LOCUS       NM_001372136            3088 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus DEAD-box helicase 17 (Ddx17), transcript variant
            1, mRNA.
ACCESSION   NM_001372136
VERSION     NM_001372136.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3088)
  AUTHORS   Hitachi,K., Nakatani,M., Takasaki,A., Ouchi,Y., Uezumi,A.,
            Ageta,H., Inagaki,H., Kurahashi,H. and Tsuchida,K.
  TITLE     Myogenin promoter-associated lncRNA Myoparr is essential for
            myogenic differentiation
  JOURNAL   EMBO Rep 20 (3) (2019)
   PUBMED   30622218
REFERENCE   2  (bases 1 to 3088)
  AUTHORS   Connerty,P., Bajan,S., Remenyi,J., Fuller-Pace,F.V. and
            Hutvagner,G.
  TITLE     The miRNA biogenesis factors, p72/DDX17 and KHSRP regulate the
            protein level of Ago2 in human cells
  JOURNAL   Biochim Biophys Acta 1859 (10), 1299-1305 (2016)
   PUBMED   27478153
REFERENCE   3  (bases 1 to 3088)
  AUTHORS   Dardenne,E., Polay Espinoza,M., Fattet,L., Germann,S.,
            Lambert,M.P., Neil,H., Zonta,E., Mortada,H., Gratadou,L.,
            Deygas,M., Chakrama,F.Z., Samaan,S., Desmet,F.O., Tranchevent,L.C.,
            Dutertre,M., Rimokh,R., Bourgeois,C.F. and Auboeuf,D.
  TITLE     RNA helicases DDX5 and DDX17 dynamically orchestrate transcription,
            miRNA, and splicing programs in cell differentiation
  JOURNAL   Cell Rep 7 (6), 1900-1913 (2014)
   PUBMED   24910439
REFERENCE   4  (bases 1 to 3088)
  AUTHORS   Samaan,S., Tranchevent,L.C., Dardenne,E., Polay Espinoza,M.,
            Zonta,E., Germann,S., Gratadou,L., Dutertre,M. and Auboeuf,D.
  TITLE     The Ddx5 and Ddx17 RNA helicases are cornerstones in the complex
            regulatory array of steroid hormone-signaling pathways
  JOURNAL   Nucleic Acids Res 42 (4), 2197-2207 (2014)
   PUBMED   24275493
REFERENCE   5  (bases 1 to 3088)
  AUTHORS   Dardenne,E., Pierredon,S., Driouch,K., Gratadou,L.,
            Lacroix-Triki,M., Espinoza,M.P., Zonta,E., Germann,S., Mortada,H.,
            Villemin,J.P., Dutertre,M., Lidereau,R., Vagner,S. and Auboeuf,D.
  TITLE     Splicing switch of an epigenetic regulator by RNA helicases
            promotes tumor-cell invasiveness
  JOURNAL   Nat Struct Mol Biol 19 (11), 1139-1146 (2012)
   PUBMED   23022728
REFERENCE   6  (bases 1 to 3088)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   7  (bases 1 to 3088)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   8  (bases 1 to 3088)
  AUTHORS   Shin,S. and Janknecht,R.
  TITLE     Concerted activation of the Mdm2 promoter by p72 RNA helicase and
            the coactivators p300 and P/CAF
  JOURNAL   J Cell Biochem 101 (5), 1252-1265 (2007)
   PUBMED   17226766
REFERENCE   9  (bases 1 to 3088)
  AUTHORS   Caretti,G., Schiltz,R.L., Dilworth,F.J., Di Padova,M., Zhao,P.,
            Ogryzko,V., Fuller-Pace,F.V., Hoffman,E.P., Tapscott,S.J. and
            Sartorelli,V.
  TITLE     The RNA helicases p68/p72 and the noncoding RNA SRA are
            coregulators of MyoD and skeletal muscle differentiation
  JOURNAL   Dev Cell 11 (4), 547-560 (2006)
   PUBMED   17011493
REFERENCE   10 (bases 1 to 3088)
  AUTHORS   Florea,L., Di Francesco,V., Miller,J., Turner,R., Yao,A.,
            Harris,M., Walenz,B., Mobarry,C., Merkulov,G.V., Charlab,R.,
            Dew,I., Deng,Z., Istrail,S., Li,P. and Sutton,G.
