LOCUS       NM_012545               5134 bp    mRNA    linear   ROD 09-APR-2024
DEFINITION  Rattus norvegicus dopa decarboxylase (Ddc), transcript variant 1,
            mRNA.
ACCESSION   NM_012545
VERSION     NM_012545.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5134)
  AUTHORS   Seo,D.C., Ju,Y.H., Seo,J.J., Oh,S.J., Lee,C.J., Lee,S.E. and
            Nam,M.H.
  TITLE     DDC-Promoter-Driven Chemogenetic Activation of SNpc Dopaminergic
            Neurons Alleviates Parkinsonian Motor Symptoms
  JOURNAL   Int J Mol Sci 24 (3), 2491 (2023)
   PUBMED   36768816
  REMARK    GeneRIF: DDC-Promoter-Driven Chemogenetic Activation of SNpc
            Dopaminergic Neurons Alleviates Parkinsonian Motor Symptoms.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5134)
  AUTHORS   Sizova,D., Velazquez,H., Sampaio-Maia,B., Quelhas-Santos,J.,
            Pestana,M. and Desir,G.V.
  TITLE     Renalase regulates renal dopamine and phosphate metabolism
  JOURNAL   Am J Physiol Renal Physiol 305 (6), F839-F844 (2013)
   PUBMED   23863468
REFERENCE   3  (bases 1 to 5134)
  AUTHORS   Voigt,A., Hubner,S., Lossow,K., Hermans-Borgmeyer,I., Boehm,U. and
            Meyerhof,W.
  TITLE     Genetic labeling of Tas1r1 and Tas2r131 taste receptor cells in
            mice
  JOURNAL   Chem Senses 37 (9), 897-911 (2012)
   PUBMED   23010799
REFERENCE   4  (bases 1 to 5134)
  AUTHORS   Rouzaud-Laborde,C., Hanoun,N., Baysal,I., Rech,J.S., Mias,C.,
            Calise,D., Sicard,P., Frugier,C., Seguelas,M.H., Parini,A. and
            Pizzinat,N.
  TITLE     Role of endothelial AADC in cardiac synthesis of serotonin and
            nitrates accumulation
  JOURNAL   PLoS One 7 (7), e34893 (2012)
   PUBMED   22829864
  REMARK    GeneRIF: The data show that endothelial AADC plays an important
            role in cardiac synthesis of 5-HT and possibly in 5-HT-dependent
            regulation of nitric oxide generation.
REFERENCE   5  (bases 1 to 5134)
  AUTHORS   Brun,L., Ngu,L.H., Keng,W.T., Ch'ng,G.S., Choy,Y.S., Hwu,W.L.,
            Lee,W.T., Willemsen,M.A., Verbeek,M.M., Wassenberg,T., Regal,L.,
            Orcesi,S., Tonduti,D., Accorsi,P., Testard,H., Abdenur,J.E.,
            Tay,S., Allen,G.F., Heales,S., Kern,I., Kato,M., Burlina,A.,
            Manegold,C., Hoffmann,G.F. and Blau,N.
  TITLE     Clinical and biochemical features of aromatic L-amino acid
            decarboxylase deficiency
  JOURNAL   Neurology 75 (1), 64-71 (2010)
   PUBMED   20505134
  REMARK    Erratum:[Neurology. 2010 Aug 10;75(6):576. Dosage error in article
            text]
REFERENCE   6  (bases 1 to 5134)
  AUTHORS   Rorsman,F., Husebye,E.S., Winqvist,O., Bjork,E., Karlsson,F.A. and
            Kampe,O.
  TITLE     Aromatic-L-amino-acid decarboxylase, a pyridoxal
            phosphate-dependent enzyme, is a beta-cell autoantigen
  JOURNAL   Proc Natl Acad Sci U S A 92 (19), 8626-8629 (1995)
   PUBMED   7567987
REFERENCE   7  (bases 1 to 5134)
  AUTHORS   Eaton,M.J., Gudehithlu,K.P., Quach,T., Silvia,C.P.,
            Hadjiconstantinou,M. and Neff,N.H.
