LOCUS       NM_001270852            5094 bp    mRNA    linear   ROD 27-MAR-2024
DEFINITION  Rattus norvegicus dopa decarboxylase (Ddc), transcript variant 3,
            mRNA.
ACCESSION   NM_001270852
VERSION     NM_001270852.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5094)
  AUTHORS   Seo,D.C., Ju,Y.H., Seo,J.J., Oh,S.J., Lee,C.J., Lee,S.E. and
            Nam,M.H.
  TITLE     DDC-Promoter-Driven Chemogenetic Activation of SNpc Dopaminergic
            Neurons Alleviates Parkinsonian Motor Symptoms
  JOURNAL   Int J Mol Sci 24 (3), 2491 (2023)
   PUBMED   36768816
  REMARK    GeneRIF: DDC-Promoter-Driven Chemogenetic Activation of SNpc
            Dopaminergic Neurons Alleviates Parkinsonian Motor Symptoms.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5094)
  AUTHORS   Sizova,D., Velazquez,H., Sampaio-Maia,B., Quelhas-Santos,J.,
            Pestana,M. and Desir,G.V.
  TITLE     Renalase regulates renal dopamine and phosphate metabolism
  JOURNAL   Am J Physiol Renal Physiol 305 (6), F839-F844 (2013)
   PUBMED   23863468
REFERENCE   3  (bases 1 to 5094)
  AUTHORS   Voigt,A., Hubner,S., Lossow,K., Hermans-Borgmeyer,I., Boehm,U. and
            Meyerhof,W.
  TITLE     Genetic labeling of Tas1r1 and Tas2r131 taste receptor cells in
            mice
  JOURNAL   Chem Senses 37 (9), 897-911 (2012)
   PUBMED   23010799
REFERENCE   4  (bases 1 to 5094)
  AUTHORS   Rouzaud-Laborde,C., Hanoun,N., Baysal,I., Rech,J.S., Mias,C.,
            Calise,D., Sicard,P., Frugier,C., Seguelas,M.H., Parini,A. and
            Pizzinat,N.
  TITLE     Role of endothelial AADC in cardiac synthesis of serotonin and
            nitrates accumulation
  JOURNAL   PLoS One 7 (7), e34893 (2012)
   PUBMED   22829864
  REMARK    GeneRIF: The data show that endothelial AADC plays an important
            role in cardiac synthesis of 5-HT and possibly in 5-HT-dependent
            regulation of nitric oxide generation.
REFERENCE   5  (bases 1 to 5094)
  AUTHORS   Brun,L., Ngu,L.H., Keng,W.T., Ch'ng,G.S., Choy,Y.S., Hwu,W.L.,
            Lee,W.T., Willemsen,M.A., Verbeek,M.M., Wassenberg,T., Regal,L.,
            Orcesi,S., Tonduti,D., Accorsi,P., Testard,H., Abdenur,J.E.,
            Tay,S., Allen,G.F., Heales,S., Kern,I., Kato,M., Burlina,A.,
            Manegold,C., Hoffmann,G.F. and Blau,N.
  TITLE     Clinical and biochemical features of aromatic L-amino acid
            decarboxylase deficiency
  JOURNAL   Neurology 75 (1), 64-71 (2010)
   PUBMED   20505134
  REMARK    Erratum:[Neurology. 2010 Aug 10;75(6):576. Dosage error in article
            text]
REFERENCE   6  (bases 1 to 5094)
  AUTHORS   Rorsman,F., Husebye,E.S., Winqvist,O., Bjork,E., Karlsson,F.A. and
            Kampe,O.
  TITLE     Aromatic-L-amino-acid decarboxylase, a pyridoxal
            phosphate-dependent enzyme, is a beta-cell autoantigen
  JOURNAL   Proc Natl Acad Sci U S A 92 (19), 8626-8629 (1995)
   PUBMED   7567987
REFERENCE   7  (bases 1 to 5094)
  AUTHORS   Eaton,M.J., Gudehithlu,K.P., Quach,T., Silvia,C.P.,
            Hadjiconstantinou,M. and Neff,N.H.
