LOCUS       NM_030993               3575 bp    mRNA    linear   ROD 26-APR-2024
DEFINITION  Rattus norvegicus dendrin (Ddn), mRNA.
ACCESSION   NM_030993
VERSION     NM_030993.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3575)
  AUTHORS   Juric,M., Balog,M., Ivic,V., Boskovic,M., Benzon,B., Racetin,A.,
            Vukojevic,K., Bocina,I., Kevic,N., Restovic,I., Szucs,K.F.,
            Gaspar,R., Heffer,M., Vari,S.G. and Filipovic,N.
  TITLE     Increased expression of dendrin in the dorsal horn of the spinal
            cord during stress is regulated by sex hormones
  JOURNAL   Neuropeptides 86, 102126 (2021)
   PUBMED   33524899
REFERENCE   2  (bases 1 to 3575)
  AUTHORS   Yaddanapudi,S., Altintas,M.M., Kistler,A.D., Fernandez,I.,
            Moller,C.C., Wei,C., Peev,V., Flesche,J.B., Forst,A.L., Li,J.,
            Patrakka,J., Xiao,Z., Grahammer,F., Schiffer,M., Lohmuller,T.,
            Reinheckel,T., Gu,C., Huber,T.B., Ju,W., Bitzer,M., Rastaldi,M.P.,
            Ruiz,P., Tryggvason,K., Shaw,A.S., Faul,C., Sever,S. and Reiser,J.
  TITLE     CD2AP in mouse and human podocytes controls a proteolytic program
            that regulates cytoskeletal structure and cellular survival
  JOURNAL   J Clin Invest 121 (10), 3965-3980 (2011)
   PUBMED   21911934
  REMARK    Erratum:[J Clin Invest. 2012 Feb 1;122(2):780]
REFERENCE   3  (bases 1 to 3575)
  AUTHORS   Schochet,T.L., Bremer,Q.Z., Brownfield,M.S., Kelley,A.E. and
            Landry,C.F.
  TITLE     The dendritically targeted protein Dendrin is induced by acute
            nicotine in cortical regions of adolescent rat brain
  JOURNAL   Eur J Neurosci 28 (10), 1967-1979 (2008)
   PUBMED   19046379
  REMARK    GeneRIF: As Dendrin is an important component of cytoskeletal
            modifications at the synapse, these results suggest that nicotine
            influences unique plasticity-related changes in the adolescent
            forebrain that differ from the adult.
REFERENCE   4  (bases 1 to 3575)
  AUTHORS   Kremerskothen,J., Kindler,S., Finger,I., Veltel,S. and Barnekow,A.
  TITLE     Postsynaptic recruitment of Dendrin depends on both dendritic mRNA
            transport and synaptic anchoring
  JOURNAL   J Neurochem 96 (6), 1659-1666 (2006)
   PUBMED   16464232
  REMARK    GeneRIF: Postsynaptic recruitment of Dendrin depends on both local
            protein synthesis and association with MAGI/S-SCAM. Its nuclear
            localization capacity functions in retrograde signaling from the
            synapse to the nucleus.
REFERENCE   5  (bases 1 to 3575)
  AUTHORS   Szpirer,C., Szpirer,J., Van Vooren,P., Tissir,F., Simon,J.S.,
            Koike,G., Jacob,H.J., Lander,E.S., Helou,K., Klinga-Levan,K. and
            Levan,G.
  TITLE     Gene-based anchoring of the rat genetic linkage and cytogenetic
            maps: new regional localizations, orientation of the linkage
            groups, and insights into mammalian chromosome evolution
  JOURNAL   Mamm Genome 9 (9), 721-734 (1998)
   PUBMED   9716657
REFERENCE   6  (bases 1 to 3575)
  AUTHORS   Herb,A., Wisden,W., Catania,M.V., Marechal,D., Dresse,A. and
            Seeburg,P.H.
  TITLE     Prominent dendritic localization in forebrain neurons of a novel
            mRNA and its product, dendrin
  JOURNAL   Mol Cell Neurosci 8 (5), 367-374 (1997)
   PUBMED   9073398
REFERENCE   7  (bases 1 to 3575)
  AUTHORS   Neuner-Jehle,M., Denizot,J.P., Borbely,A.A. and Mallet,J.
  TITLE     Characterization and sleep deprivation-induced expression
            modulation of dendrin, a novel dendritic protein in rat brain
            neurons
  JOURNAL   J Neurosci Res 46 (2), 138-151 (1996)
   PUBMED   8915891
REFERENCE   8  (bases 1 to 3575)
  AUTHORS   Rhyner,T.A., Borbely,A.A. and Mallet,J.