  TITLE     Distribution of aromatic L-amino acid decarboxylase mRNA in mouse
            brain by in situ hybridization histology
  JOURNAL   J Comp Neurol 337 (4), 640-654 (1993)
   PUBMED   7904615
REFERENCE   8  (bases 1 to 5134)
  AUTHORS   Albert,V.R., Lee,M.R., Bolden,A.H., Wurzburger,R.J. and Aguanno,A.
  TITLE     Distinct promoters direct neuronal and nonneuronal expression of
            rat aromatic L-amino acid decarboxylase
  JOURNAL   Proc Natl Acad Sci U S A 89 (24), 12053-12057 (1992)
   PUBMED   1465439
REFERENCE   9  (bases 1 to 5134)
  AUTHORS   Tanaka,T., Horio,Y., Taketoshi,M., Imamura,I., Ando-Yamamoto,M.,
            Kangawa,K., Matsuo,H., Kuroda,M. and Wada,H.
  TITLE     Molecular cloning and sequencing of a cDNA of rat dopa
            decarboxylase: partial amino acid homologies with other enzymes
            synthesizing catecholamines
  JOURNAL   Proc Natl Acad Sci U S A 86 (20), 8142-8146 (1989)
   PUBMED   2813383
REFERENCE   10 (bases 1 to 5134)
  AUTHORS   Yamazaki,N. and Sudo,J.
  TITLE     Activities of aromatic L-amino acid decarboxylase with L-dopa as
            substrate in brush-border- and basolateral membranes and cytoplasm
            obtained from rat renal cortex
  JOURNAL   Jpn J Pharmacol 46 (2), 193-196 (1988)
   PUBMED   3379830
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            M27716.1 and JAXUCZ010000014.1.
            
            On Aug 4, 2012 this sequence version replaced NM_012545.3.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (a). Variants 1 and 3
            encode the same protein (isoform a).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ219697.1, SRR26360181.907442.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-65                M27716.1           1-65
            66-1951             M27716.1           71-1956
            1952-5134           JAXUCZ010000014.1  90592304-90595486   c
FEATURES             Location/Qualifiers
     source          1..5134
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14q21"
     gene            1..5134
                     /gene="Ddc"
                     /gene_synonym="AADC"
                     /note="dopa decarboxylase"
                     /db_xref="GeneID:24311"
                     /db_xref="RGD:2494"
     exon            1..65
                     /gene="Ddc"
                     /gene_synonym="AADC"
                     /inference="alignment:Splign:2.1.0"
     exon            66..274
                     /gene="Ddc"
                     /gene_synonym="AADC"
                     /inference="alignment:Splign:2.1.0"
     CDS             74..1516
                     /gene="Ddc"
                     /gene_synonym="AADC"
                     /EC_number="4.1.1.28"
                     /note="isoform a is encoded by transcript variant 1;
                     aromatic-L-amino-acid decarboxylase; L-Dopa decarboxylase;
                     dopa decarboxylase (aromatic L-amino acid decarboxylase)"
                     /codon_start=1
                     /product="aromatic-L-amino-acid decarboxylase isoform a"
                     /protein_id="NP_036677.1"
