LOCUS       NM_001012104            1590 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Rattus norvegicus dolichyl-diphosphooligosaccharide--protein
            glycosyltransferase non-catalytic subunit (Ddost), mRNA.
ACCESSION   NM_001012104 XM_233581
VERSION     NM_001012104.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1590)
  AUTHORS   Poulsen,M.W., Andersen,J.M., Hedegaard,R.V., Madsen,A.N.,
            Krath,B.N., Monosik,R., Bak,M.J., Nielsen,J., Holst,B.,
            Skibsted,L.H., Larsen,L.H. and Dragsted,L.O.
  TITLE     Short-term effects of dietary advanced glycation end products in
            rats
  JOURNAL   Br J Nutr 115 (4), 629-636 (2016)
   PUBMED   26824730
  REMARK    GeneRIF: Data suggest expression of Rage (advanced glycosylation
            end product-specific receptor) and Ager1/Ddost can be altered by
            dietary factors; diet high in AGE (advanced glycation end products)
            up-regulates expression of Rage and Ager1/Ddost after 2 weeks.
REFERENCE   2  (bases 1 to 1590)
  AUTHORS   Roboti,P. and High,S.
  TITLE     The oligosaccharyltransferase subunits OST48, DAD1 and KCP2
            function as ubiquitous and selective modulators of mammalian
            N-glycosylation
  JOURNAL   J Cell Sci 125 (Pt 14), 3474-3484 (2012)
   PUBMED   22467853
REFERENCE   3  (bases 1 to 1590)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   4  (bases 1 to 1590)
  AUTHORS   Kelleher,D.J., Karaoglu,D., Mandon,E.C. and Gilmore,R.
  TITLE     Oligosaccharyltransferase isoforms that contain different catalytic
            STT3 subunits have distinct enzymatic properties
  JOURNAL   Mol Cell 12 (1), 101-111 (2003)
   PUBMED   12887896
REFERENCE   5  (bases 1 to 1590)
  AUTHORS   Kumar,V., Heinemann,F.S. and Ozols,J.
  TITLE     Interleukin-2 induces N-glycosylation in T-cells: characterization
            of human lymphocyte oligosaccharyltransferase
  JOURNAL   Biochem Biophys Res Commun 247 (2), 524-529 (1998)
   PUBMED   9642163
REFERENCE   6  (bases 1 to 1590)
  AUTHORS   Yamagata,T., Tsuru,T., Momoi,M.Y., Suwa,K., Nozaki,Y., Mukasa,T.,
            Ohashi,H., Fukushima,Y. and Momoi,T.
  TITLE     Genome organization of human 48-kDa oligosaccharyltransferase
            (DDOST)
  JOURNAL   Genomics 45 (3), 535-540 (1997)
   PUBMED   9367678
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC082075.1.
            
            On Feb 11, 2005 this sequence version replaced XM_233581.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC082075.1, FQ228905.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1590
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..1590
                     /gene="Ddost"
                     /note="dolichyl-diphosphooligosaccharide--protein
                     glycosyltransferase non-catalytic subunit"
                     /db_xref="GeneID:313648"
                     /db_xref="RGD:1308970"
     exon            1..161
                     /gene="Ddost"
                     /inference="alignment:Splign:2.1.0"
     CDS             2..1327
                     /gene="Ddost"
                     /EC_number="2.4.99.18"
                     /note="dolichyl-diphosphooligosaccharide--protein
                     glycosyltransferase 48 kDa subunit;
                     dolichyl-di-phosphooligosaccharide-protein
                     glycotransferase; DDOST 48 kDa subunit; oligosaccharyl
                     transferase 48 kDa subunit;
                     dolichyl-diphosphooligosaccharide-protein
                     glycosyltransferase;
                     dolichyl-diphosphooligosaccharide--protein
                     glycosyltransferase subunit (non-catalytic)"
                     /codon_start=1
                     /product="dolichyl-diphosphooligosaccharide--protein
                     glycosyltransferase 48 kDa subunit precursor"
