LOCUS       NM_031764               3532 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus discoidin domain receptor tyrosine kinase 2
            (Ddr2), mRNA.
ACCESSION   NM_031764 XM_001065242 XM_001076634
VERSION     NM_031764.3
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3532)
  AUTHORS   Titus,A.S., Ushakumary,M.G., Venugopal,H., Wang,M., Lakatta,E.G.
            and Kailasam,S.
  TITLE     Metformin Attenuates Hyperglycaemia-Stimulated Pro-Fibrotic Gene
            Expression in Adventitial Fibroblasts via Inhibition of Discoidin
            Domain Receptor 2
  JOURNAL   Int J Mol Sci 24 (1), 585 (2022)
   PUBMED   36614028
  REMARK    GeneRIF: Metformin Attenuates Hyperglycaemia-Stimulated
            Pro-Fibrotic Gene Expression in Adventitial Fibroblasts via
            Inhibition of Discoidin Domain Receptor 2.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3532)
  AUTHORS   Zhu,Y.S., Zhang,J.N., Mo,T.T., Jiang,C., Ma,R.C. and Chen,L.
  TITLE     Discoidin domain receptor 2 activation of p38 mitogen-activated
            protein kinase as an important pathway for osteonectin-regulating
            osteoblast mineralization
  JOURNAL   J Orthop Surg Res 16 (1), 711 (2021)
   PUBMED   34876214
  REMARK    GeneRIF: Discoidin domain receptor 2 activation of p38
            mitogen-activated protein kinase as an important pathway for
            osteonectin-regulating osteoblast mineralization.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3532)
  AUTHORS   Hayuningtyas,R.A., Han,M., Choi,S., Kwak,M.S., Park,I.H., Lee,J.H.,
            Choi,J.E., Kim,D.K., Son,M. and Shin,J.S.
  TITLE     The collagen structure of C1q induces wound healing by engaging
            discoidin domain receptor 2
  JOURNAL   Mol Med 27 (1), 125 (2021)
   PUBMED   34602056
  REMARK    GeneRIF: The collagen structure of C1q induces wound healing by
            engaging discoidin domain receptor 2.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3532)
  AUTHORS   Liu,Q.Q., Liu,Y.W., Xie,Y.K., Zhang,J.H., Song,C.X., Wang,J.Z. and
            Xie,B.H.
  TITLE     Amplification of DDR2 mediates sorafenib resistance through
            NF-kappaB/c-Rel signaling in hepatocellular carcinoma
  JOURNAL   Cell Biol Int 45 (9), 1906-1916 (2021)
   PUBMED   33969575
REFERENCE   5  (bases 1 to 3532)
  AUTHORS   Titus,A.S., V,H. and Kailasam,S.
  TITLE     Coordinated regulation of cell survival and cell cycle pathways by
            DDR2-dependent SRF transcription factor in cardiac fibroblasts
  JOURNAL   Am J Physiol Heart Circ Physiol 318 (6), H1538-H1558 (2020)
   PUBMED   32412792
REFERENCE   6  (bases 1 to 3532)
  AUTHORS   Agarwal,G., Kovac,L., Radziejewski,C. and Samuelsson,S.J.
  TITLE     Binding of discoidin domain receptor 2 to collagen I: an atomic
            force microscopy investigation
  JOURNAL   Biochemistry 41 (37), 11091-11098 (2002)
   PUBMED   12220173
REFERENCE   7  (bases 1 to 3532)
  AUTHORS   Olaso,E., Labrador,J.P., Wang,L., Ikeda,K., Eng,F.J., Klein,R.,
            Lovett,D.H., Lin,H.C. and Friedman,S.L.
  TITLE     Discoidin domain receptor 2 regulates fibroblast proliferation and
            migration through the extracellular matrix in association with
            transcriptional activation of matrix metalloproteinase-2
  JOURNAL   J Biol Chem 277 (5), 3606-3613 (2002)
   PUBMED   11723120
REFERENCE   8  (bases 1 to 3532)
  AUTHORS   Labrador,J.P., Azcoitia,V., Tuckermann,J., Lin,C., Olaso,E.,
            Manes,S., Bruckner,K., Goergen,J.L., Lemke,G., Yancopoulos,G.,
            Angel,P., Martinez,C. and Klein,R.