  TITLE     Distribution of aromatic L-amino acid decarboxylase mRNA in mouse
            brain by in situ hybridization histology
  JOURNAL   J Comp Neurol 337 (4), 640-654 (1993)
   PUBMED   7904615
REFERENCE   8  (bases 1 to 5094)
  AUTHORS   Albert,V.R., Lee,M.R., Bolden,A.H., Wurzburger,R.J. and Aguanno,A.
  TITLE     Distinct promoters direct neuronal and nonneuronal expression of
            rat aromatic L-amino acid decarboxylase
  JOURNAL   Proc Natl Acad Sci U S A 89 (24), 12053-12057 (1992)
   PUBMED   1465439
REFERENCE   9  (bases 1 to 5094)
  AUTHORS   Tanaka,T., Horio,Y., Taketoshi,M., Imamura,I., Ando-Yamamoto,M.,
            Kangawa,K., Matsuo,H., Kuroda,M. and Wada,H.
  TITLE     Molecular cloning and sequencing of a cDNA of rat dopa
            decarboxylase: partial amino acid homologies with other enzymes
            synthesizing catecholamines
  JOURNAL   Proc Natl Acad Sci U S A 86 (20), 8142-8146 (1989)
   PUBMED   2813383
REFERENCE   10 (bases 1 to 5094)
  AUTHORS   Yamazaki,N. and Sudo,J.
  TITLE     Activities of aromatic L-amino acid decarboxylase with L-dopa as
            substrate in brush-border- and basolateral membranes and cytoplasm
            obtained from rat renal cortex
  JOURNAL   Jpn J Pharmacol 46 (2), 193-196 (1988)
   PUBMED   3379830
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000014.1 and M27716.1.
            
            Transcript Variant: This variant (3) differs in the 5' UTR compared
            to variant 1. Variants 1 and 3 encode the same protein (isoform a).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC087032.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-25                JAXUCZ010000014.1  90665796-90665820   c
            26-1911             M27716.1           71-1956
            1912-5094           JAXUCZ010000014.1  90592304-90595486   c
FEATURES             Location/Qualifiers
     source          1..5094
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14q21"
     gene            1..5094
                     /gene="Ddc"
                     /gene_synonym="AADC"
                     /note="dopa decarboxylase"
                     /db_xref="GeneID:24311"
                     /db_xref="RGD:2494"
     exon            1..25
                     /gene="Ddc"
                     /gene_synonym="AADC"
                     /inference="alignment:Splign:2.1.0"
     exon            26..234
                     /gene="Ddc"
                     /gene_synonym="AADC"
                     /inference="alignment:Splign:2.1.0"
     CDS             34..1476
                     /gene="Ddc"
                     /gene_synonym="AADC"
                     /EC_number="4.1.1.28"
                     /note="isoform a is encoded by transcript variant 3;
                     aromatic-L-amino-acid decarboxylase; L-Dopa decarboxylase;
                     dopa decarboxylase (aromatic L-amino acid decarboxylase)"
                     /codon_start=1
                     /product="aromatic-L-amino-acid decarboxylase isoform a"
                     /protein_id="NP_001257781.1"
