LOCUS       NM_001106793            3106 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus DEAD-box helicase 23 (Ddx23), mRNA.
ACCESSION   NM_001106793 XM_001060655 XM_217050
VERSION     NM_001106793.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3106)
  AUTHORS   Sridhara SC, Carvalho S, Grosso AR, Gallego-Paez LM, Carmo-Fonseca
            M and de Almeida SF.
  TITLE     Transcription Dynamics Prevent RNA-Mediated Genomic Instability
            through SRPK2-Dependent DDX23 Phosphorylation
  JOURNAL   Cell Rep 18 (2), 334-343 (2017)
   PUBMED   28076779
REFERENCE   2  (bases 1 to 3106)
  AUTHORS   Chang TH, Tung L, Yeh FL, Chen JH and Chang SL.
  TITLE     Functions of the DExD/H-box proteins in nuclear pre-mRNA splicing
  JOURNAL   Biochim Biophys Acta 1829 (8), 764-774 (2013)
   PUBMED   23454554
  REMARK    Review article
REFERENCE   3  (bases 1 to 3106)
  AUTHORS   Baltz AG, Munschauer M, Schwanhausser B, Vasile A, Murakawa Y,
            Schueler M, Youngs N, Penfold-Brown D, Drew K, Milek M, Wyler E,
            Bonneau R, Selbach M, Dieterich C and Landthaler M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   4  (bases 1 to 3106)
  AUTHORS   Gonzalez-Begne M, Lu B, Han X, Hagen FK, Hand AR, Melvin JE and
            Yates JR.
  TITLE     Proteomic analysis of human parotid gland exosomes by
            multidimensional protein identification technology (MudPIT)
  JOURNAL   J Proteome Res 8 (3), 1304-1314 (2009)
   PUBMED   19199708
REFERENCE   5  (bases 1 to 3106)
  AUTHORS   Wahl MC, Will CL and Luhrmann R.
  TITLE     The spliceosome: design principles of a dynamic RNP machine
  JOURNAL   Cell 136 (4), 701-718 (2009)
   PUBMED   19239890
  REMARK    Review article
REFERENCE   6  (bases 1 to 3106)
  AUTHORS   Jurica MS, Licklider LJ, Gygi SR, Grigorieff N and Moore MJ.
  TITLE     Purification and characterization of native spliceosomes suitable
            for three-dimensional structural analysis
  JOURNAL   RNA 8 (4), 426-439 (2002)
   PUBMED   11991638
REFERENCE   7  (bases 1 to 3106)
  AUTHORS   Laggerbauer B, Achsel T and Luhrmann R.
  TITLE     The human U5-200kD DEXH-box protein unwinds U4/U6 RNA duplices in
            vitro
  JOURNAL   Proc Natl Acad Sci U S A 95 (8), 4188-4192 (1998)
   PUBMED   9539711
REFERENCE   8  (bases 1 to 3106)
  AUTHORS   Teigelkamp S, Mundt C, Achsel T, Will CL and Luhrmann R.
  TITLE     The human U5 snRNP-specific 100-kD protein is an RS
            domain-containing, putative RNA helicase with significant homology
            to the yeast splicing factor Prp28p
  JOURNAL   RNA 3 (11), 1313-1326 (1997)
   PUBMED   9409622
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CB612721.1, BC169082.1 and CO570626.1.
