LOCUS       NM_080906               1749 bp    mRNA    linear   ROD 05-DEC-2024
DEFINITION  Rattus norvegicus DNA-damage-inducible transcript 4 (Ddit4), mRNA.
ACCESSION   NM_080906
VERSION     NM_080906.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1749)
  AUTHORS   Li,L., Xi,L., Wu,J., Zhao,Z., Chen,Y., Liu,W., Pan,Z., Liu,M.,
            Yang,D., Chen,Z. and Fang,Y.
  TITLE     The regulatory roles of DDIT4 in TDCIPP-induced autophagy and
            apoptosis in PC12 cells
  JOURNAL   J Environ Sci (China) 125, 823-830 (2023)
   PUBMED   36375964
  REMARK    GeneRIF: The regulatory roles of DDIT4 in TDCIPP-induced autophagy
            and apoptosis in PC12 cells.
REFERENCE   2  (bases 1 to 1749)
  AUTHORS   Guo,X., Wang,Y., Zheng,D., Cheng,X. and Sun,Y.
  TITLE     LncRNA-MIAT promotes neural cell autophagy and apoptosis in
            ischemic stroke by up-regulating REDD1
  JOURNAL   Brain Res 1763, 147436 (2021)
   PUBMED   33745924
  REMARK    GeneRIF: LncRNA-MIAT promotes neural cell autophagy and apoptosis
            in ischemic stroke by up-regulating REDD1.
REFERENCE   3  (bases 1 to 1749)
  AUTHORS   Martin-Flores,N., Perez-Sisques,L., Creus-Muncunill,J., Masana,M.,
            Gines,S., Alberch,J., Perez-Navarro,E. and Malagelada,C.
  TITLE     Synaptic RTP801 contributes to motor-learning dysfunction in
            Huntington's disease
  JOURNAL   Cell Death Dis 11 (7), 569 (2020)
   PUBMED   32732871
  REMARK    GeneRIF: Synaptic RTP801 contributes to motor-learning dysfunction
            in Huntington's disease.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1749)
  AUTHORS   Park,J.A. and Lee,C.H.
  TITLE     Time-Course Change of Redd1 Expressions in the Hippocampal CA1
            Region Following Chronic Cerebral Hypoperfusion
  JOURNAL   Cell Mol Neurobiol 37 (3), 563-569 (2017)
   PUBMED   27233899
  REMARK    GeneRIF: Redd1 expressions is markedly changed in the hippocampal
            CA1 region following chronic cerebral hypoperfusion.
REFERENCE   5  (bases 1 to 1749)
  AUTHORS   Chen,Q., Zhou,Y., Richards,A.M. and Wang,P.
  TITLE     Up-regulation of miRNA-221 inhibits hypoxia/reoxygenation-induced
            autophagy through the DDIT4/mTORC1 and Tp53inp1/p62 pathways
  JOURNAL   Biochem Biophys Res Commun 474 (1), 168-174 (2016)
   PUBMED   27105917
  REMARK    GeneRIF: In conclusion, miRNA-221 exerts cytoprotective effects in
            hypoxia-reoxygenation injury in association with alterations in
            autophagic cell injury. Mir-221 may constitute is a novel
            therapeutic target in the treatment of cardiac I/R injury.
REFERENCE   6  (bases 1 to 1749)
  AUTHORS   Wang,H., Kubica,N., Ellisen,L.W., Jefferson,L.S. and Kimball,S.R.
  TITLE     Dexamethasone represses signaling through the mammalian target of
            rapamycin in muscle cells by enhancing expression of REDD1
  JOURNAL   J Biol Chem 281 (51), 39128-39134 (2006)
   PUBMED   17074751
  REMARK    GeneRIF: REDD1 functions upstream of Tuberin and Rheb to
            down-regulate mTOR signaling in response to dexamethasone
REFERENCE   7  (bases 1 to 1749)
  AUTHORS   Malagelada,C., Ryu,E.J., Biswas,S.C., Jackson-Lewis,V. and
            Greene,L.A.
