LOCUS       NM_013137               2921 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Rattus norvegicus discoidin domain receptor tyrosine kinase 1
            (Ddr1), transcript variant 1, mRNA.
ACCESSION   NM_013137
VERSION     NM_013137.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2921)
  AUTHORS   Wu,R., Pan,S., Chen,Y., Nakano,Y., Li,M., Balog,S. and Tsukamoto,H.
  TITLE     Fate and functional roles of Prominin 1+ cells in liver injury and
            cancer
  JOURNAL   Sci Rep 10 (1), 19412 (2020)
   PUBMED   33173221
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2921)
  AUTHORS   Romayor,I., Badiola,I., Benedicto,A., Marquez,J., Herrero,A.,
            Arteta,B. and Olaso,E.
  TITLE     Silencing of sinusoidal DDR1 reduces murine liver metastasis by
            colon carcinoma
  JOURNAL   Sci Rep 10 (1), 18398 (2020)
   PUBMED   33110221
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2921)
  AUTHORS   Lino,M., Ngai,D., Liu,A., Mohabeer,A., Harper,C., Caruso,L.L.,
            Schroer,S.A., Fu,F., McKee,T., Giacca,A., Woo,M. and Bendeck,M.P.
  TITLE     Discoidin domain receptor 1-deletion ameliorates fibrosis and
            promotes adipose tissue beiging, brown fat activity, and increased
            metabolic rate in a mouse model of cardiometabolic disease
  JOURNAL   Mol Metab 39, 101006 (2020)
   PUBMED   32360427
REFERENCE   4  (bases 1 to 2921)
  AUTHORS   Zhong,X., Zhang,W. and Sun,T.
  TITLE     DDR1 promotes breast tumor growth by suppressing antitumor immunity
  JOURNAL   Oncol Rep 42 (6), 2844-2854 (2019)
   PUBMED   31578591
REFERENCE   5  (bases 1 to 2921)
  AUTHORS   Chiusa,M., Hu,W., Liao,H.J., Su,Y., Borza,C.M., de Caestecker,M.P.,
            Skrypnyk,N.I., Fogo,A.B., Pedchenko,V., Li,X., Zhang,M.Z.,
            Hudson,B.G., Basak,T., Vanacore,R.M., Zent,R. and Pozzi,A.
  TITLE     The Extracellular Matrix Receptor Discoidin Domain Receptor 1
            Regulates Collagen Transcription by Translocating to the Nucleus
  JOURNAL   J Am Soc Nephrol 30 (9), 1605-1624 (2019)
   PUBMED   31383731
REFERENCE   6  (bases 1 to 2921)
  AUTHORS   Vogel,W.F., Aszodi,A., Alves,F. and Pawson,T.
  TITLE     Discoidin domain receptor 1 tyrosine kinase has an essential role
            in mammary gland development
  JOURNAL   Mol Cell Biol 21 (8), 2906-2917 (2001)
   PUBMED   11283268
REFERENCE   7  (bases 1 to 2921)
  AUTHORS   Chin,G.S., Lee,S., Hsu,M., Liu,W., Kim,W.J., Levinson,H. and
            Longaker,M.T.
  TITLE     Discoidin domain receptors and their ligand, collagen, are
            temporally regulated in fetal rat fibroblasts in vitro
  JOURNAL   Plast Reconstr Surg 107 (3), 769-776 (2001)
   PUBMED   11304604
REFERENCE   8  (bases 1 to 2921)
  AUTHORS   Bhatt,R.S., Tomoda,T., Fang,Y. and Hatten,M.E.
  TITLE     Discoidin domain receptor 1 functions in axon extension of
            cerebellar granule neurons
  JOURNAL   Genes Dev 14 (17), 2216-2228 (2000)
   PUBMED   10970885
REFERENCE   9  (bases 1 to 2921)
  AUTHORS   Vogel,W., Gish,G.D., Alves,F. and Pawson,T.
  TITLE     The discoidin domain receptor tyrosine kinases are activated by
            collagen
  JOURNAL   Mol Cell 1 (1), 13-23 (1997)
   PUBMED   9659899
REFERENCE   10 (bases 1 to 2921)
  AUTHORS   Sanchez,M.P., Tapley,P., Saini,S.S., He,B., Pulido,D. and
            Barbacid,M.