  TITLE     The collagen receptor DDR2 regulates proliferation and its
            elimination leads to dwarfism
  JOURNAL   EMBO Rep 2 (5), 446-452 (2001)
   PUBMED   11375938
REFERENCE   9  (bases 1 to 3532)
  AUTHORS   Ankoma-Sey,V., Matli,M., Chang,K.B., Lalazar,A., Donner,D.B.,
            Wong,L., Warren,R.S. and Friedman,S.L.
  TITLE     Coordinated induction of VEGF receptors in mesenchymal cell types
            during rat hepatic wound healing
  JOURNAL   Oncogene 17 (1), 115-121 (1998)
   PUBMED   9671320
REFERENCE   10 (bases 1 to 3532)
  AUTHORS   Vogel,W., Gish,G.D., Alves,F. and Pawson,T.
  TITLE     The discoidin domain receptor tyrosine kinases are activated by
            collagen
  JOURNAL   Mol Cell 1 (1), 13-23 (1997)
   PUBMED   9659899
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC161961.1.
            
            On Apr 6, 2008 this sequence version replaced NM_031764.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC161961.1, SRR8487230.15193.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132279,
                                           SAMEA5756307 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
FEATURES             Location/Qualifiers
     source          1..3532
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13q24"
     gene            1..3532
                     /gene="Ddr2"
                     /gene_synonym="Tyro10"
                     /note="discoidin domain receptor tyrosine kinase 2"
                     /db_xref="GeneID:685781"
                     /db_xref="RGD:619855"
     exon            1..87
                     /gene="Ddr2"
                     /gene_synonym="Tyro10"
                     /inference="alignment:Splign:2.1.0"
     CDS             6..2570
                     /gene="Ddr2"
                     /gene_synonym="Tyro10"
                     /EC_number="2.7.10.1"
                     /note="discoidin domain-containing receptor 2; receptor
                     protein-tyrosine kinase TKT; tyrosine-protein kinase TYRO
                     10; neurotrophic tyrosine kinase, receptor-related 3;
                     CD167b antigen; discoidin domain receptor family, member
                     2"
                     /codon_start=1
                     /product="discoidin domain-containing receptor 2
                     precursor"
                     /protein_id="NP_113952.2"
                     /db_xref="GeneID:685781"
                     /db_xref="RGD:619855"
                     /translation="MILIPRMPLVLLLLLLILGSAKAQVNPAICRYPLGMSGGHIPDE
                     DITASSQWSESTAAKYGRLDSEEGDGAWCPEIPVQPDDLKEFLQIDLRTLHFITLVGT
                     QGRHAGGHGIEFAPMYKINYSRDGNRWISWRNRHGKQVLDGNSNPYDVFLKDLEPPIV
                     ARFVRLIPVTDHSMNVCMRVELYGCVWLDGLVSYNAPAGQQFVLPGGSIIYLNDSVYD
                     GAVGYSMTEGLGQLTDGVSGLDDFTQTHEYHVWPGYDYVGWRNESATNGFIEIMFEFD
                     RVRNFTTMKVHCNNMFAKGVKIFKEVQCYFRSETSEWEPTAVYFPLVLDDVNPSARFV
                     TVPLHHRMASAIKCQYHFADTWMMFSEITFQSDAAMYNNSGALPTSPMAPTTFDPMLK
                     VDDSNTRILIGCLVAIIFILLAVIVIILWRQFWQKMLEKASRRMLDDEMTVSLSLPSE
                     SSMFNNNHSSSPSEQESNSTYDRIFPLRPDYQEPSRLIRKLPEFAPGEEESGCSGVVK
                     PAQPNGPEGVPHYAEADIVNLQGVTGGNTYSVPAVTMDLLSGKDVAVEEFPRKLLAFK
                     EKLGEGQFGEVHLCEVEGMEKFKDKDFALDVSANQPVLVAVKMLRADANKNARNDFLK
                     EIKIMSRLKDANIIRLLAVCITEDPLCMITEYMENGDLNQFLSRHEPLSSGSSNATVS
                     YANLKFMATQIASGMKYLSSLNFVHRDLATRNCLVGKNYTIKIADFGMSRNLYSGDYY