                     /db_xref="GeneID:24311"
                     /db_xref="RGD:2494"
                     /translation="MDSREFRRRGKEMVDYIADYLDGIEGRPVYPDVEPGYLRALIPT
                     TAPQEPETYEDIIRDIEKIIMPGVTHWHSPYFFAYFPTASSYPAMLADMLCGAIGCIG
                     FSWAASPACTELETVMMDWLGKMLELPEAFLAGRAGEGGGVIQGSASEATLVALLAAR
                     TKMIRQLQAASPELTQAALMEKLVAYTSDQAHSSVERAGLIGGVKIKAIPSDGNYSMR
                     AAALREALERDKAAGLIPFFVVVTLGTTSCCSFDNLLEVGPICNQEGVWLHIDAAYAG
                     SAFICPEFRYLLNGVEFADSFNFNPHKWLLVNFDCSAMWVKKRTDLTEAFNMDPVYLR
                     HSHQDSGLITDYRHWQIPLGRRFRSLKMWFVFRMYGVKGLQAYIRKHVKLSHEFESLV
                     RQDPRFEICTEVILGLVCFRLKGSNQLNETLLQRINSAKKIHLVPCRLRDKFVLRFAV
                     CSRTVESAHVQLAWEHIRDLASSVLRAEKE"
     exon            275..388
                     /gene="Ddc"
                     /gene_synonym="AADC"
                     /inference="alignment:Splign:2.1.0"
     exon            389..508
                     /gene="Ddc"
                     /gene_synonym="AADC"
                     /inference="alignment:Splign:2.1.0"
     exon            509..643
                     /gene="Ddc"
                     /gene_synonym="AADC"
                     /inference="alignment:Splign:2.1.0"
     exon            644..787
                     /gene="Ddc"
                     /gene_synonym="AADC"
                     /inference="alignment:Splign:2.1.0"
     exon            788..854
                     /gene="Ddc"
                     /gene_synonym="AADC"
                     /inference="alignment:Splign:2.1.0"
     exon            855..949
                     /gene="Ddc"
                     /gene_synonym="AADC"
                     /inference="alignment:Splign:2.1.0"
     exon            950..1017
                     /gene="Ddc"
                     /gene_synonym="AADC"
                     /inference="alignment:Splign:2.1.0"
     exon            1018..1094
                     /gene="Ddc"
                     /gene_synonym="AADC"
                     /inference="alignment:Splign:2.1.0"
     exon            1095..1114
                     /gene="Ddc"
                     /gene_synonym="AADC"
                     /inference="alignment:Splign:2.1.0"
     exon            1115..1213
                     /gene="Ddc"
                     /gene_synonym="AADC"
                     /inference="alignment:Splign:2.1.0"
     exon            1214..1315
                     /gene="Ddc"
                     /gene_synonym="AADC"
                     /inference="alignment:Splign:2.1.0"
     exon            1316..1533
                     /gene="Ddc"
                     /gene_synonym="AADC"
                     /inference="alignment:Splign:2.1.0"
     exon            1534..5134
                     /gene="Ddc"
                     /gene_synonym="AADC"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agttccaagc tgtagtttgc agagctggac tgagtggacc tgtgaagaat ccaaattcca
       61 aacaattttc aacatggatt cccgtgaatt ccggagaaga gggaaggaga tggtggatta
      121 tatagctgac tatctggacg gcattgaggg acgtccagtg taccctgacg tggagcctgg
