LOCUS       NM_001109465            1086 bp    mRNA    linear   ROD 14-APR-2024
DEFINITION  Rattus norvegicus D-aspartate oxidase (Ddo), mRNA.
ACCESSION   NM_001109465 XM_001063346
VERSION     NM_001109465.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1086)
  AUTHORS   Katane,M., Kuwabara,H., Nakayama,K., Saitoh,Y., Miyamoto,T.,
            Sekine,M. and Homma,H.
  TITLE     Biochemical characterization of d-aspartate oxidase from
            Caenorhabditis elegans: its potential use in the determination of
            free d-glutamate in biological samples
  JOURNAL   Biochim Biophys Acta Proteins Proteom 1868 (8), 140442 (2020)
   PUBMED   32376478
REFERENCE   2  (bases 1 to 1086)
  AUTHORS   Katane,M., Kuwabara,H., Nakayama,K., Saitoh,Y., Miyamoto,T.,
            Sekine,M. and Homma,H.
  TITLE     Rat d-aspartate oxidase is more similar to the human enzyme than
            the mouse enzyme
  JOURNAL   Biochim Biophys Acta Proteins Proteom 1866 (7), 806-812 (2018)
   PUBMED   29292239
REFERENCE   3  (bases 1 to 1086)
  AUTHORS   Katane,M., Kawata,T., Nakayama,K., Saitoh,Y., Kaneko,Y.,
            Matsuda,S., Saitoh,Y., Miyamoto,T., Sekine,M. and Homma,H.
  TITLE     Characterization of the enzymatic and structural properties of
            human D-aspartate oxidase and comparison with those of the rat and
            mouse enzymes
  JOURNAL   Biol Pharm Bull 38 (2), 298-305 (2015)
   PUBMED   25747990
REFERENCE   4  (bases 1 to 1086)
  AUTHORS   Katane,M., Saitoh,Y., Hanai,T., Sekine,M., Furuchi,T., Koyama,N.,
            Nakagome,I., Tomoda,H., Hirono,S. and Homma,H.
  TITLE     Thiolactomycin inhibits D-aspartate oxidase: a novel approach to
            probing the active site environment
  JOURNAL   Biochimie 92 (10), 1371-1378 (2010)
   PUBMED   20603179
REFERENCE   5  (bases 1 to 1086)
  AUTHORS   Ghosh,D. and Berg,J.M.
  TITLE     A proteome-wide perspective on peroxisome targeting signal
            1(PTS1)-Pex5p affinities
  JOURNAL   J Am Chem Soc 132 (11), 3973-3979 (2010)
   PUBMED   20178365
REFERENCE   6  (bases 1 to 1086)
  AUTHORS   Huang,A.S., Beigneux,A., Weil,Z.M., Kim,P.M., Molliver,M.E.,
            Blackshaw,S., Nelson,R.J., Young,S.G. and Snyder,S.H.
  TITLE     D-aspartate regulates melanocortin formation and function:
            behavioral alterations in D-aspartate oxidase-deficient mice
  JOURNAL   J Neurosci 26 (10), 2814-2819 (2006)
   PUBMED   16525061
REFERENCE   7  (bases 1 to 1086)
  AUTHORS   Zaar,K., Kost,H.P., Schad,A., Volkl,A., Baumgart,E. and Fahimi,H.D.
  TITLE     Cellular and subcellular distribution of D-aspartate oxidase in
            human and rat brain
  JOURNAL   J Comp Neurol 450 (3), 272-282 (2002)
   PUBMED   12209855
REFERENCE   8  (bases 1 to 1086)
  AUTHORS   Setoyama,C. and Miura,R.
  TITLE     Structural and functional characterization of the human brain
            D-aspartate oxidase
  JOURNAL   J Biochem 121 (4), 798-803 (1997)
   PUBMED   9163533
REFERENCE   9  (bases 1 to 1086)
  AUTHORS   Van Veldhoven,P.P., Brees,C. and Mannaerts,G.P.
  TITLE     D-aspartate oxidase, a peroxisomal enzyme in liver of rat and man
  JOURNAL   Biochim Biophys Acta 1073 (1), 203-208 (1991)
   PUBMED   1991137
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000020.1.
