LOCUS       NM_001006996            2181 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus DEAD-box helicase 18 (Ddx18), mRNA.
ACCESSION   NM_001006996 XM_218475
VERSION     NM_001006996.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2181)
  AUTHORS   Martin,R., Straub,A.U., Doebele,C. and Bohnsack,M.T.
  TITLE     DExD/H-box RNA helicases in ribosome biogenesis
  JOURNAL   RNA Biol 10 (1), 4-18 (2013)
   PUBMED   22922795
  REMARK    Review article
REFERENCE   2  (bases 1 to 2181)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   3  (bases 1 to 2181)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   4  (bases 1 to 2181)
  AUTHORS   Ohta,S., Bukowski-Wills,J.C., Sanchez-Pulido,L., Alves Fde,L.,
            Wood,L., Chen,Z.A., Platani,M., Fischer,L., Hudson,D.F.,
            Ponting,C.P., Fukagawa,T., Earnshaw,W.C. and Rappsilber,J.
  TITLE     The protein composition of mitotic chromosomes determined using
            multiclassifier combinatorial proteomics
  JOURNAL   Cell 142 (5), 810-821 (2010)
   PUBMED   20813266
REFERENCE   5  (bases 1 to 2181)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   6  (bases 1 to 2181)
  AUTHORS   Sekiguchi,T., Hayano,T., Yanagida,M., Takahashi,N. and Nishimoto,T.
  TITLE     NOP132 is required for proper nucleolus localization of DEAD-box
            RNA helicase DDX47
  JOURNAL   Nucleic Acids Res 34 (16), 4593-4608 (2006)
   PUBMED   16963496
REFERENCE   7  (bases 1 to 2181)
  AUTHORS   Grandori,C., Mac,J., Siebelt,F., Ayer,D.E. and Eisenman,R.N.
  TITLE     Myc-Max heterodimers activate a DEAD box gene and interact with
            multiple E box-related sites in vivo
  JOURNAL   EMBO J 15 (16), 4344-4357 (1996)
   PUBMED   8861962
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC083919.1.
            
            On Nov 22, 2004 this sequence version replaced XM_218475.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC083919.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2181
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13q11"
     gene            1..2181
                     /gene="Ddx18"
                     /gene_synonym="MrDb"
                     /note="DEAD-box helicase 18"
                     /db_xref="GeneID:308490"
                     /db_xref="RGD:1549712"
     exon            1..118
                     /gene="Ddx18"
                     /gene_synonym="MrDb"
                     /inference="alignment:Splign:2.1.0"
     CDS             34..2058
                     /gene="Ddx18"
                     /gene_synonym="MrDb"
                     /EC_number="3.6.4.13"
                     /note="DEAD (Asp-Glu-Ala-Asp) box polypeptide 18;
                     Myc-regulated DEAD box protein"
                     /codon_start=1
                     /product="ATP-dependent RNA helicase DDX18"
                     /protein_id="NP_001006997.1"
                     /db_xref="GeneID:308490"
                     /db_xref="RGD:1549712"
                     /translation="MSQLQMKLLRKKIEKRNAKLRQRNLKLQEASDRSLSQPENGDVP
                     EELGKGGKAKKALKHSVTAGSAEAQSRGVPEETVENAKVKKSPQKLTILTNGEAAAMP
                     STDPELKKKKKKKRKIGNDTEPDPKKAKTEEGTEAREEPEGAGEEPEGAGEEPEDGVK
                     EADDSEVPSLPLGVTGAFEDTSFASLSNLVNENTLKAIEEMGFKHMTEIQHKSIRPLL
                     EGRDLLAAAKTGSGKTLAFLIPVIELIVKLKFMPRNGTGVLILSPTRELAMQTFGVLK
                     ELMTHHVHTYGLIMGGSNRSAEVQKLLNGINIVVATPGRLLDHMQNTPGFMYKNLQCL
                     VIDEADRILDVGFEEELKQIIKLLPARRQTMLFSATQTRKVEDLARISLKKEPLYVGV
                     DDDKEVATVDGLEQGYVVCPSEKRFLLLFTFLKKNRKKKVMVFFSSCMSVKYHYELLN
                     YIDLPVLAIHGKQKQNKRTTTFFQFCNADSGILLCTDVAARGLDIPEVDWIVQYDPPD
                     DPKEYIHRVGRTARGLNGRGHALLILRPEELGFLRYLKQSKVPLNQFDFSWSKVSDIQ
                     SQLEKLIEKNYFLHKSAQEAYKSYIRAYDSHSLKQIFNVNNLNLPQVALSFGFKVPPF
                     VDLNVSSHDGKLKKRGGGGGFGYQKTKKVEKSKIFKHISKKPADRRQFSH"
     exon            119..406
                     /gene="Ddx18"
                     /gene_synonym="MrDb"
                     /inference="alignment:Splign:2.1.0"
     exon            407..559
                     /gene="Ddx18"
                     /gene_synonym="MrDb"
                     /inference="alignment:Splign:2.1.0"
     exon            560..695
                     /gene="Ddx18"