      181 ctaccttcgg gccctgatcc ccaccactgc cccccaggag ccagaaacat atgaggacat
      241 aatcagagac attgaaaaga taatcatgcc aggggtcaca cactggcaca gcccctactt
      301 cttcgcttac ttccccacgg ccagctccta cccagctatg cttgcggaca tgctgtgcgg
      361 ggctatcggc tgcattggct tctcctgggc tgcaagccca gcatgcacag agctggagac
      421 agtgatgatg gattggctgg ggaagatgct tgagctgcca gaggcctttt tggctggaag
      481 agctggggaa gggggaggag tgatccaggg aagtgccagc gaagccacct tggtggccct
      541 actggctgct cggactaaaa tgatccgcca gctgcaggca gcctccccag agctgacaca
      601 agctgctctc atggaaaagc ttgtcgctta cacatctgat caggcacatt cctccgtaga
      661 aagagctgga ttaattggtg gagtcaaaat aaaagcaatt ccttcagatg gcaactactc
      721 catgagagct gctgcccttc gggaggccct ggagagagac aaggcggctg gcctgattcc
      781 tttcttcgtg gttgtcaccc taggaaccac atcttgctgc tcttttgaca atctcctaga
      841 agtgggtccc atctgcaacc aggagggtgt atggctgcac attgatgctg catacgcagg
      901 cagtgccttt atctgtcctg agttccggta tcttctgaat ggcgtggagt ttgcagattc
      961 ctttaacttt aatccccaca agtggctttt ggtgaatttt gactgctctg ccatgtgggt
     1021 gaagaagaga actgacctaa ccgaagcctt taatatggac cctgtttatc tgaggcacag
     1081 tcaccaggac tcaggactca tcactgacta caggcactgg caaatcccac tggggcgaag
     1141 atttcgctcc ctgaaaatgt ggtttgtttt tagaatgtac ggagtcaagg ggctgcaggc
     1201 ttacattcga aagcacgtga agctgtctca tgagtttgag tccctggtac gccaggaccc
     1261 tcgctttgaa atttgcacgg aagtcatcct cgggttggtc tgcttccggc taaagggctc
     1321 caaccagttg aacgaaactc tcttacaaag aataaacagc gccaaaaaaa tccacttggt
     1381 tccgtgtcgt ctccgagaca agtttgtgct gcgctttgcg gtgtgctccc gcactgtgga
     1441 gtctgcccac gtgcagctgg cctgggagca catccgagat ctagcgagca gtgtgctgag
     1501 ggcagagaaa gagtaaaagc agagccgctt cagagaccca aagttgaaaa aaagtttttc
     1561 cgaaaactgg gaagagaaaa ataaccaccc ctccgtcttc gtgaaatcat gcttgtatgt
     1621 ggcgtcatgt gtgtctccaa aattaaccag aaactgctga ttgacttttc agtgacttct
     1681 caatgaagaa atactttctg cattatccag ggaaagtatt aatctgtgtg gaaattaaca
     1741 ccagtggctc tagcttctgt tctttgtgtg gccgtgattt ttgttgataa taagatgtct
     1801 cagtgttcat aaagccgtag gtggtagaaa aggcttatag aaatattttc tagggtggtt
     1861 tttggtcttt cttgccttca gatgatatct ctggctgtta acttgtcctc tgtgtggcta
     1921 aatacttaat aaacaacccg tgtgcaatac taaccgcgtt gagtcagttt tacactgtat
     1981 tagactcatt ctcgtgaacc taactgactc tttcagacat tttgtcacca tgtgtttagt
     2041 gagagtctgg tatatgtcag tcaccattca gaatcattaa caacacagca cgttctgctt
     2101 agagttcatg aattcaattt ataaaatcat tctggtttta gaggaatgtt atttttggta
     2161 ggtttatttt taagtgtgtg tgtgtgtgtt gctcatggag gccagaagag gccatcagat
     2221 cctctggagc tagagttata ggtagttata acccatctaa ttgtaggtgc gaaaaaccaa
     2281 gtaggttttc tagaagagca gtgtgcactc tttgctactt agccacctcc ccagtcccaa
     2341 catatgtgta tttttgtcct ttgaagactt tagaattgca gatggcattc ccgtgaggtc
     2401 cttgtgttat tagcaggtgt ggtggtttta tattgagtgt cccttgacag gatctagaat
     2461 catccaggag acatgccccc agggaatctc gaatttaggt tgcctatgat tatattgatt
     2521 atgttacttg aggtggtgaa aaacacccct agtgtgggtg gcatcattcc ttgggcctgg
     2581 gtcctagact gtacaaattg gacgtagggg ttatctaaaa ggctggagta tttcgtttta