  TITLE     Molecular Cloning of Forebrain mRNAs which are Modulated by Sleep
            Deprivation
  JOURNAL   Eur J Neurosci 2 (12), 1063-1073 (1990)
   PUBMED   12106067
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On Nov 27, 2020 this sequence version replaced NM_030993.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: Y09000.1, X96589.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMN12840106
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-195               JAXUCZ010000007.1  131836058-131836252 c
            196-3575            JAXUCZ010000007.1  131832270-131835649 c
FEATURES             Location/Qualifiers
     source          1..3575
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q36"
     gene            1..3575
                     /gene="Ddn"
                     /gene_synonym="Den"
                     /note="dendrin"
                     /db_xref="GeneID:25113"
                     /db_xref="RGD:2497"
     exon            1..195
                     /gene="Ddn"
                     /gene_synonym="Den"
                     /inference="alignment:Splign:2.1.0"
     CDS             149..2110
                     /gene="Ddn"
                     /gene_synonym="Den"
                     /codon_start=1
                     /product="dendrin"
                     /protein_id="NP_112255.1"
                     /db_xref="GeneID:25113"
                     /db_xref="RGD:2497"
                     /translation="MDIQASYWARGPQNRTCRLRPGSPEPPPRRPWASRVLQEATNWR
                     AGPPAEVRAREQEKRKAASQEREAKETERKRRKAGGARRSPLGQPRPELRNALRAAQP
                     TGFPVFSRPERFGQVGRAPRPSALPQGDPGVAWAGPWGGRRPGPPSYEAHLLLRGAAG
                     TAPRRRWDRPPPYVAPPSYEGPHRTLGTKRGPELSRAPTSSAPVPATTRTEGGRTKKR
                     LDPRIYRDVLGAWGLRQGRGLLGGAPGCAAARARPESCKGAVEKSSGLAAAGLNSGGD
                     GHSQAKTTGPVTEVALSGSTISSPPRPVPRSRQHLRGSRKGKEGSEEMWLPTCWLSSP
                     KKPPVRHSQTLPRPWAPGGTGWKESLGQREGTEHETLEVWKVTRRAHTLPRSSRGPAG
                     REGIFVIDATCVVIKSQYVPTPRTQQRQLAPSGESCIVSDSLRQPKPCLEEEGKGAAA
                     NPSVCQKRLLSSRVLNPPSEGREFEAEGRQQGDSSLEERSSSGLGFPVGEVNPRDAPT
                     HPGSPEHSTLGPAAPGCAGSVKGPEAAGVPRRAGGGWARTPGPYAGALREAVSRIRRH
                     TAPDSDSDEAEDLSAHSGSSDGSDTDAPGASWRNERTLPAVGNTRPREGGKTAELGDS
                     IGEILDVISQTEEGLVREDTRKTPQGKRE"
     exon            196..3575
                     /gene="Ddn"
                     /gene_synonym="Den"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gttattctcc gaggggcccg acagcccccg ggagctccag gatgaggagt ccggcagctg
       61 cctctgggtg cagaagtcca agctgttggt gattgaagtg aagactattt cctgtcatta
      121 tagccgtcgc gctgcttctc gacagtccat ggacatccag gccagctact gggcccgtgg
      181 gccccagaac cgcacgtgta ggctgcgccc cggatcccct gagccgccac cccgccgacc
      241 ctgggcctcc agggtgctgc aggaggcgac caactggcgg gcagggcccc ccgccgaggt
      301 ccgagcccga gaacaggaga aaagaaaggc ggcgtcgcag gagcgggagg ccaaggagac
      361 cgagagaaaa aggcgcaagg ctggcggggc ccgacggagt cccctaggtc agccccgccc
      421 agagctccgg aacgcccttc gggcggccca acctacaggg tttccagttt tctccagacc
      481 agagcgcttc gggcaggtgg ggcgagcgcc ccgaccatcc gcgctcccgc agggtgaccc
      541 aggggttgca tgggcggggc catggggagg cagaaggcca gggcctccta gctacgaggc
      601 tcacctgctg ctgagaggcg ctgcaggcac agccccaaga cgccgctggg accggccgcc
      661 accctacgtg gctccacctt cttatgaagg tccccacagg accctgggga ctaagcgagg
      721 cccggagctc tcccgggcgc ccacctcatc agccccagtg ccagctacca ccaggacaga