  TITLE     RTP801 is elevated in Parkinson brain substantia nigral neurons and
            mediates death in cellular models of Parkinson's disease by a
            mechanism involving mammalian target of rapamycin inactivation
  JOURNAL   J Neurosci 26 (39), 9996-10005 (2006)
   PUBMED   17005863
  REMARK    GeneRIF: In a PC12 model of Parkinson disease, RTP801
            overexpression is sufficient to promote death but does not further
            elevate death caused by 6-OHDA.
REFERENCE   8  (bases 1 to 1749)
  AUTHORS   Ellisen,L.W., Ramsayer,K.D., Johannessen,C.M., Yang,A., Beppu,H.,
            Minda,K., Oliner,J.D., McKeon,F. and Haber,D.A.
  TITLE     REDD1, a developmentally regulated transcriptional target of p63
            and p53, links p63 to regulation of reactive oxygen species
  JOURNAL   Mol Cell 10 (5), 995-1005 (2002)
   PUBMED   12453409
REFERENCE   9  (bases 1 to 1749)
  AUTHORS   Jiang,Y., Wu,J., Keep,R.F., Hua,Y., Hoff,J.T. and Xi,G.
  TITLE     Hypoxia-inducible factor-1alpha accumulation in the brain after
            experimental intracerebral hemorrhage
  JOURNAL   J Cereb Blood Flow Metab 22 (6), 689-696 (2002)
   PUBMED   12045667
  REMARK    GeneRIF: Thrombin and erythrocyte lysate are involved in HIF-1alpha
            upregulation through reducing HIF-1alpha degradation.
REFERENCE   10 (bases 1 to 1749)
  AUTHORS   Shoshani,T., Faerman,A., Mett,I., Zelin,E., Tenne,T., Gorodin,S.,
            Moshel,Y., Elbaz,S., Budanov,A., Chajut,A., Kalinski,H., Kamer,I.,
            Rozen,A., Mor,O., Keshet,E., Leshkowitz,D., Einat,P., Skaliter,R.
            and Feinstein,E.
  TITLE     Identification of a novel hypoxia-inducible factor 1-responsive
            gene, RTP801, involved in apoptosis
  JOURNAL   Mol Cell Biol 22 (7), 2283-2293 (2002)
   PUBMED   11884613
  REMARK    GeneRIF: Identification of a novel hypoxia-inducible factor
            1-responsive gene, RTP801, involved in apoptosis
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF334162.1.
            
            On Feb 21, 2013 this sequence version replaced NM_080906.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF334162.1, BC062021.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN06621351, SAMN11044071
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1749              AF334162.1         6-1754
FEATURES             Location/Qualifiers
     source          1..1749
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="20"
                     /map="20q11"
     gene            1..1749
                     /gene="Ddit4"
                     /gene_synonym="Rtp801"
                     /note="DNA-damage-inducible transcript 4"
                     /db_xref="GeneID:140942"
                     /db_xref="RGD:621731"
     exon            1..123
                     /gene="Ddit4"
                     /gene_synonym="Rtp801"
                     /inference="alignment:Splign:2.1.0"
     exon            124..378
                     /gene="Ddit4"
                     /gene_synonym="Rtp801"
                     /inference="alignment:Splign:2.1.0"
     CDS             183..872
                     /gene="Ddit4"
                     /gene_synonym="Rtp801"