     2641 aagttgtctg aatctttagg gaatagagtc ttagatctca gcttatgtcc aaacccagga
     2701 agaatacagt cttgtctaac cgtggcttat ttttagtctt actaagagct tctactgcta
     2761 tgataaaaca ccatgatcaa aagcaactag ggaaggaaag ggttgatttg actcacactt
     2821 ccacatcaca gcccatcaat gaaagaagtc aaggaagtaa ttcagggcag gaactgatgg
     2881 ttccacactt gtgcaatctg aggaaagtaa atcagtgagc agttcctcca tccctctgct
     2941 tcagaccatg cctctatatt cttgctttga gttcctgact agacttccct tgataatgga
     3001 ccgtaagctg taagaggaaa taaactcttt tctccccaag ttgcctctga tcatggtatt
     3061 tatcacaaca aaaagcagac taggagagag tcttctcagg ataggtgaca gtgggggaca
     3121 tttgatgctt atgggacaag gtccatttta tctgcctggg taaatcttgc cttttattcc
     3181 agctatacat tatccacata gaactcagta tttcaaagcc aggtgctgca cccctttagt
     3241 cccagcgctt aaggagccag aagcaggcag gctgatctct tgagttcgag gccaccctgg
     3301 tctataaagt gagttgcagt acagtcaagg ctacacagag aaaccttgtc ttgaaaaatc
     3361 aaaaccaacc aaacaaaaga gaattgagaa cgcctggacg tgtagcacgt gcatttaaat
     3421 ctgtgcttag tgcagttgct cgctggagta cagtgacctc tggtggcaat gatgctagat
     3481 gctgcctgtg tgacctcagg tgtttgcgga ttgcagacac ttctaccggg agttgagaaa
     3541 gccctagact tatcgggaca cagcagaaag ccaacaaaag acttatcctg gaacatctct
     3601 tgtctgcaat gtagcaaaga acagtcttcc tggaactgga gacccaagtc aagctgaata
     3661 cctaccagtc agcatacgga aaagccggag ctaggacaag gagctgccac cttgtggcct
     3721 catcatcatc ttgaggacaa gggaaaggga tataggagaa gaccccaagg aaaggcaggg
     3781 ctgaactttg aactagggaa tccaatcgat ggtataaatt gaaaaatgat cttattggta
     3841 ttctacagtt gaggaaacat ggtgcttacc ctatagcgtt ttggctgaaa ggatttcttt
     3901 attgtttttt tcataataat ataaactcct aaatattaat tgttttcact cgtttggtat
     3961 caaaatctgt ttcccaagca cctctctagg cgtaccataa catacccttg taaaaagtag
     4021 tgggaaaaat aatacagaat cactagcagc gtaagttgct cgcataaact ggtaatattt
     4081 gaaaaggtct ttttaaagaa actcgtgtgg ttctcaaaag cagacatgca ataaacagtt
     4141 gcaggaagaa ttatggtatg cccccatcgc ctgctcaaac cagaagcaga aggatccaca
     4201 catggaccag tttttcctaa acacaggaaa ttcacagcag ccagaggcca aaatacctca
     4261 gcttgattaa gtccctctgc tctaacctcg caagaaaagt gggctgaagt aagctgatat
     4321 caacctgtta ggtcctttcc aacagtctcg gctccctgct ttacggagct ggcccttctg
     4381 ttcctgccca gtacaagttc tcattctatt ctgtacagtg aagagggttg cttcactcat
     4441 gaatataaag gctaaggaga actttgtcag acttgttaaa attctgtctc tggttgtagg
     4501 ggagaacacc agctaatgaa aacttttcat cacgactgta cattccattc acgttaggct
     4561 accctgtatc caagggatgg ctggatctcc aatcttcact gggtctcttt caccaaggca
     4621 ggtctgcagt ggaaagctgt ggccgtcagg agaattccag ccatattcag ggaatctcag
     4681 agaaaagagc cagatttaat tttgtcccat cttctctcct atctctacaa cagtctactt
     4741 ctcacactgc ctacaaacat attttacaaa acaaaacaaa aaaccaaaat ccattattat
     4801 tgtgtgtttg tatgatgggt agaaaaaagc acacacacca agaggtcaaa ggacaactgt
     4861 gtggaatcgt tttttttttt tttctccttc cacttcttca tgggttctga aaatcaaact
     4921 aaggtcaccg ggtttgcaca gtaaacatct ttacctgaga tatcttgcta gccccccaaa
     4981 tacatttttt tttctggaag aggatgccta ttacttggga tcattttatt tctccgatca
     5041 aaacaaatta gccaactgaa ctgtacacag gcattgtctg agattacgtt tagaaactca
     5101 taaacacata aacaataaac tctcccacca agga
//