                     /protein_id="NP_001012104.1"
                     /db_xref="GeneID:313648"
                     /db_xref="RGD:1308970"
                     /translation="MKMVPRLAVRAWPLCGLLLAALGCVCASGPRTLVLLDNLNVRDT
                     HSLFFRSLKDRGFELTFKTADDPSLSLIKYGEFLYDNLIIFSPSVEDFGGNINVETIS
                     AFIDGGGSVLVAASSDIGDPLRELGSECGIEFDEEKTAVIDHHNYDVSDLGQHTLIVA
                     DTENLLKAPTIVGKSSLNPILFRGVGMVADPDNPLVLDILTGSSTSYSFFPDKPITQY
                     PHAVGRNTLLIAGLQARNNARVIFSGSLDFFSDAFFNSAVQKAAPGAQRYSQTGNYEL
                     AVALSRWVFKEEGVLRVGPVSHHRVGETAPPNAYTVTDLVEYSIVIEQLSNGKWVPFD
                     GDDIQLEFVRIDPFVRTFLKRKGGKYSVQFKLPDVYGVFQFKVDYNRLGYTHLYSSTQ
                     VSVRPLQHTQYERFIPSAYPYYASAFSMMAGLFLFSVVFLHMKEKEKSD"
     exon            162..272
                     /gene="Ddost"
                     /inference="alignment:Splign:2.1.0"
     exon            273..359
                     /gene="Ddost"
                     /inference="alignment:Splign:2.1.0"
     exon            360..463
                     /gene="Ddost"
                     /inference="alignment:Splign:2.1.0"
     exon            464..558
                     /gene="Ddost"
                     /inference="alignment:Splign:2.1.0"
     exon            559..652
                     /gene="Ddost"
                     /inference="alignment:Splign:2.1.0"
     exon            653..801
                     /gene="Ddost"
                     /inference="alignment:Splign:2.1.0"
     exon            802..949
                     /gene="Ddost"
                     /inference="alignment:Splign:2.1.0"
     exon            950..1177
                     /gene="Ddost"
                     /inference="alignment:Splign:2.1.0"
     exon            1178..1563
                     /gene="Ddost"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gatgaagatg gttccccgcc tcgctgtccg tgcctggcct ctctgcgggc tgctgctggc
       61 tgcgctcggc tgtgtctgcg ccagcggtcc ccgcaccctc gtgctgctgg acaacttgaa
      121 cgtgcgggac acgcactcac tgttcttccg cagcctgaag gaccggggct ttgagctcac
      181 cttcaagact gcagatgacc ccagtttgtc ccttattaag tacggggagt tcctctatga
      241 caaccttatc atcttttccc cgtcggtgga agattttgga ggcaacatca acgtggagac
      301 catcagtgcc ttcatcgacg gcggtggcag cgttttggtg gctgccagct ctgatatcgg
      361 tgaccctctt cgggagctag gcagtgagtg tgggattgaa tttgatgagg aaaaaacagc
      421 tgtcatcgac caccacaact acgatgtctc agaccttggc cagcacacac tcatcgtggc
      481 cgacactgag aacttgctga aggccccaac cattgttggc aagtcatctc tgaaccccat
      541 tctcttccga ggagttggaa tggtggctga ccctgacaat cccttggttt tggacatctt
      601 aacaggctct tcaacctctt actccttctt cccagataaa ccaatcaccc agtaccccca
      661 cgcagtgggg agaaatactc tgctgattgc tgggctccaa gccaggaaca atgcccgggt
      721 catcttcagt ggctccctgg acttcttcag cgatgccttc ttcaactcag cagtgcagaa
      781 ggccgccccc ggtgcacaga ggtattctca gacaggcaac tatgagctag ctgtggccct
      841 gtcccgctgg gtgttcaagg aggagggtgt ccttcgagtg gggcctgtgt cccatcaccg
      901 ggtgggcgag acggccccac ccaatgccta cactgtcact gacttggtgg agtatagcat
      961 cgtgatcgag caactctcca atggtaagtg ggtccccttt gacggagatg acattcagct
     1021 ggagtttgta cgcattgacc ccttcgtgag gaccttcctg aagaggaagg gtggcaagta
     1081 cagtgtccag ttcaagctgc cggacgtgta tggcgtgttc cagtttaaag tggattacaa
     1141 ccggctaggc tacacccacc tgtactcctc cacccaggtg tcggtgaggc cactccagca
     1201 cacgcagtat gagcgcttca ttccctcggc ctatccctac tacgccagcg ccttctccat
     1261 gatggctggg ctcttcctct ttagcgtcgt cttcttgcac atgaaggaga aggagaagtc
     1321 tgattgagcc agaacctggg acaccgcaca gcagacagcc agacttgact ggagtgggtt
     1381 ggttggggtc tgttttgttt aaggccatag gaaaatggtg cagccttacc tcagagggta
     1441 tgactatggg gcgggagaca gggaacattt ctttctgtaa gttttcaagt tcgaatcact
     1501 ctgtggcact tttaatatgt acagccaccc ccatttctaa aataaagaga actactgccc
     1561 tcaaaaaaaa aaaaaaaaaa aaaaaaaaaa
//