  TITLE     Gene and alternative splicing annotation with AIR
  JOURNAL   Genome Res 15 (1), 54-66 (2005)
   PUBMED   15632090
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000007.1 and FQ236955.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments. This variant is based on
            transcript alignments from orthologous data.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643292.30764.1,
                                           SRR26643297.26331.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-528               JAXUCZ010000007.1  112989220-112989747 c
            529-679             JAXUCZ010000007.1  112986219-112986369 c
            680-779             JAXUCZ010000007.1  112984822-112984921 c
            780-913             JAXUCZ010000007.1  112983260-112983393 c
            914-979             JAXUCZ010000007.1  112982645-112982710 c
            980-1121            JAXUCZ010000007.1  112981579-112981720 c
            1122-1282           JAXUCZ010000007.1  112981087-112981247 c
            1283-1455           JAXUCZ010000007.1  112980828-112981000 c
            1456-1566           JAXUCZ010000007.1  112979704-112979814 c
            1567-1628           JAXUCZ010000007.1  112979200-112979261 c
            1629-1688           JAXUCZ010000007.1  112978128-112978187 c
            1689-1931           JAXUCZ010000007.1  112973889-112974131 c
            1932-3066           JAXUCZ010000007.1  112971523-112972657 c
            3067-3088           FQ236955.1         1-22                c
FEATURES             Location/Qualifiers
     source          1..3088
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q34"
     gene            1..3088
                     /gene="Ddx17"
                     /note="DEAD-box helicase 17"
                     /db_xref="GeneID:315133"
                     /db_xref="RGD:1304945"
     exon            1..528
                     /gene="Ddx17"
                     /inference="alignment:Splign:2.1.0"
     CDS             479..2437
                     /gene="Ddx17"
                     /EC_number="3.6.4.13"
                     /note="isoform 1 is encoded by transcript variant 1; DEAD
                     (Asp-Glu-Ala-Asp) box polypeptide 17; probable
                     ATP-dependent RNA helicase DDX17; DEAD (Asp-Glu-Ala-Asp)
                     box helicase 17"
                     /codon_start=1
                     /product="probable ATP-dependent RNA helicase DDX17
                     isoform 1"
                     /protein_id="NP_001359065.1"
                     /db_xref="GeneID:315133"
                     /db_xref="RGD:1304945"
                     /translation="MRGGGFGDRDRDRDRGGFGARGGSGLPPKKFGNPGERLRKKKWD
                     LSELPKFEKNFYVEHPEVARLTPYEVDELRRKKEITVRGGDVCPKPVFAFHHANFPQY
                     VMDVLMDQHFTEPTPIQCQGFPLALSGRDMVGIAQTGSGKTLAYLLPAIVHINHQPYL
                     ERGDGPICLVLAPTRELAQQVQQVADDYGKCSRLKSTCIYGGAPKGPQIRDLERGVEI
                     CIATPGRLIDFLESGKTNLRRCTYLVLDEADRMLDMGFEPQIRKIVDQIRPDRQTLMW
                     SATWPKEVRQLAEDFLRDYTQINVGNLELSANHNILQIVDVCMESEKDHKLIQLMEEI
                     MAEKENKTIIFVETKRRCDDLTRRMRRDGWPAMCIHGDKSQPERDWVLNEFRSGKAPI
                     LIATDVASRGLDVEDVKFVINYDYPNSSEDYVHRIGRTARSTNKGTAYTFFTPGNLKQ
                     ARELIKVLEEANQAINPKLMQLVDHRGGGGGGGKGGRSRYRTTSSANNPNLMYQDECD
                     RRLRGVKDGGRRDSTSYRDRSETDRASYANGSGYGSPNSAFGAQAGQYTYAQGTYGAA
                     AYGTSGYTAQEYAAGTYGASSTTSTGRSSQSSSQQFSGIGRSGQQPQPLMSQQFAQPP
                     GATNMIGYMGQTAYQYPPPPPPPPPSRK"
     exon            529..679
                     /gene="Ddx17"
                     /inference="alignment:Splign:2.1.0"
     exon            680..779
                     /gene="Ddx17"
                     /inference="alignment:Splign:2.1.0"
     exon            780..913
                     /gene="Ddx17"
                     /inference="alignment:Splign:2.1.0"
     exon            914..979
                     /gene="Ddx17"
                     /inference="alignment:Splign:2.1.0"
     exon            980..1121
                     /gene="Ddx17"
                     /inference="alignment:Splign:2.1.0"
     exon            1122..1282
                     /gene="Ddx17"
                     /inference="alignment:Splign:2.1.0"
     exon            1283..1455
                     /gene="Ddx17"
                     /inference="alignment:Splign:2.1.0"
     exon            1456..1566