                     RIQGRAVLPIRWMSWESILLGKFTTASDVWAFGVTLWETFTFCQEQPYSQLSDEQVIE
                     NTGEFFRDQGRQIYLPQPAVCPDSVYKLMLSCWRRETKHRPSFQEIHLLLLQQGAE"
     exon            88..190
                     /gene="Ddr2"
                     /gene_synonym="Tyro10"
                     /inference="alignment:Splign:2.1.0"
     exon            191..422
                     /gene="Ddr2"
                     /gene_synonym="Tyro10"
                     /inference="alignment:Splign:2.1.0"
     exon            423..570
                     /gene="Ddr2"
                     /gene_synonym="Tyro10"
                     /inference="alignment:Splign:2.1.0"
     exon            571..676
                     /gene="Ddr2"
                     /gene_synonym="Tyro10"
                     /inference="alignment:Splign:2.1.0"
     exon            677..860
                     /gene="Ddr2"
                     /gene_synonym="Tyro10"
                     /inference="alignment:Splign:2.1.0"
     exon            861..1104
                     /gene="Ddr2"
                     /gene_synonym="Tyro10"
                     /inference="alignment:Splign:2.1.0"
     exon            1105..1167
                     /gene="Ddr2"
                     /gene_synonym="Tyro10"
                     /inference="alignment:Splign:2.1.0"
     exon            1168..1298
                     /gene="Ddr2"
                     /gene_synonym="Tyro10"
                     /inference="alignment:Splign:2.1.0"
     exon            1299..1509
                     /gene="Ddr2"
                     /gene_synonym="Tyro10"
                     /inference="alignment:Splign:2.1.0"
     exon            1510..1733
                     /gene="Ddr2"
                     /gene_synonym="Tyro10"
                     /inference="alignment:Splign:2.1.0"
     exon            1734..1861
                     /gene="Ddr2"
                     /gene_synonym="Tyro10"
                     /inference="alignment:Splign:2.1.0"
     exon            1862..2050
                     /gene="Ddr2"
                     /gene_synonym="Tyro10"
                     /inference="alignment:Splign:2.1.0"
     exon            2051..2285
                     /gene="Ddr2"
                     /gene_synonym="Tyro10"
                     /inference="alignment:Splign:2.1.0"
     exon            2286..2435
                     /gene="Ddr2"
                     /gene_synonym="Tyro10"
                     /inference="alignment:Splign:2.1.0"
     exon            2436..3509
                     /gene="Ddr2"
                     /gene_synonym="Tyro10"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctgaaatgat cctgattccc agaatgcctc tggtgctgct gctgctcctg ctcatcctgg
       61 gttctgcaaa agctcaggtt aatccagcca tatgtcgcta tcctctgggc atgtcaggag
      121 gccacattcc agatgaggac atcacagctt caagtcagtg gtcagaatcc acagctgcca
      181 aatatgggag gctggactct gaagaagggg atggagcttg gtgccctgag attccagtgc
      241 aacccgatga cctgaaggaa tttctgcaga ttgatttacg aaccctacac tttatcactc
      301 ttgtggggac ccagggacgc catgcagggg gtcatggcat tgaatttgca cccatgtaca
      361 agatcaacta cagtcgggat ggcaaccgct ggatctcctg gcgtaaccga catgggaaac
      421 aggtgcttga tgggaacagt aacccttatg atgttttcct gaaggatttg gagccaccca
      481 ttgtagctag atttgttcgc cttatcccag tcactgacca ctccatgaac gtgtgcatga
      541 gggtcgagct ttatggttgt gtctggctag atggcttggt atcttacaat gcacccgctg
      601 ggcagcagtt tgtactccct ggaggctcca tcatttatct gaatgattct gtctatgatg
      661 gagctgttgg gtacagtatg actgaagggc taggccagtt gactgatggg gtatctggcc
