LOCUS       NM_001106512            1573 bp    mRNA    linear   ROD 22-MAR-2023
DEFINITION  Rattus norvegicus DDRGK domain containing 1 (Ddrgk1), mRNA.
ACCESSION   NM_001106512 XM_001081180 XM_215848
VERSION     NM_001106512.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1573)
  AUTHORS   Egunsola,A.T., Bae,Y., Jiang,M.M., Liu,D.S., Chen-Evenson,Y.,
            Bertin,T., Chen,S., Lu,J.T., Nevarez,L., Magal,N.,
            Raas-Rothschild,A., Swindell,E.C., Cohn,D.H., Gibbs,R.A.,
            Campeau,P.M., Shohat,M. and Lee,B.H.
  TITLE     Loss of DDRGK1 modulates SOX9 ubiquitination in
            spondyloepimetaphyseal dysplasia
  JOURNAL   J Clin Invest 127 (4), 1475-1484 (2017)
   PUBMED   28263186
REFERENCE   2  (bases 1 to 1573)
  AUTHORS   Yoo HM, Kang SH, Kim JY, Lee JE, Seong MW, Lee SW, Ka SH, Sou YS,
            Komatsu M, Tanaka K, Lee ST, Noh DY, Baek SH, Jeon YJ and Chung CH.
  TITLE     Modification of ASC1 by UFM1 is crucial for ERalpha transactivation
            and breast cancer development
  JOURNAL   Mol Cell 56 (2), 261-274 (2014)
   PUBMED   25219498
REFERENCE   3  (bases 1 to 1573)
  AUTHORS   Xi P, Ding D, Zhou J, Wang M and Cong YS.
  TITLE     DDRGK1 regulates NF-kappaB activity by modulating IkappaBalpha
            stability
  JOURNAL   PLoS One 8 (5), e64231 (2013)
   PUBMED   23675531
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1573)
  AUTHORS   Lemaire K, Moura RF, Granvik M, Igoillo-Esteve M, Hohmeier HE,
            Hendrickx N, Newgard CB, Waelkens E, Cnop M and Schuit F.
  TITLE     Ubiquitin fold modifier 1 (UFM1) and its target UFBP1 protect
            pancreatic beta cells from ER stress-induced apoptosis
  JOURNAL   PLoS One 6 (4), e18517 (2011)
   PUBMED   21494687
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1573)
  AUTHORS   Wu J, Lei G, Mei M, Tang Y and Li H.
  TITLE     A novel C53/LZAP-interacting protein regulates stability of
            C53/LZAP and DDRGK domain-containing Protein 1 (DDRGK1) and
            modulates NF-kappaB signaling
  JOURNAL   J Biol Chem 285 (20), 15126-15136 (2010)
   PUBMED   20228063
REFERENCE   6  (bases 1 to 1573)
  AUTHORS   Tatsumi K, Sou YS, Tada N, Nakamura E, Iemura S, Natsume T, Kang
            SH, Chung CH, Kasahara M, Kominami E, Yamamoto M, Tanaka K and
            Komatsu M.
  TITLE     A novel type of E3 ligase for the Ufm1 conjugation system
  JOURNAL   J Biol Chem 285 (8), 5417-5427 (2010)
   PUBMED   20018847
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473949.1.