                     /gene="Ddx17"
                     /inference="alignment:Splign:2.1.0"
     exon            1567..1628
                     /gene="Ddx17"
                     /inference="alignment:Splign:2.1.0"
     exon            1629..1688
                     /gene="Ddx17"
                     /inference="alignment:Splign:2.1.0"
     exon            1689..1931
                     /gene="Ddx17"
                     /inference="alignment:Splign:2.1.0"
     exon            1932..3067
                     /gene="Ddx17"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tgcgcacact gccttattta ggtggaccaa caagagcact catctccgtc accggcgtaa
       61 agccattcct agaatgtctg tagcatcgcg cgcagccctc caggcgctgt ttacgtagcg
      121 tctcggctgt gcgtagcgtt aagttggagc agtctcagcg gccgccgcca ttttgtgcag
      181 ttgctgggaa gggaaggaga cgcctaaacc gtggcaccgc ccggtttgag cgtgaccaga
      241 cctcccaact gtactaacaa ccccgattct ctgagttttg ctcccgtctc cgacgagaga
      301 ggcggcgacg gtggcgtctg cgacgggaga cagcgcgtcg gagcgagaca gcgccgcgcc
      361 tgccgccgcc ccaacagcgg aggcgccgcc gccatcggtc atcactagac cagagcagca
      421 agccctcccg agctcggtca tccgtgcccc actcccagat ctttatccgt ttgggaccat
      481 gcgcggaggc ggctttgggg atcgggatcg tgaccgggac cgtggagggt ttggagcaag
      541 aggtggtagt gggcttcccc cgaagaagtt tggtaatcct ggggagcggt tacgaaaaaa
      601 gaagtgggat ttgagtgaac tccccaagtt tgagaagaat ttttatgtcg aacatccaga
      661 agtagcaaga ctgactccgt atgaggttga tgagctacgt cgaaagaagg agattacagt
      721 gagaggggga gatgtttgtc caaaaccggt ctttgccttc catcatgcaa actttccgca
      781 atatgtaatg gatgtgctga tggatcagca ctttacagaa ccaactccca ttcagtgcca
      841 gggatttcct ttggctctta gcggcaggga tatggttggc attgcacaga ctggctctgg
      901 aaagacattg gcgtatttgc tgcctgcgat tgttcatata aaccaccagc catacttgga
      961 aagaggagat ggcccaattt gtctggtgct ggctcctacc agagagcttg cccagcaggt
     1021 gcagcaggtg gccgatgact atgggaaatg ctctcggttg aagagtacgt gcatttatgg
     1081 aggtgctcct aaaggccccc agattcgaga cttggaaaga ggtgttgaga tttgcatagc
     1141 cactcctggg cgcctaatag atttcctgga gtcaggaaag acaaaccttc gccgatgtac
     1201 ttaccttgtg ttggatgagg ctgaccggat gcttgatatg ggctttgagc cccagatccg
     1261 taaaattgtt gatcaaatca ggcctgaccg gcagacacta atgtggagtg caacctggcc
     1321 aaaggaagta aggcagcttg cagaggattt cctgcgtgac tacactcaga tcaacgtggg
     1381 caatctggag ctgagtgcca accacaacat cctacagatc gtggatgtct gtatggagag
     1441 tgaaaaagat cacaaattga tccagctaat ggaagagatc atggcagaaa aggaaaataa
     1501 gactataata tttgtggaga caaagaggcg ctgtgatgac ctcactcgaa ggatgcgcag
     1561 agatggttgg ccagctatgt gtatccatgg agacaagagt caaccagaaa gagattgggt
     1621 acttaatgag ttccggtctg gaaaggcccc tatcctcatt gccacagatg tagcctcccg
     1681 tgggctagac gtggaggatg tgaagtttgt catcaactac gattatccaa acagctcaga
     1741 ggattatgtt caccgtattg gccgaacggc ccgcagcacc aacaagggca ctgcctatac
     1801 tttctttacc ccgggcaacc tgaagcaggc tagagagctg atcaaagtat tggaagaggc
     1861 caatcaggcc atcaatccaa agttgatgca gcttgtggac cacagaggtg gcggcggagg
     1921 agggggtaag ggaggccgct cacgataccg gactacttct tcagccaaca atcccaacct
     1981 gatgtatcag gatgagtgtg accggaggct tcgaggggtc aaggatggtg gtcggagaga
     2041 ttctacaagc tacagggatc gcagtgaaac cgatagagcc agttatgcta atggcagtgg
     2101 ctatggaagc ccgaattctg cctttggggc gcaagcaggc caatacacct atgctcaagg
     2161 cacctatggg gcagctgctt atggcaccag tggctacaca gcccaggagt atgctgctgg
     2221 cacttacggg gctagcagca ccacctcaac cggaaggagc tcccagagct ctagccagca
     2281 gtttagtgga ataggccgat ctgggcagca gccacagcca ctaatgtcac agcagtttgc
     2341 acagcctcca ggagctacca atatgatagg ctacatgggg cagactgctt accagtaccc
     2401 tcccccaccc cctccccctc cgccatctcg taaatgaaac tgcttggcgg gagtgactcg
     2461 tgcagatgaa ttacatctaa aggaacactg tcttttaccc ttctagacct ttgcgttttt
     2521 ttagtttttc ttttccctac cattatggtt tatctttttt taatgcagat agttaaaagt
     2581 tcactgccag gtttcttctg cccacccaaa agatccagtc tataataaca gattttgtaa
     2641 gaaaatatat atatacataa ctgactggaa aagattaatt tctttccccc aacttaatgc
     2701 atgttgagga tgtggagctg tttttcaccg taaaggtatt aggcttttgt tggagcctgt
     2761 ttatctctgg agggtgggta gggaaggact gactgctcgg caggaggtgc tgtctgctct
     2821 ttagactgct ctccttatct ggaggggcca gagggtttcc atgcacactg cccatggtgg
     2881 gttttgagtt actgatgtta ggctactcag gcctgatgaa tttttaagac tgcttttttc
     2941 agtcatttgg ctgatggctt cttaatgtgc attcaacagt taaaagtttc ctaattggtt
     3001 ttgttgtccc accccctttt cctgcagtta ttaaatatta accaggttag tgttgagtta
     3061 gaaattaaaa aaaaaaaaaa aaaaaaaa
//
