LOCUS       NM_001037201            4413 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus DExD-box helicase 21 (Ddx21), mRNA.
ACCESSION   NM_001037201 XM_228810
VERSION     NM_001037201.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4413)
  AUTHORS   Song,C., Hotz-Wagenblatt,A., Voit,R. and Grummt,I.
  TITLE     SIRT7 and the DEAD-box helicase DDX21 cooperate to resolve genomic
            R loops and safeguard genome stability
  JOURNAL   Genes Dev 31 (13), 1370-1381 (2017)
   PUBMED   28790157
REFERENCE   2  (bases 1 to 4413)
  AUTHORS   Treiber,T., Treiber,N., Plessmann,U., Harlander,S., Daiss,J.L.,
            Eichner,N., Lehmann,G., Schall,K., Urlaub,H. and Meister,G.
  TITLE     A Compendium of RNA-Binding Proteins that Regulate MicroRNA
            Biogenesis
  JOURNAL   Mol Cell 66 (2), 270-284 (2017)
   PUBMED   28431233
REFERENCE   3  (bases 1 to 4413)
  AUTHORS   Calo,E., Flynn,R.A., Martin,L., Spitale,R.C., Chang,H.Y. and
            Wysocka,J.
  TITLE     RNA helicase DDX21 coordinates transcription and ribosomal RNA
            processing
  JOURNAL   Nature 518 (7538), 249-253 (2015)
   PUBMED   25470060
REFERENCE   4  (bases 1 to 4413)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   5  (bases 1 to 4413)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   6  (bases 1 to 4413)
  AUTHORS   Zhang,Z., Kim,T., Bao,M., Facchinetti,V., Jung,S.Y., Ghaffari,A.A.,
            Qin,J., Cheng,G. and Liu,Y.J.
  TITLE     DDX1, DDX21, and DHX36 helicases form a complex with the adaptor
            molecule TRIF to sense dsRNA in dendritic cells
  JOURNAL   Immunity 34 (6), 866-878 (2011)
   PUBMED   21703541
REFERENCE   7  (bases 1 to 4413)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   8  (bases 1 to 4413)
  AUTHORS   Foster,L.J., Zeemann,P.A., Li,C., Mann,M., Jensen,O.N. and
            Kassem,M.
  TITLE     Differential expression profiling of membrane proteins by
            quantitative proteomics in a human mesenchymal stem cell line
            undergoing osteoblast differentiation
  JOURNAL   Stem Cells 23 (9), 1367-1377 (2005)
   PUBMED   16210410
REFERENCE   9  (bases 1 to 4413)
  AUTHORS   Valdez,B.C., Henning,D., Perumal,K. and Busch,H.
  TITLE     RNA-unwinding and RNA-folding activities of RNA helicase II/Gu--two
            activities in separate domains of the same protein
  JOURNAL   Eur J Biochem 250 (3), 800-807 (1997)
   PUBMED   9461305
REFERENCE   10 (bases 1 to 4413)
  AUTHORS   Sykes,D.E. and Weiser,M.M.
  TITLE     The identification of genes specifically expressed in epithelial
            cells of the rat intestinal crypts
  JOURNAL   Differentiation 50 (1), 41-46 (1992)
   PUBMED   1639225
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC105878.1.