            
            [WARNING] On May 7, 2024 this sequence was replaced by
            NM_001106512.2.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_001081180.1, XM_215848.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ231424.1, FQ214225.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMN06621351
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1573
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q36"
     gene            1..1573
                     /gene="Ddrgk1"
                     /gene_synonym="RGD1309979"
                     /note="DDRGK domain containing 1"
                     /db_xref="GeneID:296162"
                     /db_xref="RGD:1309979"
     exon            1..521
                     /gene="Ddrgk1"
                     /gene_synonym="RGD1309979"
                     /inference="alignment:Splign:2.1.0"
     CDS             359..1378
                     /gene="Ddrgk1"
                     /gene_synonym="RGD1309979"
                     /codon_start=1
                     /product="DDRGK domain-containing protein 1"
                     /protein_id="NP_001099982.1"
                     /db_xref="GeneID:296162"
                     /db_xref="RGD:1309979"
                     /translation="MVVGGAWRSGSRRRAGVAARLSVVMVGPWVYLVAAVLLIGLILF
                     LTRSRGRAAAADGEPLHNEEERTGAGQVARSWPQESEEQRTGGRPRRRRDLGSRLQAQ
                     RRAQRVTWEEVDENEGEAAVPAQEEEGVEKPAEVHPTGKIGAKKLRKLEEKQARKAQR
                     EAEEAEREERKRLESQREAEWKKEEERLRLKEEQKEEEERKAREEQARREHEEYLKLK
                     EAFVVEEEGVSETMTEEQSHSFLTEFINYIKQSKVVLLEDLAFQMGLRTQDAINRIQD
                     LLTEGTLTGVIDDRGKFIYITPEELAAVASFIRQRGRVSITELAQASNSLISWGQDLP
                     AQASV"
     exon            522..728
                     /gene="Ddrgk1"
                     /gene_synonym="RGD1309979"
                     /inference="alignment:Splign:2.1.0"
     exon            729..841
                     /gene="Ddrgk1"
                     /gene_synonym="RGD1309979"
                     /inference="alignment:Splign:2.1.0"
     exon            842..943
                     /gene="Ddrgk1"
                     /gene_synonym="RGD1309979"
                     /inference="alignment:Splign:2.1.0"
     exon            944..1066
                     /gene="Ddrgk1"
                     /gene_synonym="RGD1309979"
                     /inference="alignment:Splign:2.1.0"
     exon            1067..1105
                     /gene="Ddrgk1"
                     /gene_synonym="RGD1309979"
                     /inference="alignment:Splign:2.1.0"
     exon            1106..1162
                     /gene="Ddrgk1"
                     /gene_synonym="RGD1309979"
                     /inference="alignment:Splign:2.1.0"
     exon            1163..1211
                     /gene="Ddrgk1"
                     /gene_synonym="RGD1309979"
                     /inference="alignment:Splign:2.1.0"
     exon            1212..1573
                     /gene="Ddrgk1"
                     /gene_synonym="RGD1309979"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acagctatga gtgtttttgc gggcacgcat atctgtgtac aacgtgcgtg cttggtgtac
       61 aaggagttct gaagaaggtt tggagtcccc tggaattgaa gtcacagaag gttgtaaacc
      121 actatgtggg tgctgagaac tgaaccctga cccactggaa gagcagccag cagtctcaac
      181 tgcagactag cctccatgtc gccattatag ccagagacga cctcgaaatg ctggtctccg
      241 ggtttccact tcccgagctc tggcactttg ggtcagcagg gtctccagag ttcacagagg
      301 cctaagtcaa gccccgggtg ggggcggaac tcagcgagcg agcggctggg cagggcagat
      361 ggtagtgggc ggggcctggc gatccggttc ccgcaggcgc gctggcgttg ctgctaggct
      421 gtctgttgtc atggtggggc cctgggtgta tctggtggcg gcggttttgc tcatcggcct
      481 gatcctcttc ctgactcgca gccggggtcg ggcagcagca gctgatggag aacctctgca
      541 caatgaggaa gagagaacag gagcaggcca ggtagcccgg tcttggcccc aggagtctga
      601 agagcagaga actggaggca ggccccggcg tcggagggac ctgggcagcc gtctgcaggc
      661 ccagcgtcga gcccagcgag tgacctggga agaagtggat gagaacgagg gtgaagctgc
      721 tgttccagcc caggaggaag aaggcgttga gaagccggca gaagttcacc caacagggaa
      781 aattggagcc aagaaactac ggaagctaga ggaaaaacag gctcggaagg ctcagcgtga
      841 ggcagaagag gctgaacgtg aagagcggaa acgcctagag tcccaacgag aggcagaatg
      901 gaagaaggag gaggagcggc ttcgcctgaa ggaagaacag aaggaagagg aagagagaaa
      961 ggctcgggag gagcaggccc ggcgggagca cgaggagtac ctgaaactga aggaggcctt
     1021 tgtggtagaa gaagaaggtg ttagtgaaac catgactgag gagcagtctc acagcttcct
     1081 gacagaattc atcaactata ttaagcagtc caaggttgtg cttttggaag acctggcttt
     1141 ccagatgggc ctaaggactc aggatgccat aaaccgcatc caggacctgc tgacggaggg
     1201 gactctaaca ggtgtgattg acgaccgggg caagttcatc tacataaccc cagaggaact
     1261 ggctgctgtg gccagtttca tccgacagcg gggccgggtg tccatcactg agcttgccca
     1321 agccagcaac tccctcatct cctggggcca ggacctccct gcccaggctt cagtctgact
     1381 ccagtccctc cttgagtgta tcctgtggcc tacatgcgtc ttcatccttc cctgccagct
     1441 tggggcaggg atggagtatg accaggaagt tgtgcattaa aggcctgtga atactgctca
     1501 gcctcttgtg tgtagaaggc ctcacctggg gcctcagata aacagataaa atctagacct
     1561 cgctttatct tag
//