            
            On Sep 27, 2008 this sequence version replaced NM_001109465.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643296.40091.1,
                                           SRR26643290.55217.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760386, SAMEA5760393
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-57                JAXUCZ010000020.1  45673577-45673633
            58-232              JAXUCZ010000020.1  45675532-45675706
            233-341             JAXUCZ010000020.1  45676902-45677010
            342-518             JAXUCZ010000020.1  45683444-45683620
            519-1086            JAXUCZ010000020.1  45692064-45692631
FEATURES             Location/Qualifiers
     source          1..1086
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="20"
                     /map="20q12"
     gene            1..1086
                     /gene="Ddo"
                     /gene_synonym="DASOX; DASPO"
                     /note="D-aspartate oxidase"
                     /db_xref="GeneID:685325"
                     /db_xref="RGD:1595123"
     exon            1..57
                     /gene="Ddo"
                     /gene_synonym="DASOX; DASPO"
                     /inference="alignment:Splign:2.1.0"
     exon            58..232
                     /gene="Ddo"
                     /gene_synonym="DASOX; DASPO"
                     /inference="alignment:Splign:2.1.0"
     CDS             61..1086
                     /gene="Ddo"
                     /gene_synonym="DASOX; DASPO"
                     /EC_number="1.4.3.1"
                     /codon_start=1
                     /product="D-aspartate oxidase precursor"
                     /protein_id="NP_001102935.1"
                     /db_xref="GeneID:685325"
                     /db_xref="RGD:1595123"
                     /translation="MDTVRIAVVGAGVIGLSTAACVSQLVPRCSVTVISDRFTPDTTS
                     NVAAGMLIPPTYPDTPVPTLKRWFRETFQHLSEIARSAEAVDAGIHLVSGWQIFRSVP
                     TEEVPFWADVVLGFREMTEAELKRFPQYEFGQAFTTLKCETSAYLPWLEKRIKGSGGL
                     LLTRRIEDLWELQPSFDIVVNCSGLGSRRLVGDATVSPVRGQVLQAQAPWVKHFIRDG
                     GGLTYVYPGTSYVTLGGSRQTGDWNLSPDAELSREIFSRCCALEPSLHRACDIKEKVG
                     LRPSRPGVRLQKEILVRGEQRLPVVHNYGHGSGGISVHWGSALEATRLVMECVHTLRT
                     PASLSKL"
     exon            233..341
                     /gene="Ddo"
                     /gene_synonym="DASOX; DASPO"
                     /inference="alignment:Splign:2.1.0"
     exon            342..518
                     /gene="Ddo"
                     /gene_synonym="DASOX; DASPO"
                     /inference="alignment:Splign:2.1.0"
     exon            519..1086
                     /gene="Ddo"
                     /gene_synonym="DASOX; DASPO"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aagcaagtgt tggtgccagg gcctccggtg gattccagac tgcctcttca gagacaggtc
       61 atggacacgg tgcgtattgc ggtcgtcgga gctggcgtga tagggctgtc tactgccgcc
      121 tgcgtctccc agctggtccc ccgatgttcc gttactgtca tctcagacag gttcacacct
      181 gacaccacca gtaatgtagc agctgggatg ctcattcctc ccacgtatcc agatacgccc
      241 gtgcccacgc tgaagcgatg gtttagagag accttccagc atctttctga aatcgccagg
      301 tctgcagagg ctgtggatgc cggcattcac ctggtgtctg gctggcagat atttcgcagt
      361 gtccccactg aagaagtacc tttctgggct gatgtcgtgc tgggatttcg agagatgacc
      421 gaggctgagc tgaagcgatt ccctcagtat gagtttggcc aggcttttac caccctgaag
      481 tgcgagactt ctgcctacct cccctggctg gagaaaagga taaagggaag tggaggtctg
      541 ctactcacca ggagaataga agacctgtgg gagctgcagc catcttttga tatcgtggtc
      601 aattgctcag gcctgggaag ccgacgactt gtgggagacg ccacggtttc cccggttagg
      661 ggccaagtgc tccaggcaca ggccccttgg gtgaagcatt tcatccgcga cgggggcggg
      721 ctgacttacg tttaccctgg tacctcttat gtaaccctgg gagggagtag acagacagga
      781 gactggaatc tctccccgga tgcagaactt agcagagaga ttttctctcg atgctgcgct
      841 cttgagcctt ccctccacag agcctgcgac ataaaagaga aagtgggcct gaggcccagc
      901 aggccgggtg tgcgtctgca gaaggagatc ctagtccggg gagagcagag gctgcctgtg
      961 gtccacaact acggccatgg gagcgggggc atctcagtgc actggggatc tgctctggaa
     1021 gccaccaggc tggtgatgga atgcgtccat actctcagga ccccagcttc cctatcaaag
     1081 ctgtag
//