            
            On Nov 18, 2005 this sequence version replaced XM_228810.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC105878.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..4413
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="20"
                     /map="20q11"
     gene            1..4413
                     /gene="Ddx21"
                     /gene_synonym="Ddx21a; Ddx21b"
                     /note="DExD-box helicase 21"
                     /db_xref="GeneID:317399"
                     /db_xref="RGD:1307306"
     exon            1..131
                     /gene="Ddx21"
                     /gene_synonym="Ddx21a; Ddx21b"
                     /inference="alignment:Splign:2.1.0"
     CDS             45..2393
                     /gene="Ddx21"
                     /gene_synonym="Ddx21a; Ddx21b"
                     /EC_number="3.6.4.13"
                     /note="RH II/Gu; gu-alpha; DEAD box protein 21; nucleolar
                     RNA helicase Gu; nucleolar RNA helicase II; DEAD
                     (Asp-Glu-Ala-Asp) box polypeptide 21; DEAD
                     (Asp-Glu-Ala-Asp) box polypeptide 21a; DEAD-box helicase
                     21; DEAD (Asp-Glu-Ala-Asp) box polypeptide 21b; DEAD
                     (Asp-Glu-Ala-Asp) box helicase 21"
                     /codon_start=1
                     /product="nucleolar RNA helicase 2"
                     /protein_id="NP_001032278.1"
                     /db_xref="GeneID:317399"
                     /db_xref="RGD:1307306"
                     /translation="MPGKLRSASKSESEGTEESMETLQKPSEKKTRKEKPKSKTDEAT
                     EGVEEAASSKVKAVKKKGPSEDDVGPPKSKKAKKQEEEPQDDPASKSKTSKKKKEPLE
                     KKAPSAKTKEMKAEEPSEEEADAPKPKKTKKGKEANGDVGEKSPGLKNGLSHPKPDSS
                     STQAPGEESETEKEIPVEQKEGAFSNFPISEETVKLLKARGVNFLFPIQAKTFHHVYS
                     GKDLIAQARTGTGKTFSFAIPLIEKLQGGLQERKRGRAPQVLVLAPTRELANQVSKDF
                     SDITKKLSVACFYGGTPYGGQIERMRSGIDILVGTPGRIKDHLQNGKLDLTKLKHVVL
                     DEVDQMLDMGFADQVEEILCVAYKKDSEDNPQTLLFSATCPHWVFNVAKKYMKSTYEQ
                     VDLIGKKTQKAAITVEHLAIKCHWTERAAVIGDVIRVYSGHQGRTIIFCETKKDAQEL
                     SQNTCIKQDAQSLHGDIPQKQREITLKGFRNGNFGVLVATNVAARGLDIPEVDLVVQS
                     CPPKDVESYIHRSGRTGRAGRTGVCICFYQHKEEYQLAQVEQKAGIKFKRIGVPSATE
                     IIKASSKDAIRLLDSVPPTAIGHFKQSAEKLIEEKGAVEALAAALAHISGATSVDQRS
                     LINSQAGFVTMILRCSVEMPNISYAWKELKEQLGESIDAKVKGMVFLKGKLGVCFDVR
                     TEAVTEIKEKWHDSRRWQLTVATEQPELEGPPEGYRGGRGQRDGSRGSFRGQRGGSRN
                     FRGQGQRGGSRNFRGQRPGGGNKSNRSPNKGQKRSFSKAFGQ"
     exon            132..563
                     /gene="Ddx21"
                     /gene_synonym="Ddx21a; Ddx21b"
                     /inference="alignment:Splign:2.1.0"
     exon            564..639
                     /gene="Ddx21"
                     /gene_synonym="Ddx21a; Ddx21b"
                     /inference="alignment:Splign:2.1.0"
     exon            640..818
                     /gene="Ddx21"
                     /gene_synonym="Ddx21a; Ddx21b"
                     /inference="alignment:Splign:2.1.0"
     exon            819..936
                     /gene="Ddx21"
                     /gene_synonym="Ddx21a; Ddx21b"
                     /inference="alignment:Splign:2.1.0"
     exon            937..1122
                     /gene="Ddx21"
                     /gene_synonym="Ddx21a; Ddx21b"
                     /inference="alignment:Splign:2.1.0"
     exon            1123..1268
                     /gene="Ddx21"
