LOCUS       NM_024134                813 bp    mRNA    linear   ROD 12-AUG-2024
DEFINITION  Rattus norvegicus DNA-damage inducible transcript 3 (Ddit3),
            transcript variant 2, mRNA.
ACCESSION   NM_024134
VERSION     NM_024134.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 813)
  AUTHORS   Mou,L., Sun,D., Qu,J., Tan,X., Wang,S., Zeng,Q. and Liu,C.
  TITLE     GRP78/IRE1 and cGAS/STING pathway crosstalk through CHOP
            facilitates iodoacetic acid-mediated testosterone decline
  JOURNAL   J Hazard Mater 476, 135101 (2024)
   PUBMED   39002476
  REMARK    GeneRIF: GRP78/IRE1 and cGAS/STING pathway crosstalk through CHOP
            facilitates iodoacetic acid-mediated testosterone decline.
REFERENCE   2  (bases 1 to 813)
  AUTHORS   Ishteyaque,S., Yadav,K.S., Verma,S., Washimkar,K.R. and Mugale,M.N.
  TITLE     CYP2E1 triggered GRP78/ATF6/CHOP signaling axis inhibit apoptosis
            and promotes progression of hepatocellular carcinoma
  JOURNAL   Arch Biochem Biophys 745, 109701 (2023)
   PUBMED   37499993
  REMARK    GeneRIF: CYP2E1 triggered GRP78/ATF6/CHOP signaling axis inhibit
            apoptosis and promotes progression of hepatocellular carcinoma.
REFERENCE   3  (bases 1 to 813)
  AUTHORS   Wang,S., Duan,J., Liao,J., Wang,Y., Xiao,X., Li,L., Liu,Y., Gu,H.,
            Yang,P., Fu,D., Du,J., Li,X. and Shao,M.
  TITLE     LncRNA H19 inhibits ER stress induced apoptosis and improves
            diabetic cardiomyopathy by regulating PI3K/AKT/mTOR axis
  JOURNAL   Aging (Albany NY) 14 (16), 6809-6828 (2022)
   PUBMED   36044268
REFERENCE   4  (bases 1 to 813)
  AUTHORS   Yuan,Z., Xiao-Wei,L., Juan,W., Xiu-Juan,L., Nian-Yun,Z. and Lei,S.
  TITLE     HIIT and MICT attenuate high-fat diet-induced hepatic lipid
            accumulation and ER stress via the PERK-ATF4-CHOP signaling pathway
  JOURNAL   J Physiol Biochem 78 (3), 641-652 (2022)
   PUBMED   35315506
  REMARK    GeneRIF: HIIT and MICT attenuate high-fat diet-induced hepatic
            lipid accumulation and ER stress via the PERK-ATF4-CHOP signaling
            pathway.
REFERENCE   5  (bases 1 to 813)
  AUTHORS   Zhan,W., Chen,L., Liu,H., Long,C., Liu,J., Ding,S., Wu,Q. and
            Chen,S.
  TITLE     Pcsk6 Deficiency Promotes Cardiomyocyte Senescence by Modulating
            Ddit3-Mediated ER Stress
  JOURNAL   Genes (Basel) 13 (4), 711 (2022)
   PUBMED   35456517
  REMARK    GeneRIF: Pcsk6 Deficiency Promotes Cardiomyocyte Senescence by
            Modulating Ddit3-Mediated ER Stress.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 813)
  AUTHORS   Jousse,C., Bruhat,A., Carraro,V., Urano,F., Ferrara,M., Ron,D. and
            Fafournoux,P.
  TITLE     Inhibition of CHOP translation by a peptide encoded by an open
            reading frame localized in the chop 5'UTR
  JOURNAL   Nucleic Acids Res 29 (21), 4341-4351 (2001)
   PUBMED   11691921
REFERENCE   7  (bases 1 to 813)
  AUTHORS   Sylvester,S.L., ap Rhys,C.M., Luethy-Martindale,J.D. and
            Holbrook,N.J.
  TITLE     Induction of GADD153, a CCAAT/enhancer-binding protein
            (C/EBP)-related gene, during the acute phase response in rats.
            Evidence for the involvement of C/EBPs in regulating its expression
  JOURNAL   J Biol Chem 269 (31), 20119-20125 (1994)
   PUBMED   8051100
  REMARK    Erratum:[J Biol Chem. 1995 Jun 16;270(24):14842.. PMID: 7782352]
REFERENCE   8  (bases 1 to 813)
  AUTHORS   Aman,P., Ron,D., Mandahl,N., Fioretos,T., Heim,S., Arheden,K.,
            Willen,H., Rydholm,A. and Mitelman,F.