  TITLE     Multiple tyrosine protein kinases in rat hippocampal neurons:
            isolation of Ptk-3, a receptor expressed in proliferative zones of
            the developing brain
  JOURNAL   Proc Natl Acad Sci U S A 91 (5), 1819-1823 (1994)
   PUBMED   8127887
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DN935615.1, BC166604.1 and BX883047.1.
            
            On Oct 3, 2009 this sequence version replaced NM_013137.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Variants 1 and 2 encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC166604.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-607               DN935615.1         32-638
            608-2707            BC166604.1         608-2707
            2708-2780           BX883047.1         260674-260746       c
            2781-2921           BX883047.1         260414-260554       c
FEATURES             Location/Qualifiers
     source          1..2921
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="20"
                     /map="20p12"
     gene            1..2921
                     /gene="Ddr1"
                     /gene_synonym="Cak; Drd1; PTK3D"
                     /note="discoidin domain receptor tyrosine kinase 1"
                     /db_xref="GeneID:25678"
                     /db_xref="RGD:2252"
     exon            1..146
                     /gene="Ddr1"
                     /gene_synonym="Cak; Drd1; PTK3D"
                     /inference="alignment:Splign:2.1.0"
     exon            147..276
                     /gene="Ddr1"
                     /gene_synonym="Cak; Drd1; PTK3D"
                     /inference="alignment:Splign:2.1.0"
     CDS             189..2921
                     /gene="Ddr1"
                     /gene_synonym="Cak; Drd1; PTK3D"
                     /EC_number="2.7.10.1"
                     /note="discoidin domain receptor family, member 1;
                     epithelial discoidin domain-containing receptor 1; cell
                     adhesion kinase; tyrosine kinase DDR; tyrosine-protein
                     kinase CAK; protein-tyrosine kinase PTK-3; CD167
                     antigen-like family member A; discoidin receptor tyrosine
                     kinase; epithelial discoidin domain receptor 1;
                     protein-tyrosine kinase 3; neurotrophic tyrosine kinase
                     receptor type 4"
                     /codon_start=1
                     /product="epithelial discoidin domain-containing receptor
                     1 precursor"
                     /protein_id="NP_037269.2"
                     /db_xref="GeneID:25678"
                     /db_xref="RGD:2252"
                     /translation="MGTGTLSSLLLLLLLVTIGDADMKGHFDPAKCRYALGMQDRTIP
                     DSDISVSSSWSDSTAARHSRLESSDGDGAWCPAGPVFPKEEEYLQVDLRRLHLVALVG
                     TQGRHAGGLGKEFSRSYRLRYSRDGRRWMDWKDRWGQEVISGNEDPGGVVLKDLGPPM
                     VARLVRFYPRADRVMSVCLRVELYGCLWRDGLLSYTAPVGQTMQLSEMVYLNDSTYDG
                     YTAGGLQYGGLGQLADGVVGLDDFRQSQELRVWPGYDYVGWSNHSFPSGYVEMEFEFD
                     RLRSFQTMQVHCNNMHTLGARLPGGVECRFKRGPAMAWEGEPVRHALGGSLGDPRARA
                     ISVPLGGHVGRFLQCRFLFAGPWLLFSEISFISDVVNDSSDTFPPAPWWPPGPPPTNF
                     SSLELEPRGQQPVAKAEGSPTAILIGCLVAIILLLLLIIALMLWRLHWRRLLSKAERR
                     VLEEELTVHLSVPGDTILINNRPGPREPPPYQEPRPRGTPTHSAPCVPNGSALLLSNP
                     AYRLLLATYARPPRGPGPPTPAWAKPTNTQACSGDYMEPEKPGAPLLPPPPQNSVPHY