                     /gene_synonym="Ddx21a; Ddx21b"
                     /inference="alignment:Splign:2.1.0"
     exon            1269..1418
                     /gene="Ddx21"
                     /gene_synonym="Ddx21a; Ddx21b"
                     /inference="alignment:Splign:2.1.0"
     exon            1419..1580
                     /gene="Ddx21"
                     /gene_synonym="Ddx21a; Ddx21b"
                     /inference="alignment:Splign:2.1.0"
     exon            1581..1700
                     /gene="Ddx21"
                     /gene_synonym="Ddx21a; Ddx21b"
                     /inference="alignment:Splign:2.1.0"
     exon            1701..1774
                     /gene="Ddx21"
                     /gene_synonym="Ddx21a; Ddx21b"
                     /inference="alignment:Splign:2.1.0"
     exon            1775..1934
                     /gene="Ddx21"
                     /gene_synonym="Ddx21a; Ddx21b"
                     /inference="alignment:Splign:2.1.0"
     exon            1935..2069
                     /gene="Ddx21"
                     /gene_synonym="Ddx21a; Ddx21b"
                     /inference="alignment:Splign:2.1.0"
     exon            2070..2114
                     /gene="Ddx21"
                     /gene_synonym="Ddx21a; Ddx21b"
                     /inference="alignment:Splign:2.1.0"
     exon            2115..4381
                     /gene="Ddx21"
                     /gene_synonym="Ddx21a; Ddx21b"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgcggttgtg gaagccggta ggcctgagct gctcctgctg aataatgccg ggaaaactcc
       61 gcagtgcgtc caagtcggag tcagaaggga ccgaggagag tatggagacg ctgcagaagc
      121 caagcgagaa gaaaactaga aaagagaagc caaaatctaa gactgacgag gcaacagaag
      181 gagtggaaga ggccgcttcc tccaaagtga aagcagttaa aaagaaaggg ccttctgagg
      241 atgatgtggg tccccctaaa tccaagaagg ccaagaagca ggaggaggag cctcaagatg
      301 accctgcttc taaaagcaaa acctccaaga agaaaaagga gcccctagag aagaaagcac
      361 cctctgctaa aaccaaagaa atgaaagccg aggagccttc tgaggaagag gcagacgctc
      421 ctaagcccaa aaagacaaag aaagggaagg aagcaaacgg agatgtggga gagaagagcc
      481 ccgggctgaa gaatgggctc tcccatccca agccagactc cagctccacc caagctcccg
      541 gagaggaaag cgagacagaa aaggaaatac ccgtggagca gaaagaagga gccttctcta
      601 attttcccat atcagaagag actgtcaaac ttctcaaagc tcgtggggtg aacttcctct
      661 tccctataca agccaagaca ttccaccatg tgtacagtgg gaaggactta atcgcccagg
      721 cacgcacagg aaccgggaag accttctcct ttgccatccc tttgattgag aaacttcaag
      781 gtgggctgca agagaggaag agaggccgag cccctcaggt gctagtcctt gcacctacaa
      841 gagaattagc aaatcaagtg agcaaagact tcagtgacat caccaaaaag ctctcagtag
      901 cctgttttta tggtggaact ccctatggtg gtcaaatcga acgaatgcgg agtgggattg
      961 acatcctggt cgggacccca ggtcgtatta aagaccactt gcagaatggc aagctagacc
     1021 tcaccaaact taaacatgtt gtcctggatg aagttgatca gatgttggat atgggctttg
     1081 ctgatcaagt ggaagaaatt ttatgtgtgg catacaagaa agattctgaa gacaaccccc
     1141 aaacattgct tttctctgca acttgccctc attgggtatt taatgttgct aagaaataca
     1201 tgaaatctac atacgaacag gtggacctga ttggtaaaaa gactcagaaa gcagccataa
     1261 ctgtggagca cctggcgatt aagtgtcact ggacagagag ggcagcggtg attggggatg
     1321 tgatccgagt gtacagtggt caccaagggc gtacaatcat cttctgcgaa accaagaagg
     1381 atgcacagga gctgtcgcag aacacgtgca taaagcagga tgcccagtcc ttacatggcg
     1441 acattccaca gaagcaaagg gaaatcaccc tgaaaggttt ccgaaatggc aattttggag
     1501 ttttggtggc aaccaatgtt gctgcccgtg ggttagacat ccctgaggtt gacctggttg
     1561 ttcagagctg tccaccaaag gatgtggagt cttacattca tcgttcgggg cggacaggca
