LOCUS       NM_053414               2487 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus DEAD-box helicase 1 (Ddx1), mRNA.
ACCESSION   NM_053414 XM_343037
VERSION     NM_053414.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2487)
  AUTHORS   Li,Z., Zhou,M., Cai,Z., Liu,H., Zhong,W., Hao,Q., Cheng,D., Hu,X.,
            Hou,J., Xu,P., Xue,Y., Zhou,Y. and Xu,T.
  TITLE     RNA-binding protein DDX1 is responsible for fatty acid-mediated
            repression of insulin translation
  JOURNAL   Nucleic Acids Res 46 (22), 12052-12066 (2018)
   PUBMED   30295850
  REMARK    GeneRIF: DDX1-mediated repression of insulin translation worsens
            the situation of insulin resistance and contributes to the
            elevation of blood glucose levels in obese animals
REFERENCE   2  (bases 1 to 2487)
  AUTHORS   Jefferson,M., Donaszi-Ivanov,A., Pollen,S., Dalmay,T., Saalbach,G.
            and Powell,P.P.
  TITLE     Host factors that interact with the pestivirus N-terminal protease,
            Npro, are components of the ribonucleoprotein complex
  JOURNAL   J Virol 88 (18), 10340-10353 (2014)
   PUBMED   24965446
REFERENCE   3  (bases 1 to 2487)
  AUTHORS   Popow,J., Jurkin,J., Schleiffer,A. and Martinez,J.
  TITLE     Analysis of orthologous groups reveals archease and DDX1 as tRNA
            splicing factors
  JOURNAL   Nature 511 (7507), 104-107 (2014)
   PUBMED   24870230
REFERENCE   4  (bases 1 to 2487)
  AUTHORS   Perez-Gonzalez,A., Pazo,A., Navajas,R., Ciordia,S.,
            Rodriguez-Frandsen,A. and Nieto,A.
  TITLE     hCLE/C14orf166 associates with DDX1-HSPC117-FAM98B in a novel
            transcription-dependent shuttling RNA-transporting complex
  JOURNAL   PLoS One 9 (3), e90957 (2014)
   PUBMED   24608264
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2487)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   6  (bases 1 to 2487)
  AUTHORS   Onishi,H., Kino,Y., Morita,T., Futai,E., Sasagawa,N. and Ishiura,S.
  TITLE     MBNL1 associates with YB-1 in cytoplasmic stress granules
  JOURNAL   J Neurosci Res 86 (9), 1994-2002 (2008)
   PUBMED   18335541
REFERENCE   7  (bases 1 to 2487)
  AUTHORS   Chen,H.C., Lin,W.C., Tsay,Y.G., Lee,S.C. and Chang,C.J.
  TITLE     An RNA helicase, DDX1, interacting with poly(A) RNA and
            heterogeneous nuclear ribonucleoprotein K
  JOURNAL   J Biol Chem 277 (43), 40403-40409 (2002)
   PUBMED   12183465
REFERENCE   8  (bases 1 to 2487)
  AUTHORS   Bleoo,S., Sun,X., Hendzel,M.J., Rowe,J.M., Packer,M. and Godbout,R.
  TITLE     Association of human DEAD box protein DDX1 with a cleavage
            stimulation factor involved in 3'-end processing of pre-MRNA
  JOURNAL   Mol Biol Cell 12 (10), 3046-3059 (2001)
   PUBMED   11598190
REFERENCE   9  (bases 1 to 2487)
  AUTHORS   Karlsson,A., Helou,K., Walentinsson,A., Hedrich,H.J., Szpirer,C.
            and Levan,G.
  TITLE     Amplification of Mycn, Ddx1, Rrm2, and Odc1 in rat uterine
            endometrial carcinomas
  JOURNAL   Genes Chromosomes Cancer 31 (4), 345-356 (2001)
   PUBMED   11433525
REFERENCE   10 (bases 1 to 2487)
  AUTHORS   Godbout,R. and Squire,J.
  TITLE     Amplification of a DEAD box protein gene in retinoblastoma cell
            lines
  JOURNAL   Proc Natl Acad Sci U S A 90 (16), 7578-7582 (1993)
   PUBMED   7689221
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC082049.1.