                     AEADIVTLQGVTGGNTYAVPALPPGAVGDGPPRVDFPRSRLRFKEKLGEGQFGEVHLC
                     EVEDPQDLVTSDFPISVQKGHPLLVAVKILRPDATKNARNDFLKEVKIMSRLKDPNII
                     RLLGVCVQDDPLCMITDYMENGDLNQFLSAHQLENKVTQGLPGDRESDQGPTISYPML
                     LHVGAQIASGMRYLATLNFVHRDLATRNCLVGENFTIKIADFGMSRNLYAGDYYRVQG
                     RAVLPIRWMAWECILMGKFTTASDVWAFGVTLWEVLMLCRSQPFGQLTDEQVIENAGE
                     FFRDQGRQVYLSRPPACPQTLYELMLRCWSREPEQRPPFSQLHRFLADDALNTV"
     exon            277..379
                     /gene="Ddr1"
                     /gene_synonym="Cak; Drd1; PTK3D"
                     /inference="alignment:Splign:2.1.0"
     exon            380..608
                     /gene="Ddr1"
                     /gene_synonym="Cak; Drd1; PTK3D"
                     /inference="alignment:Splign:2.1.0"
     exon            609..756
                     /gene="Ddr1"
                     /gene_synonym="Cak; Drd1; PTK3D"
                     /inference="alignment:Splign:2.1.0"
     exon            757..856
                     /gene="Ddr1"
                     /gene_synonym="Cak; Drd1; PTK3D"
                     /inference="alignment:Splign:2.1.0"
     exon            857..1043
                     /gene="Ddr1"
                     /gene_synonym="Cak; Drd1; PTK3D"
                     /inference="alignment:Splign:2.1.0"
     exon            1044..1290
                     /gene="Ddr1"
                     /gene_synonym="Cak; Drd1; PTK3D"
                     /inference="alignment:Splign:2.1.0"
     exon            1291..1374
                     /gene="Ddr1"
                     /gene_synonym="Cak; Drd1; PTK3D"
                     /inference="alignment:Splign:2.1.0"
     exon            1375..1526
                     /gene="Ddr1"
                     /gene_synonym="Cak; Drd1; PTK3D"
                     /inference="alignment:Splign:2.1.0"
     exon            1527..1692
                     /gene="Ddr1"
                     /gene_synonym="Cak; Drd1; PTK3D"
                     /inference="alignment:Splign:2.1.0"
     exon            1693..1803
                     /gene="Ddr1"
                     /gene_synonym="Cak; Drd1; PTK3D"
                     /inference="alignment:Splign:2.1.0"
     exon            1804..2048
                     /gene="Ddr1"
                     /gene_synonym="Cak; Drd1; PTK3D"
                     /inference="alignment:Splign:2.1.0"
     exon            2049..2176
                     /gene="Ddr1"
                     /gene_synonym="Cak; Drd1; PTK3D"
                     /inference="alignment:Splign:2.1.0"
     exon            2177..2395
                     /gene="Ddr1"
                     /gene_synonym="Cak; Drd1; PTK3D"
                     /inference="alignment:Splign:2.1.0"
     exon            2396..2630
                     /gene="Ddr1"
                     /gene_synonym="Cak; Drd1; PTK3D"
                     /inference="alignment:Splign:2.1.0"
     exon            2631..2780
                     /gene="Ddr1"
                     /gene_synonym="Cak; Drd1; PTK3D"
                     /inference="alignment:Splign:2.1.0"
     exon            2781..2921
                     /gene="Ddr1"
                     /gene_synonym="Cak; Drd1; PTK3D"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggaacaggcc cccgacagct gctcgcggga gccgcctccc gacacccgag ccccgccggc
       61 gcctgagctc ccctctcgcg ccccgccacc gaggaggccc cgagccgggg ccggacgcct
      121 gggtcggccc gggagagcca ggagagagat gctgtcccct cctccatagg ccagagggat