                     /db_xref="GeneID:24311"
                     /db_xref="RGD:2494"
                     /translation="MDSREFRRRGKEMVDYIADYLDGIEGRPVYPDVEPGYLRALIPT
                     TAPQEPETYEDIIRDIEKIIMPGVTHWHSPYFFAYFPTASSYPAMLADMLCGAIGCIG
                     FSWAASPACTELETVMMDWLGKMLELPEAFLAGRAGEGGGVIQGSASEATLVALLAAR
                     TKMIRQLQAASPELTQAALMEKLVAYTSDQAHSSVERAGLIGGVKIKAIPSDGNYSMR
                     AAALREALERDKAAGLIPFFVVVTLGTTSCCSFDNLLEVGPICNQEGVWLHIDAAYAG
                     SAFICPEFRYLLNGVEFADSFNFNPHKWLLVNFDCSAMWVKKRTDLTEAFNMDPVYLR
                     HSHQDSGLITDYRHWQIPLGRRFRSLKMWFVFRMYGVKGLQAYIRKHVKLSHEFESLV
                     RQDPRFEICTEVILGLVCFRLKGSNQLNETLLQRINSAKKIHLVPCRLRDKFVLRFAV
                     CSRTVESAHVQLAWEHIRDLASSVLRAEKE"
     exon            235..348
                     /gene="Ddc"
                     /gene_synonym="AADC"
                     /inference="alignment:Splign:2.1.0"
     exon            349..468
                     /gene="Ddc"
                     /gene_synonym="AADC"
                     /inference="alignment:Splign:2.1.0"
     exon            469..603
                     /gene="Ddc"
                     /gene_synonym="AADC"
                     /inference="alignment:Splign:2.1.0"
     exon            604..747
                     /gene="Ddc"
                     /gene_synonym="AADC"
                     /inference="alignment:Splign:2.1.0"
     exon            748..814
                     /gene="Ddc"
                     /gene_synonym="AADC"
                     /inference="alignment:Splign:2.1.0"
     exon            815..909
                     /gene="Ddc"
                     /gene_synonym="AADC"
                     /inference="alignment:Splign:2.1.0"
     exon            910..977
                     /gene="Ddc"
                     /gene_synonym="AADC"
                     /inference="alignment:Splign:2.1.0"
     exon            978..1054
                     /gene="Ddc"
                     /gene_synonym="AADC"
                     /inference="alignment:Splign:2.1.0"
     exon            1055..1074
                     /gene="Ddc"
                     /gene_synonym="AADC"
                     /inference="alignment:Splign:2.1.0"
     exon            1075..1173
                     /gene="Ddc"
                     /gene_synonym="AADC"
                     /inference="alignment:Splign:2.1.0"
     exon            1174..1275
                     /gene="Ddc"
                     /gene_synonym="AADC"
                     /inference="alignment:Splign:2.1.0"
     exon            1276..1493
                     /gene="Ddc"
                     /gene_synonym="AADC"
                     /inference="alignment:Splign:2.1.0"
     exon            1494..5094
                     /gene="Ddc"
                     /gene_synonym="AADC"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 accatcctca tctctcagct gaaagttttc aacatggatt cccgtgaatt ccggagaaga
       61 gggaaggaga tggtggatta tatagctgac tatctggacg gcattgaggg acgtccagtg
      121 taccctgacg tggagcctgg ctaccttcgg gccctgatcc ccaccactgc cccccaggag
