gctcaatctt
     3481 tttacagtgg cataggaaga cggcaaaaat ttcctaaagt gcaatagatt ttcaagtgta
     3541 ttgtgccttg ttctaaaact tttattaagt aggtgcactt gacagtattg aggtcatttg
     3601 ttatggtgct atttcaatta gtctaggttt aggcccttgt acattttgcc cataactttt
     3661 tacaaagtac ttcttttatt gcacattcag agaattttat atatatgtct tgtgtgcgtg
     3721 tccttaaact tccaatctta ttttgtctct tggagattgt tgaacgcagc ttgtctagga
     3781 aagggatggg actagattct aaaatttatt tgggaccatg ggaatgatag ttgggaagaa
     3841 aactttgcac acgacagatt tctagatact ttttgctgct agttttatgt aatatttatt
     3901 gaacattttg acaaatattt atttttgtaa gcctaaaagt gattctttga aagtttaaag
     3961 aaacttgacc aaaagacagt acaaaaacac tggcacttga atgttgaatg tcaccgtatg
     4021 cgtgaaatta tatatttcgg ggtagtgtga gcttttaatg ttaagtcata ataaactctt
     4081 aagtcaaatt aagcagaccc ggcattggcg gtgtagccat aactttctga tgttagtaaa
     4141 aacaaaattg gcgacttgaa actaaatcat gccaaggttt tgatacactt gtcttaagat
     4201 attaatgaaa cacttcaaaa acactgatac aaagtgtcca gattctcaga tgtttgttgt
     4261 gtgagttttg tttagttgta ttttttttca gtgaatgtct ggcacattgc aatcctcaaa
     4321 catgtggtta tctttgttgt attggcatat tcagtgactt ggacattcag cgatagcatt
     4381 ggagcaagtc ttatcagcaa gcaatgtttt cagttatgtt tcaaagttaa gaatgggttt
     4441 aaacttgctg aacgtaaaga ttgaccctca agtcactgta gctttagtac ttgcttattg
     4501 tattagttta gatgctagca ccgcatgtgc tctgcatatt ctggttttat taaaataaaa
     4561 agttgaactg cacagtctcc tttgttgttg tcaattgtgg tttactttta gaggtgaaaa
     4621 taaagttgtg ctcttgcctg aa
//