            
            On Apr 19, 2005 this sequence version replaced XM_343037.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC082049.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2487
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q15"
     gene            1..2487
                     /gene="Ddx1"
                     /note="DEAD-box helicase 1"
                     /db_xref="GeneID:84474"
                     /db_xref="RGD:619903"
     exon            1..62
                     /gene="Ddx1"
                     /inference="alignment:Splign:2.1.0"
     CDS             47..2269
                     /gene="Ddx1"
                     /EC_number="3.6.4.13"
                     /note="DEAD box protein 1; DEAD/H-box helicase 1; DEAD/H
                     (Asp-Glu-Ala-Asp/His) box polypeptide 1; DEAD
                     (Asp-Glu-Ala-Asp) box polypeptide 1; DEAD
                     (Asp-Glu-Ala-Asp) box helicase 1"
                     /codon_start=1
                     /product="ATP-dependent RNA helicase DDX1"
                     /protein_id="NP_445866.1"
                     /db_xref="GeneID:84474"
                     /db_xref="RGD:619903"
                     /translation="MAAFSEMGVMPEIAQAVEEMDWLLPTDIQAESIPLILGGGDVLM
                     AAETGSGKTGAFSIPVIQIVYETLKDQQEGKKGKATIKTGASVLNKWQMNPYDRGSAF
                     AIGSDGLCCQSREVKEWHGCRATRGLLRGKHYYEVSCHDQGLCRVGWSTMQASLDLGT
                     DKFGFGFGGTGKKSHNKQFDNYGEEFTMHDTIGCYLDIDKGHVKFSKNGKDLGLAFEI
                     PAHIKNQALFPACVLKNAELKFNFGEEEFKFPPKDGFVALSKAPDSYVVKSQHTGNAQ
                     VSQTKFLPNAPKALIVEPSRELAEQTLNNVKQFKKYIDNPKLRELLIIGGVAARDQLS
                     VLDNGVDIVVGTPGRLDDLVSTGKLNLSQVRFLVLDEADGLLSQGYSDFINRMHNQIP
                     QITSDGKRLQVIVCSATLHSFDVKKLSEKIMHFPTWVDLKGEDSVPDTVHHVVVPVNP
                     KTDRLWERLGKNHIRTDDVHAKDNTRPGANSPEMWSEAIKILKGEYAVRAIKEHKMDQ
                     AIIFCRTKIDCDNLEQYFMQQGGGPDKKGHQFSCVCLHGDRKPHERKQNLERFKKGDV
                     RFLICTDVAARGIDIHGVPYVINVTLPDEKQNYVHRIGRVGRAERMGLAISLVATEKE
                     KVWYHVCSNRGKGCYNTRLKEDGGCTIWYNEMQLLSEIEEHLNCTISQVEPDIKVPVD
                     EFDGKVTYGQKRAAGGGNYKGHVDILAPTVQELAALEKEAQTSFLHLGYLPNQLFRTF
                     "
     exon            63..114
                     /gene="Ddx1"
                     /inference="alignment:Splign:2.1.0"
     exon            115..178
                     /gene="Ddx1"
                     /inference="alignment:Splign:2.1.0"
     exon            179..208
                     /gene="Ddx1"
                     /inference="alignment:Splign:2.1.0"
     exon            209..305
                     /gene="Ddx1"
                     /inference="alignment:Splign:2.1.0"
     exon            306..353
                     /gene="Ddx1"
                     /inference="alignment:Splign:2.1.0"
     exon            354..437
                     /gene="Ddx1"
                     /inference="alignment:Splign:2.1.0"
     exon            438..521
                     /gene="Ddx1"
                     /inference="alignment:Splign:2.1.0"
     exon            522..598
                     /gene="Ddx1"
                     /inference="alignment:Splign:2.1.0"
     exon            599..671
                     /gene="Ddx1"
                     /inference="alignment:Splign:2.1.0"
     exon            672..748
                     /gene="Ddx1"
                     /inference="alignment:Splign:2.1.0"
     exon            749..863
                     /gene="Ddx1"
                     /inference="alignment:Splign:2.1.0"
     exon            864..1002
                     /gene="Ddx1"
                     /inference="alignment:Splign:2.1.0"
     exon            1003..1063
                     /gene="Ddx1"
                     /inference="alignment:Splign:2.1.0"
     exon            1064..1162
                     /gene="Ddx1"
                     /inference="alignment:Splign:2.1.0"
     exon            1163..1252
                     /gene="Ddx1"
                     /inference="alignment:Splign:2.1.0"
     exon            1253..1441
                     /gene="Ddx1"
                     /inference="alignment:Splign:2.1.0"
     exon            1442..1493