      781 gggagggcgc acgaagaaga ggctggatcc tcgaatctac cgggatgttc taggagcttg
      841 gggtctcaga cagggacggg gactcttagg aggagctcca ggctgtgcag cagccagagc
      901 taggccagag tcttgcaaag gggctgtaga gaaaagttca ggcctagctg ctgctggcct
      961 aaacagtggt ggtgatggtc attcccaagc caaaactact ggtccagtca cggaggtcgc
     1021 tctctctggg tccacgatca gtagcccacc acgtcctgtt cccaggtcta ggcagcacct
     1081 caggggatca aggaaaggga aagaaggaag tgaggagatg tggcttccca cgtgttggct
     1141 ttcctcccct aaaaagcctc cagttaggca tagccagacc ctccccagac cctgggctcc
     1201 tggaggcacc gggtggaaag agtccctggg tcaaagagag gggacagagc atgagaccct
     1261 ggaagtctgg aaggtgaccc gccgtgccca caccctgccc cgcagttccc gaggtcccgc
     1321 tggtagagaa ggcatctttg tcattgatgc cacatgcgtg gtgataaagt cccagtacgt
     1381 tccaacccct cgaacccagc agaggcagct cgcgccctct ggggagtcat gcatcgtgag
     1441 cgacagcctc aggcaaccca aaccctgcct tgaggaggag ggcaaagggg ccgctgccaa
     1501 cccttcagtt tgccaaaagc gactgttgag cagtcgagtc ttaaacccac cgagtgaggg
     1561 tcgcgagttc gaggctgagg gcagacagca gggggattct tcattggagg agcgctcctc
     1621 cagcggtttg gggttccctg tcggcgaagt gaacccgcga gatgccccca cgcatccagg
     1681 tagcccagag cactcgacct taggcccagc ggctccggga tgcgcgggca gcgtgaaggg
     1741 cccagaagca gctggggtcc cgcggcgcgc gggcgggggc tgggcgcgga ctccagggcc
     1801 ctacgccgga gccttgcggg aagccgtgtc ccgcatccgc cgccacaccg ccccagattc
     1861 ggactcagac gaagccgagg atctcagcgc ccatagtggc tcctctgatg gaagcgacac
     1921 agacgcccca ggcgcctcct ggcggaatga gaggaccctg cctgcggttg ggaacacccg
     1981 gcccagggaa ggcgggaaga cagcagagct gggcgacagt atcggggaga ttctagatgt
     2041 catcagtcaa accgaggaag gcctcgtccg agaggacacc aggaaaacgc cacagggaaa
     2101 gagagagtga gagtgagcga cgcccctcct tgtcctcgtg tcgctcggcc cagccagcct
     2161 tgggctcacc gcgctccttt cctctctcca ggcttcgttt gcttcctttt cttctttcct
     2221 acctgtacct gttcccttga gacagaggag aggggaggaa cgagggaact gactcaagag
     2281 tcagtttcag ggaaagagag ggtgggatcc cacacctgct acattcggtg tggaactgtt
     2341 cagagaggca aagtgaaggg cagggcaggg tccctggcag gagaggaaaa gtaacggaga
     2401 ggcttttgaa cctagtgacc tagtgcagga gacagagggc ttttagcaga gaagaaatga
     2461 atgcagaatg catacactca accagcaaat tggcaagagg gctctcctag atgttacaac
     2521 tcaagtttca attccaactc tgccactgac ttagctggtg gatctcagag tgactacttt
     2581 tctgcccggg catcagggac taatgtaaat gtaaaacgag cgatttctgc ctcccattct
     2641 tttgtcccta gaattttgtg aacgagcgag tagaatttga gggttcttac ccacttctgc
     2701 catcctcagt tcggaagaca gtcagggttt tcagatttaa acgggcaaag ggcttctatt
     2761 ccaatttccc gagtttaggt gaatgctccc caaagcaggg caagataaag gtccggtcac
     2821 tgcctctggc ctgctgtgat ccaagctgga gagggaaggt agccaatgaa tcagcttgga
     2881 acacttttag gcctgcccct ttcctccatc tccgtgtcct tagtgatgct ctacgtgtta
     2941 ccggacgcag acggtatggc ccaccggata gaccctgact atctctgtgt ctctcctgga
     3001 aaacagccag gcaaggagga aggttgatca cagcagacgg tgtgggtgtg atactcgctg
     3061 tagccactac ggggcgcgcg caggtcgcgg attccccccc ggttgctggt gctcgagtgc
     3121 ccctacacca gcactgccag ttatctggat cccttatttc ccggcgccgg tttcccgcct
     3181 tgacacctcc aaaccgcgcg cggggccggg agcaggcctc cggtctccca gacttctggg
     3241 gcgcgccgag cccttctttg tattaatcca cgcctaccgg tttgagactg acattcaagt
     3301 cttttttttt ttttgtcttt ccttttcctt tttctgtttt cttttccttc tttccaaccc
     3361 tgggcacttc ctctgtgtct gccacttact agccatgtga ccttggccaa atcacttcac
     3421 ctccctgagc ctcagtttcc tcatctgtca aatgggggtt tataaacacc tacctcgcag
     3481 ggttgttgtg aggatttaat gaggtaatgt atataaagcg tcttgcacag tgcctggcac
     3541 atagtaggcg cccaataaat ctactcgtcc cttta
//