                     /note="REDD-1; HIF-1 responsive protein RTP801; protein
                     regulated in development and DNA damage response 1; HIF-1
                     responsive RTP801"
                     /codon_start=1
                     /product="DNA damage-inducible transcript 4 protein"
                     /protein_id="NP_543182.1"
                     /db_xref="GeneID:140942"
                     /db_xref="RGD:621731"
                     /translation="MPSLWDRFSSSSSSSSSSRTPAADRPPRSAWGSAAREEGLDRCA
                     SLESSDCESLDSSNSGFGPEEDSSYLDGVSLPDFELLSDPEDEHLCANLMQLLQESLS
                     QARLGSRRPARLLMPSQLLSQVGKELLRLAYSEPCGLRGALLDVCVEQGKSCHSVAQL
                     ALDPSLVPTFQLTLVLRLDSRLWPKIQGLLSSANSSLVPGYSQSLTLSTGFRVIKKKL
                     YSSEQLLIEEC"
     exon            379..1726
                     /gene="Ddit4"
                     /gene_synonym="Rtp801"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggggaggtg cgagagggct ggaaaggaca ggtccgggca gcgatcgggg gttggcatca
       61 gttcgctcac ccttcgagag gcagatcgct cttgtccgca atcttcgctg accgcgctag
      121 ctgcggcttc tgtgctcctt cgccgaacct catcaaccag cgtcctggcg tctgacctcg
      181 ccatgcctag cctttgggat cgtttctcgt cctcctcttc ctcttcgtcc tcgtcccgaa
      241 ctccggccgc tgatcggccg ccgcgctccg cctgggggtc tgcggccaga gaagagggcc
      301 ttgaccgctg cgcgagcctg gagagctcgg actgcgagtc cctggacagc agcaacagtg
      361 gctttgggcc ggaggaagac tcctcatacc tggatggggt gtctctgcct gactttgagc
      421 tgctcagtga ccccgaggat gagcacctgt gtgccaacct gatgcagctg ctgcaggaga
      481 gcctgtccca ggcgcgattg ggctcgcggc gccctgcgcg cctgctgatg ccgagccagc
      541 tgttgagcca ggtgggcaag gaactcctgc gcctggcgta cagcgagccg tgcggcctgc
      601 ggggggcact gctggacgtc tgtgtggagc aaggcaagag ctgccatagt gtggctcagc
      661 tggctctgga ccccagtcta gtgcccacct ttcagttgac cctggtgctg cgtctggact
      721 ctcgcctctg gcccaagatc cagggcctgt tgagttctgc caactcttcc ttggtccctg
      781 gttacagcca gtccctgacg ctgagcaccg gcttcagagt catcaaaaag aaactctaca
      841 gctccgagca gctgctcatt gaagagtgtt gaacttcgtc ctggaggggg gccgcactgc
      901 cccccaaagt ggagacaagg aatttctgtg gtggagaccc gcaggcaagg actgaaggac
      961 tgtcccctgt gttagaaaac tgacaatagc caccggaggg gcgcagggcc aggtgggaga
     1021 aggaagtgtt gtccaggaag tctctaggtt gtgtgcaggt ggccccctgt tggggcacat
     1081 gcccctcagt actgtagcat gaaacaaagg cttcggagcc acacaggctt ctggctggat
     1141 gtgtatgtag catgtatctt attaattttt gtattactga caagttacaa cagcagttgt
     1201 gggccagagt cagaagggca gctggtctgc actggcctct gcccgggctg tgtgctgggg
     1261 ggaggcgggg ggaggtctcc gacagtttgt cgacagatct catggtctga aaggaccgag
     1321 cttgttcgtc gtttggtttg tatcttgttt tgggggtggg gtggggggat cggagcttca
     1381 ctactgacct gttcgaggca gctatcttac agactgcatg aatgtaagaa taggaagggg
     1441 gtgggtgtta ggatcatttg ggatcttcaa cacttgaaac aaaataacac cagggagctg
     1501 catcccagcc catcccggtg ccggtgtact ggaggagtga actgtgaggg gatggggctg
     1561 aggggggtgg ggggctggaa ccctctcccc cagaggagcg ccacctgggt cttccatcta
     1621 gaactgttta catgaagata ctcacggttc atgaatacac ttgatgttca agtactaaga
     1681 cctatgcaat atttttactt ttctaataaa catgtttgtt aaaacaaaaa aaaaaaaaaa
     1741 aaaaaaaaa
//