                     /gene="Ddx1"
                     /inference="alignment:Splign:2.1.0"
     exon            1494..1640
                     /gene="Ddx1"
                     /inference="alignment:Splign:2.1.0"
     exon            1641..1732
                     /gene="Ddx1"
                     /inference="alignment:Splign:2.1.0"
     exon            1733..1805
                     /gene="Ddx1"
                     /inference="alignment:Splign:2.1.0"
     exon            1806..1878
                     /gene="Ddx1"
                     /inference="alignment:Splign:2.1.0"
     exon            1879..1921
                     /gene="Ddx1"
                     /inference="alignment:Splign:2.1.0"
     exon            1922..2017
                     /gene="Ddx1"
                     /inference="alignment:Splign:2.1.0"
     exon            2018..2138
                     /gene="Ddx1"
                     /inference="alignment:Splign:2.1.0"
     exon            2139..2463
                     /gene="Ddx1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctggaaggag ggatcgaccg ggccggcagc ggaggagtgc gggaagatgg cggccttctc
       61 cgaaatgggt gttatgcccg agattgcaca agccgtggag gagatggatt ggcttctacc
      121 cactgatatc caggcagaat ctatcccatt gatcctagga ggaggtgatg tacttatggc
      181 tgcagaaacg ggaagtggaa aaactggtgc atttagtatt ccagttatcc agatagtgta
      241 tgagactctg aaagaccaac aggaaggaaa gaaagggaaa gcaactatta aaactggtgc
      301 ttctgtgctc aacaagtggc agatgaaccc atatgataga gggtctgctt ttgcaattgg
      361 gtcagatggt ctgtgttgtc agagcagaga ggtgaaggag tggcatgggt gcagagcgac
      421 tagaggactg ctgagaggga agcactacta cgaagtatcc tgtcatgacc aagggctgtg
      481 cagagttggg tggtccacca tgcaggcttc cttagacctg ggtactgaca agtttggatt
      541 tggcttcggt ggaacaggaa agaaatctca taataaacaa tttgataatt atggagagga
      601 attcactatg catgacacca ttggatgtta cttagacatc gataaagggc acgtgaagtt
      661 ctctaagaat ggaaaagacc ttggtctggc atttgaaata cctgcacaca taaaaaacca
      721 agccctcttc cctgcctgtg ttttgaagaa tgctgaattg aaatttaact ttggtgaaga
      781 agaatttaag tttccaccaa aagatggttt tgttgctctt tccaaggccc ctgatagtta
      841 cgtcgtcaaa tcgcagcaca caggtaatgc acaggtgtca caaacaaaat ttctccctaa
      901 tgctccaaaa gctcttattg tggaaccctc cagagagtta gctgagcaaa ccttgaacaa
      961 tgtgaaacag tttaagaagt acatcgataa tcctaaattg cgggagcttc tcataattgg
     1021 tggcgttgca gctcgggatc agctctccgt tctggataat ggggttgata ttgtcgtcgg
     1081 tactccagga agattagatg atttggtgtc aactggaaag ctcaacttgt ctcaagttag
     1141 attcctggtc ctggatgaag cagatgggct tctctctcaa ggttattctg actttattaa
     1201 caggatgcac aaccagattc ctcagattac ttctgatggg aaaagacttc aggtgattgt
     1261 ttgctctgct actctgcatt cttttgatgt aaagaaacta tctgagaaga taatgcattt
     1321 tcccacgtgg gtggatttga aaggagaaga ttctgttcct gatactgtgc atcatgtcgt
     1381 tgttcctgtg aacccaaaaa ctgacaggct ctgggaaagg ctggggaaga accacattcg
     1441 aaccgatgat gtccatgcaa aggataacac aagacctggt gccaacagtc cagagatgtg
     1501 gtctgaagct attaaaatac tgaaggggga gtatgctgtc cgagcaatca aggagcacaa
     1561 gatggatcaa gcaattatct tctgtagaac gaaaattgac tgtgacaact tggagcagta
     1621 ctttatgcag caaggaggag gacctgataa aaaaggacac caattctcat gtgtatgtct
     1681 tcatggtgac agaaagcctc acgagagaaa gcagaacttg gaacgattta agaaaggaga
     1741 cgtaagattc ctgatttgca cagacgtagc tgccagagga attgacatcc acggtgttcc
     1801 ttatgttatt aatgtcaccc tgcctgatga aaagcagaat tatgtgcacc ggattggcag
     1861 agtggggcga gctgaaagga tgggcctggc tatttccctg gtggcaacag agaaagaaaa
     1921 ggtttggtat cacgtatgca gcaaccgtgg gaagggatgc tataacacta gactcaagga
     1981 agatggcggc tgtactatct ggtacaatga aatgcagcta ctttctgaga tagaagaaca
     2041 cctgaactgt accatttccc aggttgagcc agatataaag gttccagtgg atgagtttga
     2101 tgggaaagtt acatatggtc agaaaagagc tgctggcggt gggaactata aaggccatgt
     2161 ggacatcctg gcacctaccg ttcaagagtt ggctgccctt gaaaaggaag cacagacatc
     2221 tttcctacac cttggctacc ttcccaacca gctgttcaga accttctgat ttcatgtaga
     2281 tggagaagga ttggagtaat cgcgtctgta gtcttaactt aacgtggtgg tgcttctgag
     2341 cacagtgttt acagtagctg aactattact gctaactctg catgtcggca aacacaaatc
     2401 ttaggagttc ttcataaaat ggccgcctaa tgaaaataaa ttggacaact atattttcat
     2461 gaaaaaaaaa aaaaaaaaaa aaaaaaa
//