      181 caggagcgat ggggacaggg accctctcat ctctcctgct gctgctactc ttggtgacaa
      241 ttggagatgc tgacatgaag ggacattttg acccagccaa gtgccgctat gccctgggca
      301 tgcaggaccg caccattcca gacagcgata tctctgtgtc cagctcctgg tcggactcta
      361 ccgccgcccg ccacagcagg ctggaaagca gtgatggaga tggggcttgg tgccctgcag
      421 ggcctgtgtt ccccaaagaa gaggagtacc tgcaggtgga ccttcgtagg ctacacctgg
      481 tggctctggt gggcacccag ggccgccatg ctgggggtct gggcaaagag ttctcccgaa
      541 gctaccggtt gcgttactcc cgagatggcc gacgatggat ggactggaaa gacagatggg
      601 gtcaggaggt gatttcgggt aacgaggatc ctgggggagt ggtgctgaag gatctcgggc
      661 cccccatggt ggcccggctg gtccgtttct accccagggc tgaccgggtc atgagtgtct
      721 gtcttcgggt ggagctctat ggctgcctct ggcgggacgg actcttgtcc tatacagccc
      781 ccgtggggca gaccatgcaa ttatctgaga tggtgtatct caatgattcc acttacgatg
      841 gatatactgc tggagggctg cagtacggtg gtctgggcca actggcagac ggcgtggtgg
      901 ggctggatga tttcaggcag agccaggagc tgcgggtttg gccaggctat gactatgtgg
      961 gatggagcaa ccatagcttc cccagcggct acgtggagat ggagtttgag tttgaccggc
     1021 tgaggtcttt ccagaccatg caggtccact gtaacaacat gcacactctg ggagcccgcc
     1081 tcccaggcgg ggtggaatgc cggtttaaaa ggggtccggc catggcctgg gaaggagagc
     1141 ctgtacgcca tgccctgggg ggtagccttg gagaccccag agccagggcc atctcggtgc
     1201 ccctgggtgg tcacgtgggc cgcttcctgc agtgcagatt cctctttgca ggaccctggt
     1261 tactcttcag tgagatctct ttcatctcgg atgtggtgaa cgactcgtct gacaccttcc
     1321 caccagcccc ctggtggccg cctggcccgc ctcccaccaa cttcagcagc ttggagctgg
     1381 agccccgggg tcaacagcct gtggccaagg cggaggggag cccaactgcc atcctcattg
     1441 gctgcctggt ggccatcatc cttctcctcc tccttatcat tgccctgatg ctctggaggc
     1501 tgcactggcg ccggctgctc agcaaggcag agcgccgggt gttggaggag gagctgacgg
     1561 ttcacctctc tgtccctggg gacaccatcc tcatcaacaa ccgcccaggg ccccgagagc
     1621 caccccctta ccaggaaccc cggcctcggg ggactccaac tcactctgcg ccctgcgtcc
     1681 ccaatggctc tgcgttgctg ctctccaatc cggcctaccg cctccttctg gccacttacg
     1741 cccgtccccc tcgaggcccg ggccccccca cacccgcctg ggccaaaccc accaacaccc
     1801 aggcctgcag tggggactac atggagcccg agaagccggg cgccccactt ctacccccac
     1861 ctccccagaa cagcgtcccc cattacgccg aggctgacat tgtcaccctg cagggcgtca
     1921 cagggggcaa cacctacgct gttcccgcac tgcccccagg ggcggttggg gatgggcccc
     1981 ccagagtgga tttccctcgg tcacggctcc gtttcaagga gaagctcggc gagggccaat
     2041 ttggggaggt acatctctgt gaagtagagg accctcaaga tctggtcact agtgacttcc
     2101 ctatcagtgt gcaaaaggga caccccttgc tggtggcagt gaagatcctc cggccagatg
     2161 ccaccaaaaa tgccaggaat gacttcctga aggaggtaaa gatcatgtca cggctgaagg
     2221 acccaaacat catccggctc ctgggtgtgt gtgtgcagga tgaccctctc tgcatgatta
     2281 cagactacat ggagaacggt gacctgaacc aattcctcag tgcccaccag ctggagaaca
     2341 aggtcactca ggggcttcct ggggacagag agtctgacca ggggcccaca atcagctacc
     2401 ctatgctgtt acacgtgggg gcccagatcg cctctggcat gcgatatctg gccaccctta
     2461 actttgtgca tcgggacctg gccacccgga actgcttggt tggggaaaat ttcaccatca
     2521 aaatcgccga ctttggcatg agccggaatc tctacgctgg ggattattac cgtgtacagg
     2581 gccgggcagt gctgcccatc aggtggatgg cctgggagtg tatcctcatg gggaagttca
     2641 caacagccag tgatgtgtgg gccttcggag tgaccctgtg ggaggtgctt atgctctgca
     2701 ggtcacagcc cttcgggcaa ctcacagacg agcaggtcat cgagaacgcc ggcgagttct
     2761 tcagggacca gggccggcag gtatacttat ccaggccacc cgcctgcccg cagaccttgt
     2821 atgagctgat gctccggtgt tggagccggg agccggagca gcggccgccc ttctcccagc
     2881 ttcatcggtt cctggcggat gatgcactca acacagtgta a
//