  TITLE     Rearrangement of the transcription factor gene CHOP in myxoid
            liposarcomas with t(12;16)(q13;p11)
  JOURNAL   Genes Chromosomes Cancer 5 (4), 278-285 (1992)
   PUBMED   1283316
REFERENCE   9  (bases 1 to 813)
  AUTHORS   Ron,D. and Habener,J.F.
  TITLE     CHOP, a novel developmentally regulated nuclear protein that
            dimerizes with transcription factors C/EBP and LAP and functions as
            a dominant-negative inhibitor of gene transcription
  JOURNAL   Genes Dev 6 (3), 439-453 (1992)
   PUBMED   1547942
REFERENCE   10 (bases 1 to 813)
  AUTHORS   Kesterton,D.B.
  TITLE     A projectionist speaks
  JOURNAL   Med Biol Illus 27 (1), 15-19 (1977)
   PUBMED   70575
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CF977695.1, AW916370.1, U30186.1 and BF282473.1.
            
            On Oct 19, 2007 this sequence version replaced NM_024134.1.
            
            Transcript Variant: This variant (2) lacks a segment in the 5' UTR,
            compared to variant 2. Variants 1 and 2 both encode the same
            protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CF977695.1, U30186.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-14                CF977695.1         4-17
            15-98               AW916370.1         15-98
            99-393              U30186.1           91-385
            394-813             BF282473.1         1-420               c
FEATURES             Location/Qualifiers
     source          1..813
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q22"
     gene            1..813
                     /gene="Ddit3"
                     /gene_synonym="CHOP; CHOP-10; Chop10; Gadd153; RM4"
                     /note="DNA-damage inducible transcript 3"
                     /db_xref="GeneID:29467"
                     /db_xref="RGD:62391"
     exon            1..98
                     /gene="Ddit3"
                     /gene_synonym="CHOP; CHOP-10; Chop10; Gadd153; RM4"
                     /inference="alignment:Splign:2.1.0"
     exon            99..256
                     /gene="Ddit3"
                     /gene_synonym="CHOP; CHOP-10; Chop10; Gadd153; RM4"
                     /inference="alignment:Splign:2.1.0"
     CDS             119..625
                     /gene="Ddit3"
                     /gene_synonym="CHOP; CHOP-10; Chop10; Gadd153; RM4"
                     /note="C/EBP homologous protein; DDIT-3; growth arrest and
                     DNA-damage-inducible protein GADD153; c/EBP-homologous
                     protein 10; C/EBP zeta; CCAAT/enhancer-binding protein
                     homologous protein"
                     /codon_start=1
                     /product="DNA damage-inducible transcript 3 protein"
                     /protein_id="NP_077048.2"
                     /db_xref="GeneID:29467"
                     /db_xref="RGD:62391"
                     /translation="MAAESLPFAFETVSSWELEAWYEDLQEVLSSDEIGGTYISSPGN
                     EEEESKTFTTLDPASLAWLTEEPGPAEVTSTSQSPRSPDSSQSSMAQEEEEEDQGRTR
                     KRKQSGQCAARAGKQRMKEKEQENERKVAQLAEENERLKQEIERLTREVETTRRALID
                     RMVSLHQA"
     exon            257..813
                     /gene="Ddit3"
                     /gene_synonym="CHOP; CHOP-10; Chop10; Gadd153; RM4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggtcagtatc ttgagtctaa tacgtcgatc ataccatgtt gaagatgagc gggtggcagc
       61 gacagagcca aaataacagc cggaacctga ggagagagaa accggtccaa ttacagtcat
      121 ggcagctgag tctctgcctt tcgcctttga gacagtgtcc agctgggagc tggaagcctg
      181 gtatgaggat ctgcaggagg tcctgtcctc agatgaaatt gggggcacct atatctcatc
      241 cccaggaaac gaagaggaag aatcaaaaac cttcactact cttgaccctg catccctagc
      301 ttggctgact gaggagccag ggccagcaga ggtcacaagc acctcccaaa gccctcgctc
      361 tccagattcc agtcagagtt ctatggctca ggaggaagaa gaggaagatc aaggaagaac
      421 taggaaacgg aaacagagtg gtcagtgcgc agcccgggct gggaaacagc gcatgaagga
      481 gaaggagcag gagaatgaga ggaaagtggc acagcttgct gaagagaacg agcggctcaa
      541 gcaggaaatc gagcgcctga ccagggaggt agagaccaca cggcgggctc tgatcgaccg
      601 catggtcagt ctgcaccaag catgaactgt tggcatcacc tcctgtctgt ctctcccgga
      661 gtgtacccag caccatcacg ccagtgccaa gcatgtaatc tccagtgcac atgctgagga
      721 ggggactgag ggtagaccaa aggagagggg cttgtacact gtacattctt tattactgtc
      781 catacccagt aaagtgactt tgtgtgaaca ttc
//