      181 ccagaaacat atgaggacat aatcagagac attgaaaaga taatcatgcc aggggtcaca
      241 cactggcaca gcccctactt cttcgcttac ttccccacgg ccagctccta cccagctatg
      301 cttgcggaca tgctgtgcgg ggctatcggc tgcattggct tctcctgggc tgcaagccca
      361 gcatgcacag agctggagac agtgatgatg gattggctgg ggaagatgct tgagctgcca
      421 gaggcctttt tggctggaag agctggggaa gggggaggag tgatccaggg aagtgccagc
      481 gaagccacct tggtggccct actggctgct cggactaaaa tgatccgcca gctgcaggca
      541 gcctccccag agctgacaca agctgctctc atggaaaagc ttgtcgctta cacatctgat
      601 caggcacatt cctccgtaga aagagctgga ttaattggtg gagtcaaaat aaaagcaatt
      661 ccttcagatg gcaactactc catgagagct gctgcccttc gggaggccct ggagagagac
      721 aaggcggctg gcctgattcc tttcttcgtg gttgtcaccc taggaaccac atcttgctgc
      781 tcttttgaca atctcctaga agtgggtccc atctgcaacc aggagggtgt atggctgcac
      841 attgatgctg catacgcagg cagtgccttt atctgtcctg agttccggta tcttctgaat
      901 ggcgtggagt ttgcagattc ctttaacttt aatccccaca agtggctttt ggtgaatttt
      961 gactgctctg ccatgtgggt gaagaagaga actgacctaa ccgaagcctt taatatggac
     1021 cctgtttatc tgaggcacag tcaccaggac tcaggactca tcactgacta caggcactgg
     1081 caaatcccac tggggcgaag atttcgctcc ctgaaaatgt ggtttgtttt tagaatgtac
     1141 ggagtcaagg ggctgcaggc ttacattcga aagcacgtga agctgtctca tgagtttgag
     1201 tccctggtac gccaggaccc tcgctttgaa atttgcacgg aagtcatcct cgggttggtc
     1261 tgcttccggc taaagggctc caaccagttg aacgaaactc tcttacaaag aataaacagc
     1321 gccaaaaaaa tccacttggt tccgtgtcgt ctccgagaca agtttgtgct gcgctttgcg
     1381 gtgtgctccc gcactgtgga gtctgcccac gtgcagctgg cctgggagca catccgagat
     1441 ctagcgagca gtgtgctgag ggcagagaaa gagtaaaagc agagccgctt cagagaccca
     1501 aagttgaaaa aaagtttttc cgaaaactgg gaagagaaaa ataaccaccc ctccgtcttc
     1561 gtgaaatcat gcttgtatgt ggcgtcatgt gtgtctccaa aattaaccag aaactgctga
     1621 ttgacttttc agtgacttct caatgaagaa atactttctg cattatccag ggaaagtatt
     1681 aatctgtgtg gaaattaaca ccagtggctc tagcttctgt tctttgtgtg gccgtgattt
     1741 ttgttgataa taagatgtct cagtgttcat aaagccgtag gtggtagaaa aggcttatag
     1801 aaatattttc tagggtggtt tttggtcttt cttgccttca gatgatatct ctggctgtta
     1861 acttgtcctc tgtgtggcta aatacttaat aaacaacccg tgtgcaatac taaccgcgtt
     1921 gagtcagttt tacactgtat tagactcatt ctcgtgaacc taactgactc tttcagacat
     1981 tttgtcacca tgtgtttagt gagagtctgg tatatgtcag tcaccattca gaatcattaa
     2041 caacacagca cgttctgctt agagttcatg aattcaattt ataaaatcat tctggtttta
     2101 gaggaatgtt atttttggta ggtttatttt taagtgtgtg tgtgtgtgtt gctcatggag
     2161 gccagaagag gccatcagat cctctggagc tagagttata ggtagttata acccatctaa
     2221 ttgtaggtgc gaaaaaccaa gtaggttttc tagaagagca gtgtgcactc tttgctactt
     2281 agccacctcc ccagtcccaa catatgtgta tttttgtcct ttgaagactt tagaattgca
     2341 gatggcattc ccgtgaggtc cttgtgttat tagcaggtgt ggtggtttta tattgagtgt
     2401 cccttgacag gatctagaat catccaggag acatgccccc agggaatctc gaatttaggt
     2461 tgcctatgat tatattgatt atgttacttg aggtggtgaa aaacacccct agtgtgggtg
     2521 gcatcattcc ttgggcctgg gtcctagact gtacaaattg gacgtagggg ttatctaaaa
     2581 ggctggagta tttcgtttta aagttgtctg aatctttagg gaatagagtc ttagatctca