     1621 gagctggaag aacaggggtt tgcatctgct tttatcagca caaagaagag taccagttag
     1681 cacaagtgga acagaaagcg ggaattaaat ttaaacggat aggtgttcct tctgcaacag
     1741 aaataataaa agcctccagc aaagacgcaa tcaggctctt ggattctgtg cctcccactg
     1801 ctattggcca tttcaagcag tcggctgaga agctgatcga ggagaaggga gctgtagagg
     1861 ccctggccgc agctctggcc cacatctcgg gggccacatc ggtggaccag cgctccctaa
     1921 tcaactcaca agcgggcttt gtgaccatga tcctgcggtg ttctgttgag atgcccaaca
     1981 ttagttatgc ctggaaagaa cttaaggagc agctgggtga gagcatcgat gccaaagtga
     2041 aggggatggt cttcctcaaa ggaaaactgg gagtttgttt tgatgtccgc actgaagcag
     2101 tcacagaaat aaaggagaag tggcacgatt cgagacgctg gcagctcact gtggccaccg
     2161 agcagccgga gctggaagga cccccagaag gataccgagg cggcaggggc cagcgggatg
     2221 gcagccgtgg ctctttcaga ggacagcggg gtggaagcag gaacttccgg ggacagggac
     2281 agcgaggagg aagtagaaac ttcagaggac agcgaccagg aggtggcaac aaaagtaaca
     2341 ggtccccaaa caaaggccag aagcggagtt ttagtaaagc atttggtcag tgagtagagg
     2401 ccagaggaac ttgttcccac cccactgtgg acctcagagc ccgtcctgct gtcaaagccc
     2461 ccagtgcttc ctttttgatc aattctcagc ccatttcttg cagagacagg cttctgagct
     2521 gtccaactac ccatcctaaa ctctgcattt ggggaaggga tgggaatgca ttgcttcatt
     2581 tttcaacata cttcctagat ttacaaagta aaaccagcct ccgatctgcc tatctctgtg
     2641 ttctgtgtgt gcgcactggg gcctaagctc agaccctcgc acatgccctc cctacaactg
     2701 tttctctggt cccctgtaca tgtttcctac tcatcctaca aacaaagttt cccaggggtg
     2761 cctcagtctc tgggggaccg tgcgagccag ggtggataat ttttgcattc cttggcctct
     2821 tgttcccctc acaaacagtt gctgtgttta tgtctggcaa ggtttgacct gagcagtgct
     2881 tcgcagaagc catctcagac ttagctgata gaacagtttg tagccgctct agagcgcagg
     2941 cagcatgggt tcactctgtg gtgtcctcac tactgtttct tactgggtga cttgtgttcc
     3001 cgtgagttct ccagacagtg tatattggag tacattttca taggagccat gtctaaagtt
     3061 caggcccagt gtgtagactt tttcttagtt aatgagactg gataaatggc gtgtaattgc
     3121 ttctacccca cgtttggaag attgatttac caaggagtca tacagggagg gtggggctca
     3181 gttggtgttg ctgaggaagg cttcaaaaaa gccacaaaga tgtctttcat cttgacaagt
     3241 aaagaggtgg aaaagcatgc tttgagtggc gagcacttcc tgaggtgggg ctcccgaagg
     3301 gacagcacct actagtgtga gatcttttaa agggcacagt gagactagtt tgatctattg
     3361 taagatctgt tcctgacgag ctgcttctct ggctcagaga atccggctgt gacaagctat
     3421 gtcattttaa gttgttgctt tgagggaacg gaagcgtggc ccctgcctac tgctcagtgt
     3481 tcttcatctg ggaaactccc acctagcaca gaagctggag tggtggggtc ctctagccct
     3541 actagagtct gtacaggagt cctagaatag acctggaagg aaagtcagaa ccacatgctc
     3601 tggtttttgt tttataaact cagttgtttg ggtcagctaa gaccttcatt ttagttagta
     3661 cagtccttac ctcccagcct taccagaaca gcatcaaagg gctctgatac ccaatcagct
     3721 gctgtcactg aagcagtgcc cttttttcta tttaagttca gtttccccct tgaactctga
     3781 ccagatggct catcctctct gccagggatt ctttggggtt tttttctttg ttgacgactc
     3841 tctggcttgt aataaatatg ggcatgattt aatgaaacat ttcactattg ggtaagaatt
     3901 cgccatttca agatggtaga aggacatgct ggctctactt ccaagaggac agcctaaaac
     3961 taaaaccttt tgaattttga attaatgggt taccctatag aaaaaatgat ctgcggaaaa
     4021 ccaaacagtg aagggaaaga aggaaagaat ttcaattgac acaatttaaa taaaatatgg
     4081 cttttcaaat aaaggaagag aagtttcttt tgggtcacac aatctaaaca atatttatgt
     4141 ataattcagc tcttatttgg cttaaatggg cttagtggga aatgttatca tttttactat
     4201 tttctacaga gaaaatattt tccagtttat caagtaactc tggactttgg aattacctgt
     4261 ttttatgttc cagctgtcta tatagttgtt tctctgaaat tgtacataaa atgtttttac
     4321 attaaaatga attactgtat aaagtactgc attatgccat aataaagata ctaatgcttt
     4381 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaa
//