            
            On Oct 15, 2009 this sequence version replaced NM_001106793.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMD00132261, SAMD00132262
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-121               CB612721.1         1-121
            122-1720            BC169082.1         1-1599
            1721-1721           CO570626.1         355-355
            1722-3106           BC169082.1         1601-2985
FEATURES             Location/Qualifiers
     source          1..3106
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q36"
     gene            1..3106
                     /gene="Ddx23"
                     /note="DEAD-box helicase 23"
                     /db_xref="GeneID:300208"
                     /db_xref="RGD:1308685"
     exon            1..59
                     /gene="Ddx23"
                     /inference="alignment:Splign:2.1.0"
     CDS             60..2519
                     /gene="Ddx23"
                     /EC_number="3.6.1.-"
                     /note="DEAD (Asp-Glu-Ala-Asp) box polypeptide 23"
                     /codon_start=1
                     /product="probable ATP-dependent RNA helicase DDX23"
                     /protein_id="NP_001100263.2"
                     /db_xref="GeneID:300208"
                     /db_xref="RGD:1308685"
                     /translation="MAGELADKKDRDASPKEERKRSRTPERDRDRDRDRKSSPSKDRK
                     RHRSRDRRRGGSRSRSRSRSKSTERERRHKERERDKERDRSKKERERDKDGHRRDKDR
                     KRSSLSPGRGKDFKSRKDRDSKKGDEDEHGDKRPKIQPLSLEELLAKKKAEEEAEAKP
                     KFLSKAEREAEALKRRQQEVEERQKMLEEERKKRKQFQDLGRKMLEDPQERERRERRE
                     RMERETNGNEDEEGRQKIREEKDKSKELHAIKERYLGGIKKRRRTRHLNDRKFVFEWD
                     ASEDTSIDYNPLYKERHQVQLLGRGFIAGIDLKQQKREQSRFYGDLMEKRRTLEEKEQ
                     EEARLRKLRKKEAKQRWDDRHWSQKKLDEMTDRDWRIFREDYSITTKGGKIPNPIRSW
                     KDSSLPPHILEVIDKCGYKEPTPIQRQAIPIGLQNRDIIGVAETGSGKTAAFLIPLLV
                     WITTLPKIDRIEESDQGPYAIILAPTRELAQQIEEETIKFGKPLGIRTVAVIGGISRE
                     DQGFRLRMGCEIVIATPGRLIDVLENRYLVLSRCTYVVLDEADRMIDMGFEPDVQKIL
                     EHMPVSNQKPDTDEAEDPEKMLANFESGKHKYRQTVMFTATMPPAVERLARSYLRRPA
                     VVYIGSAGKPHERVEQKVFLMSESEKRKKLLAILEQGFDPPIIIFVNQKKGCDVLAKS
                     LEKMGYNACTLHGGKGQEQREFALSNLKAGAKDILVATDVAGRGIDIQDVSMVVNYDM
                     AKNIEDYIHRIGRTGRAGKSGVAITFLTKEDSAVFYELKQAILESPVSSCPPELANHP
                     DAQHKPGTILTKKRREETIFA"
     exon            60..265
                     /gene="Ddx23"
                     /inference="alignment:Splign:2.1.0"
     exon            266..376
                     /gene="Ddx23"
                     /inference="alignment:Splign:2.1.0"
     exon            377..470
                     /gene="Ddx23"
                     /inference="alignment:Splign:2.1.0"
     exon            471..536
                     /gene="Ddx23"
                     /inference="alignment:Splign:2.1.0"
     exon            537..675
                     /gene="Ddx23"
                     /inference="alignment:Splign:2.1.0"
     exon            676..809
                     /gene="Ddx23"
                     /inference="alignment:Splign:2.1.0"
     exon            810..922
                     /gene="Ddx23"
                     /inference="alignment:Splign:2.1.0"
     exon            923..1066
                     /gene="Ddx23"
                     /inference="alignment:Splign:2.1.0"
     exon            1067..1292
                     /gene="Ddx23"
                     /inference="alignment:Splign:2.1.0"
     exon            1293..1438
                     /gene="Ddx23"
                     /inference="alignment:Splign:2.1.0"
     exon            1439..1616
                     /gene="Ddx23"
                     /inference="alignment:Splign:2.1.0"
     exon            1617..1859
                     /gene="Ddx23"
                     /inference="alignment:Splign:2.1.0"
     exon            1860..2011
                     /gene="Ddx23"
                     /inference="alignment:Splign:2.1.0"
     exon            2012..2120
                     /gene="Ddx23"
                     /inference="alignment:Splign:2.1.0"