     2641 gcttatgtcc aaacccagga agaatacagt cttgtctaac cgtggcttat ttttagtctt
     2701 actaagagct tctactgcta tgataaaaca ccatgatcaa aagcaactag ggaaggaaag
     2761 ggttgatttg actcacactt ccacatcaca gcccatcaat gaaagaagtc aaggaagtaa
     2821 ttcagggcag gaactgatgg ttccacactt gtgcaatctg aggaaagtaa atcagtgagc
     2881 agttcctcca tccctctgct tcagaccatg cctctatatt cttgctttga gttcctgact
     2941 agacttccct tgataatgga ccgtaagctg taagaggaaa taaactcttt tctccccaag
     3001 ttgcctctga tcatggtatt tatcacaaca aaaagcagac taggagagag tcttctcagg
     3061 ataggtgaca gtgggggaca tttgatgctt atgggacaag gtccatttta tctgcctggg
     3121 taaatcttgc cttttattcc agctatacat tatccacata gaactcagta tttcaaagcc
     3181 aggtgctgca cccctttagt cccagcgctt aaggagccag aagcaggcag gctgatctct
     3241 tgagttcgag gccaccctgg tctataaagt gagttgcagt acagtcaagg ctacacagag
     3301 aaaccttgtc ttgaaaaatc aaaaccaacc aaacaaaaga gaattgagaa cgcctggacg
     3361 tgtagcacgt gcatttaaat ctgtgcttag tgcagttgct cgctggagta cagtgacctc
     3421 tggtggcaat gatgctagat gctgcctgtg tgacctcagg tgtttgcgga ttgcagacac
     3481 ttctaccggg agttgagaaa gccctagact tatcgggaca cagcagaaag ccaacaaaag
     3541 acttatcctg gaacatctct tgtctgcaat gtagcaaaga acagtcttcc tggaactgga
     3601 gacccaagtc aagctgaata cctaccagtc agcatacgga aaagccggag ctaggacaag
     3661 gagctgccac cttgtggcct catcatcatc ttgaggacaa gggaaaggga tataggagaa
     3721 gaccccaagg aaaggcaggg ctgaactttg aactagggaa tccaatcgat ggtataaatt
     3781 gaaaaatgat cttattggta ttctacagtt gaggaaacat ggtgcttacc ctatagcgtt
     3841 ttggctgaaa ggatttcttt attgtttttt tcataataat ataaactcct aaatattaat
     3901 tgttttcact cgtttggtat caaaatctgt ttcccaagca cctctctagg cgtaccataa
     3961 catacccttg taaaaagtag tgggaaaaat aatacagaat cactagcagc gtaagttgct
     4021 cgcataaact ggtaatattt gaaaaggtct ttttaaagaa actcgtgtgg ttctcaaaag
     4081 cagacatgca ataaacagtt gcaggaagaa ttatggtatg cccccatcgc ctgctcaaac
     4141 cagaagcaga aggatccaca catggaccag tttttcctaa acacaggaaa ttcacagcag
     4201 ccagaggcca aaatacctca gcttgattaa gtccctctgc tctaacctcg caagaaaagt
     4261 gggctgaagt aagctgatat caacctgtta ggtcctttcc aacagtctcg gctccctgct
     4321 ttacggagct ggcccttctg ttcctgccca gtacaagttc tcattctatt ctgtacagtg
     4381 aagagggttg cttcactcat gaatataaag gctaaggaga actttgtcag acttgttaaa
     4441 attctgtctc tggttgtagg ggagaacacc agctaatgaa aacttttcat cacgactgta
     4501 cattccattc acgttaggct accctgtatc caagggatgg ctggatctcc aatcttcact
     4561 gggtctcttt caccaaggca ggtctgcagt ggaaagctgt ggccgtcagg agaattccag
     4621 ccatattcag ggaatctcag agaaaagagc cagatttaat tttgtcccat cttctctcct
     4681 atctctacaa cagtctactt ctcacactgc ctacaaacat attttacaaa acaaaacaaa
     4741 aaaccaaaat ccattattat tgtgtgtttg tatgatgggt agaaaaaagc acacacacca
     4801 agaggtcaaa ggacaactgt gtggaatcgt tttttttttt tttctccttc cacttcttca
     4861 tgggttctga aaatcaaact aaggtcaccg ggtttgcaca gtaaacatct ttacctgaga
     4921 tatcttgcta gccccccaaa tacatttttt tttctggaag aggatgccta ttacttggga
     4981 tcattttatt tctccgatca aaacaaatta gccaactgaa ctgtacacag gcattgtctg
     5041 agattacgtt tagaaactca taaacacata aacaataaac tctcccacca agga
//