                     /gene_synonym="MrDb"
                     /inference="alignment:Splign:2.1.0"
     exon            696..796
                     /gene="Ddx18"
                     /gene_synonym="MrDb"
                     /inference="alignment:Splign:2.1.0"
     exon            797..1111
                     /gene="Ddx18"
                     /gene_synonym="MrDb"
                     /inference="alignment:Splign:2.1.0"
     exon            1112..1251
                     /gene="Ddx18"
                     /gene_synonym="MrDb"
                     /inference="alignment:Splign:2.1.0"
     exon            1252..1413
                     /gene="Ddx18"
                     /gene_synonym="MrDb"
                     /inference="alignment:Splign:2.1.0"
     exon            1414..1566
                     /gene="Ddx18"
                     /gene_synonym="MrDb"
                     /inference="alignment:Splign:2.1.0"
     exon            1567..1680
                     /gene="Ddx18"
                     /gene_synonym="MrDb"
                     /inference="alignment:Splign:2.1.0"
     exon            1681..1737
                     /gene="Ddx18"
                     /gene_synonym="MrDb"
                     /inference="alignment:Splign:2.1.0"
     exon            1738..1915
                     /gene="Ddx18"
                     /gene_synonym="MrDb"
                     /inference="alignment:Splign:2.1.0"
     exon            1916..2151
                     /gene="Ddx18"
                     /gene_synonym="MrDb"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgctcggtgc agacggctgg gcaacccggc aacatgtcgc agttacagat gaaactcctg
       61 cgcaagaaga tcgaaaagcg gaacgccaag ctgcggcaac ggaacctgaa gctgcaagaa
      121 gcatcagaca ggagcctgtc acagcctgaa aatggagatg tgcctgaaga actaggaaaa
      181 ggtggaaaag ctaaaaaggc cctgaagcat tctgtgactg caggctcagc agaagcacaa
      241 agtagaggcg tgcccgagga gactgtggaa aatgccaaag ttaaaaagtc accccaaaaa
      301 cttaccattt taaccaatgg agaagcagca gcaatgccat ctacagatcc agaactaaag
      361 aagaaaaaga agaagaagag gaaaattgga aatgacactg agcctgatcc caaaaaagca
      421 aaaactgaag aaggcacgga ggctcgtgag gaaccagaag gggctggtga ggaaccagaa
      481 ggggctggtg aggaaccaga agatggtgtg aaggaggcag atgacagtga ggtgcccagt
      541 ctgccgttgg gagtgacagg tgctttcgag gacacttcgt ttgcttcctt gtctaatctc
      601 gtcaatgaga acaccctgaa ggccatagaa gaaatgggct tcaagcacat gacagagatc
      661 cagcataaaa gtatcaggcc acttctggaa ggcagggatc ttctggcggc tgcgaaaacc
      721 ggcagcggca agacccttgc tttcctcatc cctgtgatcg agctcattgt caaattgaag
      781 ttcatgccca ggaatggaac aggagtcctg attctctctc ctaccagaga actggccatg
      841 cagacctttg gtgtgcttaa ggaactgatg acacaccacg ttcacacgta cgggctgatc
      901 atgggtggca gtaacaggtc tgctgaggta cagaagcttc tcaatgggat caacatcgtc
      961 gtggccaccc caggccggct cctagaccac atgcagaaca caccagggtt tatgtacaag
     1021 aacctgcagt gtctggttat cgatgaggcc gaccgtatct tggatgttgg gtttgaagaa
     1081 gaattaaagc agatcattaa acttttgcca gcacgtaggc aaaccatgct cttctctgcc
     1141 acacaaactc gaaaagttga agacttggca agaatttccc tgaaaaaaga gccattgtac
     1201 gtgggtgttg acgacgacaa agaggttgcc acagtggatg gccttgagca ggggtatgtt
     1261 gtctgtccct ctgagaagag gttccttctg cttttcacat tccttaagaa gaaccggaag
     1321 aagaaagtga tggtcttctt ttcctcctgt atgtctgtga aataccacta tgagctgctg
     1381 aactacattg acctgcctgt cttagccatc catggaaagc aaaagcaaaa taagcgaaca
     1441 accacgttct tccaattctg caacgcagat tcgggaatac tgctgtgcac tgatgtggcg
     1501 gccagagggc tggacatccc tgaagtggac tggattgttc agtacgatcc tcccgatgac
     1561 cccaaggagt acattcatcg ggtcggcaga acagcccgag gcctgaatgg aagagggcac
     1621 gccctgctca tcttgcgccc tgaagagctg ggtttccttc ggtacttgaa acaatccaag
     1681 gttccgttga atcagtttga cttctcctgg tctaaggttt ctgatattca gtctcagctg
     1741 gaaaaactga tcgaaaagaa ctactttctg cacaagtctg cccaggaagc gtacaagtcc
     1801 tacatacggg catatgactc ccactctctc aagcagatct tcaatgtcaa caacttaaat
     1861 ttgcctcaag ttgctctgtc ttttggtttt aaggtccctc cttttgttga tctgaatgtg
     1921 agcagccacg acggcaagct taaaaagaga ggtggtggtg ggggattcgg ctaccagaaa
     1981 acaaagaaag tggagaagtc caagatcttt aaacacatca gtaagaagcc agcagaccgc
     2041 aggcagttct ctcactgagg cgatctgcct tctgcctgga ctgactttgc ccaacttcct
     2101 cctcctccac ccctgctccc cagtactctt taaaaaggaa cgtttatcac aaaaaaaaaa
     2161 aaaaaaaaaa aaaaaaaaaa a
//