     exon            2121..2295
                     /gene="Ddx23"
                     /inference="alignment:Splign:2.1.0"
     exon            2296..3075
                     /gene="Ddx23"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaaagatggc gactgttcgg cgacgttgag gccgcgttag gcggttcagg cgcggggtga
       61 tggcaggaga actggctgac aagaaggacc gagacgcatc acccaaggaa gaaaggaagc
      121 gatcgcggac tcctgaaaga gatcgcgata gagaccggga ccggaagtcc tccccatcta
      181 aagaccggaa gaggcatcgc tcacgggata ggcgtcgagg aggtagtcgt tctcgctctc
      241 ggtcccgttc caagtctaca gagagggaac gacggcacaa agaacgggaa cgagataaag
      301 aacgggatcg gagtaagaag gagcgggagc gggacaagga tggccaccgg cgggacaagg
      361 accgcaagag atccagcttg tctcctggtc gaggaaaaga tttcaagtct cggaaggaca
      421 gagattctaa gaagggtgac gaggatgagc atggtgacaa gaggcctaag atccagccac
      481 tgtccctgga ggaacttctg gccaagaaaa aggctgagga agaagctgaa gctaagccta
      541 aattcctctc caaagcagag cgagaggctg aagctctgaa gcggcggcag caggaggtgg
      601 aggagcgaca gaagatgctc gaagaagaga ggaagaagag gaaacagttc caggatttgg
      661 gcaggaagat gctggaagac cctcaggaaa gggaacggag ggaacgcagg gaaaggatgg
      721 agcgagagac caatggcaac gaggatgagg agggccggca gaagatccgg gaggagaagg
      781 acaagagcaa ggagctgcac gctattaagg agcgttacct gggtggcatc aaaaaacggc
      841 gccggacaag gcatctcaat gaccgcaagt ttgtgtttga gtgggatgcg tctgaagaca
      901 cctccattga ctacaacccc ctgtacaaag aacggcacca ggtgcagctg ttggggcggg
      961 gcttcattgc gggcattgac ctaaagcagc agaagcgaga acagtcacgt ttctatggag
     1021 acctaatgga aaagagacga accctggaag aaaaggagca ggaggaagca agactccgca
     1081 aacttcgtaa gaaggaagcc aagcaacgct gggatgatcg ccactggtcc cagaagaagt
     1141 tagatgagat gacagacagg gactggcgga tctttcggga agactatagc atcaccacca
     1201 aaggtggcaa gattcccaat cctattcggt cctggaaaga ttcgtctctg cccccacata
     1261 tcttggaagt cattgataag tgtggctaca aggagccaac acctatccag cgtcaggcca
     1321 ttcccattgg gcttcagaat cgtgacatca ttggcgtggc tgagactggc agtggcaaga
     1381 cagcagcctt cctcatccca ttactggtct ggatcaccac acttcccaaa attgacagga
     1441 tcgaagagtc cgaccagggc ccttatgcca tcatcctggc tcccacccgt gaattggctc
     1501 agcagatcga ggaagagacc atcaagttcg gaaagccact aggtatccgc actgtggctg
     1561 tcattggtgg catctccaga gaggaccaag gcttcaggct acgcatgggt tgtgagattg
     1621 tgatcgccac cccaggacgt ctgattgacg tgctggagaa ccgttacctg gtgctcagcc
     1681 gctgcaccta tgtggttctg gatgaggccg acaggatgat tgacatgggc ttcgagccag
     1741 atgtgcagaa gatcctggag cacatgcctg tcagcaacca gaagccggac acggacgagg
     1801 ccgaggaccc cgagaagatg ttagccaact ttgaatcagg aaaacacaag taccgtcaaa
     1861 cagtcatgtt cacggctacc atgcctccag cggtggagcg tctagccagg agctatcttc
     1921 ggcggcctgc tgtggtgtac attggctctg caggcaagcc ccatgagcgg gtggaacaga
     1981 aggtctttct catgtcggag tcagaaaaga ggaaaaagct gctggcaatc ctggaacaag
     2041 gttttgatcc acccatcatc atctttgtca accagaagaa gggttgcgac gtgttggcca
     2101 agtctctgga gaagatgggg tacaacgcct gtacactgca tggtggcaaa ggccaggagc
     2161 agcgagaatt cgcattgtcc aacctcaagg ctggagccaa ggatattctg gtggctacag
     2221 atgtggctgg tcgtggtatc gatatccaag acgtatctat ggttgtcaac tacgacatgg
     2281 ccaaaaacat tgaagattac attcaccgaa ttggccgcac aggaagagca ggcaagagtg
     2341 gtgtagccat caccttcctc accaaagagg actcagccgt gttctatgaa ctgaagcaag
     2401 ccatcctgga gagcccagtg tcctcttgcc ctccagagct ggcaaaccac ccagatgccc
     2461 agcacaagcc aggcaccatc cttaccaaga agcgcaggga agagaccatc tttgcctgac
     2521 acagcacctg agtggatttg aagccatgct ctgaaactgg tgcctgtcct aagccctcat
     2581 gacccctcca ggctcttgtc cttggctcat gggtcttagg aagcagccag agtccctggt
     2641 ttggagcctg tgaggtgggc tccaagggaa caggaagggc tgtaggaggc aggagcagca
     2701 cgctatgggg cagctgccta gcacgatctc cagcctgaac aaacacctgg tcacctggag
     2761 gggacttcct cagcacacct gtgtgactgt acagcagtag ttgccctgag tgacccaggg
     2821 gatctggcat catgaggatt gtggaccttg gactctgtca ctctgacaac tggtttccca
     2881 ttcggagttt aaagcaggtt gagcgccctt agaactgcgc agccctgtgc cacacaacct
     2941 ctgtgccacg ggtgctgtgc actctgggca tccctcctct ccccgcccct cggagtttaa
     3001 gtcagtaatt tgttttctat tctctgagaa gataagtttg tatgttctga gaataaatac
     3061 atgaatatta aagtgaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaa
//