      721 tggatgattt tacccagacc catgaatacc atgtgtggcc cggctatgac tacgtgggat
      781 ggcggaatga gagtgctacc aatggtttca tagagatcat gtttgaattt gaccgagtca
      841 ggaattttac caccatgaag gtccactgca ataacatgtt cgctaaaggt gtgaagatct
      901 ttaaggaggt ccaatgttac ttccgctctg aaaccagcga atgggaacct actgctgtct
      961 actttcccct tgtcctggat gatgtgaacc ccagtgctcg gtttgtcacg gtgcccctcc
     1021 accatcgaat ggctagtgcc atcaaatgcc aataccattt tgccgacaca tggatgatgt
     1081 tcagcgagat cacttttcaa tcagatgctg caatgtataa taactctgga gcactcccca
     1141 cctctcctat ggcacccaca acctttgatc ccatgcttaa agtcgatgac agcaacactc
     1201 ggatcctgat tggctgcttg gtggccatca tcttcatcct gctggctgtc atcgtcatca
     1261 tcctgtggag gcaattctgg cagaagatgc tagagaaggc ttcacggagg atgctggatg
     1321 atgaaatgac agttagcctt tccctgccca gcgagtccag catgttcaat aacaaccact
     1381 cctcatcacc aagtgaacag gagtccaact ctacttatga tcgaatcttt ccccttcgcc
     1441 ctgactacca ggagccatcc agactgatcc gaaagctccc agaatttgct ccaggagagg
     1501 aagagtctgg ttgcagtggt gttgtgaagc cggcccagcc caatggacct gagggcgtgc
     1561 cccactatgc agaagccgat atagtgaatc tccagggagt aacaggtggc aacacctact
     1621 ctgtgcctgc cgtcaccatg gacctgctct cgggaaaaga tgtggctgtg gaagagttcc
     1681 ccaggaaact gttagccttc aaagagaagc tgggagaagg ccagtttggg gaggttcatc
     1741 tctgtgaagt ggagggaatg gaaaaattca aagacaaaga tttcgcacta gacgtcagtg
     1801 ctaaccagcc tgtcctggtg gccgtgaaaa tgcttcgagc agatgccaac aagaatgcca
     1861 ggaatgattt tcttaaggag ataaagatta tgtctcggct caaggacgca aacatcatcc
     1921 gtctcttagc tgtgtgcatc actgaggacc cgctctgcat gatcacggaa tacatggaaa
     1981 acggagacct caatcagttt ctttctcgcc acgagcctct aagttctggt tctagcaatg
     2041 ccacagtcag ttacgccaac ctcaagttta tggctaccca gattgcctct gggatgaagt
     2101 acctttcatc tctcaacttt gtccaccgag atctggccac acgcaactgc ttagtgggca
     2161 agaactacac catcaagata gctgactttg gaatgagcag aaacctgtac agtggtgact
     2221 actaccggat ccagggccgg gcagtgctcc ccatccgctg gatgtcctgg gaaagcatct
     2281 tgctgggcaa attcaccacg gcaagtgatg tgtgggcctt tggggtgact ctgtgggaga
     2341 ctttcacctt ttgccaggag cagccctatt cccagctgtc ggacgagcag gttattgaga
     2401 atactggaga gttcttccga gaccagggga ggcagatcta tctccctcaa ccagccgttt
     2461 gccccgactc tgtgtataag ctgatgctca gttgctggag aagagaaacc aagcaccgac
     2521 catccttcca agaaatacac cttctgcttc ttcaacaagg agctgagtga tgccatcggt
     2581 acctggcagt gttcctgtgg cccagatcct ccccacaaga cctaccgctc acccacatct
     2641 aagccactcc agctggacag tcaatggacc cgagagacag agaattagtc actctgccct
     2701 ctctgttcct cacctcctcc actgcacttc cctgttccct accattgact catatatact
     2761 tttttttaca tgaaataact aaaaaagaaa aaatatagag cagatattag taaaagaagt
     2821 gttacttgat ataccgaagg gttagataat gaagactaga aactcaagat aatttataaa
     2881 agttatgctt atgtttataa gtgtgcagat cctacaatat ttttccatgt cactttctgt
     2941 aaaaatacct ttagaaagaa aaaaacttga agaatatgaa tgtcttggga accatgagat
     3001 taggcttaag gaaaatactt agtagtcatg aagaattgca ggacttggca ttccacaact
     3061 aatgggtgat tttctgattt ggacatgact ctcagatttc tctgtctctg tctgtctatt
     3121 tgtctatcca tctgtctgtc tatctatcta tctatctatc tatctatcta tctatctatc
     3181 tatttcctca aagtgagtgc catgtactta aaaatctcta ccttgtttct tggaatgaaa
     3241 gttttcttca atcatggcca gaggtcgtgg cctacctatg aaacagggca tatgggtaga
     3301 aagaaatgtc tgttgtaaag ctggaaggac agaaggacac agaagggaaa gattgcacaa
     3361 gattcccagt agactgtggt tataggaaag gaggtccttg gaggatgact aacaagtgta
     3421 ctatttgttg gtaacatgtg aaggtcttca tctgtgtgtt ttagtgacaa cttgacttta
     3481 atcagtaaag cctagcattt tgattttaaa aaaaaaaaaa aaaaaaaaaa aa
//
